scholarly journals A Pilot Study: The Efficacy of Virgin Coconut Oil as Ocular Rewetting Agent on Rabbit Eyes

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Haliza Abdul Mutalib ◽  
Sharanjeet Kaur ◽  
Ahmad Rohi Ghazali ◽  
Ng Chinn Hooi ◽  
Nor Hasanah Safie
Keyword(s):  
Pilot Study ◽  
Coconut Oil ◽  
Study Data ◽  
Eye Drops ◽  
Virgin Coconut Oil ◽  
Open Label ◽  
Palpebral Conjunctiva ◽  
Significant Difference ◽  
Measurable Parameter ◽  
Corneal Staining

Purpose. An open-label pilot study of virgin coconut oil (VCO) was conducted to determine the safety of the agent as ocular rewetting eye drops on rabbits.Methods. Efficacy of the VCO was assessed by measuring NIBUT, anterior eye assessment, corneal staining, pH, and Schirmer value before instillation and at 30 min, 60 min, and two weeks after instillation. Friedman test was used to analyse any changes in all the measurable variables over the period of time.Results. Only conjunctival redness with instillation of saline agent showed significant difference over the period of time (P<0.05). However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P>0.05). There were no changes in the NIBUT, limbal redness, palpebral conjunctiva redness, corneal staining, pH, and Schirmer value over the period of time for each agent (P>0.05).Conclusion. VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline. These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

scholarly journals An Open-Label Pilot Study to Assess the Efficacy and Safety of Virgin Coconut Oil in Reducing Visceral Adiposity

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Kai Ming Liau ◽  
Yeong Yeh Lee ◽  
Chee Keong Chen ◽  
Aida Hanum G. Rasool
Keyword(s):  
Pilot Study ◽  
Lipid Profile ◽  
Coconut Oil ◽  
Efficacy And Safety ◽  
Virgin Coconut Oil ◽  
Small Reduction ◽  
Organ Function ◽  
Anthropometric Parameters ◽  
Open Label ◽  
Initial Measurement

Introduction. This is an open-label pilot study on four weeks of virgin coconut oil (VCO) to investigate its efficacy in weight reduction and its safety of use in 20 obese but healthy Malay volunteers. Methodology. Efficacy was assessed by measuring weight and associated anthropometric parameters and lipid profile one week before and one week after VCO intake. Safety was assessed by comparing organ function tests one week before and one week after intake of VCO. Paired t-test was used to analyse any differences in all the measurable variables. Results. Only waist circumference (WC) was significantly reduced with a mean reduction of 2.86 cm or 0.97% from initial measurement (P=.02). WC reduction was only seen in males (P<.05). There was no change in the lipid profile. There was a small reduction in creatinine and alanine transferase levels. Conclusion. VCO is efficacious for WC reduction especially in males and it is safe for use in humans.

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

scholarly journals A Pilot Study to Investigate the Efficacy of Nicotine Oral Soluble Film, Lozenge and Gum in Relief of Acute Smoking Cue-provoked Craving for Cigarette in Low Dependence Smokers

2014 ◽  
Vol 10 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Daniel Du ◽  
James Borders ◽  
Alex Selmani ◽  
William Waverczak
Keyword(s):  
Pilot Study ◽  
Early Time ◽  
Controlled Study ◽  
Nicotine Gum ◽  
Open Label ◽  
Time Points ◽  
Smoking Cues ◽  
Significant Difference ◽  
Nicotine Lozenge

Introduction: A new nicotine film that releases nicotine quickly may lead to faster craving relief.Aims: This study compares the efficacy of 2.5 mg nicotine film with 2 mg nicotine lozenge and 2 mg nicotine gum on relieving provoked craving in low dependence smokers.Methods: A randomised, open-label, active comparators controlled study was conducted in 120 subjects. Subjects were abstinent from smoking for 4 hours prior to being provoked with smoking cues. After post-provocation craving assessment, subjects were administered one dose of the 3 treatments: nicotine film, lozenge, or gum. Craving intensity was then assessed at 50 seconds, 3, 5, 7, 15, 20, 25 and 30 minutes after administration.Results/Findings: Three treatments reduced craving with similar maximum effects. The effect was maintained up to 30 minutes. Nicotine film significantly reduced more craving than lozenge at 50 seconds, 3 and 5 minutes. It also significantly reduced more craving than gum at 50 seconds and 3 minutes. There was no significant difference between lozenge and gum.Conclusions: Nicotine film, lozenge and gum have similar maximum craving relief. Nicotine film significantly reduced more craving than lozenge and gum at early time points. Nicotine film may be particularly useful to provide acute craving relief.

scholarly journals PENGARUH APLIKASI VIRGIN COCONUT OIL TERHADAP PENINGKATAN JUMLAH FIBROBLAS PADA LUKA PASCA PENCABUTAN GIGI PADA RATTUS NOVERGICUS

2015 ◽  
Vol 1 (2) ◽  
pp. 29
Author(s):  
Anggun Hibah Jannah Tamara ◽  
Yayun Siti Rochmah ◽  
Rochman Mujayanto
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Health Benefit ◽  
Coconut Oil ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Complex Biological Process ◽  
Significant Difference ◽  
Per Oral ◽  
Levene Test

Background: Wound healing is a complex biological process. Fibroblast is one of cell which is responsible for the wound healing process. Virgin Coconut Oil (VCO) have health benefit as antibacterial, antiinflamatory, antioxidant, and immunomodulatory. This research was purposed to know the influence use of VCO over the amount of fibroblast in wound healing after dental extraction.Method: Research quasi experimental with post test control group design and using 15 Rattus novergicus which were divided into three groups (control positive, VCO topical application, and VCO per oral application). Tooth removal was committed by using explorer, scalpel-blade, and arterial clamp. Then VCO applied everyday for 7 days. Day 7th Rattus novergicus were died, the socket after extraction were made into histological form, then the amount of fibroblast were counted with 5 field of views and made in average. Result: The number of fibroblast of the most numerous was VCO per oral ( 48,6 ± 49,8 ), VCO topical ( 36,2 ± 38,8 ), and control positive ( 33,4 ± 35,2 ). The results of the Saphiro Wilk test and Levene test acquired data normally distributed and homogeny, so it continued to One Way Anova and data showed there were significant difference among the groups of samples with value p<0,05.Conclusion: The conclusion of this research is VCO could increase the number of fibroblasts in wound healing after dental extractions

scholarly journals Analisis pengaruh pemberian virgin coconut oil (VCO) terhadap adhesi intraperitoneal

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Erwin . ◽  
Jimmy Panelewen ◽  
Ishak Lahunduitan
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Rattus Norvegicus ◽  
Adhesion Formation ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Chi Square ◽  
Significant Difference ◽  
Tissue Plasminogen ◽  
Anti Inflammation

Abstract: Intraperitoneal adhesion is an attachment between intraperitoneal tissue and organ in the form of fibrosis. The occurences of intraperitoneal adhesion are 67-93% after laparotomy and 97% after gynecological operation. Adhesion between wound and omentum occurs in 80% of patients; 50% involve the intestines. Prevention and inhibition of adhesion formation can be done by decreasing post traumatic inflammation. There are several substances that can be used for that purpose, inter alia: anti-inflammation, anti-histamine, anti-coagulant (heparin), anti-oxidant, proteolytic enzymes, and tissue plasminogen activator. It is already known that virgin coconut oil (VCO) has several important roles, such as: anti-inflammation, antithrombosis, mechanical barrier, and antioxidant due to its tocopherol content. This study aimed to obtain the influence of several doses of intraperitoneal VCO on intraperitoneal adhesion macroscopically and microscopically after laparotomy. This was an analytical interventional study using control. Samples were male Wistar rats (Rattus norvegicus) with an average body weight of 175-200 g. The results of Kruskal-Wallis chi-square tests were 16.381, df = 4, and Asymp sig = 0.003 (P < 0.05) for macroscopical grading (Zühlke) meanwhile 15.160, df = 4, and Asymp sig = 0.004 (P < 0.01) for microscopical grading (Yilmaz). Conclusion: There was a statistically significant difference in macroscopical grades according to Zühlke and in microscopical grades according to Yalmiz among the five groups concerning the occurence of intraperitoneal adhesion in Rattus norvegicus.Keywords: intraperitoneal adhesion, virgin coconut oil (VCO).Abstract: Adhesi intraperitonial adalah timbulnya perlengketan berupa fibrosis antara jaringan dan organ di dalam rongga abdomen. Kejadian adhesi intraperitoneal sekitar 67-93% setelah operasi laparotomi bedah dan mencapai 97% pada operasi ginekologi. Adhesi antara luka dan omentum terjadi pada 80% pasien dan sekitar 50% melibatkan usus. Untuk mencegah atau mengurangi pembentukan adhesi dapat dilakukan dengan menurunkan inflamasi pasca trauma melalui bahan atau obat anti-inflamasi, anti-histamin, anti-koagulan (heparin), anti-oksidan, enzim proteolitik, dan tissue plasminogen activator. Virgin Coconut Oil (VCO) telah diketahui berperan sebagai antiinflamasi, antitrombotik, barier mekanik, dan antioksidan dengan bahan aktif utama tokoferol. Penelitian ini bertujuan untuk mengetahui pengaruh VCO secara makroskopik dan mikroskopik terhadap adhesi intraperitoneal dengan menganalisis perbandingan dosis VCO yang diberikan intraperitoneal pada hewan coba tikus Wistar. Jenis penelitian ini analitik intervensional dengan kontrol. Hewan coba ialah tikus Wistar (Rattus norvegicus) yang diseragamkan berat badan 175-200 g, jenis kelamin jantan, dan variannya. Hasil uji Kruskal-Wallis chi-square ialah 16,381 dengan df = 4 dan Asymp sig = 0,003 (P < 0,05) untuk penilaian makroskopik (Zühlke) sedangkan nilai 15,160, dengan df = 4 dan Asymp sig = 0,004 (P < 0,01) untuk penilaian mikroskopik (Yilmaz). Simpulan: Terdapat perbedaan bermakna dalam derajat makroskopik menurut Zühlke dan derajat mikroskopik menurut Yilmaz pada ke-5 perlakuan dalam kejadian adhesi intraperitoneal pada Rattus norvegicus.Kata kunci: adhesi intraperitoneal, VCO

scholarly journals Evaluation of corneal epithelial wound healing after penetrating keratoplasty in patients receiving a new matrix therapy agent (regenerating agent)

2018 ◽  
Vol 30 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Rémy Jullienne ◽  
Thibaud Garcin ◽  
Emmanuel Crouzet ◽  
Zhiguo He ◽  
Didier Renault ◽  
...  
Keyword(s):  
Wound Healing ◽  
Standard Deviation ◽  
High Risk ◽  
Penetrating Keratoplasty ◽  
Fixed Time ◽  
Complete Healing ◽  
Eye Drops ◽  
Open Label ◽  
Significant Difference ◽  
Epithelial Wound Healing

Objectives: Complete epithelial wound healing is a milestone in early postoperative care after penetrating keratoplasty. The re-epithelialization rate after penetrating keratoplasty was measured in patients receiving a new matrix therapy agent (regenerating agent, Cacicol®) that mimics heparan sulphates. Methods: This was a prospective, open-label, uncontrolled, single-centre observational study. A total of 33 consecutive patients (33 eyes) who underwent an 8.25-mm diameter penetrating keratoplasty were treated with regenerating agent eye drops: one drop in the operating theatre immediately after graft, then on alternate days. Patients were divided into those at low risk (13 patients) and high risk (20 patients) of delayed wound healing, and follow-up was performed by digital slit lamp with fluorescein-dye testing repeated daily at a fixed time. Dye area was measured using ImageJ freeware. The main endpoint was epithelial healing after regenerating agent therapy. Results: The mean ± standard deviation time to complete healing for all patients was 2.7 ± 1.1 (median: 3, range: 1–6) days. This was obtained on Day 1 for 15% of patients, Day 2 for 33%, Day 3 for 88%, Day 4 for 94% and Day 6 for 100%. There was no significant difference between low- and high-risk patients. The area of epithelial defect decreased by a mean ± standard deviation of 75% ± 22% between Day 1 and Day 2, corresponding to a mean ± standard deviation wound-healing rate of 11.5 ± 6.5 mm2/D. There were no systemic or local side effects related to regenerating agent. Conclusion: These preliminary data suggest that regenerating agent could be a useful, non-invasive therapeutic approach in postoperative management of penetrating keratoplasty with the potential to accelerate re-epithelialization.

scholarly journals Comparative evaluation of efficacy and safety of bepotastine besilate 1.5% ophthalmic solution versus olopatadine hydrochloride 0.1% ophthalmic solution in patients with vernal keratoconjunctivitis

2021 ◽  
Vol 10 (5) ◽  
pp. 552
Author(s):  
Priya Gupta ◽  
Seema Baishnab ◽  
Parveen Rewri
Keyword(s):  
Clinical Symptoms ◽  
Ophthalmic Solution ◽  
Histamine Receptor ◽  
Vernal Keratoconjunctivitis ◽  
Eye Drops ◽  
Efficacy And Safety ◽  
Open Label ◽  
Male Predominance ◽  
Significant Difference ◽  
Symptoms And Signs

Background: Vernal keratoconjunctivitis (VKC) is a chronic, seasonally exacerbated, allergic ocular inflammation. It affect children and young adults and has male predominance. The first line of treatment often used is dual acting drugs like olopatadine and bepotastine. It combine the immediate histamine receptor antagonism, coupled with mast cell stabilization with other anti-inflammatory properties. The present study was conducted to compare the efficacy and safety of olopatadine 0.1% and bepotastine 1.5% eye drops in VKC patients.Methods: This was a prospective, open label, randomized and comparative clinical study conducted for 21 days. 65 patients of VKC of 5-15 years of either sex were randomized in two study arm. Arm A, given bepotastine 1.5% and arm B, given olopatadine 0.1% twice daily for 21 days. Symptoms and signs scoring of VKC along with safety assessment were recorded on baseline and at time of follow up on 7th day and 21st day.Results: After 3 weeks of drug therapy, patients in both arms showed improvement in the symptoms and signs scoring of VKC. There was no statistically significant difference between the two treatment arms. However, improvement in clinical parameters particularly ocular itching, which is the main complaint of patients with VKC was more in bepotastine arm as compared to olopatadine treated arm. Both the drugs were well tolerated without any serious adverse effect.Conclusions: Both olopatadine and bepotastine were found to be effective in alleviating the clinical symptoms and signs of VKC. However, bepotastine performed better in reducing ocular itch than olopatadine.

scholarly journals EFEKTIVITAS EXTRA VIRGIN COCONUT OIL DAN OLIVE OIL TERHADAP FUNGSI MEMORI DAN BELAJAR MENCIT

2019 ◽  
Vol 36 (3) ◽  
Author(s):  
Gorga Menak Sihombing ◽  
Rizna Tyrani Rumanti ◽  
Decky Gunawan
Keyword(s):  
Object Recognition ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Coconut Oil ◽  
Extra Virgin Olive Oil ◽  
Aluminium Chloride ◽  
Virgin Coconut Oil ◽  
Medium Chain Triglycerides ◽  
Object Recognition Test ◽  
Significant Difference

  THE EFFECT OF EXTRA VIRGIN COCONUT OIL AND OLIVE OIL TOWARD MEMORY AND STUDY FUNCTION IN MICEABSTRACTIntroduction: Dementia is a neurodegenerative syndrome caused by chronic progressive abnormality and multiple malfunctions of the noble functions especially in memory and learning. Medium chain triglycerides (MCT) and polyphenol in extra virgin coconut oil (EVCO) and extra virgin olive oil (EVOO) can increase cognitive function.Aim: To discover the effect of extra virgin coconut oil (EVCO), extra virgin olive oil (EVOO) on increasing memory and learning ability of mice that are induced by aluminium chloride (AlCl3).Methods: A true experimental study was conducted using a completely randomized and comparative design. Experimental subjects were 24 mice, divided into 4 groups: K1 (negative control, aquades), K2 (AlCl3 + aquades), K3 (AlCl3 + EVCO 30mL/kg/day), and K4 (AlCl3 +EVOO 30mL/kg/day). Aluminium chloride was given for 15 days, then continued by EVCO and EVOO for 15 days. The dependent variable was recognition index (RI) with object recognition test post treatment. Data was analyzed using ANOVA, continued by LSD test with α=0.05.Results: Recognition index between K3 and both K1 and K2 showed a highly significant difference, and RI between K4 and both K1 and K2 also showed a highly significant difference. K4 was better in increasing RI compared with K3 with significant difference.Discussion: Extra virgin olive oil and EVOO improved the learning function and memory of mice induced by AlCl3. Extra virgin olive oil worked better than EVCO, because EVOO contains polyphenols that can work as neuro- inflammation, neurotoxicity and neuronal dysfunction inhibitors, while EVCO contains MCT as the main energy source when nerve damage occurs.Keywords: Dementia, extra virgin coconut oil (oleum cocos), extra virgin olive oil (oleum olivae), learning, memoryABSTRAKPendahuluan: Demensia adalah sindrom neurodegeneratif yang timbul karena adanya kelainan yang bersifat kronis dan progresif disertai dengan gangguan fungsi luhur multipel terutama pada memori dan belajar. Medium chain triglycerides (MCT) dan polifenol pada extra virgin coconut oil (EVCO) dan extra virgin olive oil (EVOO) dapat meningkatkan fungsi kognitif.Tujuan: Untuk mengetahui efek pemberian EVCO, EVOO, serta membandingkan keduanya dalam meningkatkan fungsi memori dan belajar mencit yang diinduksi aluminium klorida (AlCl3).Metode: Penelitian dengan desain studi eksperimental sungguhan menggunakan rancangan acak lengkap dan bersifat komparatif, dengan subjek penelitian 24 ekor mencit Swiss Webster yang dibagi menjadi 4 kelompok: K1 (kontrol negatif, akuades), K2 (AlCl3 +akuades), K3 (AlCl3 +EVCO 30mL/kgBB/hari), dan K4 (AlCl3 + EVOO 30mL/kgBB/hari). Aluminium klorida diberikan selama 15 hari, dilanjutkan dengan pemberian EVCO dan EVOO selama 15 hari. Variabel respons adalah indeks rekognisi (IR), dengan object recognition test setelah perlakuan. Analisis data dengan ANOVA dilanjutkan uji LSD dengan α=0,05.Hasil: Perbandingan IR K3 dengan K1 dan K2 memiliki perbedaan yang sangat bermakna, sedangkan K4 dengan K1 dan K2 memiliki perbedaan yang sangat bermakna. Kelompok 4 lebih baik dalam meningkatkan IR dibandingkan K3 dengan perbedaan bermakna.Diskusi: Extra virgin coconut oil dan EVOO meningkatkan fungsi belajar dan memori mencit yang diinduksi AlCl3. Extra virgin olive oil lebih baik dibandingkan EVOO, karena EVOO mengandung polifenol yang dapat bekerja sebagai penghambat neuroinflamasi, neurotoksisitas, dan disfungsi neuron, sedangkan EVCO mengandung MCT sebagai kandungan utama yang berperan sebagai sumber energi utama bila terjadi kerusakan saraf.Kata kunci: Belajar, demensia, extra virgin coconut oil (oleum cocos), extra virgin olive oil (oleum olivae), memori  

scholarly journals Development of spicy flavored virgin coconut oil by incorporating a mixture of spices oleoresins

OCL ◽  
2020 ◽  
Vol 27 ◽  
pp. 55
Author(s):  
Dilini N. Perera ◽  
K.K.D.S. Ranaweera ◽  
R.A.U.J. Marapana ◽  
Geeth G. Hewavitharana
Keyword(s):  
Thermal Stability ◽  
Vitamin E ◽  
Lipid Oxidation ◽  
Unsaturated Fatty Acids ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Coconut Oil ◽  
Storage Period ◽  
Virgin Coconut Oil ◽  
Significant Difference

Lipid oxidation is a major cause of deterioration in the quality of cooking oils. Degradation of unsaturated fatty acids in oils directly leads to changes in nutritional value, flavor, and storage properties. Oleoresins of ginger, garlic, nutmeg, pepper, cloves, and cinnamon were extracted and incorporated into virgin coconut oil (VCO) to overcome adverse effects of lipid oxidation and changes occurrence on physicochemical properties, thermal stability, shelf life, antioxidant activity, total phenolics and sensory evaluation were conducted against same properties of VCO. Lipid oxidation was assessed in terms of free fatty acid (FFA) value and peroxide value (PV). For the comparison purpose, another oil sample was prepared by incorporating vitamin E too. Results revealed that both PV and FFA of VCO and spicy flavored oil (SFO) samples after one-week storage period were 1.93 ± 0.01 and 1.62 ± 0.02 mEq/kg and 0.36 ± 0.01 and 0.24 ± 0.01 (%) respectively. Saponification value (SV), iodine value (IV), smoke point, flashpoint, viscosity, and the specific gravity of SFO were increased and there was no significant difference in moisture content and insoluble impurities in SFO and VCO. The highest phenolic content and DPPH free radical scavenging activity were found in SFO. The thermal stability of SFO was better than VCO. Both oleoresins and vitamin E incorporated samples showed the same pattern of increment of FFA and PV during storage; however, those increments were slower than VCO. SFO was highly accepted by the sensory panelists in terms of color, aroma, taste, texture, and overall acceptability.

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