scholarly journals Squamous cell carcinoma antigens (SCCAs) are sensitive biomarkers for atopic dermatitis in children and adolescents: a cross-sectional study

2021 ◽  
Vol 11 ◽  
Author(s):  
Junya Hirayama ◽  
Takao Fujisawa ◽  
Mizuho Nagao ◽  
Yu Kuwabara ◽  
Keigo Kainuma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Atopic Dermatitis ◽  
Children And Adolescents ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Squamous cell carcinoma antigens (SCCAs) are sensitive biomarkers for atopic dermatitis in children and adolescents: a cross-sectional study

2020 ◽  
Author(s):  
Junya Hirayama ◽  
Takao Fujisawa ◽  
Mizuho Nagao ◽  
Yu Kuwabara ◽  
Keigo Kainuma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Atopic Dermatitis ◽  
Children And Adolescents ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Linear Regression Analysis ◽  
International Study ◽  
Serum Levels ◽  
Response To Treatment ◽  
Cross Sectional

Abstract Background We recently reported that squamous cell carcinoma antigen 2 (SCCA2) is a reliable biomarker for atopic dermatitis (AD) in children. To further clarify its utility, we investigated for possible effects of comorbid allergies and AD treatment on serum SCCA levels in children and adolescents.Methods Volunteers aged less than 18 years were recruited through our website. Their allergic status was elucidated using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. We also recruited pediatric patients who needed to be hospitalized because of severe AD. The serum levels of SCCA1 and SCCA2 were measured by ELISAs. In the severe AD patients, the levels of thymus and activation-regulated chemokine (TARC), SCCA1 and SCCA2 were measured before and after hospitalization. The severity of AD was assessed using the severity scoring of atopic dermatitis (SCORAD) index.Results A total of 576 participants (547 volunteers and 29 patients) were enrolled in the study. The levels of SCCA1 and SCCA2 were significantly higher in volunteers with mild AD and patients with severe AD than in healthy volunteers without allergic diseases. In contrast, the levels were not elevated in those who had mild bronchial asthma or mild allergic rhinitis without AD. TARC, SCCA1 and SCCA2 were decreased in patients with severe AD, reflecting clinical improvement in response to treatment. Linear regression analysis for predicting a decrease in the SCORAD index showed R2 values of 0.16, 0.38 and 0.48 for TARC, SCCA1 and SCCA2, respectively..Conclusions SCCAs, especially SCCA2, are sensitive biomarkers for detecting AD in children and adolescents, even in the mild stage, and for assessing the severity and response to treatment of severe AD.

Prognostic potential of CK-19 managing disseminated oral squamous cell carcinomas in Pakistan: A descriptive cross-sectional study

2020 ◽  
pp. 1-13
Author(s):  
Waqas Iqbal ◽  
Uzma Tariq ◽  
Arhama Surwaich ◽  
Surwaich Ali channa ◽  
Abdul Majid ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cross Sectional Study ◽  
Squamous Cell Carcinomas ◽  
Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Oral Squamous Cell Carcinomas

Abstract A cross-sectional study was conducted to assess the adoptability of CK-19 as a routine diagnostic assay and potential prognostic marker following disseminated oral squamous cell carcinoma in Pakistani population. The current descriptive study was conducted at Isra Dental College Hospital, Isra University, Hyderabad, Pakistan. Suspected patients of oral squamous cell carcinomas (OSCC), who visited the Isra Dental College Hospital’s outpatient department from January 2014 up to January 2015 with four year follow up (from January 2015 up to December 2019), were included after ethical approval of the Institutional board. SPSS version 21.0 was used for data analysis. Sixty cases of oral squamous cell carcinoma (OSCC) were selected for CK-19 quantification by using PCR before and after incisional biopsy.    

scholarly journals Expression of P16 biomarker in squamous cell carcinoma of uterine cervix and its association with clinico-pathological parameters: A cross-sectional study

2020 ◽  
Vol 7 (9) ◽  
pp. 3954-3961
Author(s):  
Kalyani R. ◽  
Raghuveer C.V. ◽  
Sheela S.R.
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stage Of Disease ◽  
P16 Expression

Introduction: Cervical cancer is the most common cancer among females. P16 is the surrogate marker for cervical carcinoma. This study aimed to evaluate the association of P16 marker with clinic-pathological parameters in squamous cell carcinoma of uterine cervix. Methods: This was a cross-sectional study. Histological confirmed cases of squamous cell carcinoma (SCC) of cervix were considered. All cases were evaluated for IHC P16 expression as per lower anogenital squamous terminology (LAST) criteria and correlated with clinico-pathological parameters. The data was analyzed by SPSS software version 22. Results: Out of 75 cases, P16 biomarker expression was block positive, ambiguous and negative in 67 (89.3%), 5 (6.6%), and 3 (4%) cases, respectively. There was a significant association between P16 expression and age (p = 0.005). All cases between 30-59 years of age showed block positivity. There was no significant association between P16 expression and age at marriage (p = 0.951), age at menopause (p = 0.311), parity (p = 0.554), clinical symptoms/signs, stage of disease (p = 0.28), or histopathological grade (p = 0.877). Maximum expression was seen between 40-44 years. Moreover, all cases having 1 & 2 parity showed block positivity and all stage I cases showed block positivity. Conclusion: P16 biomarker was significantly expressed in cervical cancers of the relatively younger age group and those with early stage of disease.

scholarly journals Frequency and Determinants of Tongue Lesions among Patients Reported in a Teaching Institute: A Cross-Sectional Study

2021 ◽  
pp. 59-68
Author(s):  
Mehwish Feroz Ali ◽  
Gulrukh Askary ◽  
Shahrukh Saran ◽  
Adnan Zaidi ◽  
Farwa Sajjad ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Study Design ◽  
Squamous Cell ◽  
Oral Submucous Fibrosis ◽  
Cross Sectional Study ◽  
Oral Lesions ◽  
Sectional Study ◽  
Cross Sectional

Aims: The purpose of the study is to evaluate the frequency, distribution and determinants of tongue lesions in our teaching institute. Also to find an association of common tongue lesions with various study variables. Study Design: Cross-sectional study design. Place and Duration of Study: The study was conducted at Fatima Jinnah Dental College & Hospital, Karachi, Pakistan. All the lesions presented on the tongue were included reported from January 2017 to December 2020. Methodology: There were 670 oral lesions documented in the Department of Oral Pathology and Oral Medicine out of which 93 (13.8%) represented tongue lesions. We included 93 patients with tongue lesions (45 men, 48 women; age range 18-80 years). These lesions include the atrophic tongue, geographic tongue, candidiasis, keratotic lesion, ulceration, oral pigmentation, fibroma, black hairy tongue, traumatic neuroma, herpes infection, oral submucous fibrosis, and oral squamous cell carcinoma. Results: In the study, common clinical presentations on the tongue were ulceration (29%), erythematous/depapillated tongue (22.6%), white keratotic and plaque-like lesions (21.6%), and black discoloration (8.6%). The clinical presentation was statistically associated with gender (p=0.03), age (p=0.04) and site of lesion (p<.001). Atrophic glossitis (19.4%), traumatic ulcer (12.9%), pseudomembranous candidiasis (12.9%), oral pigmentation (8.6%), oral squamous cell carcinoma (7.5%), geographic tongue (6.5%), recurrent aphthous stomatitis (6.5%), and frictional keratosis (6.5%) were most commonly reported tongue lesions. There was a relationship of tongue lesions with causes and site of the lesion (P<0.001). Conclusion: Initial tongue lesions may reflect underlying massive abnormal changes and this could be an early diagnostic parameter.  Through vigilant screening of the oral mucosa, we may be able to detect such mucosal alterations and search out the possible cause in order to provide effective treatment to the patient. In this way, we may also prevent the malignant transformation of any susceptible oral lesions.

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