Is low serum 25(OH) vitamin D a risk factor for childhood pneumonias?

BackgroundLow serum vitamin D concentrations have been reported in several autoimmune disorders.ObjectiveTo assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE).Methods378 patients from several European and Israeli cohorts were pooled and their disease activity was measured by two different methods: 278 patients had SLE disease activity-2000 (SLEDAI-2K) scores and 100 patients had European Consensus Lupus Activity Measurement (ECLAM) scores. In order to combine the two systems the scores were converted into standardised values (z-scores), enabling univariate summary statistics for the two variables (SLEDAI-2K and ECLAM). The commercial kit, LIAISON 25-OH vitamin D assay (310900-Diasorin) was used to measure serum concentration of 25-OH vitamin D in 378 patients with SLE.ResultsA significant negative correlation was demonstrated between the serum concentration of vitamin D and the standardised values (z-scores) of disease activity scores as measured by the SLEDAI-2K and ECLAM scales (Pearson's correlation coefficient r=−0.12, p=0.018).ConclusionsIn a cohort of patients with SLE originating from Israel and Europe vitamin D serum concentrations were found to be inversely related to disease activity.

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CADD-55. LOW SERUM 25 (OH) VITAMIN D LEVEL IS ASSOCIATED WITH INCREASED RISK OF PRIMARY CNS MALIGNANCY: A RETROSPECTIVE COHORT STUDY IN A VETERAN POPULATION

Neuro-Oncology ◽

10.1093/neuonc/noy148.1180 ◽

2018 ◽

Vol 20 (suppl_6) ◽

pp. vi283-vi283

Author(s):

Emmanuel Mantilla ◽

Salwa Maalouf ◽

Oni Olurinde ◽

Vikas Singh

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Increased Risk ◽

25 Oh Vitamin D ◽

Cns Malignancy ◽

Low Serum

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Associations of CYP24A1 copy number variation with vitamin D deficiency and insulin secretion

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2019-0193 ◽

2019 ◽

Vol 44 (12) ◽

pp. 1367-1370

Author(s):

Xing Li ◽

Chenling Qu ◽

Yan Wang ◽

Zhenxing Mao ◽

Chongjian Wang ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Insulin Secretion ◽

Copy Number Variation ◽

Vitamin D Deficiency ◽

Copy Number ◽

Serum Insulin ◽

Vitamin D Status ◽

Number Variation ◽

25 Oh Vitamin D

Vitamin D plays an important role in insulin secretion. As the enzyme that initiates degradation of the active metabolite of vitamin D (1,25-(OH)2 vitamin D), 24-hydroxylase encoded by CYP24A1 may be associated with insulin secretion. In this study, we aimed at investigating the association between copy number of CYP24A1 and the concentration of insulin. Included in the study were 1528 rural people from Henan Province of China. The copy number of CYP24A1 and the concentrations of serum 25(OH) vitamin D3 and insulin were determined. Association between copy number of CYP24A1 and vitamin D deficiency was investigated with logistic regression model. Correlation between copy number of CYP24A1 and serum insulin was observed by Spearman correlation. The results suggested that copy number variation of CYP24A1 was associated with vitamin D deficiency. Higher copy number of CYP24A1 was a risk factor for vitamin D deficiency (adjusted odds ratio: 1.199; 95% confidence interval: 1.028–1.397; P = 0.021). Furthermore, copy number of CYP24A1 was positive correlated with the concentration of serum insulin (r = 0.115; P < 0.001), regardless of vitamin D status, age, and body mass index (BMI). Increased copy number of CYP24A1 is associated with not only vitamin D deficiency but also increased serum insulin. Vitamin D supplement may be beneficial to individuals with high copy number of CYP24A1. Novelty Increased copy number of CYP24A1 was a risk factor of vitamin D deficiency. Increased copy number of CYP24A1 was associated with increased serum concentration of insulin independent of age, BMI, and vitamin D status.

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