scholarly journals The Value of Postoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 Levels for the Early Detection of Gastric Cancer Recurrence after Curative Resection

2014 ◽  
Vol 14 (4) ◽  
pp. 221 ◽  
Author(s):  
Eung-Chang Lee ◽  
Jun-Young Yang ◽  
Kyung-Goo Lee ◽  
Seung-Young Oh ◽  
Yun-Suhk Suh ◽  
...  
1990 ◽  
Vol 14 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Masashi Kodama ◽  
Kenji Koyama ◽  
Yukio Tsuburaya ◽  
Kouichi Ishikawa ◽  
Hirofumi Koyama ◽  
...  

Surgery Today ◽  
2016 ◽  
Vol 47 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Noriko Wada ◽  
Yukinori Kurokawa ◽  
Yasuhiro Miyazaki ◽  
Tomoki Makino ◽  
Tsuyoshi Takahashi ◽  
...  

2003 ◽  
Vol 21 (12) ◽  
pp. 2282-2287 ◽  
Author(s):  
Atsushi Nashimoto ◽  
Toshifusa Nakajima ◽  
Hiroshi Furukawa ◽  
Masatsugu Kitamura ◽  
Taira Kinoshita ◽  
...  

Purpose: To evaluate the survival benefit of adjuvant chemotherapy after curative resection in serosa-negative gastric cancer patients (excluding patients who were T1N0), we conducted a multicenter phase III clinical trial in which 13 cancer centers in Japan participated. Patients and Methods: From January 1993 to December 1994, 252 patients were enrolled into the study and allocated randomly to adjuvant chemotherapy or surgery alone. The chemotherapy comprised intravenous mitomycin 1.33 mg/m2, fluorouracil (FU) 166.7 mg/m2, and cytarabine 13.3 mg/m2 twice weekly for the first 3 weeks after surgery, and oral FU 134 mg/m2 daily for the next 18 months for a total dose of 67 g/m2. The primary end point was relapse-free survival. Overall survival and the site of recurrence were secondary end points. Results: Ninety-eight percent of patients underwent gastrectomy with D2 or greater lymph node dissection. There were no treatment-related deaths and few serious adverse events. There was no significant difference in relapse-free and overall survival between the arms (5-year relapse-free survival 88.8% chemotherapy v 83.7% surgery alone; P = .14 and 5-year survival 91.2% chemotherapy v 86.1% surgery alone; P = .13, respectively). Nine patients (7.1%) in the chemotherapy arm and 17 patients (13.8%) in the surgery-alone arm had cancer recurrence. Conclusion: There was no statistically significant relapse-free or overall survival benefit with this adjuvant chemotherapy for patients with macroscopically serosa-negative gastric cancer after curative resection, and there was no statistical difference between the two arms relating to the types of cancer recurrence. We do not recommend adjuvant chemotherapy with this regimen for this population in clinical practice.


2013 ◽  
Vol 24 ◽  
pp. iv56
Author(s):  
Fatima Zahra Hijri ◽  
Adil Najdi ◽  
Samia Arifi ◽  
Nawfel Mellas ◽  
Mohamed Amine Berraho ◽  
...  

2006 ◽  
Vol 52 (3) ◽  
pp. 382-389
Author(s):  
HIRONOBU SENGOKU ◽  
TOMOO WATANABE ◽  
NAOKI NEGAMI ◽  
YUKIHIRO YAGINUMA ◽  
MAKOTO TAKAHASHI ◽  
...  

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