scholarly journals Fibrillation of events in the cambial domains of Tilia cordata Mill.

2014 ◽  
Vol 56 (1) ◽  
pp. 19-35 ◽  
Author(s):  
Wiesław Włoch ◽  
Ewa Biczewska
Keyword(s):  
High Intensity ◽  
Single Domain ◽  
Tilia Cordata ◽  
Fusiform Cell ◽  
Low Intensity ◽  
Domain Type ◽  
Cambium Layer ◽  
One Year

The cambium and 9 annual growths from a linden stem were studied. Some of the fusiform cell ends changed their contacts-which is shown by the comparison of the cambium layer and terminal parenchyma of the phloem. This means that these ends were active in the period the layers under comparison were formed. The active ends were found in groups numbering a few to ten-odd ends alternating with groups of inactive ends. About 70% of the ends retained their activity for only one year. In the studied areas. in a given year, one direction of migration of the active ends dominated. As a rule, this configuration changed every two years. Along with the change in the configuration of the active ends, the position of the active areas also changed in such a way that after the change of configuration, the areas previously inactive became active. No migration of activity along the borders of the storeys was observed, but only its appearance and disappearance, which was called fibrillation of activity. Fibrillation of activity becomes noticeable when there is a low intensity of events. Because the active areas at a given moment are characterized by one type of configuration of events, the whole studied surface can be seen as a single domain. Fibrillation gives the impression of frequent changes of domain type, these changes, however, are of a different nature than the movement of domain borders found in cambium characterized by a high intensity of events.

scholarly journals Seasonal, Diel, and Age Differences in Activity Budgets of a Group of Bottlenose Dolphins (Tursiops truncatus) Under Professional Care

2017 ◽  
Vol 30 ◽  
Author(s):  
Rachel T. Walker ◽  
Lance J. Miller ◽  
Stan A. Kuczaj II ◽  
Moby Solangi
Keyword(s):  
High Intensity ◽  
Tursiops Truncatus ◽  
Management Practices ◽  
Bottlenose Dolphins ◽  
Social Play ◽  
Time Of Day ◽  
Activity Budgets ◽  
Low Intensity ◽  
Professional Care ◽  
One Year

Wild bottlenose dolphin (Tursiops truncatus) behavior is impacted by a number of factors including season, time of day, and age. However, less is known about how these factors may influence animals under professional care in zoos, aquariums and marine parks. Management practices such as scheduled feeding times, human interactions, lack of predators and show performances may also impact the activity budgets of dolphins. The current study examined the rest, swim and play behavior of seven dolphins (three adults, four calves) at one facility. Data were collected over the entire 24-hour day for a period of one year. Observed behaviors were recorded in mutually exclusive categories including rest, low intensity swim, high intensity swim, low intensity play, high intensity play and social play. Data were analyzed to determine how often dolphins engaged in particular behaviors and if activity budgets varied due to season, time of day and age. These dolphins spent the majority of their time in low intensity swim and low intensity play. The activity budget varied between observational periods. First, seasonal differences were found in low intensity swim, low intensity play, social play and high intensity play behaviors. In the comparison for time of day, differences were found in rest, low intensity swim, low intensity play and social play. Finally, no significant differences were found in age comparisons. Information gained from this study can help to better understand how different factors influence the behavior of bottlenose dolphins under professional care within zoos, aquariums and marine parks.

Abstract 17323: Personalizing Cholesterol Management Therapy Using Electronic Medical Records and Machine Learning

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Andrew T Ward ◽  
Jiang Li ◽  
Ashish Sarraju ◽  
Areli Valencia ◽  
David Scheinker ◽  
...  
Keyword(s):  
Machine Learning ◽  
Statin Therapy ◽  
High Intensity ◽  
Treatment Decisions ◽  
Moderate Intensity ◽  
Study Cohort ◽  
Low Intensity ◽  
One Year ◽  
Statin Use

Introduction: Optimal statin treatment decisions for primary prevention of atherosclerotic cardiovascular disease (ASCVD) rely on shared decision-making between patient and provider. We sought to develop a machine learning-based algorithm to personalize cholesterol treatment decisions using electronic medical record (EMR) data. Methods: We included EMR data for adults aged 40 to 79 with no prior ASCVD or statin therapy from an outpatient Northern California system between January 1, 2009 and December 31, 2018 with at least two visits at least 1 year apart and at least two low density lipoprotein cholesterol (LDL-C) values. The outcome was the LDL-C measured closest to one year after a patient’s second visit. We modeled four different treatment decisions: no statin use, low-intensity statin use, moderate-intensity statin use, and high-intensity statin use. We trained weighted-K-nearest-neighbor (wKNN) regression models to identify similar patients using each line of therapy to a candidate patient. The algorithm compared outcomes of these similar patients and recommended the treatment which predicted the lowest LDL-C after one year. Results: Our study cohort consisted of 50,911 patients (age 54.6 ± 9.84 years, baseline LDL-C 122 ± 34.2 mg/dL, follow-up LDL-C 121 ± 35.9 mg/dL) including 54% female, 47% Non-Hispanic White, 32% Asian, and 7.5% Hispanic patients. Among 8,551 test patients visiting in 2015 or later, 96.9%, 3.08%, and 0.05% were recommended to begin high-intensity, moderate-intensity, and low-intensity statins, respectively. With these recommendations, the LDL-C values at 1-year follow-up were predicted to be 21.5 ± 43.5 mg/dL (17.6%) lower per patient, on average (Figure). Conclusions: EMR-trained wKNN models are able to determine patient LDL-C trajectories under different lines of statin therapy. Machine learning models leveraging real-world datasets may provide useful statin therapy treatment recommendations for primary ASCVD prevention.

Inhibition rather than Enhancement of Hemostatic System Activation during Initiation of Oral Anticoagulant Treatment

1997 ◽  
Vol 77 (04) ◽  
pp. 685-689 ◽  
Author(s):  
Paul A Kyrle ◽  
Johannes Brockmeier ◽  
Ansgar Weltermann ◽  
Sabine Eichinger ◽  
Wolfgang Speiser ◽  
...  
Keyword(s):  
High Intensity ◽  
Oral Anticoagulant ◽  
Protein C ◽  
Venous Blood ◽  
Rapid Decline ◽  
Oral Anticoagulant Treatment ◽  
Shed Blood ◽  
Low Intensity ◽  
Hemostatic System ◽  
System Activation

SummaryCoumarin-induced skin necrosis is believed to be due to a transient hypercoagulable state resulting from a more rapid decline of the protein C activity relative to that of coagulation factors (F) II, IX and X during initiation of oral anticoagulant therapy. We studied hemostatic system activation during early oral anticoagulant treatment with a technique that investigates coagulation activation in the microcirculation.We determined in 10 healthy volunteers the concentrations of prothrombin fragment F1+2 (f1.2) and thrombin-antithrombin complex (TAT) in blood emerging from an injury of the microvasculature (bleeding time incision) before and after initiation of both high-inten- sity and low-intensity coumarin therapy. In addition, f1.2, TAT, activated F VII (F Vila) and the activities of FII, F VII, F X and protein C were measured in venous blood.A rapid decline of F VII and protein C was observed in venous blood with activities at 24 h of 7 ± 1% and 43 ± 2%, respectively, during the high-intensity regimen. A 20 to 30% reduction of f1.2 and TAT was seen in venous blood at 72 h with no major difference between the high- and the low-intensity regimen. F Vila levels were substantially affected by anticoagulation with a >90% reduction at 48 h during the high-intensity regimen. Following high-intensity coumarin, a >50% decrease in the fl.2 and TAT levels was found in shed blood at 48 h suggesting substantial inhibition of thrombin generation during early oral anticoagulation. An increase in the f1.2 and TAT levels was seen neither in shed blood nor in venous blood.Our data do not support the concept of a transient imbalance between generation and inhibition of thrombin as the underlying pathomechanism of coumarin-induced skin nekrosis.

Contralateral training effects of low-intensity blood-flow restricted and high-intensity unilateral resistance training

2021 ◽  
Author(s):  
Goncalo V. Mendonca ◽  
Carolina Vila-Chã ◽  
Carolina Teodósio ◽  
André D. Goncalves ◽  
Sandro R. Freitas ◽  
...  
Keyword(s):  
Blood Flow ◽  
Resistance Training ◽  
High Intensity ◽  
Training Effects ◽  
Low Intensity

scholarly journals Comparison of two different models of rehabilitation programs following total knee replacement operations

2020 ◽  
Vol 47 (1) ◽  
Author(s):  
Rabab S. Zaghlol ◽  
Sahar S. Khalil ◽  
Ahmed M. Attia ◽  
Ghada A. Dawa
Keyword(s):  
Total Knee Replacement ◽  
Knee Replacement ◽  
High Intensity ◽  
Rating Scale ◽  
Rehabilitation Program ◽  
Low Intensity ◽  
Rehabilitation Programs ◽  
Patient Reported ◽  
Total Knee ◽  
Functional Gain

Abstract Background Total knee replacement operation (TKR) is the treatment of choice in severe knee osteoarthritis (OA). Rehabilitation post-TKR is still not well studied. The aim of this study was to compare between the high-intensity (HI) rehabilitation program and the low-intensity (LI) rehabilitation program following TKR. Results At 1 month following the TKR operations, significant improvements were found in the first group compared to the second group in all the measured parameters except for the knee range of motion (ROM). At 3 and 12 months follow-up periods, there were statistically significant differences between both groups in all the evaluated parameters except for the numeric pain rating scale and the knee ROM. Conclusions Both high-intensity and low-intensity rehabilitation programs are effective; however, HI program had superior functional gain and patient-reported outcomes compared to the LI program. Moreover, HI group has a long-term functional gain.

Concentration of roselle (Hibiscus sabdariffa L) and sucrose in beverages: Effects on physicochemical characteristics and acceptance

2020 ◽  
pp. 108201322097379
Author(s):  
Jahir Antonio Barajas-Ramírez ◽  
Ana Luisa Gutiérrez-Salomón ◽  
Sonia Guadalupe Sáyago-Ayerdi
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
High Intensity ◽  
Physicochemical Characteristics ◽  
Hibiscus Sabdariffa ◽  
Color Parameters ◽  
Low Intensity ◽  
Red Color

The calyces of roselle ( Hibiscus sabdariffa L.) are used to make a refreshing drink with high content of anthocyanins and other phenolic compounds, although the process for obtaining the beverage is not standardized. In this research it was determined physicochemical characteristics, total soluble polyphenols content, antioxidant activity and acceptance for beverages prepared by decoction at four concentrations of calyces in water (1.0, 2.5, 5.0 and 10.0%) and two concentrations of sucrose (11 and 16%). Color parameters in beverages permitted to describe them as red, which turned darker as the content of hibiscus increased. Total soluble polyphenols content and antioxidant activity were directly correlated with content of calyces in beverages and inversely correlated with pH, which means that beverages with higher content of calyces could be perceived as more acidic and more intense in characteristics associated with hibiscus presence, such as acid, astringent and the presence of intense dark red color, although the higher concentration of sucrose might have contributed to mask slightly the sourness and astringency. Acceptance for hibiscus beverages allowed to observe two segments of consumers, high-intensity and low-intensity likers but both confluence in overall liking values for beverages prepared with 2.5% calyces and 16% sucrose.

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