scholarly journals Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

1998 ◽  
Vol 62 (1) ◽  
pp. 71-109 ◽  
Author(s):  
Harold Marcotte ◽  
Marc C. Lavoie
Keyword(s):  
Immune System ◽  
Oral Cavity ◽  
Microbial Ecology ◽  
Periodontal Diseases ◽  
Immunoglobulin A ◽  
Basic Knowledge ◽  
Oral Microbiota ◽  
Indigenous Bacteria ◽  
Indigenous Microbiota

SUMMARY In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an inbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.

scholarly journals Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2124
Author(s):  
Se-Young Park ◽  
Byeong-Oh Hwang ◽  
Mihwa Lim ◽  
Seung-Ho Ok ◽  
Sun-Kyoung Lee ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Gut Microbiome ◽  
Gastrointestinal Disease ◽  
Oral Microbiota ◽  
Microbial Interaction ◽  
Barrier Dysfunction ◽  
Gut Barrier ◽  
Microbial Ecosystem ◽  
Precise Diagnosis

It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

scholarly journals Bacteriocin-like activity of oral Fusobacterium nucleatum isolated from human and non-human primates

1999 ◽  
Vol 30 (4) ◽  
pp. 324-346 ◽  
Author(s):  
Elerson Gaetti-Jardim Júnior ◽  
Mario Julio Avila-Campos
Keyword(s):  
Oral Cavity ◽  
Microbial Ecology ◽  
Dental Plaque ◽  
Fusobacterium Nucleatum ◽  
Antagonistic Activity ◽  
Healthy Individuals ◽  
Bacterial Microbiota ◽  
Reference Strains

Fusobacterium nucleatum is indigenous of the human oral cavity and has been involved in different infectious processes. The production of bacteriocin-like substances may be important in regulation of bacterial microbiota in oral cavity. The ability to produce bacteriocin-like substances by 80 oral F. nucleatum isolates obtained from periodontal patients, healthy individuals and Cebus apella monkeys, was examinated. 17.5% of all tested isolates showed auto-antagonism and 78.8% iso- or hetero-antagonism. No isolate from monkey was capable to produce auto-inhibition. In this study, the antagonistic substances production was variable in all tested isolates. Most of the F. nucleatum showed antagonistic activity against tested reference strains. These data suggest a possible participation of these substances on the oral microbial ecology in humans and animals. However, the role of bacteriocins in regulating dental plaque microbiota in vivo is discussed.

scholarly journals A higiene bucal de bebês edêntulos e sua influência na microbiota bucal: os profissionais de saúde devem preconizá-la? – revisão crítica

2021 ◽  
Vol 62 (1) ◽  
pp. 108-120
Author(s):  
Dalila Miranda de Jesus ◽  
Lilian Lopes Barbosa ◽  
Thais Manzano Parisotto ◽  
Rogério Lacerda dos Santos ◽  
Hugo Lemes Carlo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Oral Hygiene ◽  
Health Professionals ◽  
Clinical Studies ◽  
Scientific Evidence ◽  
Pediatric Dentistry ◽  
Google Scholar ◽  
Oral Microbiota

Introduction: The indication of oral hygiene in edentulous babies is still controversial among health professionals, being necessary the search of this recommendation and the standardization of information. Objective: To investigate critically the evidence related to the indication of oral hygiene for edentulous babies. Methods: The search for articles was performed in the PUBMED, LILACS and GOOGLE SCHOLAR databases, in order to assess the following question: "Can oral cavity hygiene of edentulous babies influence oral microbiota? A search in 8 books of Pediatric Dentistry was also performed. Results: 317 articles were found (167-PUBMED, 146-GOOGLE SCHOLAR and 4-LILACS). There were no primary studies that evaluated the effect of oral hygiene of edentulous infants on microbiota, which impair the conduction of a systematic review. Thus, it was included for this review six studies that investigated microorganisms in the oral cavity of edentulous infants and the role of salivary immunoglobulins. Among the textbooks evaluated, only 4 indicated the oral hygiene in edentulous infants. Conclusion: According to the data, there are no primary studies that assessed the effect of oral hygiene in the oral microbiota of edentulous babies. It is relevant to conduct clinical studies in order to obtain scientific evidence about the indication or no of the oral hygiene in edentulous babies.

Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1748
Author(s):  
Se-Young Park ◽  
Byeong-Oh Hwang ◽  
Mihwa Lim ◽  
Seung Ho Ok ◽  
Sun Kyoung Lee ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Gut Microbiome ◽  
Gastrointestinal Disease ◽  
Oral Microbiota ◽  
Microbial Interaction ◽  
Barrier Dysfunction ◽  
Gut Barrier ◽  
Microbial Ecosystem ◽  
Precise Diagnosis

It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

Domestic prophylactic agents in maintaining the dental health of the elderly

2021 ◽  
pp. 5-9
Author(s):  
A. K. Iordanishvili
Keyword(s):  
Oral Cavity ◽  
Secondary Prevention ◽  
Elderly Patients ◽  
Oral Hygiene ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Oral Microbiota ◽  
Periodontal Pathogens ◽  
Dental Tissues ◽  
Group 2

Goal. To investigate dental health and oral microbiota in elderly people who use domestic care products after the completion of their sanitation.Material and methods. The prevalence and intensity of the course of dental caries, periodontal pathology, pathology of the oral mucosa, as well as the microbiota in 96 people aged 61 to 73 years were studied using conventional research methods in dentistry in elderly patients who visited a dentist for a year according to the appealability (group 1) or were under dynamic supervision and regularly carried out individual oral hygiene with the help of domestic ASEPTA products (group 2).Results. Individual prophylactic and hygienic measures for the care of the oral cavity, regularly carried out by elderly patients of group 2, significantly improved their dental health, contributed to the secondary prevention of periodontal diseases and a significant reduction in periodontal pathogens in the oral cavity.Conclusion. Elderly patients who are regularly observed by a dentist with a complex of measures for the primary and secondary prevention of dental diseases carried out 2 times a year, as well as with their proper adherence to oral care, it is possible to achieve effective treatment of the pathology of hard dental tissues, remission of inflammatory pathology of periodontal disease, and also good oral hygiene, which has a positive effect on their quality of life.

Oral probiotic and its delivery carriers to improve oral health: A review

Microbiology ◽  
2021 ◽  
Vol 167 (8) ◽  
Author(s):  
Yu-Hsuan How ◽  
Siok-Koon Yeo
Keyword(s):  
Oral Health ◽  
Oral Cavity ◽  
Health Effects ◽  
Oral Microbiota ◽  
Oral Diseases ◽  
Probiotic Product ◽  
Adherence Ability ◽  
Probiotic Delivery

In recent years, oral probiotics have been researched on their effectiveness in reducing and preventing oral diseases. Oral probiotics could be introduced into the oral cavity to keep the equilibrium of the microbiome. Hence, the delivery carrier for oral probiotics plays an important factor to ensure a high number of oral probiotics were delivered and released into the oral cavity. This review presents a brief overview of oral microbiota and the role of oral probiotics in reducing oral diseases. Moreover, important aspects of the oral probiotic product such as viability, adherence ability, health effects, safety, and delivery site were discussed. Besides that, the importance of utilizing indigenous oral probiotics was also emphasized. Oral probiotics are commonly found in the market in the form of chewing tablets, lozenges, and capsules. Hence, the oral probiotic carriers currently used in the market and research were reviewed. Furthermore, this review introduces new potential oral probiotic delivery carriers such as oral strip, bucco-adhesive gel, and mouthwash. Their effectiveness in delivering oral probiotics for oral health was also explored.

scholarly journals Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyedeh Zahra Bakhti ◽  
Saeid Latifi-Navid
Keyword(s):  
Helicobacter Pylori ◽  
Oral Cavity ◽  
Precancerous Lesions ◽  
Potential Method ◽  
Oral Microbiota ◽  
Bacterial Transmission ◽  
Underlying Mechanisms ◽  
H Pylori ◽  
Prevention Methods

AbstractGastric cancer (GC) is one of the most common malignancies causing death worldwide, and Helicobacter pylori is a powerful inducer of precancerous lesions and GC. The oral microbiota is a complex ecosystem and is responsible for maintaining homeostasis, modulating the immune system, and resisting pathogens. It has been proposed that the gastric microbiota of oral origin is involved in the development and progression of GC. Nevertheless, the causal relationship between oral microbiota and GC and the role of H. pylori in this relationship is still controversial. This study was set to review the investigations done on oral microbiota and analyze various lines of evidence regarding the role of oral microbiota in GC, to date. Also, we discussed the interaction and relationship between H. pylori and oral microbiota in GC and the current understanding with regard to the underlying mechanisms of oral microbiota in carcinogenesis. More importantly, detecting the patterns of interaction between the oral cavity microbiota and H. pylori may render new clues for the diagnosis or screening of cancer. Integration of oral microbiota and H. pylori might manifest a potential method for the assessment of GC risk. Hence it needs to be specified the patterns of bacterial transmission from the oral cavity to the stomach and their interaction. Further evidence on the mechanisms underlying the oral microbiota communities and how they trigger GC may contribute to the identification of new prevention methods for GC. We may then modulate the oral microbiota by intervening with oral-gastric bacterial transmission or controlling certain bacteria in the oral cavity.

scholarly journals Role of salivary glycopatterns for oral microbiota associated with gastric cancer

2021 ◽  
Author(s):  
Jian Shu ◽  
Hanjie Yu ◽  
Xiameng Ren ◽  
Yan Wang ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Oral Cavity ◽  
Healthy Volunteers ◽  
Human Health ◽  
Oral Microbiome ◽  
Oral Microbiota ◽  
Oral Cells

Abstract Microbiota in the oral cavity plays an important role in maintaining human health. Our previous studies have revealed significant alterations of salivary glycopatterns in gastric cancer (GC) patients, but it is unclear whether these altered salivary glycopatterns can cause the dysbiosis of oral microbiota. In this study, the oral microbiome of healthy volunteers and GC patients were detected. The neoglycoproteins were then synthesized according to the altered glycopatterns in GC patients and used to explore the effects of specific glycopattern against oral microbiota. The results showed that the fucose-neoglycoproteins could reduce the adhesion and toxicity of A. segnis to oral cells, change the glycan structures of lipopolysaccharide, and enhance the immunogenicity of A. segnis. This study revealed that the changes of salivary glycopatterns in GC patients might contribute to the dysbiosis of oral microbiota, had important implications in developing new carbohydrate drugs to maintain a balanced microbiota in the oral.

Role of antimicrobial peptides system in inflammatory periodontal diseases non-specific oral cavity protection

2021 ◽  
Vol 66 (7) ◽  
pp. 422-427
Author(s):  
N. V. Davidovich ◽  
N. V. Solovieva ◽  
A. S. Galieva ◽  
S. Yu. Lepeshkin ◽  
E. N. Bashilova ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Antimicrobial Peptides ◽  
Chronic Periodontitis ◽  
Pathogenic Bacteria ◽  
Periodontal Diseases ◽  
Control Group ◽  
Periodontal Pathogens ◽  
Local Immunity ◽  
Microbial Invasion

The system of antimicrobial peptides (AMP) is one of the most ancient mechanisms of the macroorganism resistance to infectious pathogens invasion. The aim of the study was to determine the role of the antimicrobial peptides system and periodontal pathogenic markers in the development and progression of inflammatory periodontal diseases. Gingival pocket washes (91 samples in total) for the research were received from patients with inflammatory periodontal diseases (chronic periodontitis and gingivitis) and intact periodontium. Using ELISA, the content of antimicrobial peptides was determined: human alpha-defensin (HNP 1-3), beta-defensin (HBD 1-3) and cathelicidin (LL-37). Periodontal pathogenic markers were isolated during RT-PCR. The study revealed differences in AMP concentrations by groups: level of HBD 2 in patients with chronic periodontitis was 1,36 times higher than those in the group of patients with chronic gingivitis (p=0,023) and 2,39 times higher than those in the control group (p<0,001), the content of HNP 1-3 in the group of patients with chronic periodontitis was reduced by 1,23 times compared with the indicators of the group of patients with gingivitis (p=0,045) and by 1,97 times compared with the indicators of the control group (p<0,001). The frequency of detection of periodontal pathogenic bacteria genes was 88,0% in patients with periodontitis, 76,92% in patients with gingivitis and 33,3% in the group with intact periodontium. HBD 2 content moderately correlated with the definition of P. gingivalis (r=0,612; p=0,022), T. forsythensis (r= 0,434; p=0,015), A. actinomycetemcomitans (r=0,483; p=0,006), a moderate negative correlation was detected between the content of HNP 1-3 and the release of periodontal pathogens in associations (P. gingivalis with T. forsythensis and T. denticola) (r=-0,388; p=0,031) in the group of patients with chronic periodontitis. Thus, the revealed relationships and correlations indicate shifts in the processes of reparative regeneration of the oral cavity and the regulation of local immunity in response to microbial invasion.

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