scholarly journals The Relationship between Amyotrophic Lateral Sclerosis and Parkinson’s Disease and Sleep Disorders: Pathophysiological and Clinical Approach

2021 ◽  
Author(s):  
Aqsa Ullah ◽  
Mays Alani ◽  
Omar Chaudry ◽  
Afra Janarious ◽  
Nina Tsakadze ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Amyotrophic Lateral Sclerosis ◽  
Sleep Disorders ◽  
Neurodegenerative Disorders ◽  
Clinical Approach ◽  
Spinocerebellar Ataxias ◽  
The Relationship ◽  
Lateral Sclerosis

This chapter focuses in the interrelationship between sleep and two neurodegenerative disorders: Amyotrophic Lateral Sclerosis [ALS] and Parkinson’s disease [PD]. Sleep disorders have deleterious effect on the quality of life and survival in these neurodegenerative disorders, while the reverse is also true where neurodegenerative disorders significantly impair the sleep, leading to a vast sleep complains that worsen the clinical course of these conditions. Other neurodegenerative disorders such as dementias, spinocerebellar ataxias, atypical parkinsonism, etc. will not be cover in this chapter.

scholarly journals Alzheimer’s, Parkinson’s Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement

2020 ◽  
Vol 21 (24) ◽  
pp. 9500
Author(s):  
Maria Garofalo ◽  
Cecilia Pandini ◽  
Matteo Bordoni ◽  
Orietta Pansarasa ◽  
Federica Rey ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Amyotrophic Lateral Sclerosis ◽  
Neurodegenerative Disorders ◽  
Mononuclear Cells ◽  
Expression Patterns ◽  
Rna Metabolism ◽  
Peripheral Blood Mononuclear ◽  
Non Coding Rnas ◽  
Lateral Sclerosis

Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by a progressive degeneration of the central or peripheral nervous systems. A central role of the RNA metabolism has emerged in these diseases, concerning mRNAs processing and non-coding RNAs biogenesis. We aimed to identify possible common grounds or differences in the dysregulated pathways of AD, PD, and ALS. To do so, we performed RNA-seq analysis to investigate the deregulation of both coding and long non-coding RNAs (lncRNAs) in ALS, AD, and PD patients and controls (CTRL) in peripheral blood mononuclear cells (PBMCs). A total of 293 differentially expressed (DE) lncRNAs and 87 mRNAs were found in ALS patients. In AD patients a total of 23 DE genes emerged, 19 protein coding genes and four lncRNAs. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses, we found common affected pathways and biological processes in ALS and AD. In PD patients only five genes were found to be DE. Our data brought to light the importance of lncRNAs and mRNAs regulation in three principal neurodegenerative disorders, offering starting points for new investigations on deregulated pathogenic mechanisms.

Self-Perception of Voice and Swallowing Handicap in Parkinson’s Disease

2021 ◽  
pp. 1-8
Author(s):  
Alice K. Silbergleit ◽  
Lonni Schultz ◽  
Kendra Hamilton ◽  
Peter A. LeWitt ◽  
Christos Sidiropoulos
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Duration ◽  
Self Perception ◽  
Functional Aspects ◽  
Dysphagia Handicap Index ◽  
Relationship Of ◽  
The Relationship

Background: Hypokinetic dysarthria and dysphagia are known features of Parkinson’s disease; however, self-perception of their handicapping effects on emotional, physical, and functional aspects of quality of life over disease duration is less understood. Objective: 1) Based upon patient self-perception, to determine the relationship of the handicapping effects of dysphagia and dysphonia with time since diagnosis in individuals with Parkinson’s disease; 2)To determine if there is a relationship between voice and swallowing handicap throughout the course of Parkinson’s disease. Method: 277 subjects completed the Dysphagia Handicap Index and the Voice Handicap Index. Subjects were divided into three groups based on disease duration: 0–4 years, 5–9 years, and 10 + years. Results: Subjects in the longer duration group identified significantly greater perceptions of voice and swallowing handicap compared to the shorter duration groups. There was a significant positive correlation between the DHI and VHI. Conclusion: Self-perception of swallowing and voice handicap in Parkinson’s disease are associated with later stages of disease and progress in a linear fashion. Self-perception of voice and swallowing handicap parallel each other throughout disease progression in Parkinson’s disease. Individuals may be able to compensate for changes in voice and swallowing early while sensory perceptual feedback is intact. Results support early targeted questioning of patient self-perception of voice and swallowing handicap as identification of one problem indicates awareness of the other, thus creating an opportunity for early treatment and maintenance of swallowing and communication quality of life for as long as possible.

scholarly journals Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis

2020 ◽  
Vol 127 (2) ◽  
pp. 189-203 ◽  
Author(s):  
David Devos ◽  
◽  
Z. Ioav Cabantchik ◽  
Caroline Moreau ◽  
Véronique Danel ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Amyotrophic Lateral Sclerosis ◽  
Neurodegenerative Diseases ◽  
Iron Chelation ◽  
Lateral Sclerosis
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