scholarly journals Paper mill-derived cancer research: the improbability of prostate cancer in women, and ovarian and breast cancer in men

2021 ◽  
Vol 71 (4) ◽  
pp. 255-256
Author(s):  
Jaime A. Teixeira da Silva
Endocrinology ◽  
2021 ◽  
Author(s):  
Nicole M Hwang ◽  
Laura P Stabile

Abstract Estrogen receptors (ERs) are known to play an important role in the proper development of estrogen-sensitive organs, as well as in the development and progression of various types of cancer. ERα, the first ER to be discovered, has been the focus of most cancer research, especially in the context of breast cancer. However, ERβ expression also plays a significant role in cancer pathophysiology, notably its seemingly protective nature and loss of expression with oncogenesis and progression. While ERβ exhibits anti-tumor activity in breast, ovarian, and prostate cancer, its expression is associated with disease progression and worse prognosis in lung cancer. The function of ERβ is complicated by the presence of multiple isoforms and single nucleotide polymorphisms, in addition to tissue-specific functions. This mini-review explores current literature on ERβ and its mechanism of action and clinical implications in breast, ovarian, prostate, and lung cancer.


2003 ◽  
pp. 240-244
Author(s):  
PIERRE I. KARAKIEWICZ ◽  
WILLIAM FOULKES ◽  
SIMON TANGUAY ◽  
MOSTAFA M. ELHILALI ◽  
ARMEN G. APRIKIAN

2017 ◽  
Vol 3 (2) ◽  
pp. 1-7
Author(s):  
Peter Chou ◽  
Kevin Hong ◽  
Chandler Lei ◽  
Haolin Zhang

Aside from the infrequent news pertaining to medical breakthroughs or dangers to the public, medical research, especially in the field of cancer, is rarely discussed in depth. The public does not know the process in which specific fields of medical research receive funding, or how this funding is used to limit issues such as cancer. This study aims to provide clarity on cancer research trends. The amount of research papers pertaining to different types of cancers is compared against mortality and diagnosis rates to determine the amount of research attention given to a type of cancer, in relation to its effects on the general population. Computational tools, such as Python, R, and Microsoft Excel, were used to analyze a dataset of research papers. Python was used to parse through JSON files and extract the abstract and Altmetric score of cancer research papers. R was used to count the appearance of each type of cancer in the abstracts, and create histograms describing Altmetric scores and file frequency. Microsoft Excel was used to find correlations between Altmetrics’ data and Canadian Cancer Society data, linking the amount of research to the impacts of cancer based on deaths and new cases. The analysis from these tools revealed that breast cancer was the most researched cancer by a large margin, with nearly 1,700 papers, which is approximately four times the amount of the next leading type of cancer – prostate cancer. Although there were many research papers on the field of cancer, the Altmetric scores revealed that most of these papers did not gain significant online and media attention. Comparing these results to Canadian Cancer Society data showed that breast cancer was receiving more research attention than the mortality and diagnosis rates suggest it should. There were four times more breast cancer research papers than the secondmost researched cancer, prostate cancer. This was despite the fact that breast cancer was fourth in mortality and third in new cases among all types of cancer. Inversely, lung cancer was underrepresented, with only 401 research papers, despite being the deadliest cancer in Canada.


2003 ◽  
Vol 169 (1) ◽  
pp. 240-244 ◽  
Author(s):  
PIERRE I. KARAKIEWICZ ◽  
WILLIAM FOULKES ◽  
SIMON TANGUAY ◽  
MOSTAFA M. ELHILALI ◽  
ARMEN G. APRIKIAN

Sign in / Sign up

Export Citation Format

Share Document