scholarly journals Inhibitory Effect of Linum usitatissimum and Perilla frutescens as Sources of Omega-3 Fatty Acids on Mutagenicity and Growth of Human Cancer Cell Lines

2009 ◽  
Vol 19 (12) ◽  
pp. 1737-1742 ◽  
Keyword(s):  
Fatty Acids ◽  
Cell Lines ◽  
Linum Usitatissimum ◽  
Human Cancer ◽  
Inhibitory Effect ◽  
Perilla Frutescens ◽  
Human Cancer Cell ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Human Cancer Cell Lines

scholarly journals Omega-3 polyunsaturated fatty acids of fish and their role in cancerous cell lines: A review of in-vitro studies

2019 ◽  
Vol 27 (1) ◽  
pp. 47-63
Author(s):  
Farheen Jameel ◽  
Priyanka Agarwal ◽  
Mohd. Arshad ◽  
Mohd. Serajuddin
Keyword(s):  
Fatty Acids ◽  
Side Effects ◽  
Polyunsaturated Fatty Acids ◽  
Cell Lines ◽  
Human Cancer ◽  
Incidence Rates ◽  
Omega 3 ◽  
Human Cancer Cell Lines ◽  
Research Findings

Abstract Fish are a major dietary source of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in humans since the human body lacks the necessary enzymes required to synthesize them. Diets rich in fish oil containing n-3 fatty acids have been shown to lower the incidence rates of cancer. They have also been shown to have cytotoxic or anti-proliferative effects on a variety of human cancer cell lines, and they are known to nurture overall human health without any observable side effects. The present review focused on in-vitro research findings regarding the apoptotic and anti-proliferative role of n-3 fatty acids FAs that highlight the important mechanisms and pathways of their action in inhibiting the progression of cancer. A survey of the literature indicated the paucity of information on the use of n-3 FAs in combination with other anticancer substances. Therefore, further research needs to be undertaken on the use of n-3 FAs in combination with other anticancer phytochemicals and drugs, the use of antibodies as specific carriers of n-3 FAs, and different increasing ratios of n-3/n-6 FAs that not only control the side effects of chemotherapy but also enhance its efficacy and selectivity. These FAs might also prove to be a pioneer therapy against cancer.

The inhibitory effect of oridonin on the growth of fifteen human cancer cell lines

2007 ◽  
Vol 4 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Junhui Chen ◽  
Shaobin Wang ◽  
Dongyang Chen ◽  
Guisheng Chang ◽  
Qingfeng Xin ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

scholarly journals Growth inhibitory effects of casein hydrolysates on human cancer cell lines

2010 ◽  
Vol 77 (2) ◽  
pp. 176-182 ◽  
Author(s):  
Martha Phelan ◽  
S. Aisling Aherne ◽  
Dara O'Sullivan ◽  
Richard J. FitzGerald ◽  
Nora M. O'Brien
Keyword(s):  
Dna Synthesis ◽  
Cell Lines ◽  
Cancer Cell ◽  
Trypan Blue ◽  
Human Cancer ◽  
Membrane Integrity ◽  
Inhibitory Effect ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Casein Hydrolysates

The aim of this study was to investigate the effects of unhydrolysed/intact casein and eight different sodium casein hydrolysates(a–h) on the viability and growth of human cancer cell lines. Both human Jurkat T cells and Caco-2 cells were incubated with increasing concentrations of the test compounds (0·5–10% v/v) for 24 h. Cell viability was assessed using the MTT, lactate dehydrogenase (LDH) release and Trypan Blue assays. Cell growth was monitored using the MTT, Trypan Blue and Bromodeoxyuridine (BrdU) proliferation assays. Casein hydrolysates b, c and f had an inhibitory effect on the viability and growth of both cell lines. The casein hydrolysates did not negatively affect the membrane integrity of both Jurkat and Caco-2 cells. In Jurkat cells hydrolysates a and h had an inhibitory effect on DNA synthesis after 24 h, while in Caco-2 cells DNA synthesis was not affected. In conclusion, we found that the different casein hydrolysates had cell-specific effects which target particular functions within the cell. Overall, casein hydrolysates had no effect on membrane integrity while they had varied effects on mitochondrial activity and DNA synthesis in the different cell lines.

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
Sign in / Sign up

Export Citation Format

Share Document