scholarly journals Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

2021 ◽  
Vol 15 (9) ◽  
pp. 4000-4004
Author(s):  
Rahmat Ali ◽  
Muhammad Sohrab Khan ◽  
Shakeel Ahmad ◽  
Syed Imad Hussain ◽  
Tahir Mukhtar Sayed
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Subclinical Hypothyroidism ◽  
Diabetic Peripheral Neuropathy ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Level Of Significance

Background and Objective: The diabetic Mellitus common and spiking complication is Diabetic peripheral neuropathy (DPN). It is frequently associated with thyroid dysfunction. The subclinical hypothyroidism prevalence and clinical outcomes have been investigated by various studies. The present study aims to determine the prevalence of subclinical hypothyroidism in diabetic peripheral neuropathy patients. Methods: This cross-sectional study was carried out on 164 diabetic neuropathy patients attending the medicine department of Qazi Hussain Ahmad Medical Complex, Nowshera KPK during the study period from 2020 to 2021. Patients’ demographic details, clinical history, and neurological examination were recorded. Normal free thyroxin value was set as a referential standard for subclinical hypothyroidism diagnosis among all the patients. Diabetic neuropathy patients’ clinical manifestations were recorded as per neurological screening instrument. The clinical scoring system was utilized for DPN severity categorization into mild (6-8), moderate (9-11), and severe (>12). SPSS version 20 and a logistic regression model were used for data analysis. Results: This study enrolled 164 diabetic peripheral neuropathy patients. Of the total 164, 69 (42.1%) were male and 95 (57.9%) were female. The overall mean age was 49.61±13.72 years. The prevalence of subclinical hypothyroidism was 32 [19.5%; 95% CI; 14.3%-23.7%]. The diabetic peripheral neuropathy patients with subclinical hypothyroidism had a higher prevalence of severity 86 [52.4%; 95%CI] compared to DNP patients without SCH 46 [28.04%; 95% CI] with a 3% level of significance. A higher HbA1c and HOMA-IR was found in patients with their respective values were (8.3±1.1 against 7.2±1.3) where p-value <0.001 and (3.5 ± 0.9 vs. 2.6 ± 0.8, p<0.001) respectively. Conclusion: The diabetic peripheral neuropathy patients are susceptible to have frequent subclinical hypothyroidism independently associated with severity and complications of DPN. Thyroid function should be tested in DM patients and given to DM patients with SCH. Keywords: Diabetes mellitus; Subclinical hypothyroidism; Diabetic peripheral neuropathy

scholarly journals Vitamin D Deficiency in Patients with Diabetic Peripheral Neuropathy

2019 ◽  
Vol 7 (4) ◽  
pp. 291-294
Author(s):  
Hameedullah Khan ◽  
Ihsanullah Rajar ◽  
Abdul Rauf Memon ◽  
Nadeem Naeem
Keyword(s):  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Vitamin D Deficiency ◽  
Diabetic Peripheral Neuropathy ◽  
Cross Sectional Study ◽  
Key Words Diabetes ◽  
Cross Sectional ◽  
Peripheral Diabetic Neuropathy ◽  
Diabetes Peripheral Neuropathy

Objective: To determine the frequency of vitamin D deficiency in patients presenting with diabetic peripheral neuropathyPatients and Methods: This cross sectional study was carried out in Department of Medicine and Neurology Indus Medical College, Tando Muhammad khan. from March 2017 to August 2017. Total 74 cases of Diabetes Mellitus presenting with peripheral diabetic neuropathy were selected for the study. Evolution of degree of Neuropathy was based on TCSS score as: {no neuropathy: ≤5, severe: ≥12, moderate: 9-11 and mild: 6-8}. Vitamin D level was categorized as (deficiency (0-20 ng/ml), insufficiency (21-30 ng/ml) sufficiency (>30 ng/ml), excess (>50 ng/ml) and toxicity (>100 ng/ml). All the data was entered in SPSS.Results: Total 74 patients with diabetic neuropathy were studied. Vast majority of patients 36(48.6%) were found in age group 51-60 years, Majority were males 45(60.8%). Most of the cases 35(47.3%) were with 1-3 years duration of neuropathy. Majority of patients 42(56.8%) were found with Mild peripheral neuropathy. Vitamin-D deficiency was present in 2(43.2%) cases and insufficiency was observed in 27(36.5%) cases. No significant association was found between vitamin D deficiency and severity of neuropathy.Conclusion: Vitamin D deficiency was found (43.2%) in patients of diabetic peripheral neuropathy. Vitamin screening and intake of supplement is necessary, will help to decrease the complication of peripheral neuropathy in Diabetic cases. Key words: Diabetes, Peripheral neuropathy, Vitamin D

Prevalence of alcohol use and associated factors among Dilla University Students, Dilla Town, Southern Ethiopia. 2018

2020 ◽  
Author(s):  
Yigrem Ali Chekole
Keyword(s):  
Alcohol Use ◽  
Undergraduate Students ◽  
Associated Factors ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Southern Ethiopia ◽  
P Value ◽  
Cross Sectional ◽  
Level Of Significance ◽  
The University

Abstract Introduction Compared to other deadly communicable diseases, Psychoactive Substance use is among the leading cause of death. Repeated use linked to addiction, dependence and predisposition for criminal and antisocial behaviors. Even though drug use in Africa relatively is short; however the abuse of drug in Africa is escalating rapidly. Substances use is also one of the most burning and growing public health problems in Ethiopia, as in many developing countries; alcohol is the most frequently used substance. Objective To Assess the Prevalence of alcohol Use and Associated factors among Dilla University undergraduate students in Southern Ethiopia. 2018. Methods An Institution based cross -sectional study was conducted at Dilla University among undergraduate regular students from January-February. Systematic random sampling technique was used to get a total of 803 samples of students from each year and department of the university. The collected data was coded, entered in to EPI-INFO version7.1 and analyzed by using SPSS version 20. Crude and adjusted OR were analyzed using logistic regression and the level of significance of association was determined at P- value <0.05. Result A total of 803 participants were interviewed with a response rate of 91.7%. Among the Participants, alcohol use was found to be 67.6%. (41.8%; n=336). Being 4 th year students (AOR =2.66, 95% CI: 1.64, 4.31), having friends who use substance (AOR=1.53, 95% CI: 1.09, 2.1), being Khat user (AOR= 1.48, 95% CI: 1.05, 2.09) and being Cigarette smoker (AOR=1.76, 95% CI: 1.09, 2.84) were found to be significantly associated with alcohol use. Conclusion Half of the participants found to have alcohol use. Therefore, early prevention, detection and alleviating of alcohol use should be implemented among students in the university.

scholarly journals PREDICTORS OF UPTAKE OF A POTENTIAL COVID-19 VACCINE AMONG NIGERIAN ADULTS

2021 ◽  
Author(s):  
Charles Oluwatemitope Olomofe ◽  
Victor Kehinde Soyemi ◽  
Bolaji Felicia Udomah ◽  
Adeyinka Olabisi Owolabi ◽  
Emmanuel Eziashi Ajumuka ◽  
...  
Keyword(s):  
Descriptive Analysis ◽  
Cross Sectional Study ◽  
Capital City ◽  
Vaccine Uptake ◽  
P Value ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Vaccination History ◽  
The Face ◽  
Level Of Significance

ABSTRACTBackgroundThe Coronavirus diseases (COVID-19) pandemic is not abating and there is no approved treatment yet. The development of vaccines is hoped to help in addressing this disease outbreak. However, in the face of anti-vaccines uprise, it is important to understand the factors that may influence the uptake of COVID-19 vaccines as this will influence how successful the fight against COVID-19 will be in the long term.MethodsA cross-sectional study among 776 adult Nigerians (age ≥18 years) was conducted in the 36 States of Nigeria and the Capital City with online questionnaire. The questionnaire consisted of 5 sections: socio-demographic characteristics of respondents, respondent’s knowledge of COVID-19, respondents risk perception of COVID-19, vaccination history of respondents, and willingness to receive COVID-19 vaccine. Descriptive analysis of variables was done and multivariate analysis using logistic regression was carried out to determine the predictors of uptake of a potential COVID-19 vaccine. The level of significance was predetermined at a p-value < 0.05. Data analysis was done with SPSS version 21.ResultsMost of the respondents were male (58.1%). Most participants were willing to take a potential COVID-19 vaccine (58.2%), while 19.2% would not take it with 22.6% indecisive. 53.5% would prefer a single dose COVID-19 vaccine. For vaccine uptake, being male (p= 0.002) and the perception that “vaccines are good” (p< 0.001) were the positive predictor of uptake of a potential COVID-19 vaccine.ConclusionMost Nigerians were willing to take a potential COVID-19 vaccine with the male gender and perception that “vaccines are good” being positive predictors. There is a need for public enlightenment aim at encouraging those that are indecisive or averse to receiving COVID-19 vaccines.

scholarly journals Epidemiological Pattern of Poisoning in Children under the Age of 15 Admitted to the Referral Teaching Hospitals of Yazd and Taft Cities (2014-2019)

2021 ◽  
Author(s):  
Mahdieh Momayyezi ◽  
Parisa Peigan ◽  
Hossein Fallahzadeh
Keyword(s):  
Urban Areas ◽  
Pearson Correlation ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Epidemiological Pattern ◽  
Poisoning In Children

Introduction: Understanding the epidemiological pattern and causes of poisoning is the first step to prevent and reduce complications and mortality due to poisoning in children. Given that no study has been conducted on this subject in Yazd, this study aimed to determine the epidemiology pattern of poisoning in children admitted to the referral teaching hospitals in Yazd and Taft cities during 2014-2019. Materials and Methods: This descriptive cross-sectional study was conducted on 238 children under the age of 15 who have been admitted to Shahid Sadoughi hospital in Yazd and Shahid Beheshti hospital in Taft city during 2014-2019. The data were analyzed by SPSS version 20.0 using descriptive statistics, Pearson correlation, and Chi-square. In all the statistical analyses, a P-value of less than 0.05 was considered significant. Results: The results showed that the frequency of poisonings was higher in girls (58%), in summer (31.1%), and in urban areas (82.8%). Most cases of poisoning aged less than 15 years (75.1%). The main cause of poisoning in children was drug poisoning (60.5%), followed by cleansing products (10.1%). The most common clinical manifestations included neurological signs (33.6%). During 2014-2019, the frequency of drugs and pesticide poisonings decreased; while poisoning due to drug-opioids and cleansing products increased (P = 0.04). Also, 3 deaths occurred due to poisoning during this period. Conclusion: The higher prevalence of drug and cleansing products poisoning in children under the age of 15 indicates involuntary poisoning in this group. Therefore, proper storage of these substances and more parental care can reduce poisonings in children.

scholarly journals Do we need to screen and treat pregnant women for subclinical hypothyroidism? A cross sectional study in a rural tertiary centre in Kerala, India

2017 ◽  
Vol 6 (3) ◽  
pp. 781
Author(s):  
Radha K. R. ◽  
Nishu Sugunan ◽  
Resmy C. R.
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Universal Screening ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Neonatal Hypothyroidism ◽  
In Pregnancy

Background: Hypothyroidism (HT) is associated with maternal and perinatal morbidity. Subclinical HT rather than overt occur in pregnancy, because overt HT causes infertility. Treatment of overt HT was beneficial in reducing the fetal and maternal complications, Usefulness of correcting subclinical hypothyroidism was doubtful, hence Universal screening of pregnant women was not recommended.Methods: Cross sectional study, conducted in the department of obstetrics and gynecology, Government Medical College, Thrissur, Kerala, India. 50 consecutive cases of subclinical hypothyroidism in pregnancy were analyzed for Thyroid function, antenatal, natal, postnatal complications. Perinatal complications, including neonatal hypothyroidism also noted. Statistical analysis done using computer software Epi info3.4. Data expressed in its frequency and percentage, continuous data in mean.Results: All women in the study group received levothyroxine during pregnancy from time of diagnosis. At the time of delivery 84% women were euthyroid and 16% hypothyroid. Complications like anemia 36%, abruption 4%, and postpartum hemorrhage 6% showed a statistically significant association, while pre-eclampsia 20%, preterm labor 22% had no statistically significant association. Comparing the women who are euthyroid as a result of levothyroxine supplementation to women inadequately treated, complications like anemia (33% versus 50%, p value 0.042), abruption (0% versus 4%, p value0.023), PPH (2% versus 6%, p value 0.014) were significantly less in well controlled.Conclusions: Significant association was noted between inadequately treated hypothyroidism and maternal complications like anaemia, placental abruption, placenta previa, PPH, preterm delivery, and caesarean section rate for foetal distress. Universal screening of pregnant women for thyroid status is recommended.

scholarly journals THYROID SWELLING AND IT’S ASSOCIATION WITH THYROID HORMONE STATUS AND BLOOD LIPID PROFILE: A CROSS-SECTIONAL STUDY

2021 ◽  
pp. 26-30
Author(s):  
Arup Chakraborty ◽  
Prabir Kumar Saha ◽  
Arpita Das ◽  
Bidhan Das
Keyword(s):  
Thyroid Hormone ◽  
Total Cholesterol ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Average Value ◽  
Hormone Status ◽  
Level Of Significance ◽  
Α Level ◽  
Altered Lipid

Disease of thyroid gland are among the most abundant endocrine disorder in the world second only to diabetes mellitus . Thyroid diseases namely hypothyroidism and hyperthyroidism,constitutes the most common endocrine abnormality in recent years,diagnosed either in subclinical or clinical form.One observational cross sectional study was conducted in the department of ENT, Tripura Medical College & DR.BRAM Teaching hospital involving 75 nos of subjects having thyroid swellings. Mean value of T3,T4 and TSH was different in cases of euthyroid, hypothyroid , hyperthyroid and subclinical hypothyroid subject. It was of statistically significant. Here P value of T3, T4 & TSH according to thyroid hormone status were less than 0.05(α%) level of significance.There was statistically difference in average value of T3,T4 & TSH with different thyroid hormone status at 5% level of significance.We found that 9.3% of the study subjects were having altered lipid profile.We found that 62.5% of hypothyroid subjects were having altered lipid profile . Amongst them,all subclinical hypothyroid subjects were having altered lipid profile.Whereas hyperthyroid subjects were having normal lipid profile.Two (3.07%) euthyroid cases were having altered lipid profile.We found that mean values of total cholesterol, triglyceride, HDL, LDL and VLDL was different in cases of euthyroid , hypothyroid , hyperthyroid and subclinical hypothyroid subject.It was of statistically significant.Here P value of total cholesterol,triglyceride,HDL,LDL and VLDL according to thyroid hormone status were less than 0.05(α%) level of significance. There was statistically difference in average value of total cholesterol,triglyceride,HDL,LDL and VLDL with thyroid hormone status at 5% level of significance.

scholarly journals Comparing the Diagnostic Accuracy of Simple Tests to Screen for Diabetic Peripheral Neuropathy: Protocol for a Cross-Sectional Study (Preprint)

2017 ◽  
Author(s):  
Kate Goddard ◽  
Prashanth Vas ◽  
Alistair Purves ◽  
Viktoria McMillan ◽  
Thomas Langford ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diagnostic Accuracy ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Velocity Measurement ◽  
Sural Nerve ◽  
Nerve Conduction Velocity ◽  
Cross Sectional Study ◽  
Cross Sectional

BACKGROUND Various tests are used to detect diabetic peripheral neuropathy by assessing sense perception in the feet. Tests vary in terms of time and resources required. Simple tests are those that can be conducted quickly and easily in primary care without laboratory equipment. There are some limitations to these simple tests, an example being the variable amplitude of the 128 Hz tuning fork. A new test, VibraTip (McCallan Medical, UK), might be a valuable alternative as it emits a consistent amplitude and may offer improved diagnostic accuracy. OBJECTIVE The aims of this study are to estimate the diagnostic accuracy of the VibraTip device for diabetic peripheral neuropathy against the reference standard of sural nerve conduction velocity measurement, and to assess whether the VibraTip offers superior diagnostic accuracy to other routine tests based on vibration or touch. METHODS The study will prospectively recruit adults with type 2 diabetes who are due to attend a routine follow-up clinic. A cross-sectional study design will be employed to assess the diagnostic accuracy of 5 standard index tests for peripheral neuropathy, including VibraTip. The reference test will be sural nerve conduction velocity measurement. RESULTS Funding is being sought to conduct this research. The outcomes assessed will be the diagnostic accuracy of the 5 index tests against sural nerve conduction velocity measurement, including sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio. Receiver operating characteristic curves will be constructed and compared for each test. CONCLUSIONS This study will be the first within-study comparison of 5 simple tests for screening diabetic peripheral neuropathy and will address uncertainties in the potential benefits of using VibraTip in comparison with the other tests.

scholarly journals Comparing the Diagnostic Accuracy of Simple Tests to Screen for Diabetic Peripheral Neuropathy: Protocol for a Cross-Sectional Study

2018 ◽  
Vol 7 (4) ◽  
pp. e72 ◽  
Author(s):  
Kate Goddard ◽  
Prashanth Vas ◽  
Alistair Purves ◽  
Viktoria McMillan ◽  
Thomas Langford ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diagnostic Accuracy ◽  
Diabetic Peripheral Neuropathy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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