Long-lasting adverse effects after short-term low-dose treatment with metoclopramide for vomiting

ABSTRACT:A Tourette-like syndrome (TLS) may occur after long-term neuroleptic treatment. A review of 11 cases reported in the literature is given. We describe the onset of a TLS in a 13-year old boy with childhood schizophrenia after short term, low-dose treatment with thioridazine. The syndrome resolved 5 months after neuroleptic withdrawal. Subsequent exposure to neuroleptics (mainly perphenazine) induced a recurrence of motor tics and involuntary vocalizations which resolved on drug discontinuation. Awareness that neuroleptics may induce a TLS may lead to prompt recognition and avoidance of labelling the manifestations as symptoms of the underlying psychosis or attention-seeking behaviour.

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Mental Health and Cognition in Older Cannabis Users: a Review

Canadian Geriatrics Journal ◽

10.5770/cgj.23.399 ◽

2020 ◽

Vol 23 (3) ◽

pp. 237-244

Author(s):

Blanca E. Vacaflor ◽

Olivier Beauchet ◽

G. Eric Jarvis ◽

Alessandra Schiavetto ◽

Soham Rej

Keyword(s):

Mental Health ◽

Older Adults ◽

Adverse Effects ◽

Low Dose ◽

Community Dwelling ◽

Cannabis Use ◽

Cognitive Effects ◽

Medical Cannabis ◽

Short Term ◽

The Impact

Background The impact of cannabis use on mental health and cognition in older adults remains unclear. With the recent legalization of cannabis in Canada, physicians will need up-to-date information about the mental and cognitive effects of cannabis use in this specific population. Method A narrative review was conducted to summarize the literature on mental health and cognitive effects of cannabis use in older adults using Medline (OvidSP). Results A total of 16 studies were identified, including nine cross-sectional studies on mental health comorbidities reported by older cannabis users. The self-reported prevalence of mental and substance use disorders is approximately two to three times higher in older adults who report past-year cannabis use, compared to older adults who report using more than one year ago or never using. The remaining seven clinical trials found that short-term, low-dose medical cannabis was generally well-tolerated in older adults without prior serious mental illness. However, mental/cognitive adverse effects were not systematically assessed. Conclusion Although preliminary findings suggests that low-dose, short-term medical cannabis does not carry significant risk of serious mental health and cognitive adverse effects in older adults without prior psychiatric history, epidemiological studies find a correlation between past-year cannabis use and poor mental health outcomes in community-dwelling older adults. These findings may indicate that longer term cannabis use in this population is detrimental to their mental health, although a direct causal link has not been established. Larger, longitudinal studies on the safety of medical cannabis in older adults are needed.

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A case report of neurological adverse events caused by short-term and low-dose treatment of mitotane

Medicine ◽

10.1097/md.0000000000022620 ◽

2020 ◽

Vol 99 (40) ◽

pp. e22620 ◽

Cited By ~ 1

Author(s):

Xin Liu ◽

Qiang Fu ◽

Yan Tang ◽

Jian-hua Deng ◽

Dan Mei ◽

...

Keyword(s):

Case Report ◽

Adverse Events ◽

Low Dose ◽

Short Term ◽

Dose Treatment

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Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.48.5.1469-1487.2004 ◽

2004 ◽

Vol 48 (5) ◽

pp. 1469-1487 ◽

Cited By ~ 97

Author(s):

Koen K. A. Van Rompay ◽

Laurie L. Brignolo ◽

Dennis J. Meyer ◽

Christopher Jerome ◽

Ross Tarara ◽

...

Keyword(s):

Adverse Effects ◽

Low Dose ◽

Biological Effects ◽

Daily Administration ◽

Time Range ◽

High Dose ◽

Short Term ◽

Therapeutic Benefits ◽

Short Period ◽

Renal Tubular Disorder

ABSTRACT The reverse transcriptase inhibitor 9-[2-(phosphonomethoxy)propyl]adenine (PMPA; tenofovir) was previously found to offer strong prophylactic and therapeutic benefits in an infant macaque model of pediatric human immunodeficiency virus (HIV) infection. We now summarize the toxicity and safety of PMPA in these studies. When a range of PMPA doses (4 to 30 mg/kg of body weight administered subcutaneously once daily) was administered to 39 infant macaques for a short period of time (range, 1 day to 12 weeks), no adverse effects on their health or growth were observed; this included a subset of 12 animals which were monitored for more than 2 years. In contrast, daily administration of a high dose of PMPA (30 mg/kg subcutaneously) for prolonged periods of time (>8 to 21 months) to 13 animals resulted in a Fanconi-like syndrome (proximal renal tubular disorder) with glucosuria, aminoaciduria, hypophosphatemia, growth restriction, bone pathology (osteomalacia), and reduced clearance of PMPA. The adverse effects were reversible or were alleviated following either complete withdrawal of PMPA treatment or reduction of the daily regimen from 30 mg/kg to 2.5 to 10 mg/kg subcutaneously. Finally, to evaluate the safety of a prolonged low-dose treatment regimen, two newborn macaques were started on a 10-mg/kg/day subcutaneous regimen; these animals are healthy and have normal bone density and growth after 5 years of daily treatment. In conclusion, our findings suggest that chronic daily administration of a high dose of PMPA results in adverse effects on kidney and bone, while short-term administration of relatively high doses and prolonged low-dose administration are safe.

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Short-Term Exposure to Low-Dose Ritonavir Impairs Clearance and Enhances Adverse Effects of Trazodone

The Journal of Clinical Pharmacology ◽

10.1177/0091270003251864 ◽

2003 ◽

Vol 43 (4) ◽

pp. 414-422 ◽

Cited By ~ 39

Author(s):

David J. Greenblatt ◽

Lisa L. von Moltke ◽

Jerold S. Harmatz ◽

Steven M. Fogelman ◽

Gengsheng Chen ◽

...

Keyword(s):

Adverse Effects ◽

Low Dose ◽

Short Term ◽

Short Term Exposure

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Short-term, low-dose ACTH therapy in West syndrome

Neuropediatrics ◽

10.1055/s-2005-868046 ◽

2005 ◽

Vol 36 (02) ◽

Author(s):

G Ramantani ◽

M Tzitiridou ◽

C Panteliadis

Keyword(s):

Low Dose ◽

West Syndrome ◽

Short Term ◽

Acth Therapy

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Absence of significant adverse effects from low-dose subcutaneous epinephrine in dermatologic procedures

Archives of Dermatology ◽

10.1001/archderm.133.10.1318 ◽

1997 ◽

Vol 133 (10) ◽

pp. 1318-1319 ◽

Cited By ~ 5

Author(s):

M. W. Berbaum

Keyword(s):

Adverse Effects ◽

Low Dose

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Tamoxifen inducible Cre systems: adverse effects of low dose tamoxifen treatments on the male reproductive tract

Reproduction Abstracts ◽

10.1530/repabs.1.p235 ◽

2014 ◽

Author(s):

Saloni H Patel ◽

Laura Milne ◽

Richard Sharpe ◽

Lee B Smith

Keyword(s):

Adverse Effects ◽

Low Dose ◽

Reproductive Tract ◽

Male Reproductive Tract

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Bioactive Peptides Sensitize Cells to Anticancer Effects of Oxaliplatin in Human Colorectal Cancer Xenografts in Nude Mice

Protein and Peptide Letters ◽

10.2174/0929866526666190405124955 ◽

2019 ◽

Vol 26 (7) ◽

pp. 512-522

Author(s):

Xian Li ◽

Long Xia ◽

Xiaohui Ouyang ◽

Qimuge Suyila ◽

Liya Su ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Nude Mice ◽

Low Dose ◽

Bioactive Peptides ◽

Human Colorectal Cancer ◽

Short Term ◽

Hct 116

Background: Despite new agent development and short-term benefits in patients with Colorectal Cancer (CRC), metastatic CRC cure rates have not improved due to high rates of oxaliplatin resistance and toxicity. There is an urgent need for effective tools to prevent and treat CRC and reduce morbidity and mortality of CRC patients. Exploring the effects of bioactive peptides on the antitumor to CRC was of vital importance to the clinical application. Objective: This study aimed to investigate the therapeutic impact of Anticancer Bioactive Peptides (ACBP) on anticancer effect of oxaliplatin (LOHP) in human colorectal cancer xenografts models in nude mice. Methods: HCT-116 cells were cultured in vitro via CCK-8 assays and the absorbance was measured at 450 nm. Apoptosis and cell cycle were assessed by Flow Cytometry (FCM) in vitro. HCT-116 human colorectal cancer cells inoculated subcutaneously in nude mice of treatment with PBS (GG), ACBP, LOHP, ACBP+LOHP (A+L) in vivo. The quality of life was assessed by dietary amount of nude mice, the weight of nude mice, inhibition rates, tumor weight and tumor volume. Immunohistochemistry and RT-qPCR method was conducted to determine the levels of apoptosisregulating proteins/genes in transplanted tumors. Results: ACBP induced substantial reductions in viable cell numbers and apoptosis of HCT116 cells in combined with LOHP in vitro. Compared with the control GG group, ACBP combined low dose oxaliplatin (U) group demonstrated significantly different tumor volume, the rate of apoptosis, the expression levels of Cyt-C, caspase-3,8,9 proteins and corresponding RNAs (P<0.05). The expression of pro-apoptotic proteins in the cytoplasm around the nucleus was significantly enhanced by ACBP. Short term intermittent use of ACBP alone indicted a certain inhibitory effect on tumor growth, and improve the quality of life of tumor bearing nude mice. Conclusion: ACBP significantly increased the anti-cancer responses of low dose oxaliplatin (L-LOHP), thus, significantly improving the quality of life of tumor-bearing nude mice.

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