Immunohistochemical analysis of local immune system in the oral cavity. A role of the minor salivary glands.

There are three main pairs of major salivary glands in the head and neck, namely the parotid, submandibular, and sublingual salivary glands. In addition to these major glands there are numerous minor salivary glands distributed throughout the oral cavity. These minor salivary glands are situated in the adnexal layer of the oral mucosa. This chapter covers the relevant anatomy, physiology, taking a history, clinical examination, and investigations. It then goes on to discuss xerostomia, Sjögren’s syndrome, diffuse and localized gland swelling, sialolithiasis, ranula, and disorders of the minor salivary glands.

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Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

Microbiology and Molecular Biology Reviews ◽

10.1128/mmbr.62.1.71-109.1998 ◽

1998 ◽

Vol 62 (1) ◽

pp. 71-109 ◽

Cited By ~ 236

Author(s):

Harold Marcotte ◽

Marc C. Lavoie

Keyword(s):

Immune System ◽

Oral Cavity ◽

Microbial Ecology ◽

Periodontal Diseases ◽

Immunoglobulin A ◽

Basic Knowledge ◽

Oral Microbiota ◽

Indigenous Bacteria ◽

Indigenous Microbiota

SUMMARY In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an inbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.

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Pleomorphic adenoma of the nasal septum

The Journal of Laryngology & Otology ◽

10.1017/s0022215100144299 ◽

1999 ◽

Vol 113 (5) ◽

pp. 483-485 ◽

Cited By ~ 9

Author(s):

P. Jassar ◽

N. D. Stafford ◽

A. W. MacDonald

Keyword(s):

Oral Cavity ◽

Head And Neck ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Clinical Management ◽

Nasal Septum ◽

Rare Case ◽

Minor Salivary Glands ◽

Review Of The Literature ◽

Upper Aerodigestive Tract

AbstractPleomorphic adenoma is the commonest benign tumour of the major salivary glands. It can also occur in minor salivary glands, mainly in the oral cavity, but also in other sites in the head and neck both within and outwith the upper aerodigestive tract. We present a rare case of pleomorphic adenoma of the nasal septum with consideration of the clinical management and a review of the literature.

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Polymorphous low-grade adenocarcinoma of the tongue

The Journal of Laryngology & Otology ◽

10.1017/s0022215100134681 ◽

1996 ◽

Vol 110 (7) ◽

pp. 700-703 ◽

Cited By ~ 14

Author(s):

J. I. de Diego ◽

R. Bernaldez ◽

M. P. Prim ◽

D. Hardisson

Keyword(s):

Oral Cavity ◽

Salivary Glands ◽

Current Literature ◽

Unusual Case ◽

English Literature ◽

Growth Patterns ◽

Low Grade ◽

Minor Salivary Glands ◽

Distinct Entity

AbstractPrimary adenocarcinomas of the oral cavity in minor salivary glands are distinctive lesions which can be subclassified according to their growth patterns or histomorphology. Polymorphous low-grade adenocarcinoma (PLGA) of minor salivary tissue has been recognized as a distinct entity. We report an unusual case of PLGA of the tongue. Only a few previous cases have been reported in the English literature. The treatment is discussed and a review of the current literature concerning this tumour is included.

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PO-0710 IMRT+Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands of the Oral Cavity

Radiotherapy and Oncology ◽

10.1016/s0167-8140(19)31130-2 ◽

2019 ◽

Vol 133 ◽

pp. S365

Author(s):

K. Lang

Keyword(s):

Oral Cavity ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Carbon Ion ◽

Adenoid Cystic

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Sialolithiasis of minor salivary glands

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-863720150001000092592 ◽

2015 ◽

Vol 63 (1) ◽

pp. 63-68 ◽

Cited By ~ 1

Author(s):

Isabela Fernandes SOUZA ◽

Michele Montini KAWATAKE ◽

Andresa Borges SOARES ◽

Paulo de Camargo MORAES ◽

Vera Cavalcanti de ARAÚJO ◽

...

Keyword(s):

Oral Cavity ◽

Salivary Glands ◽

Surgical Excision ◽

Minor Salivary Glands ◽

Upper Lip ◽

Lower Lip ◽

Favorable Prognosis ◽

Appropriate Treatment ◽

Treatment Plans ◽

Microscopic Findings

Sialolithiasis, or salivary calculus, is a disease of the salivary glands, characterized by the formation of mineralized structures within the excretory salivary ducts or the glandular parenchyma. Approximately 80% occur in the submandibular gland, followed by the parotid and sublingual glands. Although rare, sialolithiasis can also occur in the minor salivary glands. Although the oral cavity and upper lip are the most common sites, they can develop in any region of the oral cavity that contains minor salivary glands. Treatment is based on surgical excision of the lesion, with a favorable prognosis. This study presents three cases of sialolithiasis of minor salivary glands of the upper and lower lip, addresses their clinical characteristics and correlation with microscopic findings, diagnosis and treatment plans. Etiology and factors that should be considered during diagnosis, appropriate treatment and improved prognosis are discussed in this study.

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Oral mucocele in infant with an unusual presentation

BMJ Case Reports ◽

10.1136/bcr-2020-234669 ◽

2020 ◽

Vol 13 (6) ◽

pp. e234669

Author(s):

Rishi Suryavanshi ◽

Ahsan Abdullah ◽

Neerja Singh ◽

Madhusudan Astekar

Keyword(s):

Oral Cavity ◽

Salivary Glands ◽

Clinical Diagnosis ◽

Rare Case ◽

Histopathological Examination ◽

Benign Lesion ◽

Unusual Presentation ◽

Mucous Secretion ◽

Minor Salivary Glands ◽

Great Role

Mucocele is a benign lesion characterised by an extravasation or retention of mucous secretion in submucosal tissue from minor salivary glands. The occurrence of mucocele is common in the oral cavity, with more than 70% of cases on lower labial mucosa. The occurrence of mucocele on the tongue is considered rare and accounted for only 2.25% in the previous literature. Histopathological examination plays a great role in the confirmation of the clinical diagnosis. Management of mucocele is at times challenging. This paper highlights a rare case of mucocele in a 5-month-old infant who was successfully managed under day-care anaesthesia.

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