scholarly journals Endotoxin Tolerance as a Key Mechanism for Immunosuppression

10.5772/27368 ◽  
2012 ◽  
Author(s):  
Subhra K. ◽  
Irina N.
Keyword(s):  
Endotoxin Tolerance

Development of endotoxin tolerance in humans in vivo

2009 ◽  
Vol 37 (4) ◽  
pp. 1261-1267 ◽  
Author(s):  
Annelies Draisma ◽  
Peter Pickkers ◽  
Martijn P.W.J.M. Bouw ◽  
Johannes G. van der Hoeven
Keyword(s):  
Endotoxin Tolerance

Adiponectin Mediates Endotoxin Tolerance in Lung.

2009 ◽  
Author(s):  
J Konter ◽  
D Dwyer ◽  
S Natarajan ◽  
D Remick ◽  
A Fine ◽  
...  
Keyword(s):  
Endotoxin Tolerance

scholarly journals Reduced Ex Vivo Interleukin-8 Production by Neutrophils in Septic and Nonseptic Systemic Inflammatory Response Syndrome

Blood ◽  
1998 ◽  
Vol 91 (9) ◽  
pp. 3439-3446 ◽  
Author(s):  
Christelle Marie ◽  
Jane Muret ◽  
Catherine Fitting ◽  
Marie-Reine Losser ◽  
Didier Payen ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Ex Vivo ◽  
Endotoxin Tolerance ◽  
Systemic Inflammatory Response ◽  
Interleukin 8 ◽  
Polymorphonuclear Cells ◽  
Healthy Controls ◽  
Relative Contribution

AbstractEx vivo cytokine production by circulating lymphocytes and monocytes is reduced in patients with infectious or noninfectious systemic inflammatory response syndrome. Very few studies have addressed the reactivity of polymorphonuclear cells (PMN). To analyze further the relative contribution of systemic inflammatory response syndrome alone or in combination with infection we studied the interleukin-8 (IL-8) production by PMN isolated from patients who had undergone cardiac surgery with cardiopulmonary bypass (CPB) and patients with sepsis. Cells were activated with either lipopolysaccharide (LPS) or heat-killed streptococci. Compared with healthy controls, the release of IL-8 by PMN in both groups of patients was significantly reduced whether activated by LPS, independently of its concentration and origin, or by heat-killed streptococci. These observations suggest that stressful conditions related to inflammation, independently of infection, rapidly dampened the reactivity of circulating PMN. We investigated whether the observed diminished reactivity of PMN might reflect an endotoxin tolerance phenomenon. Our in vitro experiments with PMN from healthy controls indicated that PMN could not be rendered tolerant stricto sensu. However, our data suggested that LPS-induced mediators such as IL-10 may be responsible for the observed anergy in patients.

scholarly journals Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Ester C. S. Rios ◽  
Francisco G. Soriano ◽  
Gabor Olah ◽  
Domokos Gerö ◽  
Bartosz Szczesny ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Chromatin Remodeling ◽  
Inflammatory Mediator ◽  
Endotoxin Tolerance ◽  
Inflammatory Mediator Production

scholarly journals Mitochondrial DAMPs Induce Endotoxin Tolerance in Human Monocytes: An Observation in Patients with Myocardial Infarction

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e95073 ◽  
Author(s):  
Irene Fernández-Ruiz ◽  
Francisco Arnalich ◽  
Carolina Cubillos-Zapata ◽  
Enrique Hernández-Jiménez ◽  
Raúl Moreno-González ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Endotoxin Tolerance ◽  
Human Monocytes

scholarly journals Pulmonary Endotoxin Tolerance Protects against Cockroach Allergen-Induced Asthma-Like Inflammation in a Mouse Model

2012 ◽  
Vol 158 (2) ◽  
pp. 120-130 ◽  
Author(s):  
Sudha Natarajan ◽  
Jiyoun Kim ◽  
Jacqueline Bouchard ◽  
William Cruikshank ◽  
Daniel G. Remick
Keyword(s):  
Mouse Model ◽  
Endotoxin Tolerance ◽  
Cockroach Allergen

A sublethal dose of LPS to pregnant rats induces TNF-alpha tolerance in their 0-day-old offspring

1997 ◽  
Vol 273 (3) ◽  
pp. R1158-R1162
Author(s):  
M. Goto ◽  
T. Yoshioka ◽  
R. I. Young ◽  
T. Battelino ◽  
C. L. Anderson ◽  
...  
Keyword(s):  
Small Dose ◽  
Salmonella Enteritidis ◽  
Endotoxic Shock ◽  
Endotoxin Tolerance ◽  
Sublethal Dose ◽  
Tnf Alpha ◽  
Newborn Rats ◽  
Pregnant Rats ◽  
Necrosis Factor Alpha ◽  
Factor Alpha

The newborn has high mortality in septic shock. Induction of endotoxin tolerance may prevent endotoxic shock in the newborn. The present study showed that a small dose of Salmonella enteritidis lipopolysaccharide (S. ent. LPS), Rc mutant Escherichia coli lipopolysaccharide (J5 LPS), or tumor necrosis factor-alpha (TNF-alpha) given to pregnant rats on the 19th day of gestation induced endotoxin tolerance in their 0-day-old offspring. S. ent. LPS or J5 LPS injected into pregnant rats increased plasma endotoxin-like activity in dams, although not in their fetuses, and increased plasma TNF-alpha concentration in both dams and their fetuses. The endotoxin-tolerant newborn rats were also resistant to TNF-alpha. In those newborn rats, an LPS injection increased plasma TNF-alpha concentration and liver TNF-alpha mRNA abundance. These experiments showed that the endotoxin tolerance could be due to TNF-alpha tolerance. In conclusion, prenatal treatment of dams with a small dose of S. ent. LPS, J5 LPS, or TNF-alpha was beneficial in preventing endotoxic shock in the newborn.

Tumor necrosis factor unresponsiveness after surgery in bile duct-ligated rats

1996 ◽  
Vol 271 (6) ◽  
pp. G980-G986 ◽  
Author(s):  
A. P. Houdijk ◽  
M. A. Boermeester ◽  
R. I. Wesdorp ◽  
C. E. Hack ◽  
P. A. Van Leeuwen
Keyword(s):  
Bile Duct ◽  
Tumor Necrosis Factor ◽  
Obstructive Jaundice ◽  
Tumor Necrosis ◽  
Cytokine Production ◽  
Endotoxin Tolerance ◽  
Rat Plasma ◽  
Continuous Presence ◽  
Whole Blood Cell Cultures ◽  
Necrosis Factor

In obstructive jaundice, postoperative complications are related to gut-derived endotoxemia and possibly mediated by cytokines such as tumor necrosis factor (TNF) and interleukin-6 (IL-6). This study investigated the course of IL-6 and TNF after surgery in bile duct-ligated rats (BDL) treated with and without an enteral endotoxin binder (cholestyramine). Endotoxin in rat plasma was determined by blocking cytokine production in whole blood cell cultures stimulated by rat plasma using antibodies directed against the endotoxin (CD14) receptor. Surgery elicited a significant IL-6 response in saline-treated BDL rats (BDL-SAL). TNF, however, remained at its low preoperative levels. Cholestyramine treatment resulted in undetectable preoperative TNF and IL-6 levels, but levels of both cytokines were significantly raised after surgery. Endotoxin, as determined by the CD14 blockade test, was identified in the BDL-SAL group, before (time 0) and after surgery (2 and 4 h), whereas in the cholestyramine group endotoxin was only present at 2 h after surgery. The lack of a postoperative plasma TNF response in the BDL-SAL group in the continuous presence of endotoxin suggests endotoxin tolerance for TNF production in obstructive jaundice.

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