Rare Association of Rheumatoid Arthritis and Kartagener's Syndrome: A Common Denominator?

1980 ◽  
Vol 2 (7) ◽  
pp. 400-400 ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Common Denominator ◽  
Rare Association ◽  
Kartagener's Syndrome

scholarly journals The Complex Relationship of Periodontal Disease and Rheumatoid Arthritis

2021 ◽  
Author(s):  
Maria-Alexandra Martu ◽  
Elena Rezus ◽  
Diana Tatarciuc ◽  
Ionut Luchian ◽  
Irina-Georgeta Sufaru ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Periodontal Disease ◽  
Bone Destruction ◽  
Lifestyle Changes ◽  
Common Denominator ◽  
Inflammatory Reactions ◽  
Multifactorial Diseases ◽  
Reactive Protein ◽  
Relationship Of

The relationship between periodontitis and systemic diseases is an important part of clinical periodontal research, which has been growing steadily. Even though the etiologies of periodontal disease and rheumatoid arthritis (RA) differ, these pathologies have many common features, both being multifactorial diseases characterized by localized chronic inflammatory reactions, which are fuelled by an analogous set of cytokines (among many, the most prominent being Tumour Necrosis Factor (TNF), Interleukin (IL) 6 and 17), leading to high systemic circulating concentrations of inflammatory markers such as C-reactive protein (CRP). It was not until the discovery of peptidylarginine deiminase (PAD) mediated citrullination of proteins by Porphyromonas gingivalis that the link between the two diseases was purely speculative. This citrullination initiates a series of events which culminate in the production of anti-citrullinated protein antibodies (ACPA) and, finally, in the clinical manifestation of rheumatoid arthritis. Another common denominator is the bone destruction caused by proinflammatory cytokines secreted by T 17 helper cells (TH17) which is the pathological hallmark of both diseases. Other notable common areas are shared risk factors such as environmental and genetic risk factors. Regarding treatment, neither pathologies have a definitive cure, however, several strategies are employed, some of which are common, such as diet and lifestyle changes, and immunomodulating medication applied locally or systemically.

scholarly journals Rheumatoid Arthritis and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis): A Rare Association

2020 ◽  
Vol 31 (2) ◽  
pp. 114-119
Author(s):  
Wafia Najifa ◽  
Mohiuddin Sharif ◽  
Rajib Roy ◽  
Mahfuzul Haque ◽  
Md Robed Amin
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Wegener's Granulomatosis ◽  
Overlap Syndrome ◽  
Wegener Granulomatosis ◽  
Overlap Syndromes ◽  
Rare Association

The presentation of Rheumatoid arthritis (RA) combined with a second rheumatological disorder thatis, different RA overlap syndromes are frequently encountered in clinical practice. But RA-vasculitisoverlaps are relatively rare. This paper presents a case of Rheumatoid arthritis and Granulomatosiswith polyangiitis (Wegener granulomatosis) overlap syndrome which is first of its kind reported from Bangladesh. Bangladesh J Medicine July 2020; 31(2) : 114-119

scholarly journals Rheumatoid Arthritis, Kartagener’s Syndrome, and Hyperprolactinemia: Who Started It?

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Hussein Halabi ◽  
Israa Mulla
Keyword(s):  
Rheumatoid Arthritis ◽  
Dopamine Agonists ◽  
Respiratory Infections ◽  
Case Reports ◽  
Experimental Treatment ◽  
Chronic Stimulation ◽  
Recurrent Respiratory Infections ◽  
Kartagener's Syndrome ◽  
History Of ◽  
Stimulation Of

We report a case of an 18-year-old girl who presented to our hospital with history of recurrent respiratory infections, amenorrhea, and symmetric polyarthritis. She was diagnosed with rheumatoid arthritis (RA), Kartagener’s syndrome (KS), and hyperprolactinemia. There have been very few case reports in the literature of RA occurring in the setting of KS, theoretically proposed to be due to chronic stimulation of the immune system by recurrent infections. Furthermore, hyperprolactinemia has been hypothesized to mirror RA disease activity and case reports of treatment with dopamine agonists have led to the speculation of whether or not they represent a new line of experimental treatment in the future. Our patient was found to have both KS and hyperprolactinemia together in the setting of RA, and based on our literature search, this is the first reported case of such a combination. This strikes a very intriguing question: are these three conditions interlinked by a yet to be defined association? And treatment of which condition leads to the resolution of the other?

Coombs negative hemolytic anemia with Rheumatoid arthritis - a rare association

2015 ◽  
Vol 20 (11) ◽  
pp. 1788-1790
Author(s):  
Pooja Dhaon ◽  
Durgesh Srivastava ◽  
Siddharth Das ◽  
Urmila Dhakad ◽  
Saumya Ranjan Tripathy
Keyword(s):  
Rheumatoid Arthritis ◽  
Hemolytic Anemia ◽  
Rare Association

Talonavicular Dislocation—What Lies Beneath?

2018 ◽  
Vol 108 (5) ◽  
pp. 397-404
Author(s):  
Ioannis Konstantinidis ◽  
Panagiotis D. Symeonidis ◽  
Dimitrios Polyzos ◽  
Petros Antonarakos ◽  
Panagiotis Givissis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Medical Condition ◽  
Operative Management ◽  
Final Outcome ◽  
Common Denominator ◽  
General Medical Condition ◽  
Suitable Treatment ◽  
Rare Site ◽  
Talonavicular Dislocation ◽  
The Relationship

Background: The talonavicular joint is a rare site of dislocation. Its etiology varies and can be the result of either acute trauma or a chronic degenerative process that most commonly occurs in patients with rheumatoid arthritis or Charcot arthropathy. Our aim is to highlight the relationship between the underlying pathology of talonavicular dislocations and the final outcome in the case of operative management. Methods: We present three cases of talonavicular dislocation with the dislocation itself as the only common denominator, and a completely different etiology, natural history, treatment, and prognosis among them. Results: There was one case of a traumatic talocalcaneonavicular dislocation in a healthy individual, one case in a rheumatoid arthritis patient, and one case in a patient with diabetes mellitus. All patients were treated surgically. The outcomes were excellent, fair, and poor, respectively. Conclusions: Among many factors that influence prognosis, it is equally critical to evaluate the overall background in which the dislocation occurs so as to apply the suitable treatment. The surgeon not only needs to treat the local incident but also appreciate the general medical condition to provide the best final outcome to the patient.

Bucillamine-induced nephropathy in a child with juvenile rheumatoid arthritis and Kartagener's syndrome

2000 ◽  
Vol 42 (3) ◽  
pp. 316-318 ◽  
Author(s):  
Yukihiko Kawasaki ◽  
Junzo Suzuki ◽  
Tatsuhiko Sike ◽  
Masato Isome ◽  
Ruriko Nozawa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Kartagener's Syndrome

scholarly journals PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Aikaterini Arida ◽  
Aigli-Ioanna Legaki ◽  
Evrydiki Kravvariti ◽  
Athanasios Protogerou ◽  
Petros P. Sfikakis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Screening Tool ◽  
Ldl Receptor ◽  
Common Denominator ◽  
Age And Gender ◽  
High Importance ◽  
Ultrasound Measurements ◽  
And Gender ◽  
Circulating Levels

Background/Aims: Rheumatoid arthritis (RA) is associated with the emergence of cardiovascular disease, while chronic inflammation is considered a common denominator for their parallel progression. The Proprotein convertase subtilisin/kexin type 9 (PCSK9)/LDL-Receptor (LDLR) system is of high importance during atherogenesis, via regulating the clearance of LDL from the circulation; nevertheless the role of this molecular mechanism during RA-related atheromatosis is not known.Methods: Herein, high-resolution ultrasound measurements for arterial hypertrophy, atheromatosis and arterial stiffness as well as comprehensive biochemical profiling were performed in 85 RA patients. The circulating levels of PCSK9 and LDLR were measured and their potential associations as well as of the PCSK9/LDLR ratio with patients' characteristics and the degree of atherosclerosis were investigated.Results: Increased LDLR levels and decreased PCSK9/LDLR ratio were found in RA patients with at least 2 atheromatic plaques as compared to the ones without any plaques. In addition the levels of both PCSK9 and LDLR were positively correlated with the presence of atheromatic plaques as an age- and gender- adjusted multivariate analysis revealed.Conclusions: Our data imply that the PCSK9/LDLR system plays a significant role during RA-related atherosclerosis and may therefore be used as a screening tool for disease progression in the future.

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