Postpartum severe hyponatremia in preterm birth and mature newborns: Dangers for mother and child?

Preterm birth and risk for language delays before school entry: A sibling-control study

Development and Psychopathology ◽

10.1017/s0954579419001536 ◽

2020 ◽

pp. 1-6

Author(s):

Imac Maria Zambrana ◽

Margarete E. Vollrath ◽

Bo Jacobsson ◽

Verena Sengpiel ◽

Eivind Ystrom

Keyword(s):

Risk Factors ◽

At Risk ◽

Preterm Birth ◽

Familial Risk ◽

Language Delay ◽

Language Delays ◽

Increased Risk ◽

Mother And Child ◽

Sibling Control ◽

Before School

Abstract We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. Participants included 26,769 siblings born between gestational weeks 23 and 42. Language delay was assessed when the children were 1.5, 3, and 5 years old. To adjust for familial risk factors, comparisons were conducted between preterm and full-term siblings. Pregnancy-specific risk factors were controlled for by means of observed variables. Findings showed that preterm children born before week 37 had increased risk for language delays at 1.5 years. At 3 and 5 years, only children born before week 34 had increased risk for language delay. Children born weeks 29–33 and before week 29 had increased risk for language delay at 1.5 years (RR = 4.51, 95% CI [3.45, 5.88]; RR = 10.32, 95% CI [6.7, 15.80]), 3 years (RR = 1.50, 95% CI [1.02, 2.21]; RR = 2.78, 95% CI [1.09, 7.07]), and 5 years (RR = 1.63, 95% CI [1.06, 2.51]; RR = 2.98, 95% CI [0.87, 10.26]), respectively. In conclusion, children born preterm are at risk for language delays, with familial confounders only explaining a moderate share of the association. This suggests a cause-effect relationship between early preterm birth and risk for language delay in preschool children.

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Association between the use of antidepressants and the risk of preterm birth among pregnant women with depression: a retrospective cohort study in Taiwan

Journal of Investigative Medicine ◽

10.1136/jim-2020-001683 ◽

2021 ◽

pp. jim-2020-001683

Author(s):

Li-Fen Chen ◽

Ching-En Lin ◽

Chi-Hsiang Chung ◽

Ching-Huang Lai ◽

Wu-Chien Chien

Keyword(s):

Preterm Birth ◽

Pregnant Women ◽

Retrospective Cohort ◽

Regression Models ◽

Perinatal Depression ◽

Research Database ◽

Proportional Hazard ◽

Cox Proportional Hazard ◽

Mother And Child ◽

Cox Proportional Hazard Regression

Our study was aimed to investigate the association between the use of antidepressants and the risk of preterm birth in pregnant women who have had perinatal depression. We extracted data from the Taiwanese National Health Insurance Research Database (NHIRD) and analyzed them using multivariate Cox proportional hazard regression models. Identified from the NHIRD, we matched 1789 women aged 18–55 years who were using antidepressants during pregnancy and 1789 women who were experiencing depression but who were not using antidepressants during pregnancy for age, index date, and medical comorbidities. We enrolled the women in our study, which we conducted using 12 years’ worth of data between 2000 and 2012, and then followed up individually with them for up to 1 year to identify any occurrence of preterm birth. Results highlighted that, compared with the women with perinatal depression who were not using antidepressants during pregnancy, the women taking antidepressants had a 1.762-fold risk of preterm birth (adjusted HR=1.762, 95% CI 1.351 to 2.294, p<0.001). The use of antidepressants in women with perinatal depression may increase the risk of preterm birth. However, the decision to start, stop, or change the use of antidepressants during pregnancy requires evaluating the risks of treatment versus untreated depression for both mother and child.

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Maternal demographic and antenatal factors, low birth weight and preterm birth: findings from the mother and child in the environment (MACE) birth cohort, Durban, South Africa

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03328-6 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Prakash M. Jeena ◽

Kareshma Asharam ◽

Aweke A. Mitku ◽

Pragalathan Naidoo ◽

Rajen N. Naidoo

Keyword(s):

South Africa ◽

Preterm Birth ◽

Birth Cohort ◽

Low Birthweight ◽

Clinical Status ◽

First Trimester ◽

Logistic Regression Models ◽

Factors Associated ◽

Vaginal Deliveries ◽

Mother And Child

Abstract Background Low birthweight (LBW) and preterm birth (PB) remain the leading cause of morbidity and mortality in neonates worldwide. The aim of this study was to identify maternal demographic and antenatal factors associated with PB and LBW among low socio-economic communities. Methods Pregnant women (n = 1099) were recruited in the first trimester into the Mother and Child in the Environment (MACE) birth cohort in Durban, South Africa. Maternal factors such as demographic information, health status, residential area, occupational, personal and environmental smoking and biomass fuel use were obtained through standardised interviews, while clinical status was obtained in each trimester and antenatal information on HIV status and treatment, syphilis and conditions such as pregnancy induced hypertension, diabetes etc. was extracted from the antenatal assessments. Key outcomes of interest were preterm birth and low birthweight. The latter data was obtained from the clinical assessments performed by midwives at delivery. Logistic regression models identified factors associated with PB and LBW. Results Of the 760 live births, 16.4 and 13.5% were preterm and LBW, respectively. Mothers who delivered by caesarean section had an increased odds of having LBW babies (Adjusted odds ratio (AOR): 1.7; 95% CI: 1.1–2.7) and PB (AOR: 1.7, 95% CI: 1.1–2.7) versus normal vaginal deliveries. Mothers > 30 years (AOR: 1.8, 95% CI: 1.1–2.9) and current smokers (AOR: 2.7, 95% CI: 1.3–5.8) had an increased odds of having PB babies. Compared to younger mothers and non-smokers respectively. An effect of PB and LBW was seen among mothers with high BMI (25.0–29.9 kg/m2) (PB: AOR: 0.5, 95% CI: 0.3–0.9 and LBW: AOR: 0.5, 0.5, CI: 0.3–0.8), and obese BMI (> 30 kg/m2) (PB: AOR: 0.5, 95% CI: 0.3–0.9 and LBW: AOR: 0.4, CI: 0.2–0.7). Maternal HIV (PB AOR: 1.4 and LBW AOR: 1.2) and history of sexually transmitted infections (PB AOR: 2.7 and LBW AOR: 4.2) were not statistically significant. Conclusion Maternal age, cigarette smoking and caesarean delivery were associated with LBW and PB. Findings highlight the need of maternal health interventions to improve new-born health outcomes.

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Mediterranean-type diet and risk of preterm birth among women in the Norwegian Mother and Child Cohort Study (MoBa): a prospective cohort study

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1080/00016340801899123 ◽

2008 ◽

Vol 87 (3) ◽

pp. 319-324 ◽

Cited By ~ 54

Author(s):

Margaretha Haugen ◽

Helle Margrete Meltzer ◽

Anne Lise Brantsæter ◽

Tina Mikkelsen ◽

Marie Louise Østerdal ◽

...

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Mother And Child

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Pre-eclampsia and childhood asthma

European Respiratory Journal ◽

10.1183/13993003.00673-2016 ◽

2016 ◽

Vol 48 (6) ◽

pp. 1622-1630 ◽

Cited By ~ 6

Author(s):

Maria C. Magnus ◽

Siri E. Håberg ◽

Per Magnus ◽

Anders Engeland ◽

Per Nafstad ◽

...

Keyword(s):

Preterm Birth ◽

Relative Risk ◽

Mediation Analysis ◽

Childhood Asthma ◽

Positive Association ◽

Adjusted Relative Risk ◽

Registry Study ◽

Sibling Comparison ◽

Mother And Child ◽

Log Linear

Studies of pre-eclampsia and childhood asthma are conflicting, and none have performed a formal mediation analysis of preterm birth.We examined the association between pre-eclampsia and asthma at 7 years using national registries, including all births in Norway from 1999 to 2006 (n=406 907), and a subsample of children in the Norwegian Mother and Child Cohort Study (MoBa) (n=45 028) using log-linear regression. We performed a mediation analysis of preterm birth, and a sibling comparison to evaluate unobserved confounding.There was a positive association between pre-eclampsia and asthma in the registry study, with an adjusted relative risk of 1.31 (95% CI 1.22–1.41), but not in MoBa, which had an adjusted relative risk of 1.19 (95% CI 0.99–1.44). The odds ratios for the direct effect not mediated through preterm birth and the indirect effect in the registry linkage were 1.19 (95% CI 1.10–1.29) and 1.12 (95% CI 1.11–1.14), respectively. The sibling comparison indicated no association between pre-eclampsia and asthma (adjusted OR 1.07, 95% CI 0.87–1.33).In this large study, which used different datasets and analytic approaches, there was little evidence for an association between pre-eclampsia and childhood asthma. The association was weak and largely explained by pre-term birth and confounders shared by siblings.

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