scholarly journals Association of Fat Mass and Obesity Associated, Dopamine Receptor Type 2 and Ankyrin Repeat and Kinase Domain Containing 1 Genes with Pediatric Obesity and Metabolic Risk: A Case-Control Study

2021 ◽  
Vol 8 (1) ◽  
pp. 1-14
Author(s):  
Renata M. Pinto ◽  
◽  
Jakeline S. Fortes ◽  
Rúbia V. Monteiro ◽  
Nygell S. Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pediatric Obesity ◽  
Case Control Study ◽  
Risk Allele ◽  
Kinase Domain ◽  
Case Control ◽  
Risk Alleles ◽  
Metabolically Healthy ◽  
Control Study

Background Genetic polymorphisms that affect the availability and secretion of dopamine can affect the risk of obesity. Objectives To investigate the relationship between pediatric obesity and cardiovascular risk factors (CRF) with the polymorphisms of “Fat Mass and Obesity Associated” (FTO) rs9939609, “Dopamine Receptor type 2” (DRD2) rs6277 and “Ankyrin Repeat and Kinase Domain Containing 1” (ANKK1) rs18000497 genes. Methods Case-Control study conducted with 226 pediatric patients from 5 to 16-years of age. The two main groups, Obese (O) and Eutrophic (E), were subdivided according to the value of HOMA-IR into obese with insulin resistance (ORI) or insulin sensitivity (OSI) and eutrophic resistant (ERI) or sensitive (ESI) to insulin. According to the presence of two or more CRF, they were subdivided into metabolically unhealthy or metabolically healthy groups: Obese Metabolically Unhealthy (OMU), Obese Metabolically Healthy (OMH), Eutrophic Metabolically Unhealthy (EMU) and Eutrophic Metabolically Healthy (EMH). Polymorphisms were determined by real-time Polymerase Chain Reaction (PCR) or Restriction Fragment Length Polymorphisms (PCR-RFLP). Results In the obese group, the higher the number of risk alleles of FTO and ANKK1 genes isolated and the three genes combined, the higher the mean BMI (p<0.0001). Regarding the FTO gene: the frequency of the risk allele was: 57.7%-ERI, 37.4%-ESI (p=0.048), and the homozygous wild genotype was: 29.5%-OMU, 37.5%-OMH (p=0.02). Regarding the DRD2 gene: the genotypes with the risk allele were present in 84.6%-OMU and 67.5%-OMH (p=0.031). Regarding the ANKK1 gene: the frequency of the homozygous risk genotype was current in 15.4%-ERI and 13.5%-ESI (p<0.0001) and 62.5%-EMU and 41.5%-OMH (p=0.031). Conclusion Risk alleles of FTO, DRD2 and ANKK1 genes had an additive effect on the outcome of pediatric obesity in Brazilian children and conferred a higher risk of insulin resistance (FTO and ANKK1) and CRF.

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

2011 ◽  
Vol 5 (4) ◽  
Author(s):  
Ren-Nan Feng ◽  
Cheng Wang ◽  
Chang-Hao Sun ◽  
Fu-Chuan Guo ◽  
Chen Zhao ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Case Control Study ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Case Control ◽  
Model Assessment ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Control Study

AbstractBackground: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine. Several studies have indicated that vaspin may exert an important role in the development of metabolic disorders.Objective: Evaluate serum vaspin and its relation to clinical parameters in newly and previously diagnosed Chinese type 2 diabetes mellitus (T2DM) females as a case-control study.Materials and methods: One hundred twenty female participants (newly and previously diagnosed T2DM patients) were recruited from an affiliated hospital of Harbin Medical University. Sixty healthy female volunteers from various communities were included as controls. Anthropometric parameters, serum fasting blood glucose, fasting insulin, lipid profile, HbA1c, and vaspin were measured in each participant.Results: Serum vaspin levels were significantly lower in previously diagnosed T2DM patients (0.51±0.29 ng/mL) than in newly diagnosed T2DM patients (0.62±0.28 ng/mL) and healthy controls (0.69±0.31 ng/mL). However, there was no difference in serum vaspin between newly diagnosed T2DM patients and healthy controls. In multiple linear regression analysis, serum vaspin was significantly and positively associated with HbA1c in both newly and previously diagnosed T2DM patients, negatively associated with homeostasis model assessment of insulin resistance in previously diagnosed patients, and positively correlated with age and body mass index in healthy controls.Conclusion: Serum vaspin was significantly lower in previously diagnosed T2DM patients than in newly diagnosed T2DM patients and healthy controls. Serum vaspin might be a predictor of poor glucose control and insulin resistance in T2DM.

scholarly journals Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175388 ◽  
Author(s):  
Linda Ahenkorah Fondjo ◽  
William K. B. A. Owiredu ◽  
Samuel Asamoah Sakyi ◽  
Edwin Ferguson Laing ◽  
Michael Acquaye Adotey-Kwofie ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Status ◽  
Type 2 Diabetics ◽  
Control Study

scholarly journals Insulin Resistance and Proliferative Retinopathy: A Cross-Sectional, Case-Control Study in 115 Patients with Type 2 Diabetes

2004 ◽  
Vol 89 (9) ◽  
pp. 4371-4376 ◽  
Author(s):  
Aneliya Parvanova ◽  
Ilian Iliev ◽  
Marco Filipponi ◽  
Borislav D. Dimitrov ◽  
Monica Vedovato ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Proliferative Retinopathy ◽  
Cross Sectional ◽  
Control Study

scholarly journals Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with pre-diabetes and type 2 diabetes mellitus: A case control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0251697
Author(s):  
Fahime Zeinali ◽  
Seyed Mohsen Aghaei Zarch ◽  
Alireza Jahan-Mihan ◽  
Seyed Mehdi Kalantar ◽  
Mohammad Yahya Vahidi Mehrjardi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Case Control Study ◽  
Plasma Concentrations ◽  
Case Control ◽  
Diabetic Patients ◽  
Healthy Individuals ◽  
Tnf Α ◽  
Control Study

The prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically worldwide. Dysregulation of microRNA (miRNA) as key regulators of gene expression, has been reported in numerous diseases including diabetes. The aim of this study was to investigate the expression levels of miRNA-122, miRNA-126-3p and miRNA-146a in diabetic and pre-diabetic patients and in healthy individuals, and to determine whether the changes in the level of these miRNAs are reliable biomarkers in diagnosis, prognosis, and pathogenesis of T2DM. Additionally, we examined the relationship between miRNA levels and plasma concentrations of inflammatory factors including tumor necrosis factor alpha (TNF-α) and interleukin 6 (Il-6) as well as insulin resistance. In this case-control study, participants (n = 90) were allocated to three groups (n = 30/group): T2DM, pre-diabetes and healthy individuals as control (males and females, age: 25–65, body mass index: 25–35). Expression of miRNA was determined by real-time polymerase chain reaction (RT-PCR). Furthermore, plasma concentrations of TNF-α, IL-6 and fasting insulin were measured by enzyme-linked immunosorbent assay. Homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as an indicator of insulin resistance. MiRNA-122 levels were higher while miRNA-126-3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05). Furthermore, a positive correlation was found between miRNA-122 expression and TNF-α (r = 0.82), IL-6 (r = 0.83) and insulin resistance (r = 0.8). Conversely, negative correlations were observed between miRNA-126-3p and miRNA-146a levels and TNF-α (r = -0.7 and r = -0.82 respectively), IL-6 (r = -0.65 and r = -0.78 respectively) as well as insulin resistance (r = -0.67 and r = -0.78 respectively) (all p<0.05). Findings of this study suggest the miRNAs can potentially contribute to the pathogenesis of T2DM. Further studies are required to examine the reproducibility of these findings.

Abstract #841: Association of Depression with Type 2 Diabetes in Bangladeshi Adults- A Case Control Study

2016 ◽  
Vol 22 ◽  
pp. 183
Author(s):  
Shahjada Selim ◽  
Shahjada Selim ◽  
Shahabul Chowdhury ◽  
Mohammad Saifuddin ◽  
Marufa Mustary ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document