The Eeffect of Comparative Exercise Intensity on Lipid Peroxidation and Antioxidant System of Heart Tissue in Sprague - Dawley Rats

2002 ◽  
Vol 17 ◽  
pp. 297-308
Author(s):  
Jin Hwan Yoon ◽  
Hae Jin Park ◽  
Hui Hyuk Lee ◽  
Eun Mi Im ◽  
Young Suk Ji
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant System ◽  
Exercise Intensity ◽  
Heart Tissue ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effect of Introducing the Jordanian Common Rue (Ruta chalepensis L.) on Liver Enzymes and Lipid Peroxidation in Adult Male Sprague Dawley Rats Toxified With Paracetamol

2020 ◽  
Vol 12 (4) ◽  
pp. 298
Author(s):  
Dana N. Abdelrahim ◽  
Hamed R. Takruri ◽  
Khalid M. Al-Ismail
Keyword(s):  
Lipid Peroxidation ◽  
Hepatic Injury ◽  
Liver Enzymes ◽  
Liver Weight ◽  
Normal Diet ◽  
High Cholesterol Diet ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
Ruta Chalepensis ◽  
Sprague Dawley Rats

This study aimed to determine the effect of Ruta chalepensis L. plant on liver enzymes, liver weight and lipid peroxidation using rats toxified with paracetamol. An animal experiment was conducted using five groups of Sprague Dawley rats, 9 rats each. The groups were fed: Normal diet, high cholesterol diet, with or without the plant or the liver toxicant paracetamol (PCM). The experiment lasted six weeks; at the end of the sixth week; a single dose of 3 g paracetamol/kg body weight was given for rats of two groups, then blood and liver samples were collected. The hepatoprotective effect of the plant was evaluated using aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBL) levels as indicators. This study finds that the groups to which plant and PCM were given had significantly lower MDA levels in comparison with other groups that didn’t receive plant before PCM toxification. Tested liver enzymes levels were significantly (P < 0.05) lowered by the introduction of plant to the diet. Introducing PCM without ingestion of plant in the diet significantly (P < 0.05) increased the rats absolute liver weight. It is concluded that the use of Ruta chalepensis L. plant significantly lowered hepatic toxicity as indicated by the liver enzymes levels. Also, the plant lowered the MDA level and liver weight. The ingestion of the plant can be significantly protective against hepatic injury.

Effects of99mTc sestamibi on antioxidant defense system and lipid peroxidation in the heart of Sprague Dawley rats

2012 ◽  
Vol 30 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Gokhan Cesur ◽  
Duygu Kumbul Doguc ◽  
Mustafa Yildiz ◽  
Serdal Ogut ◽  
Mumin Polat ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

Open Medicine ◽  
2009 ◽  
Vol 4 (2) ◽  
pp. 184-191 ◽  
Author(s):  
Kerim Cayir ◽  
Ali Karadeniz ◽  
Abdulkadir Yildirim ◽  
Yildiray Kalkan ◽  
Akar Karakoc ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Therapeutic Potential ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Glutathione S Transferase ◽  
Kidney Dysfunction ◽  
Degree Of Protection ◽  
Sprague Dawley Rats ◽  
Liver And Kidney ◽  
Endogenous Antioxidants

AbstractThe present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.

Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training

1988 ◽  
Vol 64 (4) ◽  
pp. 1333-1336 ◽  
Author(s):  
H. M. Alessio ◽  
A. H. Goldfarb
Keyword(s):  
Lipid Peroxidation ◽  
Endurance Training ◽  
Acute Exercise ◽  
Oxidative Capacity ◽  
Treadmill Running ◽  
Moderate Intensity ◽  
Sprague Dawley ◽  
Moderate Intensity Exercise ◽  
Sod Activity ◽  
Sprague Dawley Rats

This study was designed to determine whether endurance training would influence the production of lipid peroxidation (LI-POX) by-products as indicated by malondialdehyde (MDA) at rest and after an acute exercise run. Additionally, the scavenger enzymes catalase (CAT) and superoxide dismutase (SOD) were examined to determine whether changes in LIPOX are associated with alterations in enzyme activity both at rest and after exercise. Male Sprague-Dawley rats (n = 32) were randomly assigned to either trained or sedentary groups and were killed either at rest or after 20 min of treadmill running. The training program increased oxidative capacity 64% in leg muscle. After exercise, the sedentary group demonstrated increased LIPOX levels in liver and white skeletal muscle, whereas the endurance-trained group did not show increases in LIPOX after exercise. CAT activity was higher in both red and white muscle after exercise in the trained animals. Total SOD activity was unaffected by either acute or chronic exercise. These data suggest that endurance training can result in a reduction in LIPOX levels as indicated by MDA during moderate-intensity exercise. It is possible that activation of the enzyme catalase and the increase in respiratory capacity were contributory factors responsible for regulating LIPOX after training during exercise.

scholarly journals HEPATOPROTECTIVE ACTIVITY OF MERREMIA BORNEENSIS AGAINST CARBON TETRACHLORIDE (CCl4)-INDUCED ACUTE LIVER DAMAGE IN RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL EVALUATION

2020 ◽  
pp. 41-45
Author(s):  
MOHAMMAD IQBAL ◽  
MUHAMMAD DAWOOD SHAH ◽  
SENTY VUN-SANG ◽  
RIANA BINTI AWANG SAMAN
Keyword(s):  
Lipid Peroxidation ◽  
Carbon Tetrachloride ◽  
Oxidative Damage ◽  
Histopathological Change ◽  
Hepatoprotective Activity ◽  
Quinone Reductase ◽  
Sprague Dawley ◽  
Glutathione S Transferase ◽  
Sprague Dawley Rats ◽  
Glutamyl Transpeptidase

Objective: The pathogenesis of various liver injuries involves oxidative damage. This research was planned to examine the effects of Mereemia borneensis extract on hepatic oxidative damage caused by carbon tetrachloride (CCl4) in rats. Methods: Sprague Dawley rats were exposed to M. borneensis (125 and 250 mg/kg b. wt.) once daily for 14 d followed by two doses of CCl4 (1.2 ml/kg b. wt.). After 2 w, the rats were sacrificed and hepatoprotective analysis was done. Results: Orally administration of CCl4 enhances serum transaminase (ALT; alanine transaminase and AST; aspartate transaminase), γ-glutamyl transpeptidase, lipid peroxidation, reduction in glutathione, catalase, glutathione reductase, glutathione peroxidase, quinone reductase and glutathione S-transferase. Pretreatment of rats with M. borneensis at 125 and 250 mg/kg body weight significantly reduced levels of ALT, AST, γ-glutamyl transpeptidase and lipid peroxidation of CCl4 treated rats. Pretreatment with M. borneensis against rats treated with CCl4, hepatic enzymatic and non-enzymatic antioxidant molecules have increased significantly. A decreased histopathological change in the liver is further evidence of the protective effect of M. borneensis. Conclusion: Our data suggest that M. borneensis can be a potential hepatoprotective agent in preventing or treating degenerative diseases that involve oxidative stress.

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