Seroprevalence of Hepatitis B surface antigen and antibody to Hepatitis C virus at a tertiary care center in Telangana

Background: Patients of thalassemia who are conventionally treated by a regular transfusion regimen are at a risk of developing transfusion transmissible infections, including hepatitis. The present study was conducted to assess the prevalence of hepatitis B and hepatitis C virus infections among repeatedly transfused thalassemia patients.Methods: A total of 207 patients of beta-thalassemia, who had received at least 10 transfusions were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibody using enzyme linked immunosorbant assay (ELISA).Results: The overall number of anti-hepatitis C antibody seropositive was 51 (24.6%) and that for hepatitis B surface antigen positives was 7 (3.38%). The prevalence rate for hepatitis B surface antigen was in agreement with average national values, but in case of anti-HCV antibodies the prevalence rate values were comparatively much higher.Conclusions: Stringent measures need to be taken on urgent basis while screening blood for anti-hepatitis C antibody and hepatitis B surface antigen including inclusion of other sensitive assay like nucleic acid test (NAT) as well as better donor recruitment.

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A Study of Seroprevalence of Hepatitis B Surface Antigen, Antibodies to Hepatitis C Virus and Human Immunodeficiency Virus in Patients Visiting Tertiary Care Centre in Bangalore

Indian Journal of Public Health Research & Development ◽

10.5958/0976-5506.2014.00018.7 ◽

2014 ◽

Vol 5 (4) ◽

pp. 86

Author(s):

Kavita Nimboor ◽

R Sujatha ◽

Saroj Golia ◽

Bhakthavatchalam

Keyword(s):

Human Immunodeficiency Virus ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Immunodeficiency Virus

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Decreasing Prevalence of Transfusion Transmitted Infection in Indian Scenario

The Scientific World JOURNAL ◽

10.1155/2014/173939 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 7

Author(s):

Tulika Chandra ◽

S. Nishat Fatima Rizvi ◽

Devisha Agarwal

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

Transmitted Disease ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Transfusion Transmitted Infection ◽

Screening Procedures

Transfusion transmitted infections are major problem associated with blood transfusion. Accurate estimates of risk of TTIs are essential for monitoring the safety of blood supply and evaluating the efficacy of currently employed screening procedures. The present study was carried out to assess the percentage of voluntary donors and replacement donors and to find out prevalence and changing trends of various TTIs blood donors in recent years. A study was carried out on blood units of voluntary and replacement donors which were collected from January 2008 to December 2012. On screening of 180,371 replacement units, seropositivity of transfusion transmitted disease in replacement donors was 0.15% in HIV, 1.67% in hepatitis B surface antigen, 0.49% in hepatitis C virus, 0.01% in VDRL, and 0.009% in malaria. Of 11,977 voluntary units, seropositivity of transfusion transmitted disease in voluntary donors was 0.08% in HIV, 0.24% in hepatitis B surface antigen, 0.001% in hepatitis C virus, 0.008% in VDRL (sexually transmitted disease), and 0.01% in malaria. From results it has been concluded that prevalence of transfusion transmitted infection (HIV, HBV, HCV, VDRL, and malaria) was more in replacement donors in comparison to voluntary donors. Extensive donor selection and screening procedures will help in improving the blood safety.

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Outcomes of Liver Transplantation in Simultaneously Hepatitis B Surface Antigen and Hepatitis C Virus RNA Positive Recipients: The Deleterious Effect of Donor Hepatitis B Core Antibody Positivity

Transplantation Proceedings ◽

10.1016/j.transproceed.2012.07.061 ◽

2012 ◽

Vol 44 (7) ◽

pp. 1960-1962 ◽

Cited By ~ 3

Author(s):

F. Tandoi ◽

R. Romagnoli ◽

S. Martini ◽

E. Mazza ◽

E. Nada ◽

...

Keyword(s):

Liver Transplantation ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B ◽

Surface Antigen ◽

Deleterious Effect ◽

Hepatitis B Surface Antigen ◽

Hepatitis C Virus Rna ◽

Virus Rna ◽

Antibody Positivity

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Seroprevalence of Blood Borne Pathogens among Health Care Workers and Their Hepatitis B Vaccination Status in Tertiary Care Hospitals in India

Global Journal of Health Science ◽

10.5539/gjhs.v9n1p280 ◽

2016 ◽

Vol 9 (1) ◽

pp. 280 ◽

Cited By ~ 1

Author(s):

Maryam Dafei ◽

Shiv K. Sarin ◽

Anjur T. Kannan ◽

Kamal Agrawal ◽

Suneela Garg ◽

...

Keyword(s):

Hepatitis C ◽

Hepatitis B ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

Tertiary Care ◽

Simple Random Sampling ◽

Hepatitis B Vaccination ◽

Cross Sectional ◽

Tertiary Care Hospitals ◽

Anti Hiv

BACKGROUND & AIM: Occupational exposure to blood-borne pathogens, mainly human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV), poses a serious risk to healthcare workers (HCWs), especially in developing countries, due to the high prevalence of these pathogens and fewer safety precautions. The aim of this study was to investigate the seroprevalence of HBV, HCV, and HIV infections and to measure the vaccination practices in HCWs at three tertiary care hospitals in Delhi, India.METHOD: In a descriptive (cross-sectional) study, the HCWs of three tertiary hospitals were selected by simple random sampling and divided into four different groups (nurses, laboratory and operational theater technicians, doctors and housekeeping workers). The participants were screened for the presence of hepatitis B surface antigen (HBs Ag), antibody to hepatitis B surface antigen (anti HBs), antibody to hepatitis C (anti HCV), and antibody to HIV (anti HIV). From June 2010 to April 2012, a structured questionnaire was administered to 850 HCWs after obtaining consent.RESULTS: Among 850 HCWs, 51.8% were nurses and 50.6% were female with a mean (SD) age of 34(8.7) years. The overall seroprevalence of HBsAg, anti-HCV, and anti-HIV was 1.1%, 0.3%, and 0.1%, respectively. There was a high proportion of HBsAg positivity among housekeeping workers (4.9%) followed by nurses (3.3%). Out of 9 positive cases of HBsAg, 66% (6) were never vaccinated and out of a total of 11 positive subjects, 72 % (8) had previous exposure in the workplace. Complete HBV vaccination was done in 78.2% (605) of the HCWs and 11.3% (75) were partially vaccinated. Only 20.1% had checked their anti-HBs. Protective (>10 IU/mL) anti-HBs was seen in 70.6% (600) of the participants, indicating that nearly one third of HCWs were not protected against HBV infection. The majority of the study subjects (63.6%) believed that they were immunized against hepatitis B and did not need to check the immunity titer.CONCLUSION: Not all HCWs were vaccinated and the majority of vaccinated subjects did not know their immunity level. Housekeeping workers had a high seropositivity rate of infections and a low rate of vaccination against HBV. Institutional policy and training were found to be of paramount importance to improve the quality of health in HCWs.

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