scholarly journals Prevalence of Decreased Vitamin D Levels is High among Veterans with Diabetes and/or CKD

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Subhashini Yaturu ◽  
Jared Davis
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Vitamin D Insufficiency ◽  
Record System ◽  
Vitamin D Levels ◽  
History Of ◽  
Computerized Patient Record ◽  
25 Oh Vitamin D

Objective. Vitamin D deficiency is associated with a variety of skeletal and extraskeletal problems. The aim of this study was to evaluate the prevalence of vitamin D deficiency among veterans in sunny Louisiana. Methods. Using the VA computerized patient record system, we searched for all 25 (OH) Vitamin D and 1, 25 (OH) vitamin D levels that were measured between 2007 and 2009. The information collected for each patient included age, body mass index, creatinine, history of diabetes and hypertension, and levels of vitamin D and PTH. We determined the number of individuals who were vitamin D insufficient and deficient. Results. Among 2990 studies evaluated, the mean concentration of 25 (OH) D was  ng/mL, and that of 1, 25 (OH) vitamin D was  ng/mL. Among them, only 695 subjects (23%) had normal values, while 889 (30%) had insufficiency, and 1405 (47%) had deficiency. Subjects with diabetes (1041) had significantly () lower levels (21 and 25 ng/mL) of both 25 (OH) and 1,25 (OH) vitamin D compared to subjects without diabetes (23 and 32 ng/mL). Similarly, subjects with chronic kidney disease (1128) had much lower vitamin D levels than subjects without CKD. Among subjects with diabetes, those with chronic kidney disease (512) had much lower levels of both 25 (OH) and 1,25 (OH) vitamin D than with those with normal creatinine levels. Conclusions. We conclude that vitamin D insufficiency and deficiency is highly prevalent in veterans, more so among subjects with diabetes and/or CKD.

scholarly journals Insulin Resistance and Vitamin D Deficiency in Patients With Chronic Kidney Disease Stage 2-3

2011 ◽  
pp. 149-155 ◽  
Author(s):  
K. ŠTEFÍKOVÁ ◽  
V. SPUSTOVÁ ◽  
Z. KRIVOŠÍKOVÁ ◽  
A. OKŠA ◽  
K. GAZDÍKOVÁ ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Insulin Sensitivity ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Chronic Kidney Disease Stage ◽  
Vitamin D Insufficiency ◽  
Disease Stage ◽  
25 Oh Vitamin D

Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range (≥30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH)2D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.

Prevalence of 25(OH) vitamin D insufficiency and deficiency in chronic kidney disease stage 5 patients on hemodialysis

2007 ◽  
Vol 11 (3) ◽  
pp. 315-321 ◽  
Author(s):  
Elisa DEL VALLE ◽  
Armando L. NEGRI ◽  
Cristina AGUIRRE ◽  
Erich FRADINGER ◽  
Jose R. ZANCHETTA
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Vitamin D Insufficiency ◽  
Disease Stage ◽  
25 Oh Vitamin D

scholarly journals Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

2021 ◽  
Vol 28 (1) ◽  
pp. E202113
Author(s):  
Sevil Karahan Yılmaz ◽  
Cuma Mertoğlu ◽  
Aylin Ayaz
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Hemodialysis Patients ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.

scholarly journals Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients

Diseases ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 5
Author(s):  
Marlene Tapper ◽  
Donovan A. McGrowder ◽  
Lowell Dilworth ◽  
Adedamola Soyibo
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Cystatin C ◽  
Thyroid Dysfunction ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
25 Oh Vitamin D

Background: The progression of chronic kidney disease (CKD) is concomitant with complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. The aim of this study is to determine serum cystatin C levels, and the prevalence of vitamin D deficiency and thyroid dysfunction in CKD patients. Methods: A cross-sectional study was conducted involving 140 CKD patients (stages 1–5) that were referred to a renal clinic. Demographic data was collected and thyroid function tests, serum 25-OH-vitamin D, cystatin C levels, and routine biochemistry tests were determined using cobas 6000 analyzer. Results: 129 (92.1%) of CKD patients had elevated serum cystatin C levels and there was a stepwise increase from stage 1–5. Overt hypothyroidism was present in one patient and nine had subclinical hypothyroidism. There was a stepwise reduction in serum 25-OH-vitamin D levels from stage 2–5, 31 (22.1%) had vitamin D insufficiency and 31 (22.1%) presented with deficiency. Conclusions: 25-OH-vitamin D deficiency and thyroid disorders are exhibited in chronic kidney disease patients and the severity of the former rises with disease progression, as indicated by elevated cystatin C levels. Routine screening and timely intervention is recommended so as to reduce the risk of cardiovascular diseases.

scholarly journals Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients

2020 ◽  
Author(s):  
Andressa Keiko Matsumoto ◽  
Michael Maes ◽  
Ana Paula Michelin ◽  
Abel Esteves Soares ◽  
Laura de Oliveira Semeão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Vitamin D Levels

Abstract Introduction: The progressive decline in 25-hydroxyvitamin D [25(OH)D] in chronic kidney disease (CKD) limits the kidney ability of synthesizing the vitamin. Vitamin D deficiency as defined by KDIGO (25(OH)D <20 ng/mL) is prevalent in CKD patients and associated to oxidative stress (OS). We studied a possible association between vitamin D deficiency and OS in pre-dialysis patients. Methods: A cross-sectional study with 206 CKD patients was carried out. Laboratory tests for 25(OH)D, 1,25(OH)2D, inflammatory markers, and OS were added to routine tests including creatinine, albumin, calcium, phosphorus, alkaline phosphatase, iPTH, glucose, hemoglobin, uric acid, total cholesterol, LDL, HDL, and triglycerides. Results: Vitamin D deficiency was present in 55 CKD patients and normal vitamin D levels were seen in 149 patients. There was a significant association between vitamin D and estimated glomerular filtration rate (eGRF). Homocysteine levels were best predicted by eGRF, sex, and age; high sensitivity C-reactive protein (hsCRP) by staging and BMI; nitric oxide metabolites (NOx) were increased in late disease; leptin was influenced by BMI and higher in women than man; and adiponectin levels were higher in women. Conclusions: OS biomarkers were not correlated with vitamin D deficiency but increased NOx were seen in stages 4-5 CKD patients. Even though a relatively large number of CKD patients was included and a broad number of OS and inflammatory biomarkers were used in this studied we failed to find an association between vitamin D levels and eGRF. More studies are needed to evaluate the influence of vitamin D status in OS in pre-dialysis CKD patients.

scholarly journals Vitamin D insufficiency in patients by way of chronic kidney disease.

2020 ◽  
Vol 27 (08) ◽  
pp. 1642-1648
Author(s):  
Fatima Abid ◽  
Rozmeen Husein ◽  
Syeda Sadia Fatima ◽  
Amber Illyas ◽  
Sassi Kanwal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Fasting Blood Glucose ◽  
Vitamin D Insufficiency ◽  
Diabetic Patients ◽  
Period 2 ◽  
Vitamin D Levels ◽  
Disease Study ◽  
Control Study

Objectives: To measure Vitamin D levels in diabetic patients with and without kidney disease. Study Design: Prospective Case Control Study. Setting: Diabetic Clinic Ward 6, Nephrology Unit Ward 22 JPMC. Period: 2 year Jan 2016 to Dec 2017. Material & Methods: 102 subjects were enrolled for the study in which their anthropometry was recorded and blood samples were collected for hemoglobin A1C, fasting blood glucose, vitamin D levels, and blood Urea Nitrogen. Results: It is identified from the experiments that vitamin D deficiency links with a prior and an additional hostile inception of diabetes. In this research the levels of Vitamin D was measured in diabetic patients with and without kidney disease and then were correlated with disease severity. Conclusion: It is concluded that vitamin D deficiency in pa­tients with CKD is not accepted so far. Whereas Patients with CKD might be connected with better existence rates, when matched to patients who did not consume vitamin D.

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