Endometrial Intraepithelial Neoplasia

2014 ◽  
Vol 138 (4) ◽  
pp. 484-491 ◽  
Author(s):  
Richard A. Owings ◽  
Charles M. Quick
Keyword(s):  
Intraepithelial Neoplasia ◽  
Current Data ◽  
Sequence Classification ◽  
National Library ◽  
Comprehensive Review ◽  
Endometrial Intraepithelial Neoplasia ◽  
Proliferative Endometrium ◽  
Reproducible Method ◽  
Review Current

Context.—Developed in conjunction with molecular and progression data, the sequence classification schema for endometrial intraepithelial neoplasia (EIN)/benign hyperplasia (BH) provides an easy to adopt and reproducible method for classification of endometrial biopsies. Objective.—To review current data supporting the use of BH/EIN to classify endometrial biopsies, and to discuss the hormone-driven endometrial sequence from anovulation/disordered proliferative endometrium through BH and EIN and their diagnostic difficulty. Data Sources.—A comprehensive review of EIN literature based on literature indexed by PubMed (National Library of Medicine) and Google Scholar. Conclusions.—The BH/EIN schema is gaining wider acceptance among pathologist and clinicians. The research leading to the EIN criteria is based on molecular and progression data. The BH/EIN schema has better reproducibility among pathologists, is intuitively easy to use, and requires understanding of endometrial physiology and neoplasia.

Congruence Between 1994 WHO Classification of Endometrial Hyperplasia and Endometrial Intraepithelial Neoplasia System

2019 ◽  
Vol 153 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Antonio Travaglino ◽  
Antonio Raffone ◽  
Gabriele Saccone ◽  
Massimo Mascolo ◽  
Maurizio Guida ◽  
...  
Keyword(s):  
Endometrial Hyperplasia ◽  
Meta Analysis ◽  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Classification Systems ◽  
World Health ◽  
Endometrial Intraepithelial Neoplasia ◽  
Subgroup Analyses ◽  
Health Organization

Abstract Objectives To assess congruence between World Health Organization (WHO) 1994 and endometrial intraepithelial neoplasia (EIN) classification systems of endometrial hyperplasia. Methods Systematic review and meta-analysis were performed by searching electronic databases for studies that classified endometrial hyperplasia according to both WHO 1994 and EIN systems. Congruence was based on the rate of specimens classified as EIN in WHO categories, which should be virtually 0.000 in nonatypical hyperplasia (NAH) and 1.000 in atypical hyperplasia (AH). Subgroup analyses were performed based on architecture complexity. Results Eight studies with 1,352 hyperplasias were included. Congruence with EIN criteria was fair in NAH (0.241) and moderate in AH (0.815). Subgroup analyses of NAH showed high congruence in simple NAH (0.065), null in complex NAH (0.517), null in simple AH (0.148), and high in complex AH (0.901). Conclusions WHO 1994 system is not congruent with the EIN system and cannot be directly translated into a dual classification.

scholarly journals Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies

Cancer ◽  
2008 ◽  
Vol 113 (8) ◽  
pp. 2073-2081 ◽  
Author(s):  
James V. Lacey ◽  
George L. Mutter ◽  
Marisa R. Nucci ◽  
Brigitte M. Ronnett ◽  
Olga B. Ioffe ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Intraepithelial Neoplasia ◽  
Endometrial Intraepithelial Neoplasia

scholarly journals Assessing the prognostic value of PAX2 and PTEN in endometrial carcinogenesis

2018 ◽  
Vol 25 (12) ◽  
pp. 981-991
Author(s):  
Emma Rewcastle ◽  
Anne Elin Varhaugvik ◽  
Einar Gudlaugsson ◽  
Anita Steinbakk ◽  
Ivar Skaland ◽  
...  
Keyword(s):  
High Risk ◽  
Prognostic Value ◽  
Progression Free Survival ◽  
Intraepithelial Neoplasia ◽  
Free Survival ◽  
Endometrial Intraepithelial Neoplasia ◽  
Progression Of Disease ◽  
Proliferative Endometrium ◽  
Progression Risk ◽  
Pax2 Expression

In order to avoid the consequences of over- and under-treatment of endometrial hyperplasia, diagnostic accuracy and progression risk assessment must be improved. The aim of this study was to assess whether PAX2 or PTEN expression could predict progression-free survival in endometrial intraepithelial neoplasia (EIN) and endometrial endometrioid carcinoma (EEC). Immunohistochemistry for detection of PAX2 and PTEN was performed on 348 endometrial samples; 75 proliferative endometrium (PE), 36 EIN and 237 EEC. Cases classified as PTEN null (1 or more glands negatively stained) were more prevalent in EEC than in PE and EIN (64% EEC vs 11% PE/EIN). A progressive decrease in PAX2 expression was observed from PE to EIN to EEC. Long-term clinical follow-up (6–310 months, median: 126) was available for 62 PE cases, all 36 EIN cases and 178 EEC cases. No patients with PE demonstrated progression to EIN or EEC. Progression of disease was observed in 10 (28%) EIN patients. These patients had significantly lower PAX2 expression than those that regressed (P = 0.005). Progression-free survival analysis revealed that EIN patients with a high-risk PAX2 expression score (H-score ≤75) had a higher probability of progression of disease in comparison to those with a low-risk score (H-score >75). PAX2 expression was not prognostic in EEC nor was PTEN status of prognostic value in either EIN or EEC. PAX2 expression analysis by means of H-score has prognostic potential for the identification of high-risk progression cases in EIN but needs to be validated in a larger cohort.

An Update on Reporting Histopathologic Prognostic Factors in Melanoma

2011 ◽  
Vol 135 (7) ◽  
pp. 825-829
Author(s):  
Doina Ivan ◽  
Victor G. Prieto
Keyword(s):  
Prognostic Factors ◽  
Personal Experience ◽  
Interobserver Variability ◽  
Tumor Staging ◽  
Current Data ◽  
Metastatic Lesions ◽  
Melanocytic Lesions ◽  
Predominant Type ◽  
Reproducible Method ◽  
Review Current

Abstract Context.—Accurate diagnosis of melanocytic lesions is essential for the adequate clinical management of patients. Thus, thorough reporting of histopathologic parameters, especially in the initial biopsies, is a critical component of both diagnosis and staging. Objective.—o review current data on histopathologic prognostic factors for melanoma, with special emphasis on their use and applicability to clinical practice. Special attention is focused on the criteria highlighted by the new 2009 version of The American Joint Committee on Cancer (AJCC) system of melanoma staging and classification. Data Sources.—Published peer-reviewed literature and personal experience of the authors. Conclusions.—When reporting melanoma, we recommend that a template be provided, including all the histologic parameters that have been proved significant in determining the tumor staging and prognosis of a patient. The template may also include other details that may be helpful in further analysis of potential complete excisional biopsies or metastatic lesions, such as predominant type of tumor cells, presence or absence of desmoplastic component, or associated benign melanocytic lesions. Although there are several drawbacks in reporting some of these histopathologic parameters (interobserver variability, occasional lack of a perfectly reproducible method for quantifying these criteria), we suggest that at least the essential histopathologic parameters highlighted by the newest version of the AJCC system for melanoma staging and classification should be included in the report.

Endometrial hyperplasia (Clinical lecture)

2016 ◽  
pp. 10-18 ◽  
Author(s):  
I.B. Vovk ◽  
◽  
N.Е. Gorban ◽  
O.Ju. Borysiuk ◽  
◽  
...  
Keyword(s):  
Key Words ◽  
Hormonal Therapy ◽  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Diagnosis And Treatment ◽  
Pathogenetic Mechanisms ◽  
Endometrial Intraepithelial Neoplasia ◽  
Mechanisms Of Development ◽  
Clinical Lecture

In clinical lecture presents modern views of endometrial hyperplasia in terms of practitioner gynecologist. The problems of classification, pathogenetic mechanisms of development of endometrial hyperplasia. Particular attention is paid to modern approaches to diagnosis and treatment of endometrial hyperplasia. Key words: hyperplasia, endometrium, classification, endometrial hyperplasia, endometrial intraepithelial neoplasia, hormonal therapy.

Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis

2020 ◽  
Vol 21 (6) ◽  
pp. 559-572 ◽  
Author(s):  
Yuan Yuan ◽  
Xiaocui Zhou ◽  
Yuanyuan Wang ◽  
Yan Wang ◽  
Xiangyan Teng ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cardiac Hypertrophy ◽  
Therapeutic Potential ◽  
Current Data ◽  
Polyphenolic Compounds ◽  
Comprehensive Review ◽  
Magnolia Officinalis

Honokiol and its isomer magnolol are poly-phenolic compounds isolated from the Magnolia officinalis that exert cardiovascular modulating effects via a variety of mechanisms. They are used as blood-quickening and stasis-dispelling agents in Traditional Chinese Medicine and confirmed to have therapeutic potential in atherosclerosis, thrombosis, hypertension, and cardiac hypertrophy. This comprehensive review summarizes the current data regarding the cardioprotective mechanisms of those compounds and identifies areas for further research.

scholarly journals Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2847
Author(s):  
Allison M. Puechl ◽  
Daniel Spinosa ◽  
Andrew Berchuck ◽  
Angeles Alvarez Secord ◽  
Kerry E. Drury ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Single Gene ◽  
Intraepithelial Neoplasia ◽  
Molecular Classification ◽  
Definitive Treatment ◽  
Time To Progression ◽  
Endometrial Intraepithelial Neoplasia ◽  
Definitive Therapy ◽  
Patients At Risk ◽  
Endometrial Cancers

Background: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LNG-IUS). Methods: Patients treated with LNG-IUS for endometrial cancer or EIN from 2013 to 2018 were evaluated. Using immunohistochemistry and single gene sequencing of POLE, patients were classified into four groups as per the Proactive Molecular Risk Classifier for Endometrial cancer (ProMisE): POLE-mutated, mismatch repair-deficient (MMRd), p53 wild type (p53wt), and p53-abnormal (p53abn). Groups were assessed relative to the primary outcome of progression or receipt of definitive treatment. Results: Fifty-eight subjects with endometrioid endometrial cancer or EIN treated with LNG-IUS were included. Of these, 22 subjects (37.9%) had endometrial cancer and 36 subjects (62.1%) had EIN. Per the ProMisE algorithm, 44 patients (75.9%) were classified as p53wt, 6 (10.3%) as MMRd, 4 (6.9%) as p53abn, and 4 (6.9%) as POLE-mutated. Of the 58 patients, 11 (19.0%) progressed or opted for definitive therapy. Median time to progression or definitive therapy was 7.5 months, with p53abn tumors having the shortest time to progression or definitive therapy. Conclusions: Molecular classification of endometrial cancer and EIN prior to management with LNG-IUS is feasible and may predict patients at risk of progression.

scholarly journals A comprehensive review of sucker rod pumps’ components, diagnostics, mathematical models, and common failures and mitigations

2021 ◽  
Author(s):  
Sherif Fakher ◽  
Abdelaziz Khlaifat ◽  
M. Enamul Hossain ◽  
Hashim Nameer
Keyword(s):  
Mathematical Models ◽  
Oil And Gas ◽  
Oil And Gas Industry ◽  
Gas Industry ◽  
Holistic View ◽  
Comprehensive Review ◽  
Artificial Lift ◽  
Sucker Rod ◽  
Sucker Rod Pump

AbstractIn many oil reservoirs worldwide, the downhole pressure does not have the ability to lift the produced fluids to the surface. In order to produce these fluids, pumps are used to artificially lift the fluids; this method is referred to as artificial lift. More than seventy percent of all currently producing oil wells are being produced by artificial lift methods. One of the most applied artificial lift methods is sucker rod pump. Sucker rod pumps are considered a well-established technology in the oil and gas industry and thus are easy to apply, very common worldwide, and low in capital and operational costs. Many advancements in technology have been applied to improve sucker rod pumps performance, applicability range, and diagnostics. With these advancements, it is important to be able to constantly provide an updated review and guide to the utilization of the sucker rod pumps. This research provides an updated comprehensive review of sucker rod pumps components, diagnostics methods, mathematical models, and common failures experienced in the field and how to prevent and mitigate these failures. Based on the review conducted, a new classification of all the methods that can fall under the sucker rod pump technology based on newly introduced sucker rod pump methods in the industry has been introduced. Several field cases studies from wells worldwide are also discussed in this research to highlight some of the main features of sucker rod pumps. Finally, the advantages and limitations of sucker rod pumps are mentioned based on the updated review. The findings of this study can help increase the understanding of the different sucker rod pumps and provide a holistic view of the beam rod pump and its properties and modeling.

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