scholarly journals A Comparative Study of Survival Rate in High Grade Glioma Tumors Being Treated by Radiotherapy Alone Versus Chemoradiation With Nitrosourea

2015 ◽  
Vol 7 (6) ◽  
Author(s):  
Mohammad Houshyari ◽  
Farzaneh Hajalikhani ◽  
Afshin Rakhsha ◽  
Parastoo Hajian
Keyword(s):  
Survival Rate ◽  
Comparative Study ◽  
High Grade Glioma ◽  
High Grade ◽  
Radiotherapy Alone ◽  
Glioma Tumors

scholarly journals Three-Year Survival Rate in All Kinds of Glioma Tumors in One Institution, Iran, 2001-2010

2020 ◽  
Vol 6 (2) ◽  
pp. 67-72
Author(s):  
Masih Rezaee ◽  
◽  
Bahram Amin Mansour ◽  
Keyword(s):  
Survival Rate ◽  
Survival Rates ◽  
Tumor Resection ◽  
High Grade Glioma ◽  
Good Prognosis ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Diffuse Astrocytoma ◽  
And Gender ◽  
Glioma Tumors

Background and Aim: The survival rate of brain tumors has not yet been reported in Iran. The purpose of this study, given the lack of such information, was to evaluate the 3-year survival rate in patients with all kinds of glioma tumors. Methods and Materials/Patients: This study was descriptive and retrospective, including 222 patients who had been diagnosed clinically with one type of glioma tumor and admitted to Al-Zahra hospital, Isfahan, Iran during 2001-2010. All patients (for minors, their parents) were contacted by phone. They were asked about the 3-year survival rate following their tumor resection surgery. Data such as patient’s age on admission, gender, histological diagnosis of tumor, and treatment regimen (surgical/non-surgical, radiation, and/or chemotherapy) were collected from medical records. The 3-year survival rate and frequency of each tumor based on age and gender were measured. Results: The 3-year survival rates for Glioblastoma Multiform (GBM) and anaplastic astrocytoma were 8.7% and 0%, respectively following surgery and chemo-radiation. These tumors were categorized as high-grade glioma with poor prognosis. The 3-year survival rate for diffuse astrocytoma, low-grade oligodendroglioma, low-grade ependymoma, and pilocytic astrocytoma following surgery and radiation were 100%, 95.2%, 100%, and 100%, respectively. These tumors were categorized as low-grade glioma, which has a good prognosis. Conclusion: In this study, the 3-year survival rate in patients with low-grade glioma following surgery and radiation was almost 100%. In contrast, the 3-year survival rate in patients with highgrade glioma following surgery and chemo-radiation was almost 0%.

Comparison of Multiple Treatment Planning Techniques for High-Grade Glioma Tumors Near to Critical Organs

2018 ◽  
Vol 41 (9) ◽  
pp. 514-519 ◽  
Author(s):  
Hande Bas Ayata ◽  
Cemile Ceylan ◽  
Ayhan Kılıç ◽  
Metin Güden ◽  
Kayıhan Engin
Keyword(s):  
Treatment Planning ◽  
High Grade Glioma ◽  
High Grade ◽  
Planning Techniques ◽  
Multiple Treatment ◽  
Glioma Tumors

scholarly journals Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneity

Theranostics ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 6361-6371 ◽  
Author(s):  
Caterina Brighi ◽  
Lee Reid ◽  
Laura A Genovesi ◽  
Marija Kojic ◽  
Amanda Millar ◽  
...  
Keyword(s):  
Comparative Study ◽  
Blood Brain Barrier ◽  
Mouse Models ◽  
High Grade Glioma ◽  
Brain Barrier ◽  
High Grade ◽  
Blood Brain

scholarly journals COT-05 Experience of fertility preservation in 3 male cases and 1 female case with high-grade glioma

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii21-ii21
Author(s):  
Noriyuki Nakayama ◽  
Tetsuya Yamada ◽  
Hirohito Yano ◽  
Yuki Kato ◽  
Toru Iwama
Keyword(s):  
Survival Rate ◽  
In Vitro Fertilization ◽  
Fertility Preservation ◽  
High Grade Glioma ◽  
Reproductive Age ◽  
High Grade ◽  
Partial Removal ◽  
Vitro Fertilization ◽  
The Right

Abstract High-grade glioma (HGG) has a low survival rate, and fertility preservation (FP) has rarely been discussed in the field of Japanese neurosurgery. We report on 4 reproductive patients, including 2 male patients who became biological fathers. Case 1 was a 23-year-old man with anaplastic oligodendroglioma (AO) of the right frontal lobe. Temozolomide maintenance therapy (TMZ-MT) was completed 42 courses after the initial surgery for economic reasons. 21 months later, a local recurrent lesion appeared, so TMZ-MT was restarted after removal this lesion. When he married at 32 years old, the couple wished a desire for childbearing. The TMZ-MT was stopped at 47 courses from the resumption and they aimed for spontaneous pregnancy. At 5 months after discontinuation of TMZ-MT, Gd-enhanced lesions increased again, so we changed the course to in vitro fertilization and resumed TMZ-MT. The couple had a biological baby at his 33 years and 10 months old. Case 2 was a 33-year-old married man with AO of the right parietal lobe. After partial removal, the FP information was explained and cryopreservation of sperm was performed. As of 23 months after the first operation, he became a biological father by in vitro fertilization. Case 3 was a 31-year-old married man with diffuse midline glioma (H3K27M mutant) in the cervical spinal cord. After partial removal, we provided FP information in the same manner, but the couple did not chose cryopreservation of sperm due to his mRS 5. Case 4 was a 24-year-old female with anaplastic astrocytoma of the brain stem. FP information was provided after stereotactic biopsy, but she chose to start radiochemotherapy without cryopreservation of eggs. Patients of reproductive age with HGG, especially oligodendroglial tumors who have a higher survival rate than astrocytic tumors, should be positively informed about FP before treatment begins.

scholarly journals Survival of High Grade Glioma Patients Treated by Three Radiation Schedules with Chemotherapy: A Retrospective Comparative Study

2017 ◽  
Vol 13 (1) ◽  
pp. 18-22
Author(s):  
Samir S. Mohamed ◽  
Hamza A. Hamza ◽  
Mohamed Alaa-Eldeen H. Mohamed ◽  
Amany G. Ali
Keyword(s):  
Comparative Study ◽  
High Grade Glioma ◽  
High Grade ◽  
Retrospective Comparative Study

scholarly journals Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Lucy Brazil ◽  
Angela L Swampillai ◽  
Ka Man Mak ◽  
Darren Edwards ◽  
Pavlina Mesiri ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
High Grade Glioma ◽  
High Grade ◽  
Newly Diagnosed ◽  
Randomized Phase Ii ◽  
Short Course ◽  
Radiotherapy Alone ◽  
Short Course Radiotherapy

Abstract Background Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. Methods We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation). Patients aged at least 70 years with newly diagnosed high-grade glioma deemed suitable for short-course radiotherapy with an ECOG performance status of 0–1 were included. Radiotherapy treatment consisted of 30 Gy, delivered as 6 fractions given over 2 weeks (5 Gy per fraction). Hydroxychloroquine was given as 200 mg orally b.d. from 7 days prior to radiotherapy until disease progression. The primary endpoint was 1-year overall survival (OS). Secondary endpoints included progression-free survival (PFS), quality of life, and toxicity. Results Fifty-four patients with a median age of 75 were randomized between May 2013 and October 2016. The trial was stopped early in 2016. One-year OS was 20.3% (95% confidence interval [CI] 8.2–36.0) hydroxychloroquine group, and 41.2% (95% CI 18.6–62.6) radiotherapy alone, with a median survival of 7.9 and 11.5 months, respectively. The corresponding 6-month PFS was 35.3% (95% CI 19.3–51.7) and 29.4% (95% CI 10.7–51.1). The outcome in the control arm was better than expected and the excess of deaths in the hydroxychloroquine group appeared unrelated to cancer. There were more grade 3–5 events in the hydroxychloroquine group (60.0%) versus radiotherapy alone (38.9%) without any clear common causation. Conclusions Hydroxychloroquine with short-course radiotherapy did not improve survival compared to radiotherapy alone in elderly patients with glioblastoma.

scholarly journals P01.121 Optune treatment does not affect quality of life in treatment of high grade glioma compared to chemo-radiotherapy alone

2018 ◽  
Vol 20 (suppl_3) ◽  
pp. iii259-iii260
Author(s):  
J Onken ◽  
U Goerling ◽  
M Heinrich ◽  
S Guenes ◽  
D Krex ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Grade Glioma ◽  
High Grade ◽  
Radiotherapy Alone
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