A Review on Analytical Method for Determination of Venlafaxine HCl in Bulk and Pharmaceutical dosage form

2021 ◽  
pp. 208-212
Author(s):  
Swamini A Dighe ◽  
Suhas S Siddheshwar ◽  
Ganesh S Shinde
Keyword(s):  
Analytical Method ◽  
Uv Spectroscopy ◽  
Major Depressive ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Antidepressant Agent ◽  
Norepinephrine Reuptake Inhibitor ◽  
Depressed Person ◽  
Serotonin Norepinephrine Reuptake Inhibitor

Venlafaxine HCl is one of the antidepressant agent which comes under the category of serotonin-norepinephrine reuptake inhibitor i.e SNRI. This medication is usually used to treat major depressive disorder in adult. It may help to improve the mood and energy level and also to regain the interest in daily activities in the depressed person. The present review focus on various approaches for the analysis on Venlafaxine in bulk and pharmaceutical dosage forms. The review represents the various analytical method like the RP-HPLC, HPTLC, UV Spectroscopy and Stability Indicating Methods which were used for the investigation of Venlafaxine in bulk and different dosage formulations.

scholarly journals A REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE AND EMTRICITABINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

2019 ◽  
Vol 7 (3) ◽  
Author(s):  
Lakade M. M ◽  
Kale R. N.
Keyword(s):  
Reverse Transcriptase ◽  
Tenofovir Disoproxil Fumarate ◽  
Analytical Methods ◽  
Quantitative Estimation ◽  
Biological Fluid ◽  
Uv Spectroscopy ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Hiv 1

Tenofovir Disoproxil Fumarate and Emtricitabine are very effectively used in the prevention of HIV-1 infections. They are generally administered as tablets. These are Nucleotide Reverse Transcriptase Inhibitors (NtRTIs), an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5′-monophosphate. Emtricitabine and Tenofovir disoproxil fumarate reveals equally prevention of the enzyme that is HIV-1 reverse transcriptase. For determination of Tenofovir disoproxil fumarate and Emtricitabine in bulk and pharmaceutical dosage form, several analytical methods including UV, HPLC, UPLC and HPTLC techniques are reported in literature. For qualitative and quantitative estimation of Tenofovir disoproxil fumarate and Emtricitabine these analytical methods can be used and also for the related degradants in bulk formulations and biological fluid. The present paper illustrates the review on analytical methods which involves the estimation of the antiviral drugs. Keywords: Emtricitabine, Tenofovir disoproxil fumarate, UV Spectroscopy, RP-HPLC, UPLC,   HPTLC.

scholarly journals Area Under the Curve Spectrophotometric Method for Determination of Irbesatran in Pharmaceutical Formulation

2017 ◽  
Vol 7 (2) ◽  
pp. 95
Author(s):  
S. Alexandar ◽  
A. Santhanam ◽  
C. Sandhu ◽  
C. Sanjaykanth ◽  
S. Sandhya ◽  
...  
Keyword(s):  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Dosage Form ◽  
Area Under The Curve ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Routine Work ◽  
Accuracy Study ◽  
Bulk Drug

<em>This study presents new spectrophotometric method for the determination of Irbesartan. So far, no Area under Curve Spectrophotometric method has been reported for the estimation of Irbesartan from pharmaceutical dosage form. This paper deals with validation and development of a method by Area Under Curve for the assay of Irbesartan from pharmaceutical dosage forms. The principle for AUC curve method is “the area under two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The area selected between 203 to 211 nm for determination of Irbesartan. The drug follows Beer-Lambert’s law over the concentration range of 5-25 μg/ml for Irbesartan. In accuracy study the % recovery of Irbesartan in bulk drug samples was ranged 96.45-93.84%, which indicates that the method was accurate. Validation of the proposed method was carried out for its accuracy, precision, and specificity according to ICH guidelines. The proposed methods can be successfully applied in routine work for the determination of Tigecycline in its pharmaceutical dosage form.</em>

scholarly journals Spectrophotometric analysis of Azithromycin and its pharmaceutical dosage forms: Comparison between Spectrophotometry and HPLC

2015 ◽  
Vol 12 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Nahid Sharmin ◽  
Nazia Sultana Shanta ◽  
Sitesh C Bachar
Keyword(s):  
Statistical Analysis ◽  
Spectrophotometric Method ◽  
Dosage Form ◽  
Dosage Forms ◽  
Spectrophotometric Analysis ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Ich Guidelines ◽  
Good Accordance

A simple, reliable, precise and sensitive UV-spectrophotometric method was developed and validated for the estimation of azithromycin in pharmaceutical dosage form and compared with official USP 2010 method. The proposed method utilizes the oxidation of azithromycin with potassium permanganate to liberate formaldehyde. This formaldehyde reacts with acetone-ammonium reagent and produces yellow colored chromogen 3,5-diacetyl-2,6-dihydrolutidine. The colored solution exhibited a maximum absorption at 412 nm which can be detected with UVspectrophotometer. The method was found linear over the concentration range 80% to 120% of the working concentration (R2=0.999). The intra- and inter-day RSD (n = 6) was ? 2.0%. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. The proposed method was successfully applied for determination of azithromycin and the results have been compared with HPLC and thus enabling the utility of this new method for routine analysis azithromycin in pharmaceutical dosage forms DOI: http://dx.doi.org/10.3329/dujps.v12i2.21981 Dhaka Univ. J. Pharm. Sci. 12(2): 171-179, 2013 (December)

NOVEL ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF BROMOFENAC SODIUM IN BULK AND PHARMACEUTICAL DOSAGE FORM BY DERIVATIVE AND AUC SPECTROSCOPIC METHOD

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (01) ◽  
pp. 87-90
Author(s):  
S Raghu ◽  
S. Muneer. ◽  
K.B. Chandra sekhar ◽  
kiran B. Siva Sai ◽  
Keyword(s):  
Spectrophotometric Method ◽  
Method Development ◽  
Spectroscopic Method ◽  
Zero Order ◽  
Order Derivative ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
First Order ◽  
Significant Difference

The present study was carried out to develop a simple and reliable derivative spectrophotometric method for the determination of bromofenac sodium in pharmaceutical dosage forms .The solutions of standard and the sample were prepared in distilled water The quantitative determination of the drug was carried out with zero order derivative (method A) values measured at 268 nm and first order (method B) derivative values measured at 258 nm , and two wavelengths 262nm and 274nm were selected for the determination AUC (method C) of integrated areas. Calibration graphs constructed at their wavelengths of determination, were linear within the concentration range of 2-12 μg/mL (r2 = 0.999) for zero order and (r2 = 0.997) first order derivative spectrophotometric method. No significant difference between the performance of the proposed methods regarding the mean values and standard deviations and is suitable for the routine quality control application of bromofenac sodium in its pharmaceutical formulations.

scholarly journals Method Development and Validation for Simultaneous Determination of Ezetimibe and Simvastatin In Combined Pharmaceutical Dosage Form By RP-HPLC Method

2013 ◽  
Vol 2 (2) ◽  
pp. 60-69 ◽  
Author(s):  
G Krishnaveni ◽  
PVV Sathyannarayana
Keyword(s):  
High Performance ◽  
Method Development ◽  
Limit Of Detection ◽  
High Performance Liquid Chromatographic ◽  
Simultaneous Estimation ◽  
Internal Diameter ◽  
Limit Of Quantification ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms

A simple, rapid reverse phase high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of Ezetimibe and Simvastatin in bulk and pharmaceutical dosage forms. Chromatography was carried out by using Chromosil C-18,column having 250 x 4.6mm internal diameter with a mixture of Methanol:Acetonitrile:0.1%Orthophosphoric Aid in the ratio of 75:20:05 (v/v/v) as mobile phase. Determination of the different analytical parameters such as linearity, precision, accuracy, and specificity, limit of detection (LOD) and limit of quantification (LOQ) was done. The calibration curve was found to be linear for each analyte in the desired concentration range. The average recovery was found to be 99.88 and 100.12 for Ezetimibe and Simvastatin respectively. The proposed method is highly sensitive, precise and accurate, which was evident from the LOD value of 1.2ppm and 0.25ppm for Ezetimibe and Simvastatin respectively and hence the present method can be applied successfully for the quantification of active pharmaceutical ingredient (API) content in the combined formulations of Ezetimibe and Simvastatin. DOI: http://dx.doi.org/10.3329/ijpls.v2i2.15450 International Journal of Pharmaceutical and Life Sciences Vol.2(2) 2013: 60-69

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