scholarly journals A Comparative Study on Ascetic Fluid Biochemical Markers in Cirrhotic Children with and Without Spontaneous Bacterial Peritonitis: A Cross-Sectional Observation

2019 ◽  
Vol 10 (3) ◽  
Author(s):  
Gholamreza Kalvandi ◽  
Mahmoud Haghighat ◽  
Naser Honar ◽  
Iraj Shahramian ◽  
Mojtaba Delaramnasab ◽  
...  
Keyword(s):  
Comparative Study ◽  
Biochemical Markers ◽  
Spontaneous Bacterial Peritonitis ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Ascetic Fluid

scholarly journals SPONTANEOUS BACTERIAL PERITONITIS (SBP);

2017 ◽  
Vol 24 (11) ◽  
pp. 1745-1748
Author(s):  
Ayesha Ghafoor ◽  
Ifrah Ahmed ◽  
Riaz Ahmed Javid
Keyword(s):  
Hepatic Encephalopathy ◽  
Spontaneous Bacterial Peritonitis ◽  
P Value ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Grade Ii ◽  
Age Range ◽  
Very High ◽  
Ascetic Fluid ◽  
Grade Iii

Objectives: To assess the SBP in patients with Hepatic Encephalopathy andits association with grades of hepatic encephalopathy. Study Design: Cross sectional study.Setting: Department of Medicine, Medina Teaching Hospital. Period: January 2017 to June2017. Material and Methods: Total 143 patients of HE having age range from 18-65 years eithermale or female selected. SBP was assessed in these selected patients. SBP defined as positivewhen ascetic fluid neutrophil count > 250/ml. West heaven criteria was used for grading of HE.Results: In present study, mean age of patients was 37.45 ± 10.63 years. Out of 143 patients,SBP was found in 77 (54%) patients. HBsAg was found positive in 58 (40.56%) patients followedby Anti-HCV was found positive in 77 (53.85%) patients and Both Anti-HCV & HBsAg was foundpositive in 8 (5.59%) patients. Total 51 (35.66%) patients were found with grade I HE followed by60 (41.96%) patients grade II, 23 (16.08%) patients grade III and 9 (6.29%) patients found withgrade IV HE. SBP was found in 36 (70.59%) patients, 32 (53.33%) patients, 5 (21.74%) patientsand 4 (44.44%) patients respectively. Statistically significant association between grade of HEand SBP was noted with p value 0.001. Conclusion: Results of present revels that frequencyof SBP is very high in cases of HE. Hepatitis C was found positive in most of the patients.Statistically insignificant association of SBP with gender was observed. But highly significantassociation of SBP with grade of HE was seen.

scholarly journals Renal impairment after Spontaneous Bacterial Peritonitis (SBP) in cirrhotic population.

2019 ◽  
Vol 26 (12) ◽  
pp. 2235-2240
Author(s):  
Asif Javaid Wakani ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan ◽  
Faqir Muhammad Awan
Keyword(s):  
Liver Cirrhosis ◽  
Renal Impairment ◽  
Serum Creatinine ◽  
Spontaneous Bacterial Peritonitis ◽  
National Hospital ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Serum Blood Urea Nitrogen ◽  
Patient’S Information ◽  
The Mean

Objectives: To evaluate the frequency of renal impairment after spontaneous bacterial peritonitis (SBP) in cirrhotic population. Study Design: The study was conducted as Descriptive Cross-Sectional. Setting: Liaquat National Hospital Karachi. Period: For six months (October 01, 2015 to March 31, 2016). Methodology: The subjects with liver cirrhosis spontaneous bacterial peritonitis (SBP) were evaluated for serum creatinine and serum blood urea nitrogen (BUN) for evaluation of renal impairment while the patient’s information was recorded on proforma and analyzed in SPSS-15.0. Results: The mean ±SD of age, BUN and serum creatinine for whole population was 50.69±10.69 years, 22.4197±11.64742 and 1.2207±0.92535. Renal impairment was detected in 40 (27.2%) individuals while it is normal in 107 (72.8%) subjects. Conclusion: The renal impairment after SBP in cirrhotic population is higher in present study.

scholarly journals Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers

2018 ◽  
Vol 30 (7) ◽  
pp. 786-791 ◽  
Author(s):  
Raim Iliaz ◽  
Tahsin Ozpolat ◽  
Bulent Baran ◽  
Kadir Demir ◽  
Sabahattin Kaymakoglu ◽  
...  
Keyword(s):  
Biochemical Markers ◽  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis

scholarly journals EVALUATION OF LEUKOCYTE ESTERASE REAGENT STRIPS TEST IN THE DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS IN CHILDREN WITH CIRRHOSIS

2015 ◽  
Vol 52 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Naser HONAR ◽  
Bita GERAMIZADEH ◽  
Seyed-Mohsen DEHGHANI ◽  
Gholamreza KALVANDI ◽  
Iraj SHAHRAMIAN ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Ascitic Fluid ◽  
Predictive Value ◽  
Spontaneous Bacterial Peritonitis ◽  
Rapid Test ◽  
Dipstick Test ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Strip Test

BackgroundSpontaneous bacterial peritonitis is defined as an ascetic fluid infection without an evident intra-abdominal surgically treatable source. Spontaneous bacterial peritonitis is one of the severe complications in patients with cirrhosis and ascites. Without early antibiotic treatment, this complication is associated with high mortality rate; therefore, early diagnosis and treatment of spontaneous bacterial peritonitis is necessary for survival. Leukocyte esterase reagent can rapidly diagnose the spontaneous bacterial peritonitis.ObjectiveThis study aimed to find out the diagnostic accuracy of leukocyte esterase dipstick test for the diagnosis of spontaneous bacterial peritonitis.MethodsA single centered hospital-based cross-sectional study was conducted during July 2013 to August 2014 on children with cirrhotic liver disease and ascites who were admitted in the Department of Pediatric Gastroenterology in Nemazee Hospital affiliated to Shiraz University of Medical Sciences (Iran). All patients underwent abdominal paracentesis, and the ascitic fluid was processed for cell count, leukocyte esterase reagent strip test (Combiscreen SL10) and culture. Spontaneous bacterial peritonitis was defined as having a polymorphonuclear count (PMN ≥250/m3) in ascitic fluid. Sensitivity, specificity, positive predictive value and negative predictive value of leukocyte esterase test were calculated according to the formula.ResultsTotally, 150 ascitic fluid sample of cirrhotic male patients (53.2%) and their mean age (4.33±1.88 years) were analyzed. Biliary atresia (n=44, 29.4%) and idiopathic neonatal hepatitis (n=29, 19.3%) were the most frequent etiology of cirrhosis. Also, abdominal pain (68.6%) and distension (64%) were the most common presenting complaint. Of all cases, 41patients (27.35%) were diagnosed to have spontaneous bacterial peritonitis (PMN ≥250/mm3). Sensitivity and specificity of leukocyte esterase reagent test according to PMNs ≥250mm3 were 87.80% and 91.74%, also on ascitic fluid culture results were 88.23% and 77.44%. Positive predictive value and negative predictive value of this test in PMNs ≥250mm3 were 80% and 95.23% and in cases with positive culture 33.33% and 98.09% were obtained, respectively. Efficiency of leukocyte esterase reagent test in diagnosing spontaneous bacterial peritonitis, according to PMNs ≥250mm3 and culture results were 90.66% and 78.66%.ConclusionThe leukocyte esterase strip test may be used as rapid test for diagnosis of spontaneous bacterial peritonitis due to its high diagnostic validity.

scholarly journals Prospective study of bedside inoculation of blood culture bottles with ascitic fluid versus delayed inoculation for the detection of spontaneous bacterial peritonitis

2017 ◽  
Vol 6 (1) ◽  
pp. 139
Author(s):  
Girish Iyyanna ◽  
Manjunath F. V. ◽  
Taruni Ng
Keyword(s):  
Blood Culture ◽  
Ascitic Fluid ◽  
Bacterial Infections ◽  
Spontaneous Bacterial Peritonitis ◽  
Culture Media ◽  
Positive Culture ◽  
Culture Methods ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Bacterial Yield

Background: Spontaneous bacterial peritonitis (SBP) is the most common bacterial infection in cirrhosis, accounting for 10%-30% of all reported bacterial infections in the patients admitted to hospital. Spontaneous bacterial peritonitis (SBP) is the most frequent and life-threatening infection in patients with liver cirrhosis. All forms of cirrhosis have been reported to be complicated by SBP. A delay in the time period between the collection of the ascitic fluid sample, and its inoculation into the blood culture media, has been one of the reasons implicated to account for low-test positivity. There was lack of studies for comparing the bacterial yield between bedside inoculated blood culture bottles with ascitic fluid over delayed inoculation in the detection of SBP. Hence this study is done to compare the bacterial yield between bedside inoculated blood culture bottles with ascitic fluid over delayed inoculation for the detection of SBP.Methods: Cross sectional study.Results: Maximum number of cases of cirrhosis with ascites with SBP was seen in the age group of 31-40years (54.4%) with mean age of study population being 39.66years, more common in males, bed side inoculation yielded more positive culture reports compared to delayed inoculation and E. coli and klebsilla being the common organisms.Conclusions: Difference between 2 culture methods in isolating organism in SBP cases was not statically significant. But, among culture positive cases, this study demonstrates that bedside inoculation of blood culture bottles is superior to delayed laboratory inoculation.

scholarly journals The pattern of microbial flora in Spontaneous bacterial peritonitis in Cirrhotic patients

2020 ◽  
pp. 62-67
Author(s):  
Sehrish Jahan Asif ◽  
Murataza Gondal ◽  
Shahida Parveen ◽  
Sumera Mushtaq ◽  
Shumaila Awan ◽  
...  
Keyword(s):  
Ascitic Fluid ◽  
Spontaneous Bacterial Peritonitis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
E Coli ◽  
Bacterial Peritonitis ◽  
Serious Infection ◽  
Culture Sensitivity ◽  
Cirrhotic Patients ◽  
Biochemical Examination

Background: Spontaneous bacterial peritonitis (SBP) is the bacterial infection of ascitic fluid in the absence of other apparent causes. It is the most prevalent and serious infection in cirrhosis and leads to significant morbidity and mortality. The frequency of SBP in hospitalized patients with cirrhosis varies from 7 to 23% in the west and it is around 33% in Pakistan. Our study aim was to determine the frequency of microbial organisms isolated from spontaneous bacterial peritonitis in cirrhotic patients. Material and Methods: We did a cross-sectional study at the Department of Medicine, Fauji Foundation Hospital Rawalpindi for 6 months. Cirrhosis was diagnosed on the bases of clinical, biochemical and ultrasonography findings. Peripheral blood samples were obtained for the evaluation of complete blood cell count, polymorphonuclear leukocyte count, albumin and coagulation parameters. At the same time, the patients underwent paracentesis and a 20ml ascitic fluid sample was taken for culture sensitivity along with routine biochemical examination from the pathology department lab at our hospital. Results: A total of 150 patients were enrolled according to the inclusion criteria of the study. The mean age (yrs) of patients was 32.3+9.31. The frequency and percentages of male and female patients were 70 (46.7) and 80 (53.3) respectively. Frequency and percentages of E Coli and streptococcal pneumonia were 94 (62.7) and 34 (22.7) respectively, whereas frequency and percentages of staph aureus and Klebsiella were 22 (14.7). Conclusion: SBP is quite common in patients with cirrhosis. It should be suspected in all such cases presenting with typical or atypical features. E Coli was the most common causative organisms in our study but gram-positive organisms were quite frequent as well. Keywords: SBP, Cirrhosis, Peritonitis.

scholarly journals SPONTANEOUS BACTERIAL PERITONITIS

2018 ◽  
Vol 25 (02) ◽  
pp. 302-306
Author(s):  
Noor Gul ◽  
Tahir Habib Rizvi ◽  
Memoona Alam
Keyword(s):  
Liver Cirrhosis ◽  
Frequency Distribution ◽  
Spontaneous Bacterial Peritonitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Medical Wards ◽  
Study Setting

Objectives: To record frequency of spontaneous bacterial peritonitis in patientsof liver cirrhosis with low ascitic protein contents. Methodology: This study included 81 patientswith liver cirrhosis with low ascitic proteins level. All the patients were evaluated for the presenceof spontaneous bacterial peritonitis which was described as frequency distribution table. StudyDesign: Cross Sectional Study. Setting: Medical wards of DHQ and Allied Hospitals (PunjabMedical College) Faisalabad. Duration of Study: 11th May 2011 to 10th November 2011.Results: Spontaneous bacterial peritonitis was present among 29 (35.8%) patients and wasnot present among 52 (64.2%) patients. Conclusion: All the patients with low ascitic proteinlevel should be evaluated for the presence of spontaneous bacterial peritonitis and antibioticprophylaxis should be considered.

Model for End-stage Liver Disease (MELD) in spontaneous bacterial peritonitis –a clinical study at a tertiary health center in Nepal

2013 ◽  
Vol 2 (2) ◽  
pp. 47-51
Author(s):  
Rahul Pathak ◽  
Kiran Niraula ◽  
Prem Krishna Khadga ◽  
Kumar Vikram Singh ◽  
Ishwar Sharma
Keyword(s):  
Liver Disease ◽  
Spontaneous Bacterial Peritonitis ◽  
Adverse Outcomes ◽  
Categorical Variables ◽  
Cross Sectional ◽  
Urea Level ◽  
Predictors Of Mortality ◽  
Bacterial Peritonitis ◽  
End Stage Liver Disease ◽  
End Stage

Background and Aims: The aim of this study was to assess the predictive value of different variables including the Model of End-stage Liver Disease (MELD) scores in hospitalized patients with spontaneous bacterial peritonitis (SBP) and its correlation with adverse outcomes. Methods: A cross-sectional study of 73 patients diagnosed with cirrhosis, ascites, and spontaneous bacterial peritonitis admitted to a gastroenterology department from February 2010 to November 2012. MELD scores were calculated using laboratory parameters and the United Network of Organ Sharing (UNOS) internet MELD tool. Results: Categorical variables and mortality status were analyzed for association by chi-square test. MELD scores and all-cause mortality were found to be positively correlated. Mortality was higher among the groups with MELD scores greater than 15. Upon stratification of the groups by mortality status, only age and urea level were novel and consistent predictors of mortality. Conclusions: In this Nepalese sample of cirrhotic patients, MELD scores along with age and urea level were confirmed as significant predictors of mortality. DOI: http://dx.doi.org/10.3126/jaim.v2i2.8776  J ournal of Advances in Internal Medicine 2013;02(02):47-51

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