Interaction between Pyridostigmine Bromide and Oxidative Stress

In this chapter the following topics will be addressed: (1) actions of the cholinergic system in the nervous system, commenting on acetylcholine metabolism and acetylcholinesterase metabolism; (2) acetylcholinesterase inhibitors as subtitle in this topic: pharmacological characterization of pyridostigmine bromide, mechanism of action, and therapeutic effect of the drug; (3) use of pyridostigmine bromide in Persian Gulf War; and (4) potential effect of pyridostigmine bromide in oxidative stress, addressing as subtitle the influence of pyridostigmine bromide on the superoxide-hydrogen peroxide imbalance model. Studies indicate that the interaction between pyridostigmine bromide and stressors could trigger genotoxicity, the mechanism associated with the induction of oxidative stress that leads to this side effect of this drug; however, this discussion needs to be better elucidated and may be more discussed as there is interaction between the pyridostigmine bromide and an endogenous oxidative imbalance caused by it or even by the possible interaction of this with genetic variations present in the antioxidant metabolism.

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Characterization of acute toxicity, genotoxicity, and oxidative stress of dimethoate in Rhinella arenarum larvae

Environmental Science and Pollution Research ◽

10.1007/s11356-021-13691-2 ◽

2021 ◽

Author(s):

Mercedes Acquaroni ◽

Julieta Peluso ◽

Gabriela Svartz ◽

Carolina Aronzon ◽

Cristina Pérez Coll

Keyword(s):

Oxidative Stress ◽

Acute Toxicity ◽

Rhinella Arenarum ◽

And Oxidative Stress

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Further characterization of the zebrafish model of acrylamide acute neurotoxicity: gait abnormalities and oxidative stress

Scientific Reports ◽

10.1038/s41598-019-43647-z ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Melissa Faria ◽

Arnau Valls ◽

Eva Prats ◽

Juliette Bedrossiantz ◽

Manuel Orozco ◽

...

Keyword(s):

Oxidative Stress ◽

Zebrafish Model ◽

Acute Neurotoxicity ◽

Gait Abnormalities ◽

And Oxidative Stress

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Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems in the response to oxidative stress

Biochemical Journal ◽

10.1042/bj20141080 ◽

2015 ◽

Vol 469 (1) ◽

pp. 45-57 ◽

Cited By ~ 27

Author(s):

Meiru Si ◽

Yixiang Xu ◽

Tietao Wang ◽

Mingxiu Long ◽

Wei Ding ◽

...

Keyword(s):

Oxidative Stress ◽

Corynebacterium Glutamicum ◽

Stress Resistance ◽

Functional Characterization ◽

Gram Positive ◽

Oxidative Stress Resistance ◽

Proton Donors ◽

New Type ◽

And Oxidative Stress

Mycothiol peroxidase, a new type of GSH peroxidase distributed in GSH-lacking high-(G+C)-content Gram-positive actinobacteria, uses both mycoredoxin and thioredoxin systems as proton donors for regeneration and oxidative stress resistance.

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Characterization of lycopene β-cyclase gene from Lycium chinense conferring salt tolerance by increasing carotenoids synthesis and oxidative stress resistance in tobacco

Molecular Breeding ◽

10.1007/s11032-015-0418-y ◽

2015 ◽

Vol 35 (12) ◽

Cited By ~ 6

Author(s):

Chao Jin ◽

Jing Ji ◽

Qing Zhao ◽

Ran Ma ◽

Chunfeng Guan ◽

...

Keyword(s):

Oxidative Stress ◽

Salt Tolerance ◽

Stress Resistance ◽

Lycium Chinense ◽

Oxidative Stress Resistance ◽

And Oxidative Stress

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Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration

Biomolecules ◽

10.3390/biom10030443 ◽

2020 ◽

Vol 10 (3) ◽

pp. 443 ◽

Cited By ~ 4

Author(s):

Sumbal Iqbal ◽

Fawad Ali Shah ◽

Komal Naeem ◽

Humaira Nadeem ◽

Sadia Sarwar ◽

...

Keyword(s):

Oxidative Stress ◽

Neuronal Injury ◽

Binding Affinities ◽

Glutathione S Transferase ◽

In Vivo Experiments ◽

Tnf Α ◽

And Oxidative Stress ◽

Necrosis Factor

Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series of novel succinamide derivatives and to further investigate the neuroprotective potential of these compounds against scopolamine-induced neuronal injury by in silico, morphological, and biochemical approaches. The characterization of all the succinamide derivatives was carried out spectroscopically via proton NMR (1H-NMR), FTIR and elemental analysis. Further in vivo experiments showed that scopolamine induced neuronal injury, characterized by downregulated glutathione (GSH), glutathione S-transferase (GST), catalase, and upregulated lipid peroxidation (LPO). Moreover, scopolamine increased the expression of inflammatory mediators such as cyclooxygenase2 (COX2), nuclear factor kappa B (NF-kB), tumor necrosis factor (TNF-α), further associated with cognitive impairment. On the other hand, treatment with succinamide derivatives ameliorated the biochemical and immunohistochemical alterations induced by scopolamine, further supported by the results obtained from molecular docking and binding affinities.

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