scholarly journals The effect of different intensities Resistance Training on expression mir-204 and transcription factors of osteogenic, Runx2 and biomechanical properties on bone in Old male Wistar rats

2021 ◽  
Vol 14 (1) ◽  
pp. 38-48
Author(s):  
ZAHRA HEMATI FARSANI ◽  
Ebrahim Banitalebi ◽  
Mohamad Faramarzi ◽  
Amin Bigham-Sadegh
Keyword(s):  
Transcription Factors ◽  
Resistance Training ◽  
Wistar Rats ◽  
Biomechanical Properties ◽  
Male Wistar Rats

scholarly journals EFFECT OF LOVASTATIN NANO DRUG DELIVERY SYSTEM ON BONE MINERAL DENSITY (BMD) AND BIOMECHANICAL PROPERTIES OF TIBIA BONES OF WISTAR RATS

2019 ◽  
pp. 42-48
Author(s):  
RAMANDEEP KAUR ◽  
Makula Ajitha
Keyword(s):  
Wistar Rats ◽  
Type I Collagen ◽  
Biomechanical Properties ◽  
Type I ◽  
Mineral Density ◽  
Bone Specific Alkaline Phosphatase ◽  
Type I Procollagen ◽  
Nanoemulsion Gel ◽  
Male Wistar Rats

Objective: In the present study, transdermal nanoemulsion (NE) gel of lovastatin was investigated for its anti-osteoporosis effect on the long bones of rat i.e. tibia. Methods: Male wistar rats (n=30, weighing 180-200g) were taken for this study and grouped as: 1) control (normal saline daily), 2) Dex (dexamethasone sodium; 25 mg/kg subcutaneously twice a week), 3) Dex+LNG5 (lovastatin nanoemulsion gel; 5 mg/kg/d transdermally daily), 4) Dex+LNG10 (lovastatin nanoemulsion gel; 10 mg/kg/d transdermally daily), and 5) Dex+ALN (alendronate sodium; 0.03 mg/kg/d orally daily). All the treatments were carried out for 60 d. At the end of the experiment, all animals were anesthetized using diethyl ether and collected blood samples from retro-orbital venous plexus of rats in dry eppendorf tubes followed by the sacrifice of animals by cervical dislocation method and collected tibia bones of both the legs for analysis. Results: Bone formation biomarkers (OC: osteocalcin, b-ALP: bone-specific alkaline phosphatase, PINP: N-terminal propeptides of type I procollagen) were significantly improved and resorption biomarkers (CTx: C-terminal cross-linking telopeptides of type-I collagen, TRAcP5b: isoform 5b of tartarate resistant acid phosphatase) were significantly reduced in the LNG5 (p<0.05) and LNG10 (p<0.05) treatment groups when compared to Dex. In vivo anti-osteoporotic results demonstrated the formation of new bone in osteoporotic rat tibias. Biomechanical strength testing demonstrated increased load-bearing capacity of rat tibias in the treated animals in comparison with the osteoporotic group (p<0.05 for LNG5 and p<0.01 for LNG10). Conclusion: Thus, the transdermal NE gel formulation of lovastatin demonstrated the greater potential for the treatment of osteoporosis.

Resistance training‐induced muscle hypertrophy is mediated by TGF‐β1‐Smad signaling pathway in male Wistar rats

2020 ◽  
Vol 235 (7-8) ◽  
pp. 5649-5665
Author(s):  
Rohollah Nikooie ◽  
Sohil Jafari‐Sardoie ◽  
Vahid Sheibani ◽  
Amir Nejadvaziri Chatroudi
Keyword(s):  
Resistance Training ◽  
Signaling Pathway ◽  
Wistar Rats ◽  
Muscle Hypertrophy ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Male Wistar Rats ◽  
Tgf Β1

scholarly journals Effects of Eight Weeks of Resistance Training on Muscle Myostatin Gene Expression and Insulin Resistance in Male Wistar Rats with Type 2 Diabetes

2019 ◽  
Vol 6 (4) ◽  
pp. 9-16
Author(s):  
Majid Hassan Qomi ◽  
Sajad Arshadi ◽  
Abdolali Banayifar ◽  
Yaser Kazemzadeh ◽  
◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Resistance Training ◽  
Wistar Rats ◽  
Myostatin Gene ◽  
Male Wistar Rats

scholarly journals 8 Weeks of Resistance Training Effect on Myostatin Gene Expression of Myocardium in Healthy Male Wistar Rats

2016 ◽  
Vol 22 (2) ◽  
pp. 111-116
Author(s):  
Amir Rashidlamir ◽  
Mohammad Reza Basami ◽  
Seyyed Reza Attarzadeh Hosseini ◽  
keyvan Hejazi ◽  
Seyyed Mohamad Motevalli Anberani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Resistance Training ◽  
Wistar Rats ◽  
Training Effect ◽  
Healthy Male ◽  
Myostatin Gene ◽  
Male Wistar Rats

scholarly journals Responses of Skeletal Muscle Hypertrophy in Wistar Rats to Different Resistance Exercise Models

2017 ◽  
pp. 317-323 ◽  
Author(s):  
T. F. LUCIANO ◽  
S. O. MARQUES ◽  
B. L. PIERI ◽  
D. R. DE SOUZA ◽  
L. V. ARAÚJO ◽  
...  
Keyword(s):  
Resistance Training ◽  
Resistance Exercise ◽  
Wistar Rats ◽  
Quadriceps Muscle ◽  
Cross Sectional ◽  
Skeletal Muscle Hypertrophy ◽  
Mtor Phosphorylation ◽  
Male Wistar Rats ◽  
Muscle Cross Sectional Area ◽  
Upstream Control

This study aimed to compare the effects of three different resistance exercise models on the quadriceps muscle cross-sectional area, as well as on mTOR phosphorylation and other pivotal molecules involved in the upstream regulation of mTOR. Twenty-four male Wistar rats were divided into untrained (control), endurance resistance training, strength resistance training, and hypertrophy resistance training (HRT) groups (n=6). After 12 weeks of training, the red portion of the quadriceps was removed for histological and Western blot analyses. The results showed that the quadriceps weight and cross-sectional areas in the exercised groups were higher than those of the untrained rats. However, the HRT group presented better results than the other two experimental groups. This same pattern was observed for mTOR phosphorylation and for the most pivotal molecules involved in the upstream control of mTOR (increase of PKB, 14-3-3, ERK, p38 MAPK, and 4E-BP1 phosphorylation, and reduction of tuberin, sestrin 2, REDD1, and phospho AMPK). In summary, our study showed that HRT leads to high levels of mTOR phosphorylation as well as of other proteins involved in the upstream regulation of mTOR.

New transcription factors involved with postnatal ventral prostate gland development in male Wistar rats during the first week

Life Sciences ◽  
2015 ◽  
Vol 143 ◽  
pp. 168-173 ◽  
Author(s):  
Umar Nishan ◽  
Danilo M. Damas-Souza ◽  
Guilherme Oliveira Barbosa ◽  
Nawshad Muhammad ◽  
Abdur Rahim ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Wistar Rats ◽  
Prostate Gland ◽  
Ventral Prostate ◽  
Male Wistar Rats ◽  
Gland Development

Outcomes of testosterone enanthate on kidney of male Wistar rats subjected to resistance training

2017 ◽  
Vol 32 (3) ◽  
pp. e107-e110
Author(s):  
S. Karbasi ◽  
M. Zaeemi ◽  
M. Mohri ◽  
A. Rashidlamir ◽  
Z. Moosavi
Keyword(s):  
Resistance Training ◽  
Wistar Rats ◽  
Testosterone Enanthate ◽  
Male Wistar Rats
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