scholarly journals High Density Lipoprotein from Egg Yolk (EYHDL) Improves Dyslipidemia by Mediating Fatty Acids Metabolism in High Fat Diet-induced Obese Mice

2019 ◽  
Vol 39 (2) ◽  
pp. 179-196 ◽  
Author(s):  
Zhihui Yu ◽  
Changyi Mao ◽  
Xing Fu ◽  
Meihu Ma
Keyword(s):  
Fatty Acids ◽  
High Density Lipoprotein ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Egg Yolk ◽  
High Density ◽  
Obese Mice ◽  
High Fat ◽  
Fatty Acids Metabolism

scholarly journals Evaluation of antiatherogenic effect of Alternanthera brasiliana Linn kuntz in rats on atherogenic diet

2019 ◽  
Vol 8 (6) ◽  
pp. 1172
Author(s):  
Urmi Choudhury ◽  
Tarali Devi ◽  
Asha Borah
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Methanolic Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Serum Total Cholesterol ◽  
Low Density ◽  
High Fat

Background: Hypercholesterolaemia is a major risk factor for systemic atherosclerosis and a well-known etiological factor for cardiovascular diseases and its complications which is a leading cause of mortality worldwide. In a recent study, the antihyperlipidemic activity of dried leaves extract of Alternanthera brasiliana has been evaluated. Hence, the present study was undertaken to investigate the anti-atherosclerotic potential of the methanolic extract of the leaves of Alternanthera brasiliana L. Kuntz (MEAB) in high fat diet induced hypercholesterolemic rat model.Methods: Thirty (30) wistar albino rats of either sex were randomly divided into five groups: first two groups received normal diet and high fat diet respectively and the remaining three groups received high fat diet supplemented with methanolic extract of Alternanthera brasiliana (MEAB) administered orally daily at two different doses: 200 mg/kg and 400 mg/kg and Atorvastatin 10 mg/kg/day orally as standard respectively. Serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) was estimated after 12 weeks. Atherogenic index was calculated from the results of lipid profile. At the end, the aorta was removed for assessment of atherosclerotic plagues.Results: Our results showed that MEAB possessed significant cholesterol lowering potency as indicated by decrease in serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) accompanied by an increase in serum high density lipoprotein (HDL-C) and reduces the atherosclerotic lesion of aorta (p <0.05).Conclusions: These results strongly suggests that MEAB can prevent the progress of atherosclerosis likely due to the effect of A. brasiliana on serum lipoproteins and its antioxidant and anti-inflammatory properties. It could be a potential therapy for the prevention and treatment of atherosclerosis.

scholarly journals Changes in high-density lipoprotein microRNA might create a lasting memory of high-fat diet

2019 ◽  
Vol 116 (7) ◽  
pp. 1237-1239
Author(s):  
Aránzazu Chamorro-Jorganes ◽  
Maryam Anwar ◽  
Costanza Emanueli
Keyword(s):  
High Density Lipoprotein ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
High Density ◽  
High Fat

scholarly journals Animal Models with Metabolic Syndrome Markers Induced by High Fat Diet and Fructose

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Larantika Hidayati ◽  
Agung Dwi Wahyu Widodo ◽  
Boerhan Hidayat
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
High Density Lipoprotein ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
High Fat ◽  
Lipid Metabolism Disorder ◽  
The Metabolic Syndrome

Metabolic syndrome is lipid and non-lipid metabolism disorder due to the association of several factors such as physiological, clinical, biochemical, and interrelated factors. People with metabolic syndrome can be diagnosed by fulfilling 3 of 5 criteria, including obesity and increased waist circumference, increased TG levels, increased blood pressure, hyperglycemia, and increased High-Density Lipoprotein (HDL) serum. The high-fat diet disrupts tissue lipid metabolism, so insulin resistance occurs due to lipotoxicity. Besides, some studies use a combination of mixtures (fructose, sucrose) and fat-rich food components to build metabolic characteristics in mice that affect human characteristics. The purpose of this study was to make an animal model with a metabolic syndrome marker induced by the High Fat Diet (HFD) consisting of pork oil and chicken egg yolk, as well as fructose from simple and economical ingredients. This study was an experimental study using experimental animals of male Rattus norvegicus strain wistar, which were grouped into three random treatment groups, namely the control group, HFD group, and High Fat Diet Fructose (HFDF) group. The number of samples used was 27 rats, with nine rats in each group. The animal was induced for four weeks, then measured levels of FPG, HD, and TG. From the research that has been done, it is found that there are significant differences in levels of Fasting Plasma Glucose (FPG), High-Density Lipoprotein (HDL), and Triglycerides (TG) (p <0.05). It can be concluded egg yolks, lard, and fructose in high-fat diets combined with fructose can increase levels of FPG, TG and reduce levels of HDL, which are markers of the metabolic syndrome used in this study.

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