scholarly journals Focal adhesion kinase induces matrix metalloproteinase-2 by involving α5β1-mediated signaling in breast cancer cell, MCF-7

2015 ◽  
Vol 2 (1) ◽  
pp. 29
Author(s):  
Amitava Chatterjee ◽  
Triparna Sen ◽  
KiratKumar Ganguly ◽  
Jaydip Biswas
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Focal Adhesion ◽  
Matrix Metalloproteinase 2 ◽  
Mcf 7

scholarly journals Scaffold Protein RACK1 inhibitor compounds prevent the Focal Adhesion Kinase mediated breast cancer cell migration and invasion potential

2021 ◽  
Author(s):  
Hemayet Ullah ◽  
Nagib Ahsan ◽  
Sivanesan Dakshanamurthy
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Focal Adhesion ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Inhibitor Compounds

Scaffold protein RACK1 mediates cancer cell migration mostly through regulation of focal adhesion (FA) assembly by promoting a focal adhesion kinase (FAK) activation downstream of the integrin clustering and adhesion at the extracellular matrix (ECM). Here we demonstrated the efficacy of our recently developed RACK1 Y246 phosphorylation inhibitor compounds (SD29 and SD29-14) to inhibit the migration and invasion of MCF7 and MDA-MB-231 breast cancer cell lines. Using multiple assays, our results confirmed that inhibitor compounds effectively prevent the filopodia/lamellipodia development and inhibits the migration of breast cancer cells. A mechanistic model of the inhibitor compounds has been developed. Migration and invasion capabilities of the cancer cells define the metastasis of cancer. Thus, our results suggest a potential therapeutic mechanism of the inhibitors to prevent metastasis in diverse cancers.

scholarly journals Studies on Focal Adhesion Kinase in human breast cancer cell MDA-MB-231

2012 ◽  
Vol 02 (01) ◽  
pp. 29-42 ◽  
Author(s):  
Kirat Kumar Ganguly ◽  
Triparna Sen ◽  
Sekhar Pal ◽  
Jaydip Biswas ◽  
Amitava Chatterjee
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Focal Adhesion ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Human Breast
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