scholarly journals Gene Delivery Systems

10.5772/56869 ◽  
2013 ◽  
Author(s):  
Andrea Pereyra ◽  
Claudia Hereu
Keyword(s):  
Gene Delivery ◽  
Delivery Systems

Gene-Delivery Systems Using Cationic Polymers

1999 ◽  
Vol 16 (2) ◽  
pp. 61 ◽  
Author(s):  
Martin C. Garnett
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Cationic Polymers

Star Shaped Poly(ethylene glycols) Yield Biocompatible Gene Delivery Systems

2015 ◽  
Vol 2 (4) ◽  
pp. 182-195 ◽  
Author(s):  
Jayanant Iemsam-Arng ◽  
Xiao Kong ◽  
Andreas G. Schatzlein ◽  
Ijeoma F. Uchegbu
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Ethylene Glycols ◽  
Poly Ethylene

scholarly journals Highly Osmotic Oxidized Sucrose-Crosslinked Polyethylenimine for Gene Delivery Systems

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 87
Author(s):  
Jaehong Park ◽  
Kyusik Kim ◽  
Sohee Jeong ◽  
Migyeom Lee ◽  
Tae-il Kim
Keyword(s):  
Gene Delivery ◽  
Reductive Amination ◽  
Transfection Efficiency ◽  
Delivery Systems ◽  
Buffering Capacity ◽  
Serum Stability ◽  
High Osmolality ◽  
Cox 2 ◽  
Serum Free Conditions ◽  
Positively Charged

In this work, highly osmotic oxidized sucrose-crosslinked polyethylenimine (SP2K) polymers were developed for gene delivery systems, and the transfection mechanism is examined. First, periodate-oxidized sucrose and polyethylenimine 2K (PEI2K) were crosslinked with various feed ratios via reductive amination. The synthesis was confirmed by 1H NMR and FTIR. The synthesized SP2K polymers could form positively charged (~40 mV zeta-potential) and nano-sized (150–200 nm) spherical polyplexes with plasmid DNA (pDNA). They showed lower cytotoxicity than PEI25K but concentration-dependent cytotoxicity. Among them, SP2K7 and SP2K10 showed higher transfection efficiency than PEI25K in both serum and serum-free conditions, revealing the good serum stability. It was found that SP2K polymers possessed high osmolality and endosome buffering capacity. The transfection experiments with cellular uptake inhibitors suggest that the transfection of SP2K polymers would progress by multiple pathways, including caveolae-mediated endocytosis. It was also thought that caveolae-mediated endocytosis of SP2K polyplexes would be facilitated through cyclooxygenase-2 (COX-2) expression induced by high osmotic pressure of SP2K polymers. Confocal microscopy results also supported that SP2K polyplexes would be internalized into cells via multiple pathways and escape endosomes efficiently via high osmolality and endosome buffering capacity. These results demonstrate the potential of SP2K polymers for gene delivery systems.

scholarly journals Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 940
Author(s):  
Chaojie Zhu ◽  
Zhiheng Ji ◽  
Junkai Ma ◽  
Zhijie Ding ◽  
Jie Shen ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Treatment ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Cancer Treatments ◽  
Recent Advances ◽  
Therapeutic Mechanisms ◽  
Bacterial Therapy ◽  
Targeting Ability ◽  
Drug And Gene Delivery

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

2021 ◽  
Vol 32 (5) ◽  
pp. 1924-1950
Author(s):  
Amir Ghaderpour ◽  
Zohreh Hoseinkhani ◽  
Reza Yarani ◽  
Sina Mohammadiani ◽  
Farshid Amiri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Delivery ◽  
Delivery Systems

Effect of Polymer Ionization on the Interaction with DNA in Nonviral Gene Delivery Systems

2003 ◽  
Vol 4 (3) ◽  
pp. 683-690 ◽  
Author(s):  
Uracha Rungsardthong ◽  
Touraj Ehtezazi ◽  
Lindsey Bailey ◽  
Steven P. Armes ◽  
Martin C. Garnett ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Nonviral Gene Delivery

scholarly journals Novel non-viral gene delivery systems composed of carbosilane dendron functionalized nanoparticles prepared from nano-emulsions as non-viral carriers for antisense oligonucleotides

2015 ◽  
Vol 478 (1) ◽  
pp. 113-123 ◽  
Author(s):  
Cristina Fornaguera ◽  
Santiago Grijalvo ◽  
Marta Galán ◽  
Elena Fuentes-Paniagua ◽  
Francisco Javier de la Mata ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Antisense Oligonucleotides ◽  
Delivery Systems ◽  
Viral Gene ◽  
Functionalized Nanoparticles ◽  
Viral Gene Delivery

Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease

Biomaterials ◽  
2021 ◽  
pp. 121360
Author(s):  
Pengzhen Wang ◽  
Peng Yang ◽  
Kang Qian ◽  
Yixian Li ◽  
Shuting Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Delivery ◽  
Delivery Systems

Non-electrostatic complexes with DNA: towards novel synthetic gene delivery systems

2000 ◽  
Vol 10 (9) ◽  
pp. 911-914 ◽  
Author(s):  
Javier Soto ◽  
Michel Bessodes ◽  
Bruno Pitard ◽  
Philippe Mailhe ◽  
Daniel Scherman ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Synthetic Gene
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