Ameliorative Effects of Methanolic Extract of Ficus exasperata (Vahl.) on Carbon Tetrachloride-Induced Hepatopathy in Albino Rats

2017 ◽  
Vol 6 (2) ◽  
pp. 21
Author(s):  
Akindele Adeyi ◽  
Blessing Akwarandu ◽  
Esther Adeyi
Keyword(s):  
Carbon Tetrachloride ◽  
Methanolic Extract ◽  
Albino Rats

scholarly journals HEPATOPROTECTIVE EFFECTS OF POLYHERBAL FORMULATION AGAINST CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN ALBINO RATS: A TOXICITY SCREENING APPROACH

2016 ◽  
Vol 10 (1) ◽  
pp. 192 ◽  
Author(s):  
Bhumika Yogi ◽  
Ashutosh Mishra
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatic Injury ◽  
Methanolic Extract ◽  
Hepatoprotective Activity ◽  
Calotropis Procera ◽  
Albino Rats ◽  
Gymnema Sylvestre ◽  
Toxicity Screening ◽  
Lawsonia Inermis ◽  
Polyherbal Formulation

ABSTRACTObjective: To investigate the hepatoprotective activity of aqueous methanolic extract of polyherbal formulation and individual extracts of Calotropisprocera, Gymnema sylvestre, and Lawsonia inermis leaves.Methods: The hepatoprotective activity of the formulation and extracts were assessed on the basis of histopathological changes in liver of carbontetrachloride-induced hepatotoxic rats.Results: The result of present studies strongly indicates that the hepatoprotective property of polyherbal formulation as evidenced by less damagedhepatocytes cells.Conclusion: Polyherbal formulation revealed excellent hepatoprotective profile as compared to individual plants due to synergistic effect producedby different phytochemicals present in the formulation.Keywords: Calotropis procera, Gymnema sylvestre, Lawsonia inermis, Carbon tetrachloride.

scholarly journals Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

2018 ◽  
Vol 04 (01) ◽  
Author(s):  
Ifeanyi Peter Onyeka ◽  
Mohammed M Suleiman ◽  
Sunday P Bako
Keyword(s):  
Methanolic Extract ◽  
Albino Rats ◽  
Euphorbia Hirta ◽  
Toxicity Effects

scholarly journals Evaluation of antidiabetic activity of fruit of Coriandrum sativum. Linn methanolic extract in Streptozocin induced diabetic wistar Albino rats

2017 ◽  
Vol 7 (1) ◽  
pp. 121
Author(s):  
Ahmed S. K. ◽  
Chakrapani Cheekavolu ◽  
Sampath D. ◽  
Sunil M.
Keyword(s):  
Research Study ◽  
Diabetes Management ◽  
Methanolic Extract ◽  
Coriandrum Sativum ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Citrate Buffer ◽  
Standard Drug ◽  
Wistar Albino Rats

Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world. Diabetes is a metabolic disorder characterized by disturbances in lipid, carbohydrate and protein metabolism. The present study to evaluate the antidiabetic potential of coriandrum sativum. linn fruits methanolic extract in streptozocin induced diabetic wistar albino rats model.Methods: Diabetes induction in wistar albino rats by administration of streptozocin (50mg/kg, i.p.) in citrate buffer. 30 wistar albino rats were divided into 5 groups (A, B, C, D, E). Group A: served as normal control, whereas Group B: diabetic control, Group C, D methanolic coriandrum sativum Linn. fruits extract (CSFME) at a dose of 100, 200mg/kg orally, Group E was given standard drug Glibenclamide (0.5mg/kg) orally. All groups are administered for the period of 14 consecutive days and blood sugar levels was measured at regular intervals up to end of the study.Results: This present research study confirms that the test drug compound CSFME has sustained oral hypoglycaemic activity and statistically significant (p ≤0.05) and which is comparable with standard drug Glibenclamide.Conclusions: This research study confirms that the CSFME has antidiabetic activity against streptozocin induced wistar diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct in the type 2 diabetes management and its complication. Further studies are necessary required to confirm the antidiabetic activity of individual phytochemical compounds of Coriandrum sativum.

scholarly journals Methanolic extract of Nepeta paulsenii as an ameliorative agent against CCl4 induced testicular damage in male albino rats

2020 ◽  
Vol 32 (1) ◽  
pp. 1168-1174 ◽  
Author(s):  
Abdul Samad ◽  
Muhammad Umar Ijaz ◽  
Asma Ashraf ◽  
Moniba Sajid ◽  
Muhammad Imran ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Albino Rats ◽  
Testicular Damage

scholarly journals Chemical and Biological Investigations of Cerbera odollam Gaertn

2018 ◽  
Vol 16 (2) ◽  
pp. 179-186 ◽  
Author(s):  
Monica Sharfin Rahman ◽  
Adnan Faisal ◽  
Choudhury Mahmood Hasan ◽  
Monira Ahsan ◽  
Mohammad Mehedi Masud
Keyword(s):  
Carbon Tetrachloride ◽  
Secondary Metabolites ◽  
Petroleum Ether ◽  
Chromatographic Separation ◽  
Methanolic Extract ◽  
Scientific Basis ◽  
Separation And Purification ◽  
Isolation And Characterization ◽  
Soluble Fractions

The present article describes the isolation and characterization of secondary metabolites from the leaves of Cerbera odollam as well as bioactivities of the crude methanolic extract and its petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF) and aqueous (AQ) soluble fractions. In this investigation, successive chromatographic separation and purification yielded β-amyrin (CO-01), lupeol (CO-02), β-sitostenone (CO-03) and triticusterol (CO-04). The study also indicated the antioxidant, cytotoxic, antimicrobial, membrane stabilizing activities and poor thrombolytic activities. Thus, the present study endeavors to provide scientific basis to establish Cerbera odollam as a potential medicinal plant.Dhaka Univ. J. Pharm. Sci. 16(2): 179-186, 2017 (December)

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