scholarly journals BIOMARKER YANG BERPOTENSI MENDETEKSI RISIKO DIABETES MELLITUS GESTASIONAL PADA MASA PRAKONSEPSI

2020 ◽  
Vol 8 (1) ◽  
pp. 58-63
Author(s):  
Rima Novisca Jasmadi ◽  
Intanri Kurniati
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Sex Hormone Binding Globulin ◽  
Low Density ◽  
Hormone Binding ◽  
Gamma Glutamyltransferase ◽  
Total Adiponectin

ABSTRAK  Pendahuluan: Diabetes mellitus gestasional adalah gangguan intoleransi glukosa pada masa kehamilan. Diabetes mellitus gestasional merupakan komplikasi yang paling sering terjadi pada kehamilan, ditemukan pada 5-9% dari kehamilan. Ibu hamil yang menderita diabetes mellitus gestasional dapat meningkatkan risiko hipertensi selama kehamilan, persalinan secara cesar, dan macrosomia (berat badan bayi yang lahir lebih dari 4000 gram). Risiko jangka panjang yang dapat dialami oleh ibu hamil dengan diabetes mellitus gestasional yaitu peningkatan risiko menderita penyakit diabetes serta penyakit kardiovaskular dan pada bayi yang dilahirkan akan meningkatkan risiko terjadinya obesitas, intoleransi glukosa, dan diabetes.  Pembahasan: Proses patogenik terjadinya diabetes mellitus gestasional sudah di mulai dari sebelum kehamilan. Identifikasi wanita yang berisiko tinggi mengalami diabetes mellitus gestasional akan sangat bermanfaat apabila dilakukan sebelum kehamilan agar dapat dilakukan intervensi pada saat prakonsepsi untuk mengurangi risiko terjadinya diabetes mellitus gestasional pada saat hamil nantinya. Ada beberapa jenis biomarker yang bisa digunakan untuk mendeteksi risiko diabetes mellitus gestasional, di antaranya total adiponectin, sex hormone-binding globulin (SHBG), total high-density lipoprotein (HDL), low-density lipoprotein (LDL) peak diameter dan gamma-glutamyltransferase (GGT).  Kesimpulan: Penggunaan lebih dari satu biomarker memiliki skor yang lebih tinggi dalam mengidentifikasi diabetes mellitus gestasional dibandingkan hanya dengan satu biomarker saja. Wanita yang diperiksa dengan 3 atau 4 biomarker memiliki peluang teridentifikasi diabetes mellitus gestasional 10 kali lipat lebih besar.  Kata kunci: Biomarker, Diabetes mellitus gestasional, Prakonsepsi   ABSTRACT  Introduction: Gestational diabetes mellitus is a glucose intolerance disorders during pregnancy. Gestational diabetes mellitus is the most common complication in pregnancy, found in 5-9% of pregnancies. Pregnant women that suffer gestational diabetes mellitus can increase risk of hypertension during pregnancy, caesarean delivery, and macrosomia (babies’ weight more than 4000 grams). Long-term risks that can be experienced by pregnant women with gestational diabetes mellitus are an increased risk of suffering from diabetes and cardiovascular disease and in babies born will increase the risk of obesity, glucose intolerance, and diabetes.  Discussion: The pathogenic process of gestational diabetes mellitus begins before pregnancy. Identification of women at high risk of having gestational diabetes mellitus will be very useful if done before pregnancy, that intervention can be done at the time of preconception to reduce the risk of developing gestational diabetes mellitus in future pregnancy. There are several types of biomarkers that can be used to detect the risk of gestational diabetes mellitus, including total adiponectin, sex hormone-binding globulin Tinjauan Pustaka    JIMKI Volume 8 No.1 | November 2019 – Februari 2020 59  (SHBG), total high-density lipoprotein (HDL), low-density lipoprotein (LDL) peak diameter and gamma-glutamyltransferase (GGT).  Conclusion: Use of more than one biomarker has a higher score in identifying gestational diabetes mellitus compared to just one biomarker. Women examined with 3 or 4 biomarkers had a 10-fold greater chance of being identified as gestational diabetes mellitus.  Keyword: Biomarkers, Gestational diabetes mellitus, Preconception  

First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study

2019 ◽  
Vol 47 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Paula J. Correa ◽  
Pia Venegas ◽  
Yasna Palmeiro ◽  
Daniela Albers ◽  
Gregory Rice ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Case Control Study ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
First Trimester ◽  
Case Control ◽  
Low Density ◽  
Control Study

AbstractObjectivesTo evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).MethodsThe study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).ResultsThe GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.ConclusionWomen who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.

scholarly journals Vitamin D status and risk factors among pregnancy of shanghai in China

2021 ◽  
Author(s):  
chun yang ◽  
Jing Wu ◽  
Sheng Ge ◽  
Wenguang Sun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Vitamin D Status

Abstract Background This study was to assess vitamin D nutritional status and risk factors among pregnancy of shanghai in China. Methods A cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. All pregnancy was measured for plasma vitamin D, total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL) or very-low-density lipoprotein (VLDL) cholesterol and triglycerides, and completed OGTTs test. Age, height, and weight variables came from their electronic medical records. Criteria for vitamin D status were: <12 ng/ml: severe deficiency; 12–19 ng/ml: deficiency; 20–29 ng/ml: insufficiency; 30–50 ng/ml: normal; and > 50 ng/ml (particularly > 60 ng/ml): possibly leading to adverse effects. Vitamin D was measured from December 2016 to April 2017. Results Our study included 953 pregnant women. The mean vitamin D level of pregnancy was 16.06 (range 10.90 to 20.60) ng/ml,and severe vitamin D deficiency was 31.79%(303); vitamin D deficiency was 40.71 %(388); vitamin D insufficiency was 25.08%(239); normal vitamin D was 2.42%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, gestational diabetes mellitus, and hyperglycemia. Conclusions It is a high prevalence of vitamin D deficiency of Chinese pregnancy in shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, gestational diabetes mellitus and hyperglycemia are risk factors for vitamin D deficiency. Public health strategies should focus on the population of pregnancy in shanghai in China.

scholarly journals Vitamin D status and vitamin D deficiency risk factors among pregnancy of Shanghai in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chun Yang ◽  
Wu Jing ◽  
Sheng Ge ◽  
Wenguang Sun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

Abstract Background There is increasing awareness that vitamin D deficiency in pregnant women may be associated with several adverse effects for the mother and newborn. The risks for vitamin D deficiency are unclear. This study was to assess vitamin D nutritional status and vitamin D deficiency risk factors among pregnant women in Shanghai in China. Methods This study is a cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. A total of 953 healthy pregnant women participated, serological examinations and other variables included serum 25-hydroxyvitamin D [25(OH)D], total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol, triglycerides at the first antenatal visit (12–14 weeks) pregnancy parity and age, body mass index (BMI) before pregnancy, and completed OGTTs test. Associations between vitamin D deficiency and possible predictors (age group, pre-pregnancy BMI, parity, and gestational hyperlipemia) were assessed with a multinomial logistic regression analysis. And also used to investigate the effects of 25(OH)D and the other variables on the occurrence of gestational diabetes mellitus. Results The mean vitamin D level of pregnancy was 16 (a range from 11 to 21) ng/ml, and severe vitamin D deficiency was 31.8% (303); vitamin D deficiency was 40.7% (388); vitamin D insufficiency was 25.1% (239); normal vitamin D was 2.4%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, and hyperlipemia. The increasing level of vitamin D nutritional status in pregnancy is significantly related to reducing gestational diabetes mellitus. Vitamin D deficiency is a risk factor for gestational diabetes mellitus. Conclusions It is a high prevalence of vitamin D deficiency in Chinese pregnancy in Shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, and hyperlipemia are risk factors for vitamin D deficiency. Vitamin D deficiency is a risk factor for gestational diabetes mellitus. Public health strategies to prevent vitamin D deficiency should focus on those risks to promote health pregnancy of Shanghai in China.

scholarly journals Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

Open Medicine ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 70-86
Author(s):  
Fatemeh Alsadat Rahnemaei ◽  
Reza Pakzad ◽  
Azam Amirian ◽  
Iraj Pakzad ◽  
Fatemeh Abdi
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Low Density

Abstract Gestational diabetes mellitus (GDM) can have adverse effects on pregnancy. GDM is associated with changes in the lipid profile of pregnant women. Finding out the early ways to diagnose GDM can prevent the adverse outcomes. This meta-analysis study aimed to determine the effect of GDM on lipid profile. PubMed, ProQuest, Web of Science, Scopus, Science Direct, Google Scholar, and ClinicalTrial were systematically searched for published articles relating to GDM until 2021 according to PRISMA guidelines. Newcastle Ottawa scale was used to assess the quality of the studies. Thirty-three studies with a sample size of 23,792 met the criteria for entering the meta-analysis. Pooled standardized mean difference (SMD) for total cholesterol (TC) and triglyceride (TG) was 0.23 mg/dL (95% CI: 0.11–0.34) and 1.14 mg/dL (95% CI: 0.91–1.38), respectively. The mean of TC and TG in people with GDM was higher than that in normal pregnant women. A similar pattern was observed for the very low-density lipoprotein (VLDL) and TG/high-density lipoprotein (HDL) ratio, with pooled SMD of 0.99 mg (95% CI: 0.71–1.27) and 0.65 mg (95% CI: 0.36–0.94), respectively. Pooled SMD for HDL was −0.35 mg/dL (95% CI: −0.54 to −0.16), women with GDM had a mean HDL lower than normal pregnant women. Although pooled SMD was higher for low-density lipoprotein (LDL) in the GDM group, this difference was not significant (0.14 [95% CI: −0.04 to 0.32]). Of all the lipid profiles, the largest difference between the GDM and control groups was observed in TG (SMD: 1.14). Elevated serum TG had the strongest effect on GDM. Higher levels of TC, LDL, VLDL, and TG/HDL ratio, and lower level of HDL were exhibited in GDM group. So, these markers can be considered as a reliable marker in the diagnosis of GDM.

scholarly journals Sex hormone binding globulin as a valuable biochemical marker in predicting gestational diabetes mellitus

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Manal Abdalla Tawfeek ◽  
Eman Mohamad Alfadhli ◽  
Abdulfatah Marawan Alayoubi ◽  
Hesham Ahmad El-Beshbishy ◽  
Fawzia Ahmad Habib
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Biochemical Marker ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Effects of structured exercise regime on lipid profile and renal function tests in gestational diabetes mellitus patients-A pilot study

2020 ◽  
pp. 1-9
Author(s):  
Wardah Ajaz Qazi ◽  
Muhammad Naveed Babur ◽  
Arshad Nawaz Malik ◽  
Nadia Ahmed Bokhari ◽  
Mirza Shamim Baig ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Third Trimester ◽  
The Third ◽  
Exercise Regime ◽  
Renal Function Tests

Abstract Objectives: To determine the effects of structured exercise regime on biochemical markers of patients of gestational diabetes mellitus during the third trimester. Methods: The two-arm pilot study was conducted at the Fauji Foundation Hospital, Rawalpindi, Pakistan, from March to July 2019, and comprised women aged 20-40 years with gestational age >20 weeks who were diagnosed with gestational diabetes mellitus and who were able to do 6min walk test under severity level on the 0-10 Borg scale. The subjects were randomized into two groups using the sealed envelope method. The intervention group received 5 weeks of structured exercise programme. including aerobics, stabilisation and pelvic floor muscle training, while the control group only received postural education. Data was noted at baseline and after intervention, and was analysed using SPSS 20. Results: Of the 16 subjects, there were 8(50%) in each of the two groups. The mean age was 31.5±4.17 years in the interventional group and it was 35.0±6.30 years in the control group. Serum low-density lipoprotein and serum creatinine showed significant differences between the groups (p<0.05), while the rest of markers were non-significant (p>0.05). Conclusion: Structured exercise regime was found to have a positive effect in reducing serum low-density lipoprotein and serum creatinine levels in gestational diabetes mellitus during the third trimester. Key Words: Gestational diabetes mellitus, Lipid profile, Renal function tests, Structured exercise regime, Third trimester.

Sign in / Sign up

Export Citation Format

Share Document