High Protein Substitutes for Gluten in Gluten-Free Bread

Gluten-free products have come into the market in order to alleviate health problems such as celiac disease. In this review, recent advances in gluten-free bread are described along with plant-based gluten-free proteins. A comparison with animal-based gluten-free proteins is made reporting on different high protein sources of animal origin. Sea microorganisms- and insect-based proteins are also mentioned, and the optimization of the structure of gluten-free bread with added high protein sources is highlighted along with protein digestibility issues. The latter is an issue for consideration that can be manipulated by a careful design of the mixture in terms of phenolic compounds, soluble carbohydrates and fibres, but also the baking process itself. Additionally, the presence of enzymes and different hydrocolloids are key factors controlling quality features of the final product.

Diarylureas as Antitumor Agents

The diarylurea is a scaffold of great importance in medicinal chemistry as it is present in numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti-inflammatory properties. Some diarylureas, serine-threonine kinase or tyrosine kinase inhibitors, were recently reported in literature. The first to come into the market as an anticancer agent was sorafenib, followed by some others. In this review, we survey progress over the past 10 years in the development of new diarylureas as anticancer agents.

COLHEITA DO CAFÉ DE QUALIDADE: CUSTO E RETORNO PARA OS PRODUTORES DA REGIÃO DE MANTIQUEIRA DE MINAS - MG

COLHEITA DO CAFÉ DE QUALIDADE: CUSTO E RETORNO PARA OS PRODUTORES DA REGIÃO DE MANTIQUEIRA DE MINAS - MG LUCAS SILVEIRA1, MAURA SEIKO TSUTSUI ESPERANCINI2, FRANKLIN DE SOUZA BARBOSA3, ROGÉRIO PERES SORATTO4 1 Departamento de Engenharia Rural e Socioeconomia, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. [email protected] 2 Departamento de Engenharia Rural e Socioeconomia, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. [email protected] 3 Departamento de Engenharia Rural e Socioeconomia, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. [email protected] 4 Departamento de Produção Vegetal, Universidade Estadual Paulista ‘Júlio de Mesquita Filho’, Av. Universitária, 3780 – Altos do Paraíso, 18610-034, Botucatu, São Paulo, Brasil. [email protected] RESUMO: O segmento de cafés tornou-se um mercado bastante complexo no que tange gerenciamento das lavouras, gestão de custos de produção e comercialização das sacas de café produzidas. O objetivo deste estudo é verificar o impacto dos custos de diferentes métodos de colheita no preço final de venda, bem como verificar os ganhos monetários obtidos na produção de cafés especiais no município de Carmo de Minas (MG). Os dados deste estudo buscam subsidiar a tomada de decisão quanto ao tipo de colheita e aos retornos esperados em termos de preços de venda do produto. A metodologia adotada foi a de conversão das unidades de campo (balaios) para a unidade de comercialização do café (sacas de 60 kg). Os dados levantados permitem ao produtor desenvolver estratégias de manejo da lavoura de café para que atendam aos padrões do mercado, maximizando o retorno sobre os custos de colheita adotada. Dentre os métodos de colheita avaliados, a colheita manual selecionada tem maior potencial de retornos vantajosos para um sistema de produção de cafés especiais em Carmo de Minas (MG). Palavras-chaves: custo de colheita, cafés especiais, métodos de colheita. SPECIALTY COFFEE HARVEST: COST AND BENEFIT TO FARMERS IN THE MANTIQUEIRA DE MINAS AREA – MG ABSTRACT: Coffee market has become an overly complex market in terms of crop, cost, and sales management. The aim of this study was to verify the impact of different harvesting methods costs on sales price as well as to verify economic profits obtained by specialty coffees in Carmo de Minas (MG). The data addresses the decision-making regarding the picking system and the expected returns in terms of sales prices. The methodology foresees the conversion of field units (balaio) to coffee sales units (bags of 60 kg). The data collected allows the producer to develop coffee crop management strategies to come into the market standards, maximizing returns among the harvest costs. Amid the picking methods evaluated, the hand-picked coffee has the greatest potential for beneficial returns for a special coffee production system in Carmo de Minas (MG). Keywords: harvesting cost, specialty coffee, harvesting systems.

The Pathogenesis Mechanism, Structure Properties, Potential Drugs and Therapeutic Nano-particles Against the Small Oligomers of Amyloid-β

: Alzheimer’s Disease (AD) is a devastating neurodegenerative disease affects millions of people in the world. The abnormal aggregation of amyloid b protein (Aβ) is regarded as the key event in AD onset. Meanwhile, the Aβ oligomers are believed to be the most toxic species of Aβ. Recent studies show that the Aβ dimers, which are the smallest form of Aβ oligomers, also have the neurotoxicity in the absence of other oligomers in physiological conditions. In this review we focus on the pathogenesis, structure and potential therapeutic molecules against small Aβ oligomers, as well as the nano-particles (NPs) in the treatment of AD. In this review, we firstly focus on the pathogenic mechanism of Aβ oligomers, especially the Aβ dimers. The toxicity of Aβ dimer or oligomers which attributes to the interactions with various receptors and the disruption of membrane or intracellular environments were introduced. Then the structure properties of Aβ dimers and oligomers are summarized. Although some structural information such as the secondary structure content are characterized by experimental technologies, the full detailed structures are still absent. Following that, the small molecules targeting Aβ dimers or oligomers are collected, nevertheless, all of these ligands are failed to come into the market, rising controversy of the Aβ-related “amyloid cascade hypothesis”. At last, the recent progresses about the nano-particles as the potential drugs or the drug delivery to the Aβ oligomers are present.

Covid-19 Pandemic: Mental Dynamics of Quarantine and Social Isolation

This paper explores the two major preventive concepts of the unpredictable life-threatening viral infection caused by Coronavirus that is ravaging the entire world from the beginning of the year 2020, as it pertains to mental health. Through scientific consultations, the expectation is that effective vaccine for the Coronavirus disease-2019 (COVID-19) may not come into the market this year. Two (among others) preventive measures, namely Social Distancing and Quarantine are suggested by the World Health Organization (WHO). Using the principle of explorative research, this study established the flipside of quarantine and social distancing from the metal health perspective. It was discovered that there is a relationship between a long period of self-isolation and a high probability of concerned persons having anxiety, stress, and depression, which gradually leads to mental and emotional health issues. Consequently, mental health affects the overall health and affects how we handle different situations during the Covid-19 pandemic. By considering this important matter, this article recommended different ways to improve mental health during the pandemic in the quest to keep oneself away from psychological issues arising due to the Covid-19 situation.

Assessment of rational use of fixed dose combinations in hypertension in a tertiary care teaching hospital in north India

Background: Fixed-dose combination (FDC) agents could be considered as an effective therapy in chronic illnesses like hypertension, which have multifactorial etiology. At present, many FDCs have come into the market without being assessed for their efficacy, safety and rationality by the drug regulatory authorities. The objective of the present study was to assess the rational use of fixed dose drug combinations in hypertension.Methods: It was a cross-sectional observational study conducted in the cardiology outpatient department of ASCOMS and H, Sidhra, Jammu, Jammu and Kashmir from February 2016 to July 2016. In the study 92 prescriptions of hypertensive patients who were on anti-hypertensive fixed-dose drug combinations (FDCs) were recruited after thoroughly evaluated for inclusion and exclusion criteria. Data obtained includes the demographic profile of the patients, pattern of the prescribed FDCs in hypertension, evaluation of the rationality of the FDCs based upon the comprehensive seven-point criteria developed by Panda et al.Results: In the present study, about sixteen different anti-hypertensive FDCs were observed in the prescriptions of 92 patients during six-month period. It was observed that about 93.75% of FDCs were dual drug combinations. Among the dual drug combinations, most commonly used combination was Olmesartan (ARB; Angiotensin receptor blocker) + Amlodipinine (Calcium channel blocker) in 17.4% of patients. It was also observed that among the 16 different anti-hypertensive fixed dose combinations analysed, 12 FDCs (75%) were found to be rational and 4 FDCs (25%) were found to be irrational.Conclusions: In the present study it was found that 75% of the FDCs prescribed were rational and 25% were irrational. Therefore, before marketing the FDCs proper assessment of their efficacy, safety and rationality should be done.

UX (User Experience)-Driven Website Design Utilizing Analytic Hierarchy Process (AHP) Multi-Attribute Decision Modeling

The success of an organization's website is determined by the user's experience (UX). Yet many organizations continue to struggle to find tools to strategically analyze the UX's satisfaction with their websites and overall online presence. While there have been numerous studies offering “best practices” for website design, most of these are dated and do not take into consideration UX's experience and social media tools that come into the market. In this chapter, over 900 surveys were conducted on Inc. Magazine's Top 500 list (2011-13) of fastest growing companies in the United States. The analysis of these surveys resulted in a list of shared elements (best practices) common to the websites surveyed. Through the use of the analytic hierarchy process (AHP) multi-attribute decision model, the authors developed a measure by which companies can assess their customer's experience and compare it to these best practices model. This model provides an internally consistent, robust model against which to measure an organization's website based on the user's experience (UX).

Development of a Measurement Instrument for Website Design Utilizing Analytic Hierarchy Process (AHP) Multi-Attribute Decision Modeling

For many organizations their websites are the first impression customers have of their companies. The impact and importance of web design on organizations continues to dramatically increase. Yet many organizations continue to struggle to find tools to strategically analyze their websites and overall online presence. While there have been numerous studies offering “best practices” for website design, most of these are dated and do not take into consideration new applications and social media tools that come into the market. In our research over 900 surveys were conducted on Inc. Magazine's Top 500 list (2011-13) of fastest growing companies in the United States. The analysis of these surveys resulted in a list of shared elements (best practices) common to the websites surveyed. Through the use of the Analytic Hierarchy Process (AHP) Multi-attribute Decision Model, we developed a measure by which companies can assess their web presence in comparison to this best practices model. This model provides an internally consistent, robust model against which to measure an organization's website.

Paper 12: Carbon

The nature of natural and industrial carbons is described, with some recommendations for designing components, in particular, methods which are available for processing final articles to size without machining. Typical applications are briefly reviewed subdivided under the following headings: mechanical applications; electrical applications; and other industrial applications (in this section the various commercial forms of carbon are also reviewed). The paper concludes with a review of several new forms of carbon which have come into the market in the last few years.

Paestan Pottery: a Revision and a Supplement

Since the end of 1935, when my Paestan Pottery was written, well over a hundred vases belonging to this fabric have come to light. Many of them have been found as a result of excavations carried out in recent years in and around Paestum itself, notably at Arenosola, Oliveto Citra, Altavilla and Pontecagnano, and are therefore of considerable importance as confirming the location of the manufacturing centre in Paestum. Other previously unknown vases have come into the market from private collections and several ‘lost’ vases have reappeared. Further, an opportunity to revisit during 1951 most of the ‘major collections in the museums of Western Europe and America has enabled me to add several vases to the list as well as to correct a number of errors. There have also been some important new publications on the subject. In 1935 Marzullo published a preliminary study of the painted tombs discovered at Paestum three years earlier (Tombe dipinte scoperte nel territorio pestano), and a fuller and better illustrated account of the pottery finds, together with a publication of related material from other nearby sites, appeared in two articles by Giovanni Patroni, entitled ‘Vasi Pestani’, in the Rassegna Storica Salernitana ii (1939), pp. 221–258 with figs. 1–37, and in (1940), 3–36 with figs. 38–72, to which, for the sake of convenience, I shall in future refer as VP. A bell-krater acquired by the Ashmolean Museum in 1942 was published by Beazley in AJA xlviii (1944), pp. 357–366, in an article entitled ‘A Paestan Vase’, in which he made some important observations on the workshop of Asteas and Python. The time, therefore, seems ripe for the issue of a supplement to my original publication in order to incorporate the new vases, of which many of the most significant are here illustrated, and to make such revisions to the text and lists of attributions as seem called for in the light of the new evidence now to hand.