Biotechnology Venture Investing and Neurodegenerative Medicine: Promise of New Approaches to Cure an Ailing Model

2014 ◽  
Vol 20 (1) ◽  
Author(s):  
Dushon DeVere Riley ◽  
Mark Cochran
Keyword(s):  
Public Health ◽  
Venture Capital ◽  
Neurodegenerative Diseases ◽  
New Technologies ◽  
Genetic Knowledge ◽  
Venture Capitalists ◽  
Financial Model ◽  
The Public ◽  
Public Market ◽  
Public Health Challenges

Neurodegenerative diseases are one of the leading public health challenges of the next 50 years. Pharmaceutical therapies have traditionally targeted the later stages of neurodegenerative diseases; however, this strategy - as the recent failures of clinical trials for Alzheimer’s drugs have highlighted - has been unsuccessful. Venture capital has underperformed as well during this time, as many new companies have been unable to maintain growth once they reach the public market and have produced less than desirable returns. As a result, venture capitalists have opted for later-stage financing. Nevertheless, new technologies are being developed to answer the question of how to best address neurodegeneration. New tools of detection will allow for much earlier diagnosis and a much greater chance of discovering and applying effective treatments. Realizing that genetic knowledge is insufficient to produce innovative treatments for neurodegenerative diseases, scientists have begun to apply the genetic knowledge attained towards a future of individualized treatments. As these new tools of detection converge with an increased ability to create very precise individual solutions, the risk of successful future investments should come down and provide the potential for outsized returns that have traditionally governed the venture capital financial model.

scholarly journals Effectiveness of Face Coverings in Mitigating the COVID-19 Pandemic in the United States

2021 ◽  
Vol 18 (7) ◽  
pp. 3666
Author(s):  
Olukayode James Ayodeji ◽  
Seshadri Ramkumar
Keyword(s):  
Public Health ◽  
United States ◽  
District Of Columbia ◽  
Preventive Measure ◽  
The United States ◽  
Protective Measure ◽  
Sharp Change ◽  
The Public ◽  
Public Health Challenges ◽  
Effective Preventive Measure

The COVID-19 pandemic has been one of the biggest public health challenges of the 21st century. Many prevalent measures have been taken to prevent its spread and protect the public. However, the use of face coverings as an effective preventive measure remains contentious. The goal of the current study is to evaluate the effectiveness of face coverings as a protective measure. We examined the effectiveness of face coverings between 1 April and 31 December 2020. This was accomplished by analyzing trends of daily new COVID-19 cases, cumulative confirmed cases, and cases per 100,000 people in different U.S. states, including the District of Columbia. The results indicated a sharp change in trends after face covering mandates. For the 32 states with face covering mandates, 63% and 66% exhibited a downward trend in confirmed cases within 21 and 28 days of implementation, respectively. We estimated that face covering mandates in the 32 states prevented approximately 78,571 and 109,703 cases within 21- and 28-day periods post face covering mandate, respectively. A statistically significant (p = 0.001) negative correlation (−0.54) was observed between the rate of cases and days since the adoption of a face covering mandate. We concluded that the use of face coverings can provide necessary protection if they are properly used.

Zoom; or, Obsolescence

2021 ◽  
Vol 65 (3) ◽  
pp. 181-200
Author(s):  
W.B. Worthen
Keyword(s):  
Public Health ◽  
New Technologies ◽  
Virus Transmission ◽  
Electronic Media ◽  
Theatrical Production ◽  
Health Concerns ◽  
The Public

The signal modality of theatrical production during the pandemic crisis of 2020–21 has been Zoom theatre. While Zoom theatre responds to public health concerns regarding virus transmission, it also articulates a vision of performance at the intersection of the public and the private, at the juncture between theatre and electronic media, and as a representation of theatre as a humanizing technology. Theatre has suggestively foregrounded new technologies under the sign of obsolescence, and in the affective register of nostalgia.

scholarly journals A Review of the Public Health Challenges of Salmonella and Turtles

2020 ◽  
Vol 7 (2) ◽  
pp. 56
Author(s):  
Hamid Reza Sodagari ◽  
Ihab Habib ◽  
Majedeh Pakzad Shahabi ◽  
Narelle A. Dybing ◽  
Penghao Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Animal Origin ◽  
Indirect Contact ◽  
Children Under Five ◽  
The Public ◽  
Under Five ◽  
Human Salmonellosis ◽  
Public Health Challenges ◽  
Client Education

Non-typhoidal Salmonella serovars are recognized as zoonotic pathogens. Although human salmonellosis is frequently associated with ingestion of contaminated foods of animal origin, contact with animals may also be a significant source of Salmonella infection, especially contact with turtles, which have shown to be an important reservoir of Salmonella, specifically through their intestinal tracts. Turtles are among the most common reptiles kept as house pets that may pose a public health risk associated with Salmonella exposure, especially among infants and young children. This review discusses the literature reporting the link between turtles and Salmonella as well as turtle-associated human salmonellosis in the last ten years. In most outbreaks, a high proportion of patients are children under five years of age, which indicates that children are at the greatest risk of turtle-associated salmonellosis. Therefore, turtles should not be preferred as recommended pets for children under five years of age. Reducing turtle stress to minimise Salmonella shedding as well as providing client education handouts at the points of sale of these animals may reduce the risk of transmitting such significant pathogen to humans. Further studies are required to investigate the role of both direct contact with turtles as well as indirect contact through cross-contamination in the transmission of turtles-associated Salmonella to humans.

Public health challenges during the COVID-19 outbreak in Nepal: a commentary

2020 ◽  
Vol 34 (4) ◽  
pp. 373-376 ◽  
Author(s):  
Sharmistha Sharma ◽  
Jeevan Bhatta
Keyword(s):  
Public Health ◽  
Design Methodology ◽  
Health Workers ◽  
Health Interventions ◽  
Content Type ◽  
The Public ◽  
Public Health Challenges ◽  
Current Scenario ◽  
Public Health Officials ◽  
The Government

PurposeThe purpose of this paper is to depict the current scenario of coronavirus diseases 2019 (COVID-19) in Nepal, how the government is tackling this pandemic as well as look at the public health challenges that Nepal is facing and might face in the future.Design/methodology/approachThis paper is a viewpoint of COVID-19 activities conducted in Nepal.FindingsNepal is vulnerable to COVID-19, as it shares borders with China and India. Cases have started to be seen in different parts of Nepal. Government of Nepal has started various measures to control the spread of the virus such as deploying health workers, information sharing via different mediums. However, there are still many challenges that the government and public health officials need to be concerned about as well.Originality/valueThis paper provides information about the situation of COVID-19 in Nepal, how the government is handling, and public health challenges that may arise. This paper can be beneficial for further public health interventions.

Effectives of private equity and venture capital investments comparing with stock and bond market

2017 ◽  
Vol 18 (2) ◽  
pp. 57-70
Author(s):  
Piotr Zasępa
Keyword(s):  
Venture Capital ◽  
Private Equity ◽  
Flow Characteristics ◽  
Bond Market ◽  
Capital Investments ◽  
The Public ◽  
Public Market ◽  
Equivalent Method ◽  
Rate Of Returns ◽  
Venture Capital Investments

This paper examines approach and possibility of comparison of venture capital rate of returns with specific public benchmarks. Rate of return that are used by the public market analytics do not fit within venture capital cash flow characteristics. One of the methods that are presented in this article is Public Market Equivalent which enable simple comparison of venture capital rate of returns with effects of the public index or bond market for Bond Market Equivalent method.

scholarly journals Keeping Public Health Surveillance Practice up to Speed: a Training Strategy to Build Capacity

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Kathleen Laberge ◽  
Lisa Jensen ◽  
Dr. Philip Abdelmalik ◽  
Katie Rutledge-Taylor ◽  
Lena Shah
Keyword(s):  
Public Health ◽  
New Technologies ◽  
Public Health Practice ◽  
Training Strategy ◽  
Learner Outcomes ◽  
Health Community ◽  
Public Health Challenges ◽  
Fluid Environment ◽  
Surveillance Practice ◽  
Public Health Practitioners

Surveillance practice is evolving rapidly: globalization of health threats, emergence of infectious diseases, and explosion of easily accessible new technologies. This fluid environment challenges the public health community, but provides it with a fertile environment to innovate and improve its practice. As surveillance is a core function of public health practice, public health practitioners need to be well equipped to achieve this function and address present and future public health challenges. We developed a training course that focused on the practical use of surveillance concepts and principles. We are sharing findings on the development of the course and learner outcomes.

scholarly journals Potential Applications of Emerging Technologies in Disease Surveillance

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Jay Huang ◽  
Wayne Loschen
Keyword(s):  
Public Health ◽  
Health Professionals ◽  
Disease Surveillance ◽  
Public Health Surveillance ◽  
New Technologies ◽  
Emerging Technologies ◽  
Surveillance Systems ◽  
The Public ◽  
Public Health Professionals ◽  
Health Field

ObjectiveThe objective of this presentation is to explore emerging technologies and how they will impact the public health field. New technologies such as blockchain, artificial intelligence (AI), and the Internet of Things (IoT) will likely be incorporated into epidemiological methods and processes. This presentation will provide an overview of these technologies and focus on how they may impact public health surveillance in the future.IntroductionWith the increase in the amount of public health data along with the growth of public health informatics, it is important for epidemiologists to understand the current trends in technology and the impact they may have in the field. Because it is unfeasible for public health professionals to be an expert in every emerging technology, this presentation seeks to provide them with a better understanding of how emerging technologies may impact the field and the level of expertise required to realize benefits from the new technologies. Furthermore, understanding the capabilities provided by emerging technologies may guide future training and continuing education for public health professionals.MethodsAnalysis of current capabilities and potential advances in emerging technologies such as blockchain, AI, and IoT were performed by reviewing articles and whitepapers. In addition to a literature review, interviews will be performed with public health experts to determine how the emerging technologies align with current practices and the extent to which they may solve existing public health surveillance challenges.ResultsThe literature review revealed many emerging technologies and potential applications in the public health field, including:BlockchainBlockchains can serve as electronic health information exchanges that hold the metadata and access information for patient electronic health records (EHRs).1 These systems can ensure data privacy protections while also facilitate relevant data sharing from EHRs to disease surveillance systems. Furthermore, blockchain technology can be used in food supply chain management systems. During food contamination events, epidemiologists can trace through the blockchain to identify possible sources of the contamination.2AIAI can be used to improve the prediction and detection capabilities of disease surveillance systems. Machine learning algorithms can reveal patterns in the data and enable faster anomaly detection. Furthermore, machine learning models can be trained on data to create predictive models.IoTUrban IoT systems can monitor environmental indices including water and air quality, energy consumption, waste management, and traffic congestion in smart cities.3 The data collected from such systems can be incorporated into more comprehensive disease surveillance systems and assist epidemiologists in better understanding populations and environmental risk factors.We will analyze and discuss such prospective applications with public health professionals to determine their potential impact on public health processes and practices in the next one, five, and ten years.ConclusionsBlockchain, AI, IoT and other emerging technologies have applications in public health surveillance and impact the field to varying degrees. In addition to technological advances, there will be barriers to adoption that must be overcome before the value provided by the technologies can be realized. Many new technologies will require significant collaboration between public health departments, healthcare providers, and other partners to successfully incorporate the technologies into epidemiological processes. These collaborations include forming consortiums to exchange data in a blockchain and working with IoT providers for data access. Some technologies will require public health professionals to obtain additional training before they can take full advantage of the capabilities provided, while other technologies may be implemented by external partners allowing epidemiologists to utilize the new capabilities without the need to completely understand the underlying concepts. As emerging technologies are introduced into the public health field, a strong understanding of their capabilities and suitable applications will allow public health professionals to fully capture the benefits provided by the new technologies.References1. Ekblaw A, Azaria A, Halamka JD, Lippman A. A Case Study for Blockchain in Healthcare:“MedRec” prototype for electronic health records and medical research data. InProceedings of IEEE open & big data conference 2016 Aug 22 (Vol. 13, p. 13).2. Yiannas F. A New Era of Food Transparency Powered by Blockchain. Innovations: Technology, Governance, Globalization. 2018 Jul;12(1-2):46-56.3. Zanella A, Bui N, Castellani A, Vangelista L, Zorzi M. Internet of things for smart cities. IEEE Internet of Things Journal. 2014 Feb 14;1(1):22-32.

PP50 Microcosting With Time-Driven Activity-Based Costing Applied On Brazilian HTA System: ECMO Case Study

2018 ◽  
Vol 34 (S1) ◽  
pp. 85-86
Author(s):  
Ana Paula B S Etges ◽  
Priscila da Rosa ◽  
Regina K Notti ◽  
Luciane N Cruz ◽  
Madeni Doebber ◽  
...  
Keyword(s):  
Public Health ◽  
Health System ◽  
New Technologies ◽  
Public Health System ◽  
Critical Element ◽  
Activity Based Costing ◽  
The Real ◽  
The Public ◽  
Cardiorespiratory Failure ◽  
Implementation Costs

Introduction:Extracorporeal circulatory membrane oxygenation (ECMO) is a technology that allows recovery of adults in cardiorespiratory failure with encouraging results, but is not available in the Brazilian universal public health system (SUS) due to high implementation costs. Time-driven activity based costing (TDABC) is applied to measure processes in an economic perspective by identifying opportunities to make processes more efficient through the reduction of resources used in each activity. The literature has explored the use of TDABC to measure costs related with clinical procedures and technologies in microcosting studies, identifying opportunities to improve the process by making it more efficient. This research measures the real costs to implement ECMO in Brazil to compare with the current public reimbursement system.Methods:This study applied TDABC using data from 6 patients to measure costs of ECMO intervention considering the public perspective in Brazil. In sequence, standard price payed by SUS was used to estimate the current reimbursement amount received by the hospital for ECMO procedure. Cost variable analysis was conducted to understand when and how patients receiving ECMO are using hospital resources. Cost data were collected from an academic public hospital using an average of 18 months (2016–2017) for the department costs.Results:The real average cost was USD 128,923. Most significant resource costs was medical staff, particularly for the three survivor patients, and the ECMO equipment presented the second highest cost. ECMO activities were separated into: before implantation of ECMO, period using ECMO, intensive care post-ECMO and rehabilitation, being the period where ECMO is the most expensive, particularly in nurse and physician costs. The SUS average was USD 31,437, which shows a difference of USD 97,485 between the real ECMO cost and the public reimbursement in Brazil.Conclusions:A critical element of the propagation of ECMO in Brazil and its reimbursement by public health system is the high cost and out-of-date standard payments by the Ministry of Health. Effort to implement a trustworthy method to guide decisions of SUS for the adoption and financing new technologies is essential to contribute to the optimization of public health policies in a country with a universal health system and limited resources dedicated to health sectors.

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