Lick Creek, Indiana

2017 ◽  
Author(s):  
Cheryl Janifer LaRoche
Keyword(s):  
North Carolina ◽  
African Americans ◽  
Orange County ◽  
Focal Point ◽  
Free Blacks ◽  
Underground Railroad ◽  
Northwest Ordinance ◽  
Northwest Territory ◽  
Relationship Of ◽  
The Relationship

This chapter examines the relationship of Quakers and free Blacks in Lick Creek to the Underground Railroad. The Lick Creek settlement once existed in the southeast corner of Paoli Township, Orange County, in southern Indiana. In 1817, freeborn African Americans came to the area and purchased land in what later became the Lick Creek settlement. Blacks also came accompanying Quakers fleeing persecution in North Carolina. With the opening of frontier lands for settlement, free Blacks, encouraged by the antislavery provisions of the Northwest Ordinance, joined the country's westward passage to the Northwest Territory. This chapter first provides a background on Quakers and free Blacks at Lick Creek before focusing on William Paul Quinn's arrival in Indiana, where he built AME churches that became an important focal point of the Lick Creek community. It then considers the antislavery efforts of free Blacks, Quakers, and citizens of conscience working on the Underground Railroad on behalf of escaped slaves. It also discusses the participation of Indiana's Blacks in the Civil War.

The Relationship of the −5, −8, and −24 Variant Alleles in African Americans to Triosephosphate Isomerase (TPI) Enzyme Activity and to TPI Deficiency

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2959-2962 ◽  
Author(s):  
Arthur Schneider ◽  
Linda Forman ◽  
Beryl Westwood ◽  
Catherine Yim ◽  
James Lin ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
African American ◽  
African Americans ◽  
Triosephosphate Isomerase ◽  
Small Subset ◽  
Nucleotide Substitutions ◽  
Severe Deficiency ◽  
American Society ◽  
Relationship Of ◽  
The Relationship

Abstract In 424 African-American and 75 white subjects, we found that the −5 (TPI 592 A→G), −8 (TPI 589 G→A), and −24 (TPI 573 T→G) variants in the triosephosphate isomerase (TPI) gene occurred frequently (41.0%) in the African-American subjects but did not occur in the whites. These data suggest that this set of polymorphisms may turn out to be one of the higher-incidence molecular markers of African lineage, a surprising finding because others had reported that these nucleotide substitutions were restricted to a small subset of African Americans who had been characterized as TPI-deficiency heterozygotes. Additionally, we investigated the relationship of these variants to TPI-enzyme activity. Although the variant substitutions (occurring in three haplotypes: −5 alone, −5 −8, and −5 −8 −24) were associated with moderate reduction in enzyme activity, severe-deficiency heterozygotes could not be identified with certainty, and none of the haplotypes were restricted to subjects with marked reduction of enzyme activity. Three subjects were homozygous for the −5 −8 haplotype, a finding inconsistent with the putative role of this haplotype as the cause of a null variant incompatible with life in homozygotes. Despite these findings, the possibility remains that the −5 −8 or −5 −8 −24 haplotypes may in some instances contribute to compound heterozygosity and clinical TPI deficiency. © 1998 by The American Society of Hematology.

scholarly journals Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

2018 ◽  
Vol 132 (23) ◽  
pp. 2509-2518 ◽  
Author(s):  
Gargi Mahapatra ◽  
S. Carrie Smith ◽  
Timothy M. Hughes ◽  
Benjamin Wagner ◽  
Joseph A. Maldjian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
White Matter ◽  
African Americans ◽  
Mitochondrial Function ◽  
Brain Morphology ◽  
Intracranial Volume ◽  
Peripheral Blood Mononuclear ◽  
Relationship Of ◽  
The Relationship

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.

Black Curriculum Orientations: A Preliminary Inquiry

1993 ◽  
Vol 63 (3) ◽  
pp. 321-339 ◽  
Author(s):  
William Watkins
Keyword(s):  
United States ◽  
Urban Education ◽  
African Americans ◽  
Curriculum Development ◽  
Educational Experience ◽  
The United States ◽  
Historical Reality ◽  
Relationship Of ◽  
The Relationship ◽  
Race And Culture

In this article, William Watkins presents a historical discussion that traces the development of six different curriculum orientations in the educational experience of African Americans. He begins by pointing out that Black curriculum development is inextricably tied to Black America's experience of slavery and oppression in the United States. Watkins then outlines the six orientations, each of which represents African Americans' differing, although sometimes overlapping, sociopolitical responses to their historical reality. The author concludes that, because of the oppressiveness and separateness of U.S. society, Black curriculum orientations will continue to develop as both a part of and separate from the mainstream curriculum movement. Finally,he suggests that further study of the relationship of ethnicity, race, and culture to curriculum may be revealing as we examine contemporary urban education.

Family, Church, Community

2017 ◽  
Author(s):  
Cheryl Janifer LaRoche
Keyword(s):  
African American ◽  
Family Relations ◽  
Black Churches ◽  
Black Families ◽  
Free Blacks ◽  
Underground Railroad ◽  
Church And Community ◽  
The Relationship ◽  
American Churches ◽  
Church Organizations

This chapter explores the roles played by family, church, and community in the Black Underground Railroad movement. By mapping Black settlements, it clarifies and exposes the relationship between African American churches, settlements, and historic Underground Railroad routes. It shows how Black families sustained an important family organizational structure that drove the Underground Railroad. It explains how African American communities connected through family relations and intermarriage, church organizations, benevolent societies, and the fraternal structure of the Prince Hall Masons. It considers how maintaining family connections motivated escape from slavery, particularly when imminent sale threatened to break up the family. Finally, it highlights the ways that Black churches and their ministers helped free Blacks, or self-liberated men and women, to succeed in winning freedom for themselves and their loved ones.

scholarly journals SUN-580 PCSK9 and Lp(a): Association Between PCSK9 Level and Larger Apo(a) Isoform Size in African-Americans and Caucasians

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Enkhmaa Byambaa ◽  
Kyoungmi Kim ◽  
Wei Zhang ◽  
Kevin Truax ◽  
Anuurad Erdembileg ◽  
...  
Keyword(s):  
African Americans ◽  
Genetic Factors ◽  
African American Families ◽  
Apolipoprotein A ◽  
Causal Risk Factor ◽  
The Mean ◽  
Race Ethnicity ◽  
Age Range ◽  
Relationship Of ◽  
The Relationship

Abstract Introduction: An elevated level of lipoprotein(a) [Lp(a)] is an independent causal risk factor for cardiovascular disease. Non-genetic factors do not appreciably influence Lp(a) levels due to a strong genetic control. However, inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to reduce Lp(a) levels. The association of PCSK9 with Lp(a) level and its major genetic determinant—apolipoprotein(a) [apo(a)] size—is not fully understood. In this study, we assessed the relationship between PCSK9, Lp(a) level, apo(a) size, age, and race/ethnicity. Methods: Healthy Caucasian and African-American families were recruited from the general population (age range: 6–74 years, N=267). PCSK9 and Lp(a) levels were assayed enzymatically; apo(a) isoform and LPA allele sizes and isoform-specific Lp(a) levels were determined. Results: In all participants, PCSK9 levels differed significantly by race/ethnicity, age, and sex. Thus, the mean PCSK9 levels were significantly higher in African-Americans vs. Caucasians (104 ± 29 vs. 95 ± 30 ng/mL, respectively, p=0.020), in adults vs. children (102 ± 29 vs. 92 ± 31 ng/mL, respectively, p=0.001) and in females vs. males (103 ± 30 vs. 94 ± 29 ng/mL, respectively, p=0.007). PCSK9 levels were not associated with total plasma Lp(a) levels neither in all participants nor in ethnicity-specific analyses. However, PCSK9 levels were significantly and positively associated with isoform-specific Lp(a) levels carried by the larger apo(a) size in all subjects (r=0.139, p=0.0361). In race/ethnicity analyses, a significant association was seen for African-Americans (r=0.268, p=0.0199), but not for Caucasians. In contrast, there were no significant associations of PCSK9 with isoform-specific Lp(a) levels for the smaller apo(a) sizes in all participants nor in ethnic-specific analyses. Of note, PCSK9 levels were significantly negatively associated with the larger apo(a) isoform sizes in all participants (r=-0.139, p=0.0366). Although significant in both groups, heritability of PCSK9 level was higher in Caucasians than in African-Americans (47% vs. 22%, respectively). Conclusions: Among African-Americans, but not Caucasians, PCSK9 levels were associated with isoform-specific Lp(a) levels carried on larger, but not smaller, apo(a) sizes. The findings illustrate a diverging relationship of PCSK9 with isoform-specific Lp(a) levels.

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