scholarly journals Incidence of Metabolic Syndrome and Its Risk Factors among Type 2 Diabetes Clinic Attenders in Isfahan, Iran

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mohsen Janghorbani ◽  
Masoud Amini
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Adult Treatment Panel ◽  
Oral Agent ◽  
Diabetes Clinic ◽  
Factors Associated ◽  
The Mean

Aim. At present, little data exist about incidence and the risk factors associated with metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). The objectives of present study were to assess the incidence and risk factors of MetS in people with T2DM. Methods. During the mean (SD) follow-up period of 11.7 (4.8) years, 3,047 patients with T2DM and free of MetS at baseline have been examined to determine incidence and predictors of progression to MetS. A modified the National Cholesterol Education Program—Adult Treatment Panel III definition with body mass index (BMI) instead of waist circumference was used for the MetS. Results. The prevalence of MetS was 63.2% (95% CI: 62.3, 64.1). The incidence of MetS was 28.5 (95% CI: 26.8, 30.2) (25.9 men and 30.9 women) per 1,000 patient-years based on 35,677 patient-years of follow-up. Multivariate analysis revealed that higher BMI and education, lower and treatment with oral agent or insulin were associated with MetS. Conclusion. These are the first estimate of incidence and risk factors of MetS in patients with T2DM in Iran. These findings showed that the natural course of MetS is dynamic. The clinical management of patients with T2DM will contribute significantly to MetS prevention.

scholarly journals Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Małgorzata Waluś-Miarka ◽  
Maria Kapusta ◽  
Przemysław Miarka ◽  
Ewa Kawalec ◽  
Barbara Idzior-Waluś
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ldl Cholesterol ◽  
Inflammation Marker ◽  
Diabetes Clinic ◽  
Factors Associated ◽  
Inflammatory State ◽  
The Mean

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the regulation of LDL metabolism. There is evidence that circulating PCSK9 is a cardiovascular risk factor. In this study, we determined factors associated with circulating PCSK9 in a group of patients with type 2 diabetes mellitus (DM2). Material included 116 consecutive patients with DM2 from outpatient diabetes clinic. Circulating PCSK9, PTX3, apolipoprotein (apo) B100, apo B48, and apo C3 levels were determined by ELISA, apo A1 by immunoturbidimetry. The mean (sd) age of patients was 59.1 (11.1) years, the mean (sd) values of serum PCSK9 were 255.4 (106.97) ng/ml. Circulating PCSK9 correlated negatively with age ( r = − 0.21 , p < 0.05 ) and HbA1c ( r = − 0.21 , p < 0.05 ) and positively with BMI ( r = 0.21 , p < 0.05 ), total cholesterol ( r = 0.59 ), LDL-cholesterol ( r = 0.50 ), triglyceride ( r = 0.35 ), apo B100 ( r = 0.43 ), apo A1 ( r = 0.43 ) ( p < 0.001 for all), apo C3 ( r = 0.29 , p < 0.01 ), and apo B48 ( r = 0.25 , p < 0.01 ) concentration and FLI ( r = 0.26 , p < 0.01 ). Strong correlation between PTX3 and PCSK9 levels was observed ( r = 0.47 , p < 0.001 ). Multiple stepwise backward regression analysis with PCSK9 as dependent variable revealed that PTX3, apo B100, apo A1, apo B48, and BMI were significantly positive and the presence of NAFLD and HbA1c negatively associated with PCSK9 concentrations. These variables together explain 57% of PCSK9 variability; the strongest relationship was observed between PCSK9 and PTX3 and apo B100. Our results indicate that circulating PCSK9 is significantly associated with inflammation marker PTX3 as well as atherogenic lipids and apolipoproteins C3, B100, and B48, which might be of value in understanding interactions between development of atherosclerosis and inflammatory state in DM2 patients.

Abstract P177: Discordantly Normal ApoB Relative To Elevated LDL-C In Persons With Metabolic Disorders: A Marker Of Atherogenic Heterogeneity

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Alexander C Razavi ◽  
Lydia A Bazzano ◽  
Jiang He ◽  
Marie Krousel-Wood ◽  
Kirsten S Dorans ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Carotid Plaque ◽  
Metabolic Disorders ◽  
Atherosclerotic Cardiovascular Disease ◽  
Ascvd Risk

Introduction: A significant proportion of persons with metabolic syndrome, prediabetes, or type 2 diabetes do not develop atherosclerotic cardiovascular disease (ASCVD). Discordantly normal apolipoprotein B (ApoB) relative to elevated LDL-cholesterol (LDL-C) may help to explain underlying heterogeneity in ASCVD risk among these individuals. Hypothesis: We hypothesized that discordantly normal ApoB (<90 mg/dL) relative to elevated LDL-C ( > 100 mg/dL) would be associated with a lower atherosclerosis burden among individuals with metabolic disorders. Methods: There were 331 Bogalusa Heart Study participants with metabolic syndrome (n=107), prediabetes (n=291), or type 2 diabetes (n=34) and LDL-C > 100 who were free of carotid plaque at baseline (2001-02) and underwent carotid ultrasound at follow-up (2013-16). Carotid plaque was defined as a focal wall thickening >1.5 mm. Modified Poisson regression with robust error variance estimated the long-term absence of plaque for normal ApoB after adjusting for established risk factors. Results: Participants were on average 36.3 years old at baseline, 202 (61.0%) were women, and 93 (29.9%) were African American. Overall, LDL-C explained 42.3% of the variability in ApoB as the lipoprotein markers were only modestly correlated (r=0.65). Participants with ApoB <90 (51.1%) were more likely to remain free of carotid plaque compared to those with ApoB > 90 (74.6% versus 57.4%, p=0.001, Figure ). In multivariable modeling, persons with ApoB <90 were 21% more likely to have long-term absence of plaque (RR=1.21, 95% CI: 1.03-1.43), independent of traditional ASCVD risk factors, including LDL-C. Conclusions: More than half of persons with metabolic disorders and elevated LDL-C had normal ApoB with a lower burden of carotid atherosclerosis over 13 years follow-up. ApoB better represents the atherogenic lipid burden among persons with metabolic disorders compared to LDL-C and may be especially helpful for persons with the pattern of high triglycerides and low HDL-cholesterol.

scholarly journals Risk factors for type 2 diabetes in groups stratified according to metabolic syndrome: a 10-year follow-up of The Tromsø Study

2010 ◽  
Vol 26 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Josepha Joseph ◽  
Johan Svartberg ◽  
Inger Njølstad ◽  
Henrik Schirmer
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome

scholarly journals Prognosis of COVID-19 patients with type 2 diabetes

2021 ◽  
Vol 12 (1) ◽  
pp. 126-139
Author(s):  
Brunda M ◽  
Spandana Peddareddy ◽  
Arushi Moha ◽  
Mahesh DM ◽  
Samriddha Thapa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Comprehensive Analysis ◽  
Control Of Diabetes ◽  
Test Of Significance ◽  
The Mean ◽  
D Dimer

Background: The pandemic of COVID-19, a disease caused by novel coronavirus SARS-CoV-2, is associated with significant morbidity and mortality. Recent data showed that hypertension, diabetes mellitus, cardiovascular diseases, and chronic obstructive pulmonary disease were the most prevalent comorbidities in COVID-19 patients. Additionally, data indicate that hypertension, diabetes and cardiovascular diseases are important risk factors for progression and unfavourable outcome in COVID-19 patients. Poorly controlled Type 2 diabetes mellitus was associated with severe progression of disease. Hence, large studies with comprehensive analysis of all risk factors and longer follow-up are necessary. Methods and analysis: A single-centre retrospective cross-sectional study of 300 patients that were SARS-CoV-2 positive from May to October 2020 was done. Data was entered into Microsoft excel data sheet and was analysed using SPSS 22 version software. Chi-square test or Fischer’s exact test (for 2x2 tables only) was used as test of significance for qualitative data. Independent t test was used as test of significance to identify the mean difference between two quantitative variables. ANOVA (Analysis of Variance) was used as test of significance to identify the mean difference between more than two quantitative variables. P value (Probability that the result is true) of <0.05 was considered as statistically significant after assuming all the rules of statistical tests. Data collected was analyzed in a group of patients who were sub divided into 2 groups diabetics and Non diabetics. The parameters studied included laboratory markers: D dimer, CRP, Lactate Dehydrogenase, Ferritin levels. To assess the glycemic control HbA1C levels were assessed. The outcome parameters considered were Oxygen requirement, assessing the requirement of intensive care and duration of stay in the hospital Conclusion: The patients with higher HbA1c values were found to have higher CRP and D-dimer values and required ICU shift and prolonged hospital stay. Hence, good control of diabetes will reduce the worsening of disease. In a country like India, where most of the population do not have health insurance cover proper control of diabetes, can reduce the burden on family. Hence, large studies with comprehensive analysis of all risk factors and longer follow-up are necessary.

scholarly journals Hypertension in Non-Type 2 Diabetes in Isfahan, Iran: Incidence and Risk Factors

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Mohsen Janghorbani ◽  
Ashraf Aminorroaya ◽  
Masoud Amini
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Multivariate Analyses ◽  
Male Gender ◽  
Outpatient Clinics ◽  
Antihypertensive Medications ◽  
Routinely Collected Data ◽  
The Mean

Objective.To estimate the incidence of and risk factors for the development of hypertension (HTN) in people with T1D using routinely collected data.Method.The mean 16-year incidence of HTN was measured among 1,167 (557 men and 610 women) nonhypertensive patients with T1D from Isfahan Endocrine and Metabolism Research Center outpatient clinics, Iran. HTN was defined as a systolic blood pressure (BP) of 140 mm Hg or higher and/or a diastolic BP 90 mm Hg or higher and/or use of antihypertensive medications. The mean (standard deviation [SD]) age of participants was 20.6 years (10.5 years) with a mean (SD) duration of diabetes of 3.6 years (4.8 years) at registration.Results.The prevalence of HTN at baseline was 9.7% (95% CI: 8.2, 11.5). Among the 1,167 patients free of HTN at registration who attended the clinic at least twice in the period 1992–2016, the incidence of HTN was 9.6 (8.0 women and 11.3 men) per 1000 person-years based on 18,870 person-years of follow-up. Multivariate analyses showed that male gender, older age, higher triglyceride, and higher systolic BP were significantly and independently associated with the development of HTN in this population.Conclusion.These findings will help the identification of those patients with T1D at particular risk of HTN and strongly support the case for vigorous control of BP in patients with T1D.

scholarly journals Incidence and Associated Factors of Type 2 Diabetes: A Community-Based Cohort Study in the Central Region of Rural Community in Thailand

2019 ◽  
Vol 31 (1) ◽  
pp. 72-83
Author(s):  
Annop Kittithaworn ◽  
Royal Dy ◽  
Panadda Hatthachote ◽  
Ram Rangsin ◽  
Mathirut Mungthin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cohort Study ◽  
Rural Community ◽  
Community Based ◽  
Factors Associated ◽  
Obesity Hypertension ◽  
Associated Risk Factors

The present study aimed to evaluate the incidence of type 2 diabetes mellitus (T2DM) and associated risk factors among adults in a rural community of Thailand. A prospective cohort study was conducted in a rural community of Thailand. Among 1358 nondiabetics ≥18 years, fasting plasma glucose (FPG) was measured at baseline in 2008 to 2010 and at follow-up evaluation in 2015. After follow-up of 5213 person-years, 122 new cases of T2DM were ascertained corresponding to cumulative incidence of 23.40 per 1000 person-years. The independent factors associated with T2DM were age, male, prehypertension, hypertension, waist circumference, and impaired FPG. The incidence of T2DM in Thailand is high, and many risk factors are converging. The focus of public health efforts should be on abdominal obesity, hypertension, and impaired FPG. Special attention in terms of preventive strategies must be paid to individuals with impaired FPG, as this state is the most prominent predictor of developing T2DM.

453-P: Metabolic Syndrome Severity Score, All-Cause Mortality, and Incident Vascular Events in Type 2 Diabetes: A 13-Year, Single-Centre, Follow-Up Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 453-P
Author(s):  
MONIA GAROFOLO ◽  
ELISA GUALDANI ◽  
DANIELA LUCCHESI ◽  
LAURA GIUSTI ◽  
VERONICA SANCHO-BORNEZ ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Severity Score ◽  
Single Centre ◽  
Vascular Events ◽  
Follow Up Study ◽  
All Cause Mortality
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