Vascularized Ulnar Bone Grafts for Limb-Sparing Surgery for the Treatment of Distal Radial OsteosarcomaS

2011 ◽  
Vol 47 (2) ◽  
pp. 98-111 ◽  
Author(s):  
Susan C. Hodge ◽  
Daniel Degner ◽  
Richard Walshaw ◽  
Brian Teunissen

The objective of this retrospective study was to compare vascularized free or roll-in ulnar bone grafts for limb-sparing surgery in dogs with radial osteosarcoma with the cortical allograft, metal endoprosthesis, or distraction osteogenesis techniques. Overall, the ulnar graft techniques used in this study demonstrated excellent healing properties. Complications included recurrence of the tumor in 25% (2/8) of the dogs, metastasis in 50% (4/8) of the dogs, implant loosening in 37.5% (3/8) of the dogs, implant failure in 12.5% (1/8) of the dogs, and infection in 62.5% (5/8) of the dogs. Mean survival time was 29.3 mo (range, 9 to 61 mo). The mean metastasis-free interval was 33.67 mo (range, 8 to 54 mo). Tumors recurred locally in two dogs at 10 mo and 20 mo postoperatively. This study yielded similar long-term complications as other limb-sparing options (such as cortical allografts and metal endoprostheses) and allowed dogs to bear weight on the operated limb with acceptable limb function. More research is needed regarding specific healing times for ulnar vascularized grafts, time until implant removal, and the extent of radial bone that could ultimately be replaced by the ulna.

2000 ◽  
Vol 36 (6) ◽  
pp. 501-509 ◽  
Author(s):  
SD Gottfried ◽  
CA Popovitch ◽  
MH Goldschmidt ◽  
C Schelling

Thirty-six cats with bronchogenic carcinoma metastatic to the digit were identified. The mean age was 12.7 years, with no breed or sex predilection. Records from 19 cases were available for review. These cats presented with a primary complaint of lameness that involved primarily weight-bearing digits and the third phalanx. None had respiratory signs, despite the presence of pulmonary carcinoma. Course of disease was consistent in the 19 cases, with a mean survival time of 58 days from initial presentation. Amputation of affected digits was rarely palliative due to development of lesions in other digits and progressive nonrespiratory disease.


Author(s):  
Rafique Umer Harvitkar ◽  
Abhijit Joshi

Abstract Introduction Laparoscopic fundoplication (LF) has almost completely replaced the open procedure performed for gastroesophageal reflux disease (GERD) and hiatus hernia (HH). Several studies have suggested that long-term results with surgery for GERD are better than a medical line of management. In this retrospective study, we outline our experience with LF over 10 years. Also, we analyze the factors that would help us in better patient selection, thereby positively affecting the outcomes of surgery. Patients and Methods In this retrospective study, we identified 27 patients (14 females and 13 males) operated upon by a single surgeon from 2010 to 2020 at our institution. Out of these, 25 patients (12 females and 13 males) had GERD with type I HH and 2 (both females) had type II HH without GERD. The age range was 24 to 75 years. All patients had undergone oesophago-gastro-duodenoscopy (OGD scopy). A total of 25 patients had various degrees of esophagitis. Two patients had no esophagitis. These patients were analyzed for age, sex, symptoms, preoperative evaluation, exact procedure performed (Nissen’s vs. Toupet’s vs. cruroplasty + gastropexy), morbidity/mortality, and functional outcomes. They were also reviewed to examine the length of stay, length of procedure, complications, and recurrent symptoms on follow-up. Symptoms were assessed objectively with a score for six classical GERD symptoms preoperatively and on follow-up at 1-, 4- and 6-weeks postsurgery. Further evaluation was performed after 6 months and then annually for 2 years. Results 14 females (53%) and 13 males (48%) with a diagnosis of GERD (with type I HH) and type II HH were operated upon. The mean age was 46 years (24–75 years) and the mean body mass index (BMI) was 27 (18–32). The range of duration of the preoperative symptoms was 6 months to 2 years. The average operating time dropped from 130 minutes for the first 12 cases to 90 minutes for the last 15 cases. The mean hospital stay was 3 days (range: 2–4 days). In the immediate postoperative period, 72% (n = 18) of the patients reported improvement in the GERD symptoms, while 2 (8%) patients described heartburn (grade I, mild, daily) and 1 (4%) patient described bloating (grade I, daily). A total of 5 patients (20%) reported mild dysphagia to solids in the first 2 postoperative weeks. These symptoms settled down after 2 to 5 weeks of postoperative proton-pump inhibitor (PPI) therapy and by adjusting consistency of oral feeds. There was no conversion to open, and we observed no perioperative mortality. There were no patients who underwent redo surgeries in the series. Conclusion LF is a safe and highly effective procedure for a patient with symptoms of GERD, and it gives long-term relief from the symptoms. Stringent selection criteria are necessary to optimize the results of surgery. Experience is associated with a significant reduction of operating time.


2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Yingying Zhu ◽  
Liming Gao ◽  
Yunxiao Meng ◽  
Wenwen Diao ◽  
Xiaoli Zhu ◽  
...  

Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous which present a wide spectrum of pathological and clinical manifestations. Fourteen patients with histologically demonstrated LNEC were collected and analyzed retrospectively. The 14 cases were classified into 3 subtypes: typical carcinoid in 2, atypical carcinoid in 5, and small cell neuroendocrine carcinoma in 7. The mean survival time of the 14 patients in this study was 112.5 months (95% CI, 81.5–143.6). Surgeries were performed for 2 patients of typical carcinoid, and they were alive with no evidence of recurrence after 24 and 47 months of follow-ups. Patients in the atypical carcinoid group were treated with surgeries and postoperative radiotherapy. After 58.4 months of follow-ups (range: 9–144), 2 patients showed no evidence of disease and 1 was lost to follow-up after 72 months. The other 2 patients died of other unrelated diseases. In the small cell neuroendocrine carcinoma group, a combination of chemotherapy and radiotherapy was applied. The mean survival time was 79.7 months (95% CI, 37.9–121.4), and the 5-year survival rate was 53.6%. In conclusion, the clinical behaviors, treatment protocols, and prognosis are different for each subtype of LNECs.


1956 ◽  
Vol 186 (3) ◽  
pp. 554-556
Author(s):  
Donn L. Smith ◽  
Irvin I. Kibbey ◽  
Max E. Bierwagen ◽  
J. R. Cruse

Intravenous administration of colloidal saccharated iron oxide prior to intestinal traumatization in the albino rat resulted in a significant reduction of the mean survival time. Sodium gold thiosulfate and colloidal manganese hydroxide employed in the same manner did not significantly alter mean survival times. ACTH and cortisone did not modify the deleterious effects of iron in experimental traumatic shock. A decrease in soluble liver iron was observed when traumatization followed the injection of iron. It was concluded that the reduction of mean survival time in iron injected, traumatized animals was due to a specific action of iron and is not the result of generalized heavy metal toxicity.


2007 ◽  
Vol 17 (4) ◽  
pp. 550-556 ◽  
Author(s):  
P.M. Puska ◽  
A.H.A. Tarkkanen

Purpose To evaluate in a retrospective study the long-term usefulness of red 647 nm krypton and 670 nm diode laser for transscleral contact cyclophotocoagulation (CPC) in the treatment of therapy-resistant inflammatory glaucoma. Methods The authors treated 48 eyes of 38 consecutive patients (mean age 36.8 years, range 6–81 years) with therapy-resistant inflammatory glaucoma secondary to chronic uveitis (45/48), chronic scleritis (1/48), or combined scleritis with keratouveitis (2/48) using transscleral red 647 nm Krypton or 670 nm Diode laser. All eyes had failed maximum tolerated medical therapy and 19/48 (40%) eyes also previous antiglaucoma surgery. Laser power at the scleral surface was 0.35 to 0.45 W and the application time 10 seconds each. The follow-up was 42.8± 40.0 (range 2–145) months. Results The mean preoperative intraocular pressure (IOP) of 35.6±8.1 mmHg fell to 6–21 mmHg level in 75% after one or repeated CPC. Among adult patients this was achieved in 85%, among children in 54%. More than one treatment was needed in 52%. No cases of hypotony, phthisis bulbi, or other devastating complications occurred. Conclusions Transscleral CPC using red 647 nm krypton or 670 nm diode laser is an effective and well-tolerated procedure for the treatment of therapy-resistant inflammatory glaucoma in adults. CPC can be considered before incisional antiglaucoma surgery with a shunt or antimetabolites is undertaken


2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Ding Shi ◽  
Dong Wu ◽  
Yongpan Liu ◽  
Feng Ji ◽  
Yinsu Bao

Objectives. This study is aimed at evaluating the efficacy and safety of the big end double-layer uncovered self-expanding metal stents (SEMS) for the treatment of gastric outlet obstruction (GOO) caused by distal stomach cancer.Methods. Seventy three patients receiving big end double-layer uncovered SEMS for the treatment of GOO caused by distal gastric cancer will be included in this multicenter prospective clinical trial. The main outcome measures included the functional outcome, the complications, the reinterventional rates, the average treatment charges, and the mean survival time. Monthly telephone calls were needed to assess the food intake until the patients died.Results. The technical and the clinical success rates were 98.6%. The stent obstruction caused by tumor ingrowth was observed in one patient (1.4%). The incidence of food impaction was 2.9% (2/70) and the reinterventional rate was 4.3% (3/70). However, stent migration and obstruction caused by overgrowth were not observed. No perforation and severe bleeding were observed. The median cost of endoscopic stenting and total hospitalization (including reinterventions) for the big end double-layer uncovered SEMS in this study was $2945 and $3408, respectively. The mean survival time was 212.5 days.Conclusions. The placement of big end double-layer uncovered SEMS is a safe and effective modality and has the potential to be one of the options for the treatment of GOO caused by the distal gastric cancer.


2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yangying Liao ◽  
Haibo Luo ◽  
Zhizhong He ◽  
Yongpei Kuang ◽  
Peifen Chen ◽  
...  

To explore the antitumor effect of hypoxia-inducible factor-1α short hairpin RNA (HIF-1α shRNA) delivered by ultrasound targeted microbubble destruction (UTMD) and transcatheter arterial embolization (TAE) on rats with hepatic cancer. After the models of transplantation hepatoma were established, Wistar rats were randomly divided into 4 groups: Control group, UTMD group, TAE group, and UTMD+TAE group. Contrast-enhanced ultrasound (CEUS) was used to monitor tumor size on day 14 after four different treatments. Western blotting and immunohistochemistry were applied to measure the protein level of HIF-1α and VEGF in the hepatic cancer tissue. In comparison with UTMD+TAE group (21.25±10.68 days), the mean survival time was noticeably shorter in the Control group and TAE group (13.02±4.30 days and 15.03±7.32 days) (p<0.05, respectively). There was no statistical difference between UTMD+TAE group and UTMD group of the mean survival time (p>0.05). In addition, our results proved that the tumor sizes in UTMD+TAE group were obviously smaller than those in other groups (p<0.05, respectively). By CEUS, we clearly found that the tumor size was the smallest on day 14 in the UTMD+TAE group. The western blotting and immunohistochemistry results proved that the protein levels of HIF-1α and VEGF in UTMD+TAE group were obviously lower than those in TAE group and Control group on days 7 and 14 (p<0.05, respectively). However, there was no statistical difference between UTMD+TAE group and UTMD group (p>0.05). In this study we tried to explore the antitumor effect through a combination of UTMD-mediated HIF-1α shRNA transfection and TAE on rats with hepatic cancer. Our results showed that UTMD-mediated HIF-1α shRNA transfection and TAE can obviously silence HIF-1α and VEGF expression, thereby successfully inhibiting the growth of the tumor.


1963 ◽  
Vol 18 (2) ◽  
pp. 387-392 ◽  
Author(s):  
E. R. Stiehm

The tolerance to high positive (headward) acceleration at levels of 20–80 G was studied in normal and hypothermic rats. Normal rats have a mean survival time of 680 sec at 20 G, but this decreases to 105 sec at 30 G. Only slight decreases are noted at higher G, suggesting that 30 G is the point at which cerebral circulation is interrupted. Hypothermia at 22.5 C decreases acceleration tolerance at 20 G, but markedly increases acceleration tolerance at 30 G and above. At 40 G this effect is maximal, and the mean survival time for hypothermic rats is 252 sec, compared to 75 sec for controls, an increase of 236%. These different effects of hypothermia on acceleration tolerance suggest that there are two distinct syndromes of physiologic failure during positive acceleration. One is a “cardiac” syndrome, occurring at 20 G and below, characterized by partial maintenance of cerebral circulation until cardiac failure ensues, and the other is a “cerebral” syndrome, occurring at 30 G and above, characterized by immediate interruption of cerebral circulation and respiratory paralysis. Submitted on May 17, 1962


2016 ◽  
Vol 27 (11) ◽  
pp. 1392-1400 ◽  
Author(s):  
Mi-si Si ◽  
Yi-wen Shou ◽  
Yi-tian Shi ◽  
Guo-li Yang ◽  
Hui-ming Wang ◽  
...  

1995 ◽  
Vol 43 (3) ◽  
pp. 303 ◽  
Author(s):  
I Parer

The mean survival times of small groups of rabbits challenged with myxoma virus have been used to estimate survival rates and to allocate virulence grades to field strains of myxoma virus. The slope of the regression Line relating survival percentage to mean survival time in days was shown to be less steep than has been previously estimated. This overestimation of the regression slope has, in the past, resulted in most field strains of myxoma virus being allocated to the Grade III level of virulence when allocation to Grade I would have been more appropriate.


Sign in / Sign up

Export Citation Format

Share Document