scholarly journals Demographic characteristics of subjective cognitive decline studies’ samples. A systematic review

2021 ◽  
Author(s):  
Natália Menegassi Pedrini ◽  
Matheus da Silva Calabresi Machado ◽  
Matheus Fernando Manzolli Ballestero ◽  
Francisco de Assis Carvalho do Vale
Keyword(s):  
Systematic Review ◽  
Health Services ◽  
Cognitive Decline ◽  
Early Stage ◽  
Demographic Characteristics ◽  
Subjective Cognitive Decline ◽  
Self Perception ◽  
The Mean ◽  
Number Of Publications ◽  
High Level

Background: Subjective cognitive decline (SCD) consists on self-perception of cognition decline without an objective impairment. It has gotten attention from researchers because it may be an early stage of Alzheimer’s disease, before dementia Objectives: This research aimed to determine the characteristics of the SCD studies’ samples across the countries. Methods: It was searched for complete articles from 2014 to 2020 on MEDLINE, PubMed, EMBASE and others, using the keyword “Subjective Cognitive Decline” and its respective translations in both Spanish and Portuguese. Results: Of 3,470 papers, 487 were eligible. The mean age of SCD participants was 71.98 in 2014 to 66.14 in 2020, (mean 66.81) as the number of participants, there were 104 in 2014 and 5233 in 2020 (mean: 1729), and 59% of the participants were women. The mean scholar years were 13.4, in 2014 there were 8 articles and 167 in 2020. Conclusions: The increased number of publications and samples represents the crescent importance of the theme. The decrease in the mean age, possibly demonstrates efforts to an earlier detection of the condition. The majority of women, could represent a prevalence of this gender on the disease, or be related with the fact that woman participate more in scientific studies and also use the health services more than men. The high level of scholarly contrasts with the wrong conception of dementia being related only to poor education, showing that it also affects higher levels of schooling.

scholarly journals Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Andrea Brioschi Guevara ◽  
Melanie Bieler ◽  
Daniele Altomare ◽  
Marcelo Berthier ◽  
Chantal Csajka ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Executive Functions ◽  
Cognitive Decline ◽  
Physical Training ◽  
Cognitive Enhancement ◽  
Memory Performance ◽  
Subjective Cognitive Decline ◽  
Strategic Learning

AbstractCognitive complaints in the absence of objective cognitive impairment, observed in patients with subjective cognitive decline (SCD), are common in old age. The first step to postpone cognitive decline is to use techniques known to improve cognition, i.e., cognitive enhancement techniques.We aimed to provide clinical recommendations to improve cognitive performance in cognitively unimpaired individuals, by using cognitive, mental, or physical training (CMPT), non-invasive brain stimulations (NIBS), drugs, or nutrients. We made a systematic review of CMPT studies based on the GRADE method rating the strength of evidence.CMPT have clinically relevant effects on cognitive and non-cognitive outcomes. The quality of evidence supporting the improvement of outcomes following a CMPT was high for metamemory; moderate for executive functions, attention, global cognition, and generalization in daily life; and low for objective memory, subjective memory, motivation, mood, and quality of life, as well as a transfer to other cognitive functions. Regarding specific interventions, CMPT based on repeated practice (e.g., video games or mindfulness, but not physical training) improved attention and executive functions significantly, while CMPT based on strategic learning significantly improved objective memory.We found encouraging evidence supporting the potential effect of NIBS in improving memory performance, and reducing the perception of self-perceived memory decline in SCD. Yet, the high heterogeneity of stimulation protocols in the different studies prevent the issuing of clear-cut recommendations for implementation in a clinical setting. No conclusive argument was found to recommend any of the main pharmacological cognitive enhancement drugs (“smart drugs”, acetylcholinesterase inhibitors, memantine, antidepressant) or herbal extracts (Panax ginseng, Gingko biloba, and Bacopa monnieri) in people without cognitive impairment.Altogether, this systematic review provides evidence for CMPT to improve cognition, encouraging results for NIBS although more studies are needed, while it does not support the use of drugs or nutrients.

scholarly journals The Diagnostic Concordance of Whole Slide Imaging and Light Microscopy: A Systematic Review

2016 ◽  
Vol 141 (1) ◽  
pp. 151-161 ◽  
Author(s):  
Edward Goacher ◽  
Rebecca Randell ◽  
Bethany Williams ◽  
Darren Treanor
Keyword(s):  
Systematic Review ◽  
Light Microscopy ◽  
Primary Diagnosis ◽  
Cochrane Library ◽  
Whole Slide Imaging ◽  
Tissue Samples ◽  
The Mean ◽  
Diagnostic Concordance ◽  
High Level ◽  
The Cochrane Library

Context.—Light microscopy (LM) is considered the reference standard for diagnosis in pathology. Whole slide imaging (WSI) generates digital images of cellular and tissue samples and offers multiple advantages compared with LM. Currently, WSI is not widely used for primary diagnosis. The lack of evidence regarding concordance between diagnoses rendered by WSI and LM is a significant barrier to both regulatory approval and uptake. Objective.—To examine the published literature on the concordance of pathologic diagnoses rendered by WSI compared with those rendered by LM. Data Sources.—We conducted a systematic review of studies assessing the concordance of pathologic diagnoses rendered by WSI and LM. Studies were identified following a systematic search of Medline (Medline Industries, Mundelein, Illinois), Medline in progress (Medline Industries), EMBASE (Elsevier, Amsterdam, the Netherlands), and the Cochrane Library (Wiley, London, England), between 1999 and March 2015. Conclusions.—Thirty-eight studies were included in the review. The mean diagnostic concordance of WSI and LM, weighted by the number of cases per study, was 92.4%. The weighted mean κ coefficient between WSI and LM was 0.75, signifying substantial agreement. Of the 30 studies quoting percentage concordance, 18 (60%) showed a concordance of 90% or greater, of which 10 (33%) showed a concordance of 95% or greater. This review found evidence to support a high level of diagnostic concordance. However, there were few studies, many were small, and they varied in quality, suggesting that further validation studies are still needed.

scholarly journals Prognostic Role of Tissue and Circulating MicroRNA-200c in Malignant Tumors: a Systematic Review and Meta-Analysis

2015 ◽  
Vol 35 (3) ◽  
pp. 1188-1200 ◽  
Author(s):  
Yingjie Shao ◽  
Yiting Geng ◽  
Wendong Gu ◽  
Jin Huang ◽  
Honglei Pei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Tumors ◽  
Early Stage ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Circulating Microrna ◽  
Prognostic Role ◽  
Altered Expression ◽  
High Level

Background: Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may serve as prognostic biomarkers. We performed a systematic review and meta-analysis to evaluate the prognostic role of miR-200c expression in different cancers. Methods: Studies were recruited by searching PubMed, Embase and the Cochrane Library (last search update was May 2014) and assessed by further quality evaluation. Results: A total of 25 studies dealing with various carcinomas were identified for systematic review. Among them, 18 studies were ultimately included in the meta-analysis. Our results indicated that the expression of tissue miR-200c was not associated with OS and PFS in various carcinomas; however, downregulation of tissue miR-200c did predict poor OS of patients with stage I disease (HR=0.41, 95% CI 0.25-0.68, P=0.001). Furthermore, overexpression of blood miR-200c was significantly related to poor OS and PFS (HR=3.07 95% CI 1.58-5.96 P=0.001, HR=2.26 95% CI 1.66-3.08 P<0.001, respectively), especially in patients with advanced disease. Conclusion: This systematic review and meta-analysis clarified that low expression of miR-200c in primary tissue was significantly associated with poor survival in cancer patients at early stage, whereas a high level of blood miR-200c predicted poor prognosis in patients with advanced tumors.

scholarly journals Is Brain Connectome Research the Future Frontier for Subjective Cognitive Decline? A Systematic Review

2019 ◽  
Author(s):  
Ioulietta Lazarou ◽  
Spiros Nikolopoulos ◽  
Stavros Dimitriadis ◽  
Ioannis Kompatsiaris ◽  
Martha Spylioti ◽  
...  
Keyword(s):  
Systematic Review ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Network ◽  
Subjective Cognitive Decline ◽  
Research Activity ◽  
Brain Connectome ◽  
Advanced Stages ◽  
Multiple Network ◽  
The Brain

Objective: We performed a systematic literature review on Subjective Cognitive Decline (SCD) in order to examine whether the resemblance of brain connectome and functional connectivity (FC) alterations in SCD with respect to MCI, AD and HC can help us draw conclusions on the progression of SCD to more advanced stages of dementia.Methods: We searched for studies that used any neuroimaging tool to investigate potential differences of brain connectome in SCD with respect to HC, MCI, and AD.Results: Sixteen studies were finally included in the review. Apparent FC connections and disruptions were observed in the white matter, default mode and gray matter networks in SCD with regards to HC, MCI, and AD. Interestingly, more apparent connections in SCD were located over the posterior regions, while an increase of FC over anterior regions was observed as the disease progressed. Conclusions: Elders with SCD present a significant disruption of the brain network, which in most of the cases is worse than HC across multiple network parameters. Significance: The present review provides comprehensive and balanced coverage of a timely target research activity around SCD and the design of network-based biomarkers for the accurate detection of SCD.

Education, APOE ɛ4, and Cognition in Individuals with Subjective Cognitive Decline with Worry in the SILCODE Study

2021 ◽  
Vol 18 ◽  
Author(s):  
Guanqun Chen ◽  
Li Lin ◽  
Kun Yang ◽  
Ying Han
Keyword(s):  
Linear Regression ◽  
Cognitive Decline ◽  
Multiple Linear Regression ◽  
Early Stage ◽  
Linear Regression Analysis ◽  
Subjective Cognitive Decline ◽  
Linear Regression Models ◽  
Cognitive Domains ◽  
Apoe Ε4 ◽  
Positive Effect

Background: Education could offer a protective effect on cognition in individuals with Subjective Cognitive Decline (SCD), which is considered to be the early stage of Alzheimer’s Dis- ease (AD). However, the effect of education on cognition in SCD individuals with SCD-plus fea- tures is not clear. Objective: The aim of the study was to explore the effect of education on cognition in SCD individ- uals with SCD-plus features. Methods: A total of 234 individuals with SCD were included from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Cognition was assessed across 4 domains (memory, executive, lan- guage, and general cognitive functions). Multiple linear regression models were constructed to ex- amine the effect of education on cognitive scores in individuals without worry (n=91) and with wor- ry (n=143). Furthermore, we assessed differences in effects between APOE ε4 noncarriers and APOE ε4 carriers in both groups. Results : Multiple linear regression analysis showed a positive effect of education on memory, ex- ecutive, and language cognition in individuals without worry and all cognitive domains in individu- als with worry. Furthermore, we found a positive effect of education on executive cognition in APOE ε4 noncarriers without worry and language and general cognition in APOE ε4 carriers with- out worry. Meanwhile, education had a positive effect on all cognitive domains in APOE ε4 noncar- riers with worry and executive, language, and general cognition in APOE ε4 carriers with worry. Conclusion: This study indicates that education has the potential to delay or reduce cognitive dec- line in SCD individuals with SCD-plus features.

scholarly journals Is brain connectome research the future frontier for subjective cognitive decline? A systematic review

2019 ◽  
Vol 130 (10) ◽  
pp. 1762-1780 ◽  
Author(s):  
Ioulietta Lazarou ◽  
Spiros Nikolopoulos ◽  
Stavros I. Dimitriadis ◽  
Ioannis (Yiannis) Kompatsiaris ◽  
Martha Spilioti ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Brain Connectome ◽  
The Future

scholarly journals Subjective cognitive decline as a predictor of future cognitive decline: a systematic review

2020 ◽  
Vol 14 (3) ◽  
pp. 248-257
Author(s):  
Vladimir Anatolevich Parfenov ◽  
Vladimir Vladimirovich Zakharov ◽  
Anastasia Romanovna Kabaeva ◽  
Natalya Vasilyevna Vakhnina
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Neuropsychological Tests ◽  
Memory Impairment ◽  
Cognitive Capacity ◽  
Subjective Cognitive Decline ◽  
Level Of Functioning ◽  
People With Dementia ◽  
Prospective Longitudinal

ABSTRACT. Over 44 million people suffer from dementia around the world. Researchers estimated that there will be 48.1 million people with dementia by 2020 and 90.3 million by 2040. In addition to dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) relate to cognitive impairment. It has been established that MCI precedes dementia, however the significance of SCD is still unclear. Recent studies suggest that SCD could be a risk factor for objective cognitive impairment. SCD is defined as а self-estimated decline in cognitive capacity in comparison to an individual’s previous level of functioning, which cannot be determined by neuropsychological tests. Objectives: To perform a systematic review of prospective longitudinal cohort studies that assessed the risk of MCI and dementia among people with SCD. Methods: A search was carried out for all available peer-reviewed articles in English related to SCD in PubMed and PsychINFO databases from database initiation through January 2020. The keywords used for the search were ‘subjective cognitive (or memory) impairment (or decline or complaints)’. Three authors separately determined the inclusion or exclusion of all articles retrieved for full-text evaluation. Results: The chance of progression to dementia in the SCD group was 2.17 (95% confidence interval [95%CI] 1.53‒3.07; p<0.05) compared to normal aging. Furthermore, the SCD group was 2.15 times more likely to progress to MCI than the group without SCD (95%CI 1.39‒3.30; p=0.005). Conclusions: SCD might precede cognitive impairment, however, more detailed longitudinal studies should be conducted.

Subjective Cognitive Decline and APOE ɛ4: A Systematic Review

2018 ◽  
Vol 65 (1) ◽  
pp. 303-320 ◽  
Author(s):  
Jordan I. Ali ◽  
Colette M. Smart ◽  
Jodie R. Gawryluk
Keyword(s):  
Systematic Review ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline

Impact of SARS-CoV-2 pandemic on bariatric patients in Podlaskie Voivodeship in Poland

2021 ◽  
Vol 93 (6) ◽  
pp. 1-5
Author(s):  
Agnieszka Popławska ◽  
Joanna Jamiołkowska ◽  
Paulina Woźniewska ◽  
Krzysztof Drygalski ◽  
Urszula Kościuczuk ◽  
...  
Keyword(s):  
Mean Value ◽  
Demographic Characteristics ◽  
Bariatric Procedure ◽  
First Case ◽  
Risk Of Mortality ◽  
Significant Difference ◽  
Bariatric Patients ◽  
The Mean ◽  
High Level ◽  
The Impact

Background: The first case of COVID-19 (Coronavirus Disease 2019) in Poland was reported on March 4th, 2020 and resulted in cancellation of bariatric procedures during the lockdown in Poland. The lockdown caused difficult access to all means of medical care. The study was conducted show the impact of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus) pandemic on bariatric patients’ status in one of Polish regions. Methods: The survey was designed and distributed to bariatric patients. The questionnaire was divided into two parts: demographic characteristics of participants and part concerned the impact of the pandemic on bariatric patients. Results: 116 bariatric patients participated in the survey. 109 of them (94%) reported at least one accompanying disease. The mean value of the willingness to perform the bariatric procedure among women it was 8.8 (±2.2 SD) and men 8.5 (±2.3 SD). The mean value of the impact of SARS-CoV-2 pandemic on the willingness to perform the bariatric in the group of women was 3.0 (±3.0 SD) and in the group of men - 3.2 (±3.0 SD). Statistical analysis shows that there is no statistically significant difference between those date. Conclusions: Despite the pandemic and higher risk of mortality and complications after COVID-19 infection, bariatric patients declare the high level of willingness to perform the bariatric procedure and the impact of SARS-CoV-2 pandemic does not play an important role in a process of deciding to undergo the bariatric procedure. Delay of surgery can significantly increase the disease load in these patients, so cancelling or postponing treatment is not advisable.

Sign in / Sign up

Export Citation Format

Share Document