scholarly journals SPATIO-TEMPORAL DATA ANALYSIS WITH NON-LINEAR FILTERS: BRAIN MAPPING WITH fMRI DATA

2011 ◽  
Vol 19 (3) ◽  
pp. 189
Author(s):  
Karsten Rodenacker ◽  
Klaus Hahn ◽  
Gerhard Winkler ◽  
Dorothea P Auer
Keyword(s):  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Digital Data ◽  
Linear Filters ◽  
Brain Functions ◽  
Non Linear ◽  
Long Time ◽  
Spatio Temporal ◽  
Sensory Activation ◽  
Temporal Data Analysis

Spatio-temporal digital data from fMRI (functional Magnetic Resonance Imaging) are used to analyse and to model brain activation. To map brain functions, a well-defined sensory activation is offered to a test person and the hemodynamic response to neuronal activity is studied. This so-called BOLD effect in fMRI is typically small and characterised by a very low signal to noise ratio. Hence the activation is repeated and the three dimensional signal (multi-slice 2D) is gathered during relatively long time ranges (3-5 min). From the noisy and distorted spatio-temporal signal the expected response has to be filtered out. Presented methods of spatio-temporal signal processing base on non-linear concepts of data reconstruction and filters of mathematical morphology (e.g. alternating sequential morphological filters). Filters applied are compared by classifications of activations.

scholarly journals Power spectrum of halo intrinsic alignments in simulations

2020 ◽  
Vol 501 (1) ◽  
pp. 833-852
Author(s):  
Toshiki Kurita ◽  
Masahiro Takada ◽  
Takahiro Nishimichi ◽  
Ryuichi Takahashi ◽  
Ken Osato ◽  
...  
Keyword(s):  
Power Spectrum ◽  
Large Scale ◽  
Signal To Noise Ratio ◽  
Cosmological Parameters ◽  
Three Dimensional ◽  
Power Spectra ◽  
Acoustic Oscillations ◽  
Matter Power Spectrum ◽  
Sample Covariance ◽  
Non Linear

ABSTRACT We use a suite of N-body simulations to study intrinsic alignments (IA) of halo shapes with the surrounding large-scale structure in the ΛCDM model. For this purpose, we develop a novel method to measure multipole moments of the three-dimensional power spectrum of the E-mode field of halo shapes with the matter/halo distribution, $P_{\delta E}^{(\ell)}(k)$ (or $P^{(\ell)}_{{\rm h}E}$), and those of the auto-power spectrum of the E-mode, $P^{(\ell)}_{EE}(k)$, based on the E/B-mode decomposition. The IA power spectra have non-vanishing amplitudes over the linear to non-linear scales, and the large-scale amplitudes at k ≲ 0.1 h−1 Mpc are related to the matter power spectrum via a constant coefficient (AIA), similar to the linear bias parameter of galaxy or halo density field. We find that the cross- and auto-power spectra PδE and PEE at non-linear scales, k ≳ 0.1 h−1 Mpc, show different k-dependences relative to the matter power spectrum, suggesting a violation of the non-linear alignment model commonly used to model contaminations of cosmic shear signals. The IA power spectra exhibit baryon acoustic oscillations, and vary with halo samples of different masses, redshifts, and cosmological parameters (Ωm, S8). The cumulative signal-to-noise ratio for the IA power spectra is about 60 per cent of that for the halo density power spectrum, where the super-sample covariance is found to give a significant contribution to the total covariance. Thus our results demonstrate that the IA power spectra of galaxy shapes, measured from imaging and spectroscopic surveys for an overlapping area of the sky, can be used to probe the underlying matter power spectrum, the primordial curvature perturbations, and cosmological parameters, in addition to the standard galaxy density power spectrum.

scholarly journals Spatially expandable fiber-based probes as a multifunctional deep brain interface

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Shan Jiang ◽  
Dipan C. Patel ◽  
Jongwoon Kim ◽  
Shuo Yang ◽  
William A. Mills ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Brain Regions ◽  
Simultaneous Recording ◽  
Electrophysiological Recording ◽  
High Signal ◽  
Brain Functions ◽  
Fiber Probes ◽  
Deep Brain

AbstractUnderstanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires miniaturized neural interfaces that integrate into brain tissue without altering its properties. Existing neural interface technologies have been shown to provide high-resolution electrophysiological recording with high signal-to-noise ratio. However, with single implantation, the physical properties of these devices limit their access to one, small brain region. To overcome this limitation, we developed a platform that provides three-dimensional coverage of brain tissue through multisite multifunctional fiber-based neural probes guided in a helical scaffold. Chronic recordings from the spatially expandable fiber probes demonstrate the ability of these fiber probes capturing brain activities with a single-unit resolution for long observation times. Furthermore, using Thy1-ChR2-YFP mice we demonstrate the application of our probes in simultaneous recording and optical/chemical modulation of brain activities across distant regions. Similarly, varying electrographic brain activities from different brain regions were detected by our customizable probes in a mouse model of epilepsy, suggesting the potential of using these probes for the investigation of brain disorders such as epilepsy. Ultimately, this technique enables three-dimensional manipulation and mapping of brain activities across distant regions in the deep brain with minimal tissue damage, which can bring new insights for deciphering complex brain functions and dynamics in the near future.

Videogrammetric Methods in Velocimetry

1998 ◽  
Vol 51 (6) ◽  
pp. 387-413 ◽  
Author(s):  
Th. Dracos ◽  
A. Gruen
Keyword(s):  
High Speed ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Light Sheet ◽  
Digital Data ◽  
Simultaneous Imaging ◽  
Observation Volume ◽  
Stage Of Development ◽  
Long Time ◽  
Lagrangian Measurements

Photogrammetry has been successfully applied in surveying and mapping for a long time. New imaging techniques, digital data acquisition and storage and powerful computing facilities transformed photogrammetry into videogrammetry, a technique applied in many fields for precise and reliable position measurements. Two applications of videogrammetry in fluid mechanics are presented in this article. Both are at their present stage of development suited for three-dimensional velocity measurements in liquids. One is based on tracking particles seeded in the liquid by using three to four synchronized video-cameras (PTV). It allows one to determine accurately the velocity vectors at a large number of points inside a thick observation volume and also to follow the trajectories of these particles for sufficiently long time periods. It is especially well suited for Lagrangian measurements in flows. The other tracks small three-dimensional patterns in flows of liquids tagged by fluorescent dye (LIFV). The three-dimensional Laser Induced Fluorescence images needed are obtained by sweeping rapidly a thin laser-light sheet with simultaneous imaging using a high speed solid-state camera. The method yields the shift and deformations of the liquid volumes associated with these patterns and allows one to determine velocity vectors and their derivatives simultaneously and accurately at a large number of points inside the observation volume. This review article includes 100 references.

scholarly journals Spatially expandable fiber-based probes as a multifunctional deep brain interface

2020 ◽  
Author(s):  
Shan Jiang ◽  
Dipan C. Patel ◽  
Jongwoon Kim ◽  
Shuo Yang ◽  
William A. Mills ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Brain Regions ◽  
Simultaneous Recording ◽  
Electrophysiological Recording ◽  
High Signal ◽  
Brain Functions ◽  
Fiber Probes ◽  
Deep Brain

AbstractUnderstanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires miniaturized neural interfaces that integrate into brain tissue without altering its properties. Existing neural interface technologies have been shown to provide high-resolution electrophysiological recording with high signal-to-noise ratio. However, with single implantation, the physical properties of these devices limit their access to one, small brain region. To overcome this limitation, we developed a platform that provides three-dimensional coverage of brain tissue through multisite multifunctional fiber-based neural probes guided in a helical scaffold. Chronic recordings from the spatially expandable fiber probes demonstrate the ability of these fiber probes capturing brain activities with a single-unit resolution for long observation times. Furthermore, using Thy1-ChR2-YFP mice we demonstrate the application of our probes in simultaneous recording and optical/chemical modulation of brain activities across distant regions. Similarly, varying electrographic brain activities from different brain regions were detected by our customizable probes in a mouse model of epilepsy, suggesting the potential of using these probes for the investigation of brain disorders such as epilepsy. Ultimately, this technique enables three-dimensional manipulation and mapping of brain activities across distant regions in the deep brain with minimal tissue damage, which can bring new insights for deciphering complex brain functions and dynamics in the near future.

Cryomicroscopy of crotoxin complex crystals at 400 KV

1989 ◽  
Vol 47 ◽  
pp. 826-827
Author(s):  
Jaap Brink ◽  
Wah Chiu
Keyword(s):  
Signal To Noise Ratio ◽  
3D Structure ◽  
Three Dimensional ◽  
Carbon Films ◽  
Depth Of Field ◽  
Basic Subunit ◽  
Ewald Sphere ◽  
Diffraction Patterns ◽  
Complex Crystals ◽  
Acidic Subunit

The crotoxin complex is a potent neurotoxin composed of a basic subunit (Mr = 12,000) and an acidic subunit (M = 10,000). The basic subunit possesses phospholipase activity whereas the acidic subunit shows no enzymatic activity at all. The complex's toxocity is expressed both pre- and post-synaptically. The crotoxin complex forms thin crystals suitable for electron crystallography. The crystals diffract up to 0.16 nm in the microscope, whereas images show reflections out to 0.39 nm2. Ultimate goal in this study is to obtain a three-dimensional (3D-) structure map of the protein around 0.3 nm resolution. Use of 100 keV electrons in this is limited; the unit cell's height c of 25.6 nm causes problems associated with multiple scattering, radiation damage, limited depth of field and a more pronounced Ewald sphere curvature. In general, they lead to projections of the unit cell, which at the desired resolution, cannot be interpreted following the weak-phase approximation. Circumventing this problem is possible through the use of 400 keV electrons. Although the overall contrast is lowered due to a smaller scattering cross-section, the signal-to-noise ratio of especially higher order reflections will improve due to a smaller contribution of inelastic scattering. We report here our preliminary results demonstrating the feasability of the data collection procedure at 400 kV.Crystals of crotoxin complex were prepared on carbon-covered holey-carbon films, quench frozen in liquid ethane, inserted into a Gatan 626 holder, transferred into a JEOL 4000EX electron microscope equipped with a pair of anticontaminators operating at −184°C and examined under low-dose conditions. Selected area electron diffraction patterns (EDP's) and images of the crystals were recorded at 400 kV and −167°C with dose levels of 5 and 9.5 electrons/Å, respectively.

Effects of Velvet Antler Polypeptide-Collagen/Chitosan Materials on Proliferation of Osteoblast

2013 ◽  
Vol 380-384 ◽  
pp. 4295-4298
Author(s):  
Wen He Zhu ◽  
Jun Jie Xu ◽  
Wei Zhang ◽  
Yan Li ◽  
Xiao Jing Lu ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Bone Defect ◽  
Three Dimensional ◽  
Chitosan Scaffold ◽  
Release Drug ◽  
Dimensional Network ◽  
Velvet Antler ◽  
Result Show ◽  
Long Time ◽  
Velvet Antler Polypeptide

A highly osteogenic hybrid bioabsorbable scaffold was developed for bone reconstruction. Though the use of a bioabsorbable collagen and chitosan scaffold for loading velvet antler polypeptide to repair bone defect and drug treatment. Velvet antler polypeptide and collagen were extracted for developing the compounded material. The SEM results show that the collagen and chitosan scaffold maintain the natural three dimensional network structures. The cell proliferation experiment result show that the can promote the osteoblast proliferation for a long time . These results indicated that this compound scaffold can sustainable to release drug and is a good material in bone defect and drug treatment.

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