Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

2011 ◽  
Vol 5 (4) ◽  
Author(s):  
Ren-Nan Feng ◽  
Cheng Wang ◽  
Chang-Hao Sun ◽  
Fu-Chuan Guo ◽  
Chen Zhao ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Case Control Study ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Case Control ◽  
Model Assessment ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Control Study

AbstractBackground: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine. Several studies have indicated that vaspin may exert an important role in the development of metabolic disorders.Objective: Evaluate serum vaspin and its relation to clinical parameters in newly and previously diagnosed Chinese type 2 diabetes mellitus (T2DM) females as a case-control study.Materials and methods: One hundred twenty female participants (newly and previously diagnosed T2DM patients) were recruited from an affiliated hospital of Harbin Medical University. Sixty healthy female volunteers from various communities were included as controls. Anthropometric parameters, serum fasting blood glucose, fasting insulin, lipid profile, HbA1c, and vaspin were measured in each participant.Results: Serum vaspin levels were significantly lower in previously diagnosed T2DM patients (0.51±0.29 ng/mL) than in newly diagnosed T2DM patients (0.62±0.28 ng/mL) and healthy controls (0.69±0.31 ng/mL). However, there was no difference in serum vaspin between newly diagnosed T2DM patients and healthy controls. In multiple linear regression analysis, serum vaspin was significantly and positively associated with HbA1c in both newly and previously diagnosed T2DM patients, negatively associated with homeostasis model assessment of insulin resistance in previously diagnosed patients, and positively correlated with age and body mass index in healthy controls.Conclusion: Serum vaspin was significantly lower in previously diagnosed T2DM patients than in newly diagnosed T2DM patients and healthy controls. Serum vaspin might be a predictor of poor glucose control and insulin resistance in T2DM.

scholarly journals Alterations of liver enzymes in T2DM: a case control study

2018 ◽  
Vol 5 (6) ◽  
pp. 1521
Author(s):  
Chandrashekhar G. S.
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Case Control Study ◽  
Liver Enzymes ◽  
Fasting Blood Glucose ◽  
Case Control ◽  
Diabetic Patients ◽  
Histopathological Analysis ◽  
Control Study

Background: Liver plays an important role in regulation of blood glucose in fed state as well as in fasting. Diabetes mellitus can result as a consequence of liver disorder and vice versa. Objective of the present study is to compare the liver enzymes in type 2 diabetic patients as compared to non-diabetic patients.Methods: A case- control study was conducted in Clinical Biochemistry Laboratory, Adarsha Super speciality Hospital, Udupi from April 2018 to August 2018. The data of 174 diabetic patients and 118 healthy people as controls was collected. Fasting blood glucose, aspartate aminotransferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) were estimated in the study subjects.Results: It was found that AST levels (47.55±4.69U/L) in diabetics extremely significantly high as compared to controls (33.51±2.33U/L). ALT levels were insignificantly high in diabetics compared to controls. ALP was significantly elevated (p=0.0002) in diabetics. Correlation study showed a weak positive correlation between AST, ALT and blood glucose. Odds ratio showed a higher risk of liver enzyme elevation in diabetics. Risk of elevation of AST was found to be 1.65 times high and ALT was 1.25 times high in diabetics compared to non-diabetics.Conclusions: Diabetics had high liver enzymes as compared to non-diabetics. An association was found between type 2 diabetes mellitus and liver enzymes. For better characterization of cause and effect, further studies need to be done on alterations in liver function tests along with the histopathological analysis of liver biopsy samples.

scholarly journals Ethnic differences in CAPN10 SNP-19 in type 2 diabetes: a North-West Indian case control study and evidence from meta-analysis

2013 ◽  
Vol 95 (5) ◽  
pp. 146-155 ◽  
Author(s):  
RUBINA SHARMA ◽  
KAWALJIT MATHAROO ◽  
ROHIT KAPOOR ◽  
HIMANSHI CHOPRA ◽  
AJS BHANWER
Keyword(s):  
Indian Population ◽  
Case Control Study ◽  
Meta Analysis ◽  
West Indian ◽  
Case Control ◽  
Healthy Controls ◽  
North West ◽  
The North ◽  
Control Study

SummaryCalpain 10 (CAPN10) variants have been associated with the genetic susceptibility to type 2 diabetes (T2D). In the present case-control study, we analysed the distribution of SNP-19 insertion/deletion (I/D) polymorphism in a total of 607 samples (103 T2D cases and 102 healthy controls) from Brahmin; (100 T2D cases and 100 healthy controls) from Bania and (100 T2D cases and 102 healthy controls) from Jat Sikh ethnic groups of the North-West Indian population. Increased frequency of I allele and II genotype was found in T2D in Brahmin ethnic group [P = 0·003, OR = 2·83 (1·43–5·61 at 95% CI)]. Significant correlation between II genotype and body mass index (BMI) was also observed [P = 0·003, OR = 3·31 (1·52–7·20 at 95% CI)]. No association for the genotypes and alleles was seen in Banias and Jat Sikhs. Our data suggests that SNP-19 I/D variation in the CAPN10 gene is modulated by ethnicity and influences the susceptibility to T2D in the North-West Indian population. We also performed a meta-analysis of relevant studies to assess the validity of this association. Data from 13 case-control studies with 15 760 samples comprising of 8395 T2D cases and 7365 controls were finally analysed. Significant heterogeneity between individual studies was evident in dominant and codominant models. The results of present meta-analysis indicate an association of T2D with carriers of DD genotype of CAPN10 I/D polymorphism. However, further analyses on a larger sample size are required to establish a conclusive association in meta-analysis.

scholarly journals Plasma metabolites associated with healthy Nordic dietary indexes and risk of type 2 diabetes—a nested case-control study in a Swedish population

2018 ◽  
Vol 108 (3) ◽  
pp. 564-575 ◽  
Author(s):  
Lin Shi ◽  
Carl Brunius ◽  
Ingegerd Johansson ◽  
Ingvar A Bergdahl ◽  
Bernt Lindahl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Plasma Metabolites ◽  
Healthy Controls ◽  
Swedish Population ◽  
Nordic Diet ◽  
Control Study

ABSTRACT Background Epidemiologic evidence on the association of a healthy Nordic diet and future type 2 diabetes (T2D) is limited. Exploring metabolites as biomarkers of healthy Nordic dietary patterns may facilitate investigation of associations between such patterns and T2D. Objectives We aimed to identify metabolites related to a priori-defined healthy Nordic dietary indexes, the Baltic Sea Diet Score (BSDS) and Healthy Nordic Food Index (HNFI), and evaluate associations with the T2D risk in a case-control study nested in a Swedish population-based prospective cohort. Design Plasma samples from 421 case-control pairs at baseline and samples from a subset of 151 healthy controls at a 10-y follow-up were analyzed with the use of untargeted liquid chromatography-mass spectrometry metabolomics. Index-related metabolites were identified through the use of random forest modelling followed by partial correlation analysis adjustment for lifestyle confounders. Metabolite patterns were derived via principal component analysis (PCA). ORs of T2D were estimated via conditional logistic regression. Reproducibility of metabolites was assessed by intraclass correlation (ICC) in healthy controls. Associations were also assessed for 10 metabolites previously identified as linking a healthy Nordic diet with T2D. Results In total, 31 metabolites were associated with BSDS and/or HNFI (−0.19 ≤ r ≤ 0.21, 0.10 ≤ ICC ≤ 0.59). Two PCs were determined from index-related metabolites: PC1 strongly correlated to the indexes (r = 0.27 for BSDS, r = 0.25 for HNFI, ICC = 0.45) but showed no association with T2D risk. PC2 was weakly associated with the indexes, but more strongly with foods not part of the indexes, e.g., pizza, sausages, and hamburgers. PC2 was also significantly associated with T2D risk. Predefined metabolites were confirmed to be reflective of consumption of whole grains, fish, or vegetables, but not related to T2D risk. Conclusions Our study did not support an association between healthy Nordic dietary indexes and T2D. However, foods such as hamburger, sausage, and pizza not covered by the indexes appeared to be more important for T2D risk in the current population.

scholarly journals Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study

Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 294 ◽  
Author(s):  
Sijing Chen ◽  
Xiaoling Jin ◽  
Zhilei Shan ◽  
Shuzhen Li ◽  
Jiawei Yin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Inverse Association ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Association of Fat Mass and Obesity Associated, Dopamine Receptor Type 2 and Ankyrin Repeat and Kinase Domain Containing 1 Genes with Pediatric Obesity and Metabolic Risk: A Case-Control Study

2021 ◽  
Vol 8 (1) ◽  
pp. 1-14
Author(s):  
Renata M. Pinto ◽  
◽  
Jakeline S. Fortes ◽  
Rúbia V. Monteiro ◽  
Nygell S. Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pediatric Obesity ◽  
Case Control Study ◽  
Risk Allele ◽  
Kinase Domain ◽  
Case Control ◽  
Risk Alleles ◽  
Metabolically Healthy ◽  
Control Study

Background Genetic polymorphisms that affect the availability and secretion of dopamine can affect the risk of obesity. Objectives To investigate the relationship between pediatric obesity and cardiovascular risk factors (CRF) with the polymorphisms of “Fat Mass and Obesity Associated” (FTO) rs9939609, “Dopamine Receptor type 2” (DRD2) rs6277 and “Ankyrin Repeat and Kinase Domain Containing 1” (ANKK1) rs18000497 genes. Methods Case-Control study conducted with 226 pediatric patients from 5 to 16-years of age. The two main groups, Obese (O) and Eutrophic (E), were subdivided according to the value of HOMA-IR into obese with insulin resistance (ORI) or insulin sensitivity (OSI) and eutrophic resistant (ERI) or sensitive (ESI) to insulin. According to the presence of two or more CRF, they were subdivided into metabolically unhealthy or metabolically healthy groups: Obese Metabolically Unhealthy (OMU), Obese Metabolically Healthy (OMH), Eutrophic Metabolically Unhealthy (EMU) and Eutrophic Metabolically Healthy (EMH). Polymorphisms were determined by real-time Polymerase Chain Reaction (PCR) or Restriction Fragment Length Polymorphisms (PCR-RFLP). Results In the obese group, the higher the number of risk alleles of FTO and ANKK1 genes isolated and the three genes combined, the higher the mean BMI (p<0.0001). Regarding the FTO gene: the frequency of the risk allele was: 57.7%-ERI, 37.4%-ESI (p=0.048), and the homozygous wild genotype was: 29.5%-OMU, 37.5%-OMH (p=0.02). Regarding the DRD2 gene: the genotypes with the risk allele were present in 84.6%-OMU and 67.5%-OMH (p=0.031). Regarding the ANKK1 gene: the frequency of the homozygous risk genotype was current in 15.4%-ERI and 13.5%-ESI (p<0.0001) and 62.5%-EMU and 41.5%-OMH (p=0.031). Conclusion Risk alleles of FTO, DRD2 and ANKK1 genes had an additive effect on the outcome of pediatric obesity in Brazilian children and conferred a higher risk of insulin resistance (FTO and ANKK1) and CRF.

scholarly journals Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175388 ◽  
Author(s):  
Linda Ahenkorah Fondjo ◽  
William K. B. A. Owiredu ◽  
Samuel Asamoah Sakyi ◽  
Edwin Ferguson Laing ◽  
Michael Acquaye Adotey-Kwofie ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Status ◽  
Type 2 Diabetics ◽  
Control Study

scholarly journals Urine transferrin as an early endothelial dysfunction marker in type 2 diabetic patients without nephropathy: a case control study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
José Juan Sánchez-Hidalgo ◽  
Juan Antonio Suárez-Cuenca ◽  
José Juan Lozano-Nuevo ◽  
Víctor Hugo García-López ◽  
María Graciela Leal-Gutiérrez ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type 2 Diabetic Patients ◽  
Early Diabetic Nephropathy ◽  
Type 2 Diabetic ◽  
Control Study

Abstract Background Albumin, along with other proteins, is abnormally eliminated via the urine during early stages of diabetic nephropathy. Moreover, endothelial dysfunction (ED) accompanying early diabetic nephropathy may develop even before microalbuminuria is detectable. Transferrin has a molecular weight comparable to albumin, whereas transferrinuria and microalbuminuria in a 24-h urine sample may comparably reflect early diabetic nephropathy. Whereas transferrin metabolism is related with ED during very early diabetic nephropathy has not been elucidated yet. This case–control study aimed to evaluate the relation between ED and urine transferrin, even before early diabetic nephropathy is present. Methods Patients were enrolled from two study sites in Mexico City: Ticomán General Hospital (healthy controls); and a Specialized Clinic for the Management of the Diabetic Patient (cases). All patients provided written informed consent. The primary endpoint was the correlation between urinary transferrin concentration and ED measured in type 2 diabetic patients without albuminuria. ED was evaluated by ultrasonographic validated measurements, which included carotid intima-media thickness (CIMT) and flow mediated dilation (FMD). Plasma biomarkers included glycated hemoglobin, creatinine, cholesterol and triglycerides, as well as urine albumin, transferrin and evidence of urinary tract infection. Results Sixty patients with type 2 Diabetes Mellitus (t2DM; n = 30) or without t2DM (n = 30), both negative for microalbuminuria, were recruited. The group with t2DM were older, with higher values of HbA1c and higher ED. This group also showed significant differences in urine transferrin and urine/plasma transferrin ratio, as compared with healthy controls (14.4 vs. 18.7 mg/mL, p = 0.04, and 74.2 vs. 49.5; p = 0.01; respectively). Moreover, urine transferrin correlated with higher CIMT values (r = 0.37, p = 0.04), being particularly significant for t2DM population. CIMT also correlated with time from t2DM diagnosis (r = 0.48, p < 0.001) and HbA1c (r = 0.48; p < 0.001). Conclusion Urine transferrin correlated with subclinical atherogenesis in patients with t2DM without renal failure, suggesting its potential to identify cardiovascular risk in patients at very early nephropathy stage without microalbuminuria.

Leptinemia among Obese Omani Adults Newly Diagnosed with Type 2 Diabetes Mellitus: A Case-control Study

2013 ◽  
Vol 13 (3) ◽  
pp. 208-214
Author(s):  
Mostafa I. Waly ◽  
Amanat Ali ◽  
Yahya M. Al-Farsi ◽  
Neeru Bhatt ◽  
Hashim Al-Kilani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Newly Diagnosed ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document