scholarly journals The Release Kinetics of Melatonin from Innovative Dosage Forms: The Role of the Fractal Geometry of the “Vehicle”

2020 ◽  
Author(s):  
Natassa Pippa ◽  
Costas Demetzos
Keyword(s):  
Fractal Geometry ◽  
Release Kinetics ◽  
Dosage Forms ◽  
Kinetics Of

scholarly journals Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

2021 ◽  
Author(s):  
Lorenzo Lisuzzo ◽  
Giuseppe Cavallaro ◽  
Stefana Milioto ◽  
Giuseppe Lazzara
Keyword(s):  
Salicylic Acid ◽  
Release Kinetics ◽  
Halloysite Nanotubes ◽  
Drug Molecules ◽  
Sodium Diclofenac ◽  
Tunable Release ◽  
Feature Based ◽  
Kinetics Of ◽  
Filling Mechanism

AbstractIn this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and $$\zeta$$ ζ -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.

scholarly journals Investigation of the Role of Cholesterol Superlattice in Release Kinetics of Drugs from Stealth Liposomes

2012 ◽  
Vol 102 (3) ◽  
pp. 83a ◽  
Author(s):  
Nicole Haloupek ◽  
Justin Rafferty ◽  
Kayla Haloupek ◽  
Emmanuel Tejada ◽  
Tamara Mamistvalova ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Stealth Liposomes ◽  
Kinetics Of

The role of microsphere fabrication methods on the stability and release kinetics of ovalbumin encapsulated in polyanhydride microspheres

2006 ◽  
Vol 23 (8) ◽  
pp. 832-843 ◽  
Author(s):  
Amy S. Determan ◽  
Jennifer R. Graham ◽  
Katherine A. Pfeiffer ◽  
Balaji Narasimhan
Keyword(s):  
Release Kinetics ◽  
The Stability ◽  
Kinetics Of

scholarly journals Sustained release of the antitumor drug paclitaxel from poly(3-hydroxybutyrate)-based microspheres

2011 ◽  
Vol 57 (2) ◽  
pp. 232-240 ◽  
Author(s):  
A.P. Bonartsev ◽  
G.M. Soboleva ◽  
K.V. Shaytan ◽  
M.P. Kirpichnikov ◽  
S.G. Yakovlev ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Antitumor Drug ◽  
Sustained Action ◽  
Novel Drug ◽  
Kinetics Of ◽  
Prolonged Drug Release

Development of systems of medicines with sustained action on the basis of biodegradable polymers is a promising trend in modern pharmacology. Polyhydroxyalkanoates (POA) attract increasing attention due to their biodegradability and high biocompatibility, which make them suitable for development of novel drug dosage forms. We obtained microspheres on the basis of poly(3-hydroxybutyrate) (PHB) loaded with the antitumor drug paclitaxel. Morphology, drug release kinetics and effect on tumor cells in vitro of microspheres were studied. The data on the kinetics of drug release, biocompatibility and biological activity of the biopolymer microspheres in vitro showed that the studied system of prolonged drug release had lower toxicity and higher efficiency compared to the traditional dosage forms of paclitaxel.

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