Pharmacological Effect of Irvingia gabonensis Leaf Extracts on Cat Blood Pressure

10.5580/e17 ◽  
2011 ◽  
Vol 9 (1) ◽  
Keyword(s):  
Blood Pressure ◽  
Pharmacological Effect ◽  
Leaf Extracts ◽  
Irvingia Gabonensis

Effect of Cydonia oblonga Mill. fruit and leaf extracts on blood pressure and blood rheology in renal hypertensive rats

2014 ◽  
Vol 152 (3) ◽  
pp. 464-469 ◽  
Author(s):  
Wenting Zhou ◽  
Elzira Abdusalam ◽  
Parida Abliz ◽  
Nadira Reyim ◽  
Shuge Tian ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Rheology ◽  
Hypertensive Rats ◽  
Cydonia Oblonga ◽  
Leaf Extracts ◽  
Renal Hypertensive Rats

Effect of Cydonia oblonga Mill. leaf extracts or captopril on blood pressure and related biomarkers in renal hypertensive rats

2014 ◽  
Vol 153 (3) ◽  
pp. 635-640 ◽  
Author(s):  
Wen-ting Zhou ◽  
Adil Abdurahman ◽  
Elzira Abdusalam ◽  
Wuliya Yiming ◽  
Parida Abliz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Cydonia Oblonga ◽  
Leaf Extracts ◽  
Renal Hypertensive Rats

scholarly journals Pharmacological effect of Allium sativum on coagulation, blood pressure, diabetic nephropathy, neurological disorders, spermatogenesis, antibacterial effects

2019 ◽  
Vol 4 (2) ◽  
pp. 386-398
Author(s):  
Seyyed Abbas Hashemi ◽  
◽  
Sayeh Ghorbanoghli ◽  
Ali Asghar Manouchehri ◽  
Mahdi Babaei Hatkehlouei ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Nephropathy ◽  
Neurological Disorders ◽  
Allium Sativum ◽  
Pharmacological Effect ◽  
Antibacterial Effects

Solanum macrocarpon Leaf Extracts Reduced Blood Pressure and Heart Rate After Oral Administration to Spontaneously Hypertensive Rats

2019 ◽  
Vol 17 (3) ◽  
pp. 282-290 ◽  
Author(s):  
Olayinka A. Oluwagunwa ◽  
Adeola M. Alashi ◽  
Rotimi E. Aluko
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Leaf Extracts ◽  
Spontaneously Hypertensive ◽  
Vitro Analysis ◽  
Gallic Acid Equivalent ◽  
In Vitro Analysis

The aim of this work was to determine the ability of polyphenol-enriched aqueous vegetable leaf extracts to ameliorate blood pressure and heart rate dysfunctions in spontaneously hypertensive rats (SHRs). Solanum macrocarpon (SM), a common edible vegetable leaf in West Africa was cultivated using varying levels (0-80 kg/ha) of urea that was applied at planting (T1) or 2 weeks after planting (T2). In vitro analysis showed that total polyphenolic compounds varied from 489.87 ± 5.66 to 513.56 ± 1.42 mg gallic acid equivalent/g dry wt of extract. Rutin, caffeic acid and myricetin were the major polyphenols quantified in the extracts. All the extracts inhibited in vitro activities of renin and angiotensin converting enzyme to varying extents. Two extracts (SM40T1 and SM80T2) were orally administered to SHRs at 100 or 500 mg/kg body wt. Results showed that systolic blood pressure was reduced to a similar level by SM40T1 (10.8 mmHg) and SM80T2 (10.5 mmHg) for the 100 mg/kg body wt dose; the 500 mg/kg body wt dose produced similar values. Diastolic blood pressure and heart rate were also depressed by the two extracts with similar effects observed for both doses. We conclude that the leaf extracts could serve as potential ingredients to formulate antihypertensive functional foods and nutraceuticals.

scholarly journals Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Authentia Sokpe ◽  
Merlin L. K. Mensah ◽  
George A. Koffuor ◽  
Kwesi P. Thomford ◽  
Richmond Arthur ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Kidney Function ◽  
Blood Count ◽  
Persea Americana ◽  
Full Blood Count ◽  
Annona Muricata ◽  
Leaf Extracts ◽  
Induced Hypertension ◽  
Liver And Kidney ◽  
Antihypertensive Properties

Introduction. In the management of hypertension (a cardiovascular disease and the leading metabolic risk factor in noncommunicable diseases) with herbal medicines, efficacy and safety are of uttermost concern. This study sought to establish hypotensive, antihypertensive, drug interaction, and safety for use of the aqueous leaf extracts of Annona muricata (AME), Persea americana (PAE), or their combination products (CAPE). Methodology. Systolic and diastolic blood pressure (SBP and DBP), mean arterial blood pressure (MAP), and heart rate (HR) were measured in normotensive Sprague-Dawley rats treated with 50–150 mg/kg of AME, PAE, or CAPE to establish a hypotensive effect. “Combination index” was calculated to establish interaction between AME and PAE. The antihypertensive effect of CAPE was established by measuring SBP, DBP, MAP, and HR in ethanol-sucrose- and epinephrine-induced hypertension. Full blood count, liver and kidney function tests, and urinalysis were determined in ethanol/sucrose-induced hypertension to establish safety for use. Results. AME, PAE, and CAPE significantly ( p ≤ 0.001 ) decreased BP in both normotensive and hypertensive animals. Effects of CAPE 1, CAPE 2, and CAPE 3 were synergistic (combination indices of 0.65 ± 0.07, 0.76 ± 0.09, and 0.87 ± 0.07, respectively). There was a significant decrease ( p ≤ 0.01 − 0.001 ) in SBP and MAP with 100 mg/kg CAPE 1 and 75 mg/kg CAPE 2 treatment in hypertension as well as with nifedipine ( p ≤ 0.001 ) treatment. Epinephrine-induced hypertension in anesthetized cats was significantly and dose-dependently inhibited ( p < 0.05 − 0.001 ) by 25–100 mg/ml CAPE 1 and 37.5–75 mg/ml CAPE 2. CAPE administration had no deleterious effect ( p > 0.05 ) on full blood count, liver and kidney function, and urine composition in hypertensive rats. Conclusion. The aqueous leaf extracts of Annona muricata, Persea americana, and their combination products possess antihypertensive properties, with combination products showing synergism and safety with use.

scholarly journals Lipid ratios in adriamycin-induced pre-eclamptic Wistar rats exposed to methanolic plant extracts

2021 ◽  
Vol 25 (9) ◽  
pp. 1617-1623
Author(s):  
K. Atoe ◽  
M. Idu ◽  
B. Ikhajiagbe ◽  
A.G. Bakre
Keyword(s):  
Blood Pressure ◽  
Plant Extracts ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Third Trimester ◽  
Leaf Extracts ◽  
The Third ◽  
Lipid Ratios

The study accessed the lipid ratios in preeclamptic Wistar rats exposed to methanolic leaf extracts of Jatropha cacus, Alchonnea cordifolia, and Secamone afzelii. Plant samples (leaves) were washed severally with distilled water, air-dried, and crushed to powder and were filtered, then soaked in 200ml of methanol for 12 hours. The LD50 was determined to ascertain the safety of the plant extracts for use. Female Wistar rats, aged 3 days apart, used in the study, were acclimatized for one week. Peeclampsia was induced used the Adriamycin Model. Results showed that there was elevation of blood pressure (bp) due to preeclampsia. At 3rd trimester, systolic bp (177 mmHg) was higher than at postpartum (160 mmHg). The administration of plant extracts caused a significant reduction in systolic (127 – 150 mmHg) and diastolic (86 – 103 mmHg) bp during the 3rd trimester.  Proteinuria was reduced to trace levels when Alchonnea cordifolia was used. Total cholesterol levels were higher in the third trimester (71.6 mg/dl) and postpartum (74.3 mg/dl), respectively. Preeclampsia was linked to similar increases in triglycerides, and low density lipoprotein cholesterol; with a reduction in high density lipoprotein cholesterol. The treatment with the various plant extracts lowered the incidence of arteriosclerotic cardiovascular events during preeclampsia. Although the extracts had a negative effect on systolic blood pressure and proteinuria during the third trimester, indicating that they were beneficial in reducing preeclampsia outcomes, there was no effect on blood pressure or proteinuria during the postpartum period.

scholarly journals PHYTOSYNTHESIS AND CHARACTERIZATION OF IRON NANOCOMPOSITES BY IRVINGIA GABONENSIS (OGBONO) AQUEOUS AND ETHANOL LEAF EXTRACTS

2020 ◽  
Vol 8 (5) ◽  
pp. 256-265
Author(s):  
Sifon Emem Ebong ◽  
Pereware Adowei ◽  
Gloria Ukalina Obuzor
Keyword(s):  
Broad Band ◽  
Visual Observation ◽  
Spherical Particles ◽  
Nano Composites ◽  
Leaf Extracts ◽  
Nano Composite ◽  
Alcohol Extract ◽  
Irvingia Gabonensis ◽  
Ethanol Extracts

The need for emerging materials based on nano-composites from green plants, or non-useful materials for adsorption process is on the increase. The objective of this research was to evaluate the phytosynthesis and characterization of iron nano-composites (Fe.NCs) formed by aqueous and ethanol extracts of Irvingia gabonensis (Ogbono) tree leaves. The composites were characterized by visual observation, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Visual observation of the iron oxide nano-composites synthesized was confirmed by change in colour from yellow to brown within minutes of formation. The FTIR characterization showed that, phenolic groups were involved in the phytosynthesis of the iron nano-composites with the presence of –OH and –NH groups at 3348.54cm-1 and -C-N- group at 1635.69 cm-1 for aqueous extract and broad band of –OH and -NH stretch at 3363.97cm-1 and -C-H-stretch at 2978-2901.04cm-1 attributed to alkanes in alcohol extract. There was also –OH stretch at 2885.60cm-1 and Fe-O group at 671.25cm-1 in Fe. NCs with Fe-O stretch observed at 583.33cm-1 in I. gabonensis iron nano-composite. Cube-like structures, irregular shapes and sizes with individual, spherical particles forming aggregates and chains were revealed by the SEM micrographs, these are recognized attributes of strong magnetic properties of iron. The particle sizes are 30 and 45 nm for aqueous and alcohol extracts respectively, which could provide large surface area for contaminant adsorption. Conclusively, photosynthesis of Fe. NCs using water and ethanol extracts of I. gabonensis (Ogbono leaves) could be an effective one-step pathway for nano-composite production from eco-friendly, safe and less toxic green plant material.

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