scholarly journals Perspective Chapter: Recent Advances in Musculo-Skeletal Ultrasound

2021 ◽  
Author(s):  
Felix Okechukwu Erondu
Keyword(s):  
Peripheral Nerve ◽  
Diagnostic Tool ◽  
Diagnostic Yield ◽  
Musculoskeletal Ultrasound ◽  
Therapeutic Interventions ◽  
Ultrasound Images ◽  
Doppler Techniques ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Medical imaging specialists continue to explore better ways of demonstrating pathology and anatomy of the musculo-skeletal system. The continuous quest is fuelled by the desire to improve diagnostic yield, perform procedures more quickly and accurately, reduce risks to patient or operator, achieve better cost efficiency and utilize less complex methodologies. In many instances, musculoskeletal ultrasound acts as a screening, diagnostic tool but also guide and monitor therapeutic interventions. The paper outlines the use of ultrasound in the imaging of peripheral nerve disorders, traumatic and atraumatic joint disorders, Doppler techniques such as super micro vascular Imaging and sono-elastography. Refinements in probe technology and application of digital and novel proprietary software, have continued to improve the resolution of ultrasound images and with finer details on a scale not previously possible. With increasing experience and standardization of protocols, Musculoskeletal ultrasound will continue to play a great role in the diagnostic work-up and treatment of related disorders.

scholarly journals A meningitis carcinomatosa komplex megjelenése

2021 ◽  
Vol 162 (43) ◽  
pp. 1744-1748
Author(s):  
Boglárka Orbán-Szigeti ◽  
Anikó Papp ◽  
Anita Kamondi ◽  
György Tibor Szekeres
Keyword(s):  
Interdisciplinary Cooperation ◽  
Therapeutic Interventions ◽  
Somatization Disorder ◽  
Carcinomatous Meningitis ◽  
Past Medical History ◽  
Internal Conflicts ◽  
Diagnostic Work ◽  
Personality Features ◽  
Work Up ◽  
Diagnostic Work Up

Összefoglaló. Az emlőtumor miatt kezelt, majd gondozott beteget – több tünetmentes év után – fejfájás, szédülés, ataxia, megváltozott, furcsa viselkedés, emlékezetzavar és dezorientáció miatt neurológiai, majd belgyógyászati osztályokon vizsgálták. Az alapos kivizsgálás ellenére a tüneteit magyarázó organikus eltérést nem igazoltak, ugyanakkor már a kezdetektől felmerült a szomatizációs tünetképzés lehetősége, ezért pszichiátriai osztályos felvételére került sor. Az elvégzett vizsgálatok, illetve a klinikai kép regresszív állapotot valószínűsítettek. Terápiás próbálkozásaink ellenére a páciens állapota romlott, végül a megismételt neurológiai vizsgálatok meningitis carcinomatosát igazoltak. Az esettel szemléltetni kívánjuk, hogy a beteg premorbid működési nívója, személyiségstruktúrája hogyan képes befolyásolni az ellátószemélyzetet, milyen külső és belső konfliktusokat válthat ki. A diagnózishoz vezető folyamat bemutatásával fel kívánjuk hívni a figyelmet az interdiszciplináris együttműködés fontosságára. Orv Hetil. 2021; 162(43): 1744–1748. Summary. Our patient with known breast cancer in her past medical history was hospitalized – after several asymptomatic years – for headache, dizziness, ataxia, changed behaviour and disorientation. Thorough internal and neurologic investigations did not find any disease underlying her symptoms, therefore the possibility of somatization disorder was raised. Despite lege artis therapeutic interventions carried out on the psychiatry ward, the patient’s condition deteriorated and repeated neurological examinations eventually revealed carcinomatous meningitis. With this case, we would like to illustrate how the patient’s premorbid function level and personality features might influence the attitude and opinion of the health care personnel, and what kind of external and internal conflicts might be triggered. By presenting the complexity of the diagnostic work-up, we would like to emphasize the importance of interdisciplinary cooperation in the interest of our patients. Orv Hetil. 2021; 162(43): 1744–1748.

scholarly journals Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis

2019 ◽  
Vol 5 (4) ◽  
pp. 00203-2019 ◽  
Author(s):  
Maria Jacob ◽  
Hélder Novais Bastos ◽  
Patrícia Caetano Mota ◽  
Natália Melo ◽  
Rui Cunha ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Diagnostic Yield ◽  
Tertiary Hospital ◽  
Definitive Diagnosis ◽  
Diagnostic Tools ◽  
Histological Features ◽  
Transbronchial Lung Cryobiopsy ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

IntroductionTransbronchial lung cryobiopsy (TBLC) is an endoscopic technique proven to be useful in diagnostic approach to interstitial lung disease (ILD), but its role in sarcoidosis is not fully established. The aim of the present study was to assess the diagnostic yield of TBLC in sarcoidosis and its safety profile.MethodsRetrospective analysis of patients, evaluated in a tertiary hospital ILD outpatient clinic, who underwent TBLC in the diagnostic work-up. TBLC was performed in accordance with the 2018 expert statement from the Cryobiopsy Working Group.Results32 patients were included (mean±sd age 47.7±12.6 years, 59.4% male) and divided into three groups: highly likely sarcoidosis (n=21), possible sarcoidosis (n=6) and unlikely sarcoidosis (n=5). A mean of 2.8±0.8 TBLCs were performed. The definitive diagnosis was established by TBLC in 20 out of 27 patients with suspected sarcoidosis. Two patients were diagnosed with sarcoidosis by other methods performed afterwards. TBLC leaded to other diagnosis as well, such as fungal infection (n=1), hypersensitivity pneumonitis (n=1) and silicosis (n=3), making the diagnostic yield for suspected sarcoidosis of TBLC of 92.6%. TBLC was also able to show compatible histological features in five patients whom sarcoidosis was not previously considered. The complications reported overall were pneumothorax in five (15.6%) patients and moderate bleeding in one (3.1%) case.ConclusionIn this cohort, TBLC was a safe, reliable and useful procedure in sarcoidosis diagnosis. These results suggest that TBLC can be used successfully in those cases where a definitive diagnosis could not be reached with the usual and less-invasive diagnostic tools.

Small bowel neuroendocrine tumors: A critical analysis of diagnostic work-up and operative approach.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 203-203
Author(s):  
Cecilia Grace Ethun ◽  
Lauren McLendon Postlewait ◽  
Gillian G. Baptiste ◽  
Nina Le ◽  
Mia R. McInnis ◽  
...  
Keyword(s):  
Small Bowel ◽  
Neuroendocrine Tumors ◽  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Operative Approach ◽  
Curative Intent ◽  
Primary Tumors ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

203 Background: Small bowel neuroendocrine tumors (SB-NET) are rare, and often small and multifocal. They are difficult to localize preoperatively and can be overlooked during operative exploration. The optimal work-up and operative approach is not known. Methods: Patients who underwent resection of SB-NET at a single institution from 2000-2014 were included. Primary aim was to describe the diagnostic work-up, pathologic characteristics, and compare minimally-invasive (MIS) to open resection. Results: 93pts underwent resection for SB-NET. Median age was 61yrs; 52% were male. On presentation, 71% of pts were symptomatic and underwent an average of 3 diagnostic tests prior to resection: 45% had octreoscans, which identified the region of primary disease in 85%; 11% had small bowel enteroscopy, with a 10% diagnostic yield; 19% had capsule endoscopy, which saw a lesion in 83%, but in only 21% was the correct number of tumors seen. The diagnostic yield of capsule was 28% overall, but 82% in pts presenting with GI bleeding. 79pts (85%) underwent curative-intent resections. Median tumor size was 1.8cm and multiple primary tumors were seen in 34pts(42%), of whom 50% had > 3 tumors. 37% had metastatic and 70% had LN positive disease. 27pts underwent MIS resections vs 66 open. MIS pts were younger (56vs61yrs;p0.035) and less likely to have obstructive symptoms (4vs24%;p = 0.19) and metastatic disease at resection (19vs44%;p = 0.038). Compared to open, the MIS group had smaller (1.7vs2.4cm;p = 0.03) and fewer tumors resected (2vs5;p = 0.049), but similar LN yield (13vs12;p = 0.7). In pts without metastases undergoing curative-intent resection, MIS approach was still associated with fewer tumors removed compared to open (1.5vs4;p = 0.034). Conclusions: Capsule endoscopy appears to be better than small bowel enteroscopy at identifying occult small bowel neuroendocrine tumors, particularly when pts present with bleeding, but still may underestimate tumor burden. While MIS may be appropriate in select patients, recognizing the limitations of preoperative evaluation is critical when selecting the operative approach for these tumors, as heightened operative vigilance is often required.

Pulmonary Artery Sling: A New Diagnostic Tool and Clinical Review

PEDIATRICS ◽  
1982 ◽  
Vol 69 (4) ◽  
pp. 472-475
Author(s):  
Karen S. Rheuban ◽  
Nancy Ayres ◽  
J. Gordon Still ◽  
Bennett Alford
Keyword(s):  
Computed Tomography ◽  
Pulmonary Artery ◽  
Diagnostic Tool ◽  
Vascular Ring ◽  
Vascular Anomaly ◽  
Pulmonary Artery Sling ◽  
Cardiovascular Malformation ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

The pulmonary artery sling is a vascular anomaly that produces severe respiratory disease in infancy. The differential diagnosis is lengthy, and the diagnostic work-up frequently includes such invasive maneuvers as bronchography, bronchoscopy, and cardiac catheterization. In this paper the use of a new noninvasive diagnostic tool, computed tomography, to aid in the diagnosis of this form of vascular ring, is discussed and a review of salient features of this cardiovascular malformation is presented.

scholarly journals Is hysterolaparoscopy a real theranostic approach for anatomical barriers in female fertility? A future argument

2018 ◽  
Vol 7 (6) ◽  
pp. 2423
Author(s):  
Namita Agrawal ◽  
Poonam Yadav ◽  
S. Fayyaz ◽  
Brinderjeet Kaur
Keyword(s):  
Real Time ◽  
Female Fertility ◽  
Therapeutic Interventions ◽  
Secondary Infertility ◽  
Female Patients ◽  
Primary Infertility ◽  
Diagnostic Work ◽  
Infertility Patients ◽  
Work Up ◽  
Diagnostic Work Up

Background: Hysterolaparoscopy is a modality that provides the real time abdomino-pelvic view during diagnosis in infertile female patients and any pathology is noticed can be tackled at the same time. So we investigate the theranostic application of hysterolaparoscopy in structural causes of female infertility in present study.Methods: Authors prospectively evaluate 157 female patients (mean age 27.7 years) diagnosed as infertile, underwent hysterolaparoscopy during diagnostic work-up.  All the enlisted patients fulfilled the criteria of infertility. The noticed anatomical abnormalities in the hysterolaparoscopy were tackled at the same time if possible.Results: Of the 157 infertile female patients, 93 (~59.2%) were of primary infertility and remaining 64 (~41.8%) were secondary infertility patients. Hysterolaparoscopy showed abnormalities in 125/157 (~85.0%) patients. The detected hysterolaparoscopic abnormalities were distributed in 77/93 (~82.8%) primary and 48/64 (~75.0%) secondary infertility patients. Of the 125 patients with abnormal hysterolaparoscopic findings, 121 (~96.8%) experienced for active therapeutic interventions. All of the 48 secondary infertility patients with hysterolaparoscopic abnormalities experienced for active hysterolaparoscopic interventions. Of 77 patients with hysterolaparoscopic abnormality in primary infertility group, 73 (~94.8%) experienced active intervention. Only four patients with streak ovaries and hypoplastic uterus, few tiny fibroids and adenomyosis did not undergo for active hysterolaparoscopic intervention.Conclusions: Authors concluded that hysterolaparoscopy has a better theranostic approach for the anatomical barriers of female fertility so it can be performed in the initial phases of the infertility diagnostic work-up.

scholarly journals International consensus recommendations on the diagnostic work-up for malformations of cortical development

2020 ◽  
Vol 16 (11) ◽  
pp. 618-635 ◽  
Author(s):  
Renske Oegema ◽  
Tahsin Stefan Barakat ◽  
Martina Wilke ◽  
Katrien Stouffs ◽  
Dina Amrom ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Cortical Development ◽  
Abnormal Development ◽  
Malformations Of Cortical Development ◽  
Feeding Difficulties ◽  
Consensus Recommendations ◽  
Number Of Patients ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

AbstractMalformations of cortical development (MCDs) are neurodevelopmental disorders that result from abnormal development of the cerebral cortex in utero. MCDs place a substantial burden on affected individuals, their families and societies worldwide, as these individuals can experience lifelong drug-resistant epilepsy, cerebral palsy, feeding difficulties, intellectual disability and other neurological and behavioural anomalies. The diagnostic pathway for MCDs is complex owing to wide variations in presentation and aetiology, thereby hampering timely and adequate management. In this article, the international MCD network Neuro-MIG provides consensus recommendations to aid both expert and non-expert clinicians in the diagnostic work-up of MCDs with the aim of improving patient management worldwide. We reviewed the literature on clinical presentation, aetiology and diagnostic approaches for the main MCD subtypes and collected data on current practices and recommendations from clinicians and diagnostic laboratories within Neuro-MIG. We reached consensus by 42 professionals from 20 countries, using expert discussions and a Delphi consensus process. We present a diagnostic workflow that can be applied to any individual with MCD and a comprehensive list of MCD-related genes with their associated phenotypes. The workflow is designed to maximize the diagnostic yield and increase the number of patients receiving personalized care and counselling on prognosis and recurrence risk.

Abstract TP218: Transoesophageal Echocardiography in the Diagnostic Work-up of Patients With Embolic Stroke of Undetermined Source: A Necessary Investigation That Should Not Be Overlooked

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Georgios Tsivgoulis ◽  
Aristeidis H Katsanos ◽  
Rohini Bhole ◽  
Alexandra Frogoudaki ◽  
Sotirios Giannopoulos ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Tertiary Care ◽  
Previous History ◽  
Transoesophageal Echocardiography ◽  
Atrial Septal Aneurysm ◽  
Diagnostic Work ◽  
Definition Of ◽  
The Impact ◽  
Work Up ◽  
Diagnostic Work Up

Background&Purpose: The currently proposed criteria for the definition of embolic strokes of undetermined source (ESUS) do not include investigation with transesophageal echocardiography (TEE) among the mandatory diagnostic work-up. We sought to evaluate the diagnostic yield of TEE in consecutive patients fulfilling ESUS criteria. Methods: We prospectively evaluated ischemic stroke (IS) patients fulfilling ESUS criteria from three tertiary care stroke centers during a twelve month period. All patients underwent additional diagnostic work-up with TEE to estimate both the diagnostic yield and the impact of TEE findings in the therapeutic management of patients with ESUS. Results: We identified 61 patients with ESUS who underwent investigation with TEE [mean age 44.3±11.5 years; 49.2% males; median NIHSS=5 (IQR, 3-8)]. TEE revealed additional findings in 52.4% (95%CI by the adjusted Wald method: 40.2%-64.5%) of the patients. Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) were reported in 27.8% (95%CI: 18.1%-40.2%) and 13.1% (95%CI: 6.5%-24.1%) of the study population respectively. The concurrence of PFO and ASA was reported in 4 patients (6.5%, 95%CI: 2.1%-16.1%). The presence of valvular vegetations was documented in 2 patients (3.2%; 95%CI: 0%-11.8%), while thrombus was found in the left atrium of one patient (1.6%, 95%CI: 0%-9.5%). Complex aortic arch atheromatosis was reported in 6.5% (95%CI: 2.1%-16.1%) of the patients. Neither myxomas, nor ventricular septal defects were found in TEE examinations. TEE findings changed the management in 16.4% (95%CI: 8.9%-27.8%) of the patients. Anticoagulants were initiated in 5 patients, while the other 2 patients with endocarditis received treatment with intravenous antibiotics. Finally, 3 of the 61 patients underwent a PFO-closure procedure due to the large size of the shunt and the previous history of recurrent cryptogenic IS. Conclusions: Our findings suggest that ESUS patients should undergo investigation with TEE in search of potential cardioembolic or aortogenic sources. TEE findings may have a decisive impact on the selection of the appropriate therapeutic approach for these patients.

Primary Tumours of the Spine: Differential Diagnosis, Epidemiology and Diagnostic Work Up

2017 ◽  
Author(s):  
Stefano Boriani ◽  
Luca Boriani
Keyword(s):  
Differential Diagnosis ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Clinical Presentation and Diagnostic Work Up in Spinal Trauma

2017 ◽  
Author(s):  
Emiliano Vialle
Keyword(s):  
Clinical Presentation ◽  
Spinal Trauma ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

scholarly journals Stroke masquerading as cardiac arrest: the artery of Percheron

2021 ◽  
Vol 14 (1) ◽  
pp. e238681
Author(s):  
Megan Quetsch ◽  
Sureshkumar Nagiah ◽  
Stephen Hedger
Keyword(s):  
Cardiac Arrest ◽  
Clinical Assessment ◽  
Altered Consciousness ◽  
Cognitive Changes ◽  
Consciousness Level ◽  
Artery Of Percheron ◽  
Conscious Level ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

The artery of Percheron (AOP) is a rare arterial variant of the thalamic blood supply. Due to the densely packed collection of nuclei it supplies, an infarction of the AOP can be devastating. Here we highlight a patient who had an AOP stroke in the community, which was initially managed as cardiac arrest. AOP strokes most often present with vague symptoms such as reduced conscious level, cognitive changes and confusion without obvious focal neurology, and therefore are often missed at the initial clinical assessment. This case highlights the importance of recognising an AOP stroke as a cause of otherwise unexplained altered consciousness level and the use of MRI early in the diagnostic work-up.

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