scholarly journals Tourette-like Syndrome Following Low Dose Short-term Neuroleptic Treatment

1986 ◽  
Vol 13 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Samarthji Lal ◽  
Esam AlAnsari
Keyword(s):  
Low Dose ◽  
Drug Discontinuation ◽  
Neuroleptic Treatment ◽  
Short Term ◽  
Dose Treatment ◽  
Childhood Schizophrenia ◽  
Subsequent Exposure ◽  
Motor Tics ◽  
Neuroleptic Withdrawal

ABSTRACT:A Tourette-like syndrome (TLS) may occur after long-term neuroleptic treatment. A review of 11 cases reported in the literature is given. We describe the onset of a TLS in a 13-year old boy with childhood schizophrenia after short term, low-dose treatment with thioridazine. The syndrome resolved 5 months after neuroleptic withdrawal. Subsequent exposure to neuroleptics (mainly perphenazine) induced a recurrence of motor tics and involuntary vocalizations which resolved on drug discontinuation. Awareness that neuroleptics may induce a TLS may lead to prompt recognition and avoidance of labelling the manifestations as symptoms of the underlying psychosis or attention-seeking behaviour.

scholarly journals A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor

Blood ◽  
2014 ◽  
Vol 123 (15) ◽  
pp. 2308-2316 ◽  
Author(s):  
David H. McDermott ◽  
Qian Liu ◽  
Daniel Velez ◽  
Lizbeeth Lopez ◽  
Sandra Anaya-O’Brien ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Low Dose ◽  
Phase 1 ◽  
Cxcr4 Antagonist ◽  
Phase 1 Clinical Trial ◽  
Dose Treatment ◽  
Whim Syndrome ◽  
Key Points

Key Points Plerixafor can be given safely to WHIM syndrome patients twice daily for a 6-month period and appears promising as a treatment.

scholarly journals THALIDOMIDE FOR PATIENTS WITH THALASSEMIA INTERMEDIA: A RETROSPECTIVE MULTICENTER CLINICAL STUDY

2020 ◽  
Vol 12 (1) ◽  
pp. e2020021
Author(s):  
Kun Yang ◽  
Yi Wu ◽  
Yali Zhou ◽  
Tianhong Zhou ◽  
Li Wang ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Laboratory Data ◽  
Drug Discontinuation ◽  
Therapeutic Effects ◽  
Efficacy And Safety ◽  
Thalassemia Intermedia ◽  
Short Term ◽  
Long Term Follow Up

Objective: This study focused on the efficacy and safety of thalidomide for patients with thalassemia intermedia (TI) in a multicenter trial. Methods：Clinical and laboratory data of 62 patients subjected to thalidomide therapy in four centers were retrospectively analyzed. We evaluated the efficacy and safety of thalidomide in the short-term (three months) and long-term follow-up (12 and 24 months). Response to thalidomide was defined as follows: Main Responder (MaR) showing an increase in Hb level of >2.0 g/dl or removal from blood transfusion and Minor Responder (MiR) achieving elevated hemoglobin (Hb) level of 1.0-2.0 g/dl or ≥50% reduction in blood transfusion frequency. Results：The overall response rate (ORR) of 62 patients with TI was 93.5% (58/62), with MaR and MiR rates accounting for 62.9% (39/62) and 30.6% (19/62) in short-term follow-up and 66.1% (41/62) and 27.4% (17/62) in long-term follow-up, respectively. The clinical response during long-term follow-up was maintained and the Hb level remained stable during the observation period. The response was still observed in patients with dose reduction despite a slight decrease in Hb level. However, Hb decreased rapidly to the baseline level after drug discontinuation. No effect of thalidomide on spleen size in nonsplenectomized patients was evident. Minimal side-effects were documented throughout, except peripheral neurotoxicity in one patient. Nevertheless, the mean serum ferritin (SF) level was significantly increased after treatment. Conclusion: Thalidomide had significant therapeutic effects on patients with TI, and the response was sustained with acceptable short-term and long-term adverse reactions. While these preliminary results support the potential long-term efficacy and safety of thalidomide as a therapeutic agent for TI, several issues need to be addressed before its application in the clinic.

Long-Term Low-Dose Treatment With Reserpine of Cholesterol-Fed Rabbits Reduces Cholesterol in Plasma, Non-High Density Lipoproteins and Arterial Walls

2002 ◽  
Vol 40 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Shahida Shafi ◽  
Irina P. Stepanova ◽  
Colin Fitzsimmons ◽  
David E. Bowyer ◽  
Gustav V. R. Born
Keyword(s):  
Low Dose ◽  
High Density ◽  
High Density Lipoproteins ◽  
Dose Treatment ◽  
Arterial Walls

Contrasting seed germination responses to red and far-red light in Leptospermum scoparium and Melicytus ramiflorus

2000 ◽  
Vol 27 (11) ◽  
pp. 1069
Author(s):  
Helen Herron ◽  
John Clemens ◽  
Dennis H. Greer
Keyword(s):  
Seed Germination ◽  
Red Light ◽  
Green Light ◽  
Photon Flux ◽  
Short Term ◽  
Short Term Exposure ◽  
Subsequent Exposure ◽  
R:Fr Ratio ◽  
Leptospermum Scoparium

Effects of red light (R) and far-red light (FR), and selected photon flux densities (PFD) of photosynthetically active radiation (PAR) on seed germination in the photoblastic, primary colonising species Leptospermum scoparium J. R. et G. Forst. and the late secondary successional Melicytus ramiflorus J. R. et G. Forst. were studied. A continuous R dose response curve forL. scoparium germination was developed, unifying data from experiments using long-term exposure to PAR with those following short-term exposure to R. The threshold R dose needed to effect germination was ~0.1 mmol m –2 , and the response was saturated at 1000 mmol m –2 . Stimulation of germination by R was reversed by a subsequent exposure to FR. These features are consistent with a low-fluence response mediated by phytochrome B. FR reversal of germination was achieved at a dose two orders of magnitude lower than that of R required to induce initial germination. However, when both R and FR were provided simultaneously, the FR dose needed to even partially inhibit germination (34% compared to > 95% in controls) was two orders of magnitude higher than the R dose (R:FR ratio = 0.007). Germination in L. scoparium was also stimulated in up to 12% of seed upon diurnal exposure to FR, or by green light (~2 mol m –2 ), indicating a very-low-fluence response mediated by phytochrome A also operating in this species. In contrast, seed germination in M. ramiflorus was relatively unresponsive to R, and secondary dormancy was induced by high PFD (515 mol m –2 s –1 ).

Effect of short-term, low-dose treatment with tamoxifen in patients with primary dysmenorrhea

2006 ◽  
Vol 22 (12) ◽  
pp. 698-703 ◽  
Author(s):  
Piotr Pierzyński ◽  
Jolanta Świątecka ◽  
Edward Oczeretko ◽  
Piotr Laudański ◽  
Satish Batra ◽  
...  
Keyword(s):  
Low Dose ◽  
Primary Dysmenorrhea ◽  
Short Term ◽  
Dose Treatment

scholarly journals Long-term low-dose antibiotics in recalcitrant chronic rhinosinusitis: a retrospective analysis

2012 ◽  
Vol 50 (1) ◽  
pp. 45-55
Author(s):  
W.J.M. Videler ◽  
K. van Hee ◽  
S.M. Reinartz ◽  
C. Georgalas ◽  
F.W. van der Meulen ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Outpatient Clinic ◽  
Low Dose ◽  
Group Discussion ◽  
Sinus Surgery ◽  
Dose Treatment ◽  
Intranasal Corticosteroids ◽  
Significant Difference ◽  
Sinonasal Mucosa

Introduction: In recalcitrant Chronic RhinoSinusitis (CRS) treatment with intranasal corticosteroids, short-term antibiotics and even sinus surgery is frequently insufficient. Long-term low-dose administration of antibiotics has been suggested as a treatment option in these patients. We analysed the outpatient clinic population treated with different long-term low-dose antibiotics at the AMC Amsterdam. Patients and methods: Eligible patients, who were treated with trimethoprim-sulfamethoxazole or macrolides, were retrospectively identified from our outpatient clinic in 2009. The two main outcome measures were sinonasal complaints and nasal endoscopic findings. A 5-point grading scale was used to score the results compared with the pre-treatment situation. This was measured at several time-points during, and after the antibiotic course, and at the end of the follow-up term. Results: Seventy-six patients were included, 53 per cent had asthma and all of them had undergone sinus surgery. Seventy-eight per cent showed improvement of the symptoms, and 84 per cent demonstrated improvement of the sinonasal mucosa at the end of the course. No significant difference was found between the trimethoprim-sulfamethoxazole and macrolide group. Discussion: Long-term low-dose treatment with antibiotics seems to improve CRS symptoms and the appearance of the sinonasal mucosa on nasal endoscopy. However, at this stage, strong conclusions are immature because no placebo-group has been included. Despite increasing use of long-term low-dose treatment of recalcitrant CRS in referral centres, hard clinical evidence is lacking. More research is urgently required.

Long-Term and Low-Dose Treatment with Cabergoline Induces Macroprolactinoma Shrinkage

1998 ◽  
Vol 53 (5) ◽  
pp. 287-289
Author(s):  
Annamaria Colao ◽  
Antonella Di Sarno ◽  
Maria Luisa Landi ◽  
Sossio Cirillo ◽  
Francesca Sarnacchiaro ◽  
...  
Keyword(s):  
Low Dose ◽  
Dose Treatment
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