Arrhythmogenic right ventricular cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder resulting in fibrofatty replacement of the myocardium. Genetic mutations in genes encoding for desmosome proteins result in a ventricular myocardium prone to arrhythmias and heart failure. Although ARVC is known for a few decades, most of the outcomes in pregnancy are reported recently. Pregnancy leads to significant physiological changes with excess mechanical stress on the myocardium. All the retrospective studies suggest that pregnancy is well tolerated in these patients despite the high risk of arrhythmias and heart failure. Our review focuses on the most up-to-date evidence on the management of ARVC patients during the antepartum and postpartum period.

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Epsilon Wave Resolution Following Epicardial Ablation in Arrhythmogenic Right Ventricular Cardiomyopathy

JACC: Clinical Electrophysiology ◽

10.1016/j.jacep.2020.07.013 ◽

2020 ◽

Vol 6 (11) ◽

pp. 1470-1471

Author(s):

Adam Lee ◽

Satoshi Higuchi ◽

Edward P. Gerstenfeld

Keyword(s):

Right Ventricular ◽

Arrhythmogenic Right Ventricular Cardiomyopathy ◽

Ventricular Cardiomyopathy ◽

Epicardial Ablation

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A Novel Mutation of the Plakophilin-2 Gene in a Child with Early Onset Arrhythmogenic Right Ventricular Cardiomyopathy and Intractable Arrhythmia

The Indian Journal of Pediatrics ◽

10.1007/s12098-021-03679-8 ◽

2021 ◽

Vol 88 (5) ◽

pp. 504-504

Author(s):

Stasa Krasic ◽

Vladislav Vukomanovic ◽

Svetozar Putnik ◽

Jovan Kosutic ◽

Sanja Ninic ◽

...

Keyword(s):

Right Ventricular ◽

Early Onset ◽

Novel Mutation ◽

Arrhythmogenic Right Ventricular Cardiomyopathy ◽

Ventricular Cardiomyopathy ◽

Plakophilin 2

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Prevalence of atrial arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis

European Heart Journal ◽

10.1093/ehjci/ehaa946.0504 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

P Rujirachun ◽

P Wattanachayakul ◽

N Charoenngam ◽

A Winijkul ◽

P Ungprasert

Keyword(s):

Atrial Fibrillation ◽

Cohort Studies ◽

Right Ventricular ◽

Atrial Tachycardia ◽

Arrhythmogenic Right Ventricular Cardiomyopathy ◽

Meta Analysis ◽

Atrial Arrhythmia ◽

Funding Source ◽

Ventricular Cardiomyopathy ◽

Pooled Prevalence

Abstract Background and objectives Little is known about atrial involvement in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Recent studies have suggested that atrial arrhythmia (AA), including atrial fibrillation (AF), atrial flutter (AFL), and atrial tachycardia (AT), was common among these patients although the reported prevalence varied considerably across the studies. Methods We searched for published articles indexed in MEDLINE and EMBASE databases from inception through Sep 22, 2019 to identify cohort studies of patients with ARVC that described the prevalence of atrial arrhythmia among the participants. The pooled prevalence across studies was calculated. Results A total of 16 cohort studies with 1,986 patients with ARVC were included into this meta-analysis. The pooled prevalence of overall AA among patients with ARVC was 17.9% (95% CI, 13.0%–24.0%; I2 88%), the pooled prevalence of AF of 12.9% (95% CI, 9.6%–17.0%; I2 78%), the pooled prevalence of AFL of 5.9% (95% CI, 3.7%–9.2%; I2 70%), and the pooled prevalence of AT of 7.1% (95% CI, 3.7%–13.0%; I2 49%). Conclusions AA is common among patient with ARVC with the pooled prevalence of approximately 18%, which is substantially higher than the reported prevalence of AA in general population. Funding Acknowledgement Type of funding source: None

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