scholarly journals Personalised Precision Medicine- a Novel Approach for Oral Cancer Management

2021 ◽  
Author(s):  
Deepa Jatti Patil ◽  
Rakesh Nagaraju
Keyword(s):  
Oral Cancer ◽  
Precision Medicine ◽  
Cancer Diagnosis ◽  
Poor Prognosis ◽  
Neck Region ◽  
Empirical Therapy ◽  
Treatment Modalities ◽  
Cancer Management ◽  
Novel Approach

Oral Cancer is one of the most common malignancies of the head and neck region. Despite technological advancements and improvements in Oral cancer diagnosis and treatment modalities, the 5-year survival rate remains low and is associated with poor prognosis and high mortality rate especially when detected at a later stage. The empirical therapy followed for the treatment of oral cancer includes surgery, radiotherapy and chemotherapy. The treatments are not equally efficacious for all patients, are associated with side effects and poor prognosis. The need of the hour is early diagnosis and tailored treatment therapies for individual patients. With the advent of immunotherapy, the cancer treatment has moved toward personalised precision medicine which tailors’ treatments to each individual. Personalised precision medicine incorporates, molecular profiling of tumours with OMICS technology, biomarkers and companion diagnostics to build databases of patients and devise tailor made treatment approaches for individual patients. This article discusses the role of precision medicine in OSCC prevention, detection, and management by reviewing our understanding of OC from both genetic and OMICS perspectives.

scholarly journals Specific role of targeted molecular therapy in treatment of oral squamous cell carcinoma

2017 ◽  
Vol 04 ◽  
pp. 1
Author(s):  
Pankaj Gupta ◽  
P. Sivasankari ◽  
◽  
Keyword(s):  
Oral Cancer ◽  
Social Life ◽  
Neck Region ◽  
Molecular Therapy ◽  
Treatment Modalities ◽  
Targeted Molecular Therapy ◽  
Head And Neck Region ◽  
Timely Completion

Oral cancer is a potentially fatal disease that constitutes an important portion of tumors that occur in the head and neck region. Oral cancer can affect overall and mental health, appearance, employment, social life, and family living. The disease can cause serious changes in the functioning of the upper aero digestive tract that affects the quality of life in patients. The use of conventional treatment modalities (surgery, radiation, and/or chemotherapy) depends on tumor respectability and location as well as whether an organ preservation approach is feasible. However, their role in oral cancer treatment is nonselective and can cause damage to normal tissue. In particular, chemo radiotherapy is associated with systemic toxicities that often reduce patient compliance and prevent timely completion of therapy. The development of targeted therapies to target select pathways involved in carcinogenesis, potentially decrease systemic toxicities and morbidities associated with cancer burden and hence improve the prognosis in cancer patients. In the present article, the role of various targeted molecules in the treatment of oral cancer is discussed.

On the role of physicians in oral cancer diagnosis

Oral Oncology ◽  
2020 ◽  
Vol 108 ◽  
pp. 104843
Author(s):  
José M. García-Martín ◽  
María J. García-Pola ◽  
Pablo Varela-Centelles ◽  
Juan M. Seoane-Romero
Keyword(s):  
Oral Cancer ◽  
Cancer Diagnosis

The Role of the Dental Team in Preventing and Diagnosing Cancer: 3. Oral Cancer Diagnosis and Screening

Dental Update ◽  
2005 ◽  
Vol 32 (6) ◽  
pp. 326-337 ◽  
Author(s):  
Crispian Scully ◽  
Laurence Newman ◽  
Jose Vicente Bagan
Keyword(s):  
Oral Cancer ◽  
Cancer Diagnosis

The role of liquid biopsies in prostate cancer management

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Chi-Ju Kim ◽  
Liang Dong ◽  
Sarah Amend ◽  
Yoon-Kyoung Cho ◽  
Kenneth Pienta
Keyword(s):  
Prostate Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Liquid Biopsy ◽  
Liquid Biopsies ◽  
Cancer Management ◽  
The Common ◽  
Prostate Cancer Management

Liquid biopsy has emerged as a complement to invasive tissue biopsy to guide cancer diagnosis and treatment. The common liquid biopsy biomarkers are circulating tumor cells (CTCs), extracellular vesicles (EVs),...

The role of molecular techniques in preventing oral cancer and improving its poor prognosis: an illusion?

2002 ◽  
Vol 31 (4) ◽  
pp. 246-248 ◽  
Author(s):  
Michele Davide Mignogna ◽  
Stefano Fedele ◽  
Elvira Ruoppo ◽  
Lucio Lo Russo
Keyword(s):  
Oral Cancer ◽  
Poor Prognosis ◽  
Molecular Techniques

O131. Lapse in oral cancer staging? Role of three dimensional CT scan in oral cancer diagnosis and staging

2009 ◽  
Vol 3 (1) ◽  
pp. 100
Author(s):  
M. Kar ◽  
S. Thulkar ◽  
S.V.S. Deo ◽  
S. Kumar ◽  
S. Datta Gupta ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Ct Scan ◽  
Cancer Diagnosis ◽  
Three Dimensional ◽  
Cancer Staging

Role of miRNA in cancer diagnosis, prognosis, therapy and regulation of its expression by Epstein–Barr virus and human papillomaviruses: With special reference to oral cancer

Oral Oncology ◽  
2015 ◽  
Vol 51 (8) ◽  
pp. 731-737 ◽  
Author(s):  
Jatinder Pal Singh Chawla ◽  
Nageshwar Iyer ◽  
Kanwaldeep Singh Soodan ◽  
Atul Sharma ◽  
Sunpreet Kaur Khurana ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Special Reference ◽  
Cancer Diagnosis ◽  
Epstein Barr Virus ◽  
Human Papillomaviruses ◽  
Barr Virus ◽  
Epstein Barr

Starring role of Biomarkers and Anticancer Agents as a Major Driver in Precision Medicine of Cancer Therapy

2021 ◽  
Vol 22 ◽  
Author(s):  
Suman Kumar Ray ◽  
Sukhes Mukherjee
Keyword(s):  
Precision Medicine ◽  
Anticancer Agents ◽  
Individual Characteristics ◽  
Treatment Modalities ◽  
Genetic Profile ◽  
Malignant Growth ◽  
New Era ◽  
Life Context ◽  
Contemporary Medicine

: Precision medicine represents the most modern contemporary medicine trend, based on enormous amounts of data relating to people's health, individual characteristics, and life context using the most appropriate strategies to prevent and cure them. Precision medicine in cancer coordinates most precisely and viable treatment to every individual cancer patient based on the disease's genetic profile. Precision medicine changes the standard one size fits all medication model, which has focused on average responses to care. Significantly, consolidating different modern methodologies for streamlining and checking anticancer drugs can have continuous effects on understanding results. Precision medicine can help explicit anticancer treatments using various drugs and even in discovery, thus becoming the paradigm of future cancer medicine. Cancer biomarkers are a significant focus point in precision medicine, and findings of different biomarkers make this field more promising and challenging. Naturally, genetic instability and the collection of extra changes in malignant growth cells are ways that cancer cells use to adapt and survive in a hostile environment, for example, one made by these treatment modalities. Precision medicine is centered around recognizing which treatments are best for individual patients, dependent on their malignant growth and genetic characterization. This new era of genomics, which is progressively referred to as precision medicine, has ignited a new episode in the relationship between genomics and anticancer drug development.

Role of PD-L1 in Oral Cancer: From the Perspective of Immuno-oncology

2020 ◽  
Author(s):  
Moomal Aslam Khan
Keyword(s):  
Oral Cancer ◽  
Immune Checkpoint ◽  
Defense Mechanism ◽  
Immune Checkpoint Blockade ◽  
Immune Defense ◽  
Treatment Modalities ◽  
Original Research ◽  
Clinical Implications ◽  
Tumor Escape

Oral cancers are prevalent in our region and their management requires an upgrade in terms of advanced techniques. Immunotherapy is a novel therapeutic approach across the world that has shown significance in the sphere of oncology. Tumor cells escape detection from the immune surveillance mechanism resulting in proliferation. Through cancer immunotherapy, body’s own immune defense mechanism is stimulated with the aid of immunomodulating drugs. Scientists are underway studying the tumor microenvironment where immune editing takes place resulting in tumor escape and evasion. Many immune checkpoint proteins are being studied for clinical implications, however, the immune checkpoint blockade of Programmed death ligand-1(PD-L1) has proven to be successful and FDA approved in certain tumors. Role of increased expression of PD-L1 in oral cancer has been explored with variable results. Most researches have related it with tumor progression and prognosis. This review focuses on the importance of PD-L1 as an emerging immune checkpoint inhibitor, emphasizing its expression in cancers, particularly in oral cancer. The information was retrieved from reliable search engines e.g. PubMed, Medline, Google scholar and others, through original research papers and reviews published hitherto, from 2010-2019. It is essential to explore advanced treatment modalities for oral cancer especially via immunotherapy. Furthermore, additional studies on PD-L1 expression in OSCC are required including standardized protocols to reach definitive conclusions for clinical implications.

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