Basal cell carcinoma: Histopathological spectrum at a tertiary care center

Background: Dermoscopy is useful in the diagnosis of basal cell carcinoma (BCC). However, most descriptions of the dermoscopic features of BCCs are in Caucasians (skin types I-III) and there is a paucity of data in dark-skinned Indian patients. Aims: The aim of this study was to describe the various dermoscopic features of BCC in dark-skinned patients from South India and correlate these with the histopathologic subtypes. Methods: A retrospective observational study of biopsy-proven cases of BCC was conducted at a tertiary care center in South India using nonpolarized contact dermoscopy. Results: Sixty BCCs in 35 patients predominantly of skin phototypes IV or V were studied. These included 32 nodular, 27 superficial and 1 infiltrative type of BCC. The most common dermoscopic features noted were maple leaf-like areas (61.7%), blue-white veils (53.4%), ulceration (48.4%) and short fine telangiectases (46.7%). Ulceration, blue-white veils and arborizing vessels were significantly associated with nodular BCCs, while maple leaf-like areas, red-white structureless areas, multiple small erosions and spoke wheel areas were noted with superficial BCCs. Limitations: The limitations of this study include its retrospective nature, the use of only nonpolarized light for examination, the lack of other histopathological variants of BCC as well as the lack of a comparison group. Conclusion: We report a dermoscopic study of BCC in dark-skinned patients from Puducherry, South India. The blue-white veil was observed in half of the patients and was significantly associated with nodular BCCs. The addition of the blue-white veil to the diagnostic criteria for pigmented BCC could improve the diagnostic accuracy of dermoscopy in Indian patients.

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Basal cell carcinoma- a prospective clinico epidemiological and pathological study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20172475 ◽

2017 ◽

Vol 5 (6) ◽

pp. 2712 ◽

Cited By ~ 2

Author(s):

V. Ammasaigoundan ◽

V. N. S. Ahamed Shariff ◽

A. Ramesh

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Health Workers ◽

Tertiary Care ◽

Malignant Tumour ◽

Care Hospital ◽

Female Ratio ◽

Histological Variant ◽

Public Health Workers

Background: Basal cell carcinoma is the most common malignant tumour of the skin worldwide. The objective was to find out the age and sex incidence of basal cell carcinoma in patients attending the outpatient department of dermatology and to find out the various clinical and histopathological features of basal cell carcinoma.Methods: It was a prospective observational study carried out in a tertiary care hospital, Chennai, Tamilnadu, India. Patients with clinical diagnosis of basal cell carcinoma were included in the study after thorough history, clinical examination, routine and special investigations like skin biopsy.Results: Out of 20 patients with basal cell carcinoma 6 were males and 14 were females with a male to female ratio of 1:2.33. Most commonly affected age group was 50-70 years (70%). Distribution of BCC in our study was confined to head and neck area. Most common morphological subtype encountered in this study was nodular/nodulo-ulcerative BCC (70%), followed by pigmented type (25%) and superficial BCC (5%). The most common histological variant observed in present study was nodular type (55%), followed by pigmented variant (25%), adenoid (5%), basisquamous (5%), superficial BCC (5%) and BCC with sebaceous differentiation (5%).Conclusions: This study highlights a paradoxically increasing trend of BCC with female predilection. Early detection and treatment of lesions are crucial to decrease the functional and cosmetic disfigurement and also this study highlights the importance of improving awareness among general practitioners, public health workers and general population.

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Aesthetic Reconstruction of Face following Excision of Basal Cell Carcinoma in a Tertiary Care Institution.

International Journal of Medical Reviews and Case Reports ◽

10.5455/ijmrcr.aestheticreconstructionoffacefollowingexcisionofbasalcellcarcinoma ◽

2021 ◽

pp. 1

Author(s):

Mangesh Pawar ◽

Aneesh Suresh ◽

Ishita Katyal ◽

Apurva Agrawal ◽

Suparna Prerepa

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Tertiary Care ◽

Care Institution ◽

Tertiary Care Institution

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Tu1691 - Squamous Cell Carcinoma of Rectum: A Rural Tertiary Care Center Experience

Gastroenterology ◽

10.1016/s0016-5085(18)34427-5 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-1352-S-1353

Author(s):

Burt Cagir ◽

Ashley Berlot ◽

Hilary Keller

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Center

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Histopathological Spectrum of Cutaneous Basal Cell Carcinoma- An 11 Year Retrospective Study in a Tertiary Care Hospital in Southern Karnataka

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/50277.15475 ◽

2021 ◽

Author(s):

Namratha Ravishankar ◽

Vijaya Basavaraj ◽

Reshma Raju

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Clinical Data ◽

Basal Cell ◽

Tertiary Care ◽

Histological Evaluation ◽

Care Hospital ◽

Tertiary Care Centre ◽

Pigmented Lesions ◽

Malignant Skin

Introduction: Basal Cell Carcinoma (BCC) is a slow growing, locally invasive, malignant skin tumour with increasing incidence in recent decades. Various histological subtypes of BCC have been described which include nodular, superficial, adenoid, keratotic, basosquamous, and morpheiform. Aim: To analyse the clinical data of patients with BCC and the histomorphological spectrum of BCCs in a population of Southern Karnataka. Materials and Methods: This was an 11 year retrospective descriptive observational study of all histologically confirmed BCCs diagnosed in the Department of Pathology in a tertiary care centre in Southern Karnataka from January 2010 to January 2021. Detailed clinical data of 64 patients including age, gender, clinical diagnosis and anatomic location were analysed. Results: The maximum number of BCCs occurred in the sixth decade with a slight female preponderance. Head and neck lesions were the most common and uncommon sites noted included the vulva and axilla. Most cases presented as an irregular plaque followed by presentation as an ulcerative lesion. Pigmentation was noted in 18 (28%) cases clinically. Majority of patients (63/64 or 98.4%) had a single lesion. Histological types included nodular, superficial, adenoid, basosquamous and BCC with sebaceous differentiation. Nodular BCC was the most commonly encountered type in our setting, followed by superficial BCC. Only one case of basosquamous carcinoma showed evidence of metastasis to lymph nodes. Conclusion: Histological evaluation of BCC is of paramount importance not only to establish the diagnosis but also to predict behaviour and risk of recurrence. In addition to the diagnosis, pathologist should also describe subtypes of the tumour which has a prognostic implication. This study reveals the morphological spectrum of BCC in the population of southern Karnataka and reveals significant patterns in anatomical distribution of BCC. It also highlights a significant percentage of BCCs presenting as pigmented lesions in the Indian population.

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Cutaneous Squamous Cell Carcinoma of the Forearm: Clinical Features and Outcomes at a Single Academic Tertiary Care Center in a Rural Setting

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2020.08.089 ◽

2020 ◽

Author(s):

Margaret Johnston ◽

Cari E. Carpenter ◽

Kathryn Potter ◽

Maxwell Knapp ◽

Katelyn Shea ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Clinical Features ◽

Squamous Cell ◽

Care Center ◽

Tertiary Care ◽

Cutaneous Squamous Cell Carcinoma ◽

Rural Setting ◽

Tertiary Care Center

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A Retrospective Study of the Diagnostic Accuracy of In Vivo Reflectance Confocal Microscopy for Basal Cell Carcinoma Diagnosis and Subtyping

Journal of Clinical Medicine ◽

10.3390/jcm8040449 ◽

2019 ◽

Vol 8 (4) ◽

pp. 449 ◽

Cited By ~ 7

Author(s):

Mihai Lupu ◽

Iris Popa ◽

Vlad Voiculescu ◽

Daniel Boda ◽

Constantin Caruntu ◽

...

Keyword(s):

Retrospective Study ◽

Confocal Microscopy ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Tertiary Care ◽

Reflectance Confocal Microscopy ◽

Predictive Values ◽

Tertiary Care Centers

Current national and European guidelines recommend distinct management approaches for basal cell carcinoma (BCC) based on tumor location, size, and histopathological subtype. In vivo reflectance confocal microscopy (RCM) is a non-invasive skin imaging technique which may change the diagnostic pathway for BCC patients. This study aimed to determine the sensitivity and specificity of RCM for BCC diagnosis, assess the predictive values of several confocal criteria in correctly classifying BCC subtypes, and evaluate the intraobserver reliability of RCM diagnosis for BCC. We conducted a retrospective study in two tertiary care centers in Bucharest, Romania. We included adults with clinically and dermoscopic suspect BCCs who underwent RCM and histopathological examination of excision specimens. For RCM examinations, we used the VivaScope 1500 and histopathology of the surgical excision specimen was the reference standard. Of the 123 cases included in the analysis, BCC was confirmed in 104 and excluded in 19 cases. RCM showed both high sensitivity (97.1%, 95% CI (91.80, 99.40)) and specificity (78.95%, 95% CI (54.43, 93.95)) for detecting BCC. Several RCM criteria were highly predictive for BCC subtypes: cords connected to the epidermis for superficial BCC, big tumor islands, peritumoral collagen bundles and increased vascularization for nodular BCC, and hyporefractile silhouettes for aggressive BCC. Excellent intraobserver agreement (κ = 0.909, p < 0.001) was observed. This data suggests that RCM could be used for preoperative diagnosis and BCC subtype classification in patients with suspected BCCs seen in tertiary care centers.

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