Rational Use of Drugs and Irrational Drug Combinations

10.5580/2b59 ◽  
2012 ◽  
Vol 10 (1) ◽  
Keyword(s):  
Drug Combinations ◽  
Rational Use

scholarly journals Assessment of rational use of fixed dose combinations in hypertension in a tertiary care teaching hospital in north India

2018 ◽  
Vol 5 (5) ◽  
pp. 1263 ◽  
Author(s):  
Rohini Gupta ◽  
Apoorva Malhotra ◽  
Pavan Malhotra
Keyword(s):  
Tertiary Care ◽  
Drug Combinations ◽  
North India ◽  
Fixed Dose ◽  
Cross Sectional ◽  
Jammu And Kashmir ◽  
Rational Use ◽  
Dose Combination ◽  
Come Into The Market ◽  
Dual Drug

Background: Fixed-dose combination (FDC) agents could be considered as an effective therapy in chronic illnesses like hypertension, which have multifactorial etiology. At present, many FDCs have come into the market without being assessed for their efficacy, safety and rationality by the drug regulatory authorities. The objective of the present study was to assess the rational use of fixed dose drug combinations in hypertension.Methods: It was a cross-sectional observational study conducted in the cardiology outpatient department of ASCOMS and H, Sidhra, Jammu, Jammu and Kashmir from February 2016 to July 2016. In the study 92 prescriptions of hypertensive patients who were on anti-hypertensive fixed-dose drug combinations (FDCs) were recruited after thoroughly evaluated for inclusion and exclusion criteria. Data obtained includes the demographic profile of the patients, pattern of the prescribed FDCs in hypertension, evaluation of the rationality of the FDCs based upon the comprehensive seven-point criteria developed by Panda et al.Results: In the present study, about sixteen different anti-hypertensive FDCs were observed in the prescriptions of 92 patients during six-month period. It was observed that about 93.75% of FDCs were dual drug combinations. Among the dual drug combinations, most commonly used combination was Olmesartan (ARB; Angiotensin receptor blocker) + Amlodipinine (Calcium channel blocker) in 17.4% of patients. It was also observed that among the 16 different anti-hypertensive fixed dose combinations analysed, 12 FDCs (75%) were found to be rational and 4 FDCs (25%) were found to be irrational.Conclusions: In the present study it was found that 75% of the FDCs prescribed were rational and 25% were irrational. Therefore, before marketing the FDCs proper assessment of their efficacy, safety and rationality should be done.

The Rational use of Cocaine in Surgery

1896 ◽  
Vol 41 (1064supp) ◽  
pp. 17013-17014
Author(s):  
Claude A. Dundore
Keyword(s):  
Rational Use

A RETROSPECTIVE STUDY ON ANTIBIOTIC USAGE IN A TERTIARY CARE HOSPITAL

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Anna Joy ◽  
Aparna Anand ◽  
Arathy R Nath ◽  
Meera S Nair ◽  
Dr. K. G. Prasanth
Keyword(s):  
Retrospective Study ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Sensitivity Test ◽  
Actual Process ◽  
Care Hospital ◽  
Rational Use ◽  
Antibiotic Susceptibility Test ◽  
Antibiotic Sensitivity Test ◽  
Rational Use Of Antibiotics

Antibiotics are one of the most commonly prescribed drugs today. Rational use of antibiotics is therefore extremely important as their injudicious use can adversely affect the patient. Drug Utilization Evaluation (DUE) is a system of ongoing systematic criteria based evaluation of drug that will help to ensure that medicines are used appropriately. It is drug/disease specific and can be structured so that it will assess the actual process of prescribing, dispensing, or administration of drug. The retrospective study was conducted At Pk Das Institute of Medical Sciences, Palakkad, Kerala for a duration of 6 months (February 2017 - January 2018). A source of data includes Patient case sheets &medication charts, nursing charts, culture & sensitivity reports. The inclusion criterion includes Patients aged between 18- 80 year, prescribed with oral and parenteral antibiotics. . On analyzing the gender, male gender (n= 111, 55.5%) were higher in numbers as compared to female counterparts (n=89, 44.5%). In our study the majority of the patients prescribed with antibiotics were with the clinical assessment of COPD (n=39, 19.5%), UTI (n=37, 18.5%) and LRTI (n=28, 14%), Bronchial asthma (n=19, 9.5%) respectively. On analyzing the data based on antibiotic sensitivity test, antibiotic test were performed and followed in (n=64,32%)prescriptions and in (n=47,23.5%)prescriptions were test is not followed respectively. In (n=89,44.5%) prescriptions, antibiotic sensitivity test is not performed. On analysis of antibiotics prescribed, the most commonly prescribed antibiotics were cephalosporins, of these ceftriaxone was highly prescribed of all (n=95). The high percentage of antibiotic prescriptions may indicate a high probability of irrational use. This study also point out irrational use of antibiotics are more leading to resistance, misuse and serious problems. So certain strategies should be put forward to strengthen rational use of antibiotics. Keywords: Antibiotics, Antibiotic Susceptibility Test, Irrational use, Resistance

On the rational use of slaughter by-products in sausage production

2020 ◽  
Vol 3 (1) ◽  
pp. 20-25
Author(s):  
A.I. Zharinov ◽  
O.V. Kuznetsova ◽  
L.A. Tekutieva
Keyword(s):  
Rational Use ◽  
By Products

Implementation the GIS technology to the control system of rational use of forest resources in Mykolaiv re-gion

2015 ◽  
Vol 0 (1) ◽  
Author(s):  
Viktor L. Tymchenko ◽  
Olena L. Hirzheva ◽  
Inna V. Tymchenko ◽  
Maryna A. Kyrylchuk
Keyword(s):  
Control System ◽  
Forest Resources ◽  
Gis Technology ◽  
Rational Use

Ecological Enlightenment: System Approach

2013 ◽  
pp. 112-116
Author(s):  
Galina I. Kukatova
Keyword(s):  
Environmental Education ◽  
Natural Resources ◽  
System Approach ◽  
Ecological Knowledge ◽  
Rational Use

The article is devoted to the problems of protection and rational use of natural resources of the Bryansk region, the environmental education of the population and propaganda of ecological knowledge and the activities of the regional libraries in this area.

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