scholarly journals An Open-Label Pilot Study to Assess the Efficacy and Safety of Virgin Coconut Oil in Reducing Visceral Adiposity

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Kai Ming Liau ◽  
Yeong Yeh Lee ◽  
Chee Keong Chen ◽  
Aida Hanum G. Rasool
Keyword(s):  
Pilot Study ◽  
Lipid Profile ◽  
Coconut Oil ◽  
Efficacy And Safety ◽  
Virgin Coconut Oil ◽  
Small Reduction ◽  
Organ Function ◽  
Anthropometric Parameters ◽  
Open Label ◽  
Initial Measurement

Introduction. This is an open-label pilot study on four weeks of virgin coconut oil (VCO) to investigate its efficacy in weight reduction and its safety of use in 20 obese but healthy Malay volunteers. Methodology. Efficacy was assessed by measuring weight and associated anthropometric parameters and lipid profile one week before and one week after VCO intake. Safety was assessed by comparing organ function tests one week before and one week after intake of VCO. Paired t-test was used to analyse any differences in all the measurable variables. Results. Only waist circumference (WC) was significantly reduced with a mean reduction of 2.86 cm or 0.97% from initial measurement (P=.02). WC reduction was only seen in males (P<.05). There was no change in the lipid profile. There was a small reduction in creatinine and alanine transferase levels. Conclusion. VCO is efficacious for WC reduction especially in males and it is safe for use in humans.

scholarly journals A Pilot Study: The Efficacy of Virgin Coconut Oil as Ocular Rewetting Agent on Rabbit Eyes

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Haliza Abdul Mutalib ◽  
Sharanjeet Kaur ◽  
Ahmad Rohi Ghazali ◽  
Ng Chinn Hooi ◽  
Nor Hasanah Safie
Keyword(s):  
Pilot Study ◽  
Coconut Oil ◽  
Study Data ◽  
Eye Drops ◽  
Virgin Coconut Oil ◽  
Open Label ◽  
Palpebral Conjunctiva ◽  
Significant Difference ◽  
Measurable Parameter ◽  
Corneal Staining

Purpose. An open-label pilot study of virgin coconut oil (VCO) was conducted to determine the safety of the agent as ocular rewetting eye drops on rabbits.Methods. Efficacy of the VCO was assessed by measuring NIBUT, anterior eye assessment, corneal staining, pH, and Schirmer value before instillation and at 30 min, 60 min, and two weeks after instillation. Friedman test was used to analyse any changes in all the measurable variables over the period of time.Results. Only conjunctival redness with instillation of saline agent showed significant difference over the period of time (P<0.05). However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P>0.05). There were no changes in the NIBUT, limbal redness, palpebral conjunctiva redness, corneal staining, pH, and Schirmer value over the period of time for each agent (P>0.05).Conclusion. VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline. These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

scholarly journals Efficacy and Safety of Reslizumab in Patients with Severe Asthma with Inadequate Response to Omalizumab: A Multicenter, Open-Label Pilot Study

2019 ◽  
Vol 7 (7) ◽  
pp. 2277-2283.e2 ◽  
Author(s):  
Luis A. Pérez de Llano ◽  
Borja G. Cosío ◽  
Christian Domingo ◽  
Isabel Urrutia ◽  
Irina Bobolea ◽  
...  
Keyword(s):  
Pilot Study ◽  
Severe Asthma ◽  
Inadequate Response ◽  
Efficacy And Safety ◽  
Open Label

scholarly journals Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study

2019 ◽  
Vol 54 (5) ◽  
pp. 633-639 ◽  
Author(s):  
John E. Eaton ◽  
Kevin M. Nelson ◽  
Andrea A. Gossard ◽  
Elizabeth J. Carey ◽  
James H Tabibian ◽  
...  
Keyword(s):  
Pilot Study ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Efficacy And Safety ◽  
Open Label

scholarly journals Effect of Virgin Coconut Oil Supplementation on Obese Rats’ Anthropometrical Parameters and Gut Bacteroidetes and Firmicutes Change Ratio

CORD ◽  
2016 ◽  
Vol 32 (1) ◽  
pp. 14
Author(s):  
Amadeus Driando Ahnan
Keyword(s):  
Gut Microbiota ◽  
Molecular Mechanisms ◽  
Coconut Oil ◽  
Fold Increase ◽  
Abdominal Circumference ◽  
Sprague Dawley ◽  
Virgin Coconut Oil ◽  
Anthropometric Parameters ◽  
Standard Curve ◽  
Sprague Dawley Rats

Previous clinical trials using virgin coconut oil (VCO) showed a potential anti-obesity effect, including for human, by reducing the waist circumference. However, there was not discovered any research that examined its anti-obesity effect in relation with gut microbiota parameters as one of current approaches of obesity parameters, for example Firmicutes and Bacteroidetes. This research was conducted to examine the effect of VCO supplementation on the change of Firmicutes and Bacteroidetes in comparison to the anthropometrical parameters. The experiment was done using 14 days obese-induced female Sprague-Dawley rats supplemented with 0.01% w/w and 0.02% w/w VCO for 28 days. The anthropometric data collection consisted of body weight (BW), body mass index (BMI), abdominal circumference (AC), and body length (BL). Ratio changes in –fold increase between Day 28 and Day 0 of Bacteroidetes and Firmicutes were retrieved by using relative quantification normalized against unit mass calculation, using the cycle threshold values from real-time polymerase chain reaction (RT-PCR) method with SYBR Green fluorescence and standard curve derived from tenfold 5 points dilution series of recombinant plasmid for efficiency calculation. VCO supplementation stimulated significant increase on anthropometric parameters on BW and AC (p<0.05), while insignificant changes were shown on Bacteroidetes and Firmicutes ratio with tendency of increasing and decreasing respectfully, with no significance. The result indicated that VCO supplementation in the given doses promoted pro-obesity effect on key anthropometric parameters, while showed potential anti-obesity effect on the gut microbiota parameter. Further researches were needed especially in determining the effective dose to promote the anti-obesity effect of VCO and revealing any possible cellular and molecular mechanisms.

Sign in / Sign up

Export Citation Format

Share Document