Effect Of Panretinal Laser Photocoagulation On The Concentration Of Enzymatic Antioxidants In The Serum Of Diabetic Patients Single Vs Multiple Sittings.

10.5580/2c1d ◽  
2012 ◽  
Vol 13 (1) ◽  
Keyword(s):  
Laser Photocoagulation ◽  
Diabetic Patients ◽  
Enzymatic Antioxidants

scholarly journals Anti-angiogenic therapy for diabetic macular edema

2018 ◽  
Vol 11 (4) ◽  
pp. 51-66
Author(s):  
Fedor E. Shadrichev ◽  
Nyurguyana N. Grigor'eva ◽  
Elizaveta S. Rozhdestvenskaya
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Laser Photocoagulation ◽  
Severe Disease ◽  
Diabetic Patients ◽  
Vegf Inhibitors ◽  
Angiogenic Therapy ◽  
Examination Quality ◽  
Endothelial Growth Factor

Diabetic retinopathy remains one of the greatest challenges for healthcare system worldwide despite the fact that the incidence of visual acuity impairment in diabetic population has decreased due to examination quality improvement and dynamic observation of patients. Visual acuity impairment in diabetic patients is often related to diabetic macular edema. Until recently, laser photocoagulation of the retina was regarded as gold standard for diabetic macular edema treatment. Laser photocoagulation of the retina provides visual acuity stabilization rather than improvement. Since early 2000s, pharmacological approach to this severe disease has been established. As vascular endothelial growth factor (VEGF) is one of the crucial factors involved in the pathogenesis of diabetic retinal disorders, VEGF inhibitors are now recognized as a treatment of choice for diabetic macular edema. This article considers results of different clinical trials investigating anti-VEGF therapy efficacy in DME treatment.

Ophthalmic treatment of diabetic retinopathy

2020 ◽  
pp. 171-178
Author(s):  
Ramesh R. Sivaraj ◽  
Jonathan M. Gibson
Keyword(s):  
Diabetic Retinopathy ◽  
High Risk ◽  
Group Intervention ◽  
Laser Photocoagulation ◽  
Interdisciplinary Approach ◽  
High Risk Group ◽  
Diabetic Patients ◽  
Diabetic Maculopathy ◽  
Operative Assessment ◽  
Ophthalmic Treatment

The ophthalmic treatment of diabetic retinopathy is aimed at preserving vision and requires an interdisciplinary approach. The main treatments used for proliferative retinopathy and diabetic maculopathy include laser photocoagulation, intra-vitreal, and peri-ocular drug injections, or a combination of both. In advanced cases of diabetic retinopathy (DR), vitrectomy and retinal surgery may help preserve vision. Cataract surgery in diabetic patients is extremely successful, but overall these patients are usually considered to be at risk of more complications than the general population. Those patients with pre-existing DR at the time of surgery should be regarded as a high risk group and will require careful pre-operative assessment and post-operative review. In this group, intervention with laser photocoagulation and intra-vitreal pharmacotherapy may be necessary.

Reversible changes of visual acuity and pattern-electroretinograms after blue-green argon laser photocoagulation of diabetic patients

1989 ◽  
Vol 72 (2) ◽  
pp. 105-113
Author(s):  
I. Gottlob ◽  
F. H. Prskavec ◽  
N. Stelzer ◽  
I. Hienert ◽  
H. Weghaupt ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Laser Photocoagulation ◽  
Argon Laser ◽  
Diabetic Patients ◽  
Argon Laser Photocoagulation

scholarly journals Role of oxidative stress in hearing impairment in patients with type two diabetes mellitus

2009 ◽  
Vol 123 (9) ◽  
pp. 957-963 ◽  
Author(s):  
İ Aladag ◽  
A Eyibilen ◽  
M Güven ◽  
Ö Atış ◽  
Ü Erkokmaz
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Hearing Loss ◽  
Hearing Impairment ◽  
Protein Oxidation ◽  
Serum Levels ◽  
Control Group ◽  
Diabetic Patients ◽  
Enzymatic Antioxidants ◽  
Insulin Dependent Diabetic

AbstractObjective:Although many clinical investigations have found a relationship between hearing loss and diabetes mellitus, the pathophysiology of this effect remains controversial. To date, the mechanisms of hearing loss in diabetic patients have been explained in terms of microangiopathy, neuropathy and encephalopathy. However, many reports indicate that some diabetic complications are associated with oxidative stress related to the diabetes itself. In the present study, we hypothesised that oxidative stress may be a cause of hearing loss in diabetic patients.Methods:The study group comprised non-insulin dependent diabetic patients with no signs of microangiopathy or peripheral neuropathy. The control group comprised sex-, age- and body weight matched, non-diabetic subjects. Auditory function was evaluated using pure tone audiometry and tympanometry. Subjects with normal hearing and sensorineural hearing loss were included in the study, whereas subjects with conductive hearing loss were excluded. Both the study group (n = 63) and the control group (n = 37) were divided into subgroups based on the presence and absence of hearing loss. Oxidative stress was evaluated by measuring serum indicators of protein oxidation and lipid peroxidation, serum levels of nitric oxide and various non-enzymatic antioxidants, and the activity of various enzymatic antioxidants.Results:The non-insulin dependent diabetic patients had significantly higher serum levels of protein oxidation products, nitric oxide, enzymatic antioxidant activity (i.e. glutathione peroxidase and superoxide dismutase), compared with the control group (p < 0.05). When we compared the groups in relation to the presence of hearing loss, the nitric oxide level was significantly increased in the diabetic group with good hearing, compared with diabetic patients with hearing loss (p = 0.014). In the diabetic group, a clear, negative correlation was observed between serum levels of nitric oxide and vitamins C and E, and hearing impairment (r = −0.395,r = −0.318,r = −0.500, respectively). There was also a positive correlation between serum vitamin C concentrations and hearing levels in the control group (r = 0.417).Conclusion:These results suggest that oxidative stress may play an important role in hearing impairment in diabetic patients. In this process, increased protein oxidation appears to be more important than lipid peroxidation. Nitric oxide may have a protective effect on hearing, as may some nonenzymatic antioxidants such as vitamin C and E.

A Clinical Study of Diabetic Retinopathy

2003 ◽  
Vol 42 (148) ◽  
Author(s):  
KJD Karki
Keyword(s):  
Diabetic Retinopathy ◽  
Clinical Study ◽  
High Risk ◽  
Key Words ◽  
Laser Treatment ◽  
Proliferative Diabetic Retinopathy ◽  
Laser Photocoagulation ◽  
Visual Loss ◽  
Diabetic Patients ◽  
Vitrectomy Surgery

A clinical study of diabetic retinopathy was conducted from March- May 2002 to diagnose a patient’sdiabetic retinopathy level and identify eyes of proliferative diabetic retinopathy and maculopathy so thatthese patients could get appropriate and timely laser photocoagulation surgery and other surgical modalitiesto reduce the risk of visual loss. This study shows that out of 248 diabetic patients examined, 45.9% patientshad retinal changes. The potential candidates for panretinal and focal laser treatment were the patientswith very severe non-proliferative diabetic retinopathy (NPDR) (3.5%), early proliferative diabeticretinopathy (PDR) or high-risk PDR (3.5%), and maculopathy (8.8%).Key Words: Diabetic retinopathy, Laser photocoagulation surgery and vitrectomy Surgery.

Photocoagulation for Diabetic Macular Edema

2020 ◽  
pp. 169-176
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Laser Photocoagulation ◽  
Argon Laser ◽  
Diabetic Patients ◽  
Nonproliferative Diabetic Retinopathy ◽  
Argon Laser Photocoagulation ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant

The Early Treatment Diabetic Retinopathy Study (ETDRS) was a randomized clinical trial involving nearly four thousand diabetic patients with early proliferative retinopathy, moderate to severe nonproliferative retinopathy, and/or diabetic macular edema in each eye. This paper (ETDRS report number 1) describes the findings in the subgroup of eyes in the ETDRS that were identified as having mild to moderate nonproliferative diabetic retinopathy and macular edema. The analysis showed that immediate focal argon laser photocoagulation of “clinically significant” diabetic macular edema substantially reduced the risk of visual loss, increased the chance of visual improvement, decreased the frequency of persistent macular edema, and caused only minor visual field losses. The authors recommended immediate focal argon laser photocoagulation for all eyes with clinically significant macular edema and mild or moderate nonproliferative diabetic retinopathy, regardless of the level of visual acuity.

scholarly journals Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats

2019 ◽  
Vol 9 (4-A) ◽  
pp. 167-175
Author(s):  
S. Suhasini ◽  
C. Elanchezhiyan ◽  
G. Chandirasegaran
Keyword(s):  
Lipid Peroxidation ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Oxidative Status ◽  
Diabetic Patients ◽  
Enzymatic Antioxidants ◽  
Metabolizing Enzymes ◽  
Liver And Kidney ◽  
Ethanolic Leaf Extract ◽  
In Cells

In diabetic patients, hyperglycemia is developed due to increased hepatic glucose production and impaired utilization of glucose in cells, which leads to oxidative stress in cells. Ipomoea pes-caprae has been widely used as an oral treatment for many diseases. The aim of the present study is to assess the effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin (STZ) induced experimental diabetic rats. Experimental diabetic rats were induced by intraperitoneal administration of 55 mg/kg b.w of STZ. Diabetic rats were treated with I. pes-caprae ethanolic leaf extract at a concentration of 300 mg/kg b.w and glibenclamide (6 mg/kg b.w) for 45 days. Diabetic rats exhibited significant (P < 0.05) decline in the activity of glucokinase and glucose-6-phosphate dehydrogenase, enzymatic antioxidants (SOD, CAT and GPx) and non-enzymatic antioxidants (GSH, vitamin E and vitamin C), while lipid peroxidation markers (LOOH and TBARS) and glucose-6-phosphatase and fructose-1, 6-bisphosphatase were found to be significantly increased. Further in diabetic rats, the histopathology of pancreas, liver and kidney showed abnormal histo-architecture. The treatment with Ipomoea pes-caprae ethanolic leaf extract notably reversed the abnormal levels in carbohydrate metabolizing enzymes, restored the oxidative status and abnormal structures in pancreas, liver and kidney to near normal levels. Keywords: Diabetes, antioxidant, lipid peroxidation, Ipomoea pes-caprae and carbohydrate metabolizing enzymes.

Effect of laser photocoagulation before vitrectomy to hypoxia inducible factor-1alfa and intracellular adhesive molecule-1 in diabetic patients: a randomized clinical trial

2021 ◽  
Vol 30 (2) ◽  
pp. 204
Author(s):  
Andi Arus Victor ◽  
Vivi Rizka Yandandri ◽  
Tjahjono Darminto Gondowiardjo ◽  
Rahayuningsih Dharma ◽  
Sri Widia Jusman ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Laser Photocoagulation ◽  
Hypoxia Inducible Factor ◽  
Diabetic Patients ◽  
Adhesive Molecule
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