scholarly journals Effect of pregelatinization and carboxymethylation on starches from African rice and Fonio: Influence on release of low melting-point drug Starch modifications for drug release

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Adebisi Adeola ◽  
Kofi Asare-Addo ◽  
Michael Ayodele Odeniyi ◽  
Omobolanle A Omoteso ◽  
Waseem Kaialy
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
African Rice ◽  
Starch Modifications

Mechanism of Drug Release From Temperature-Sensitive Formulations Composed of Low-Melting-Point Microcrystalline Wax

2019 ◽  
Vol 108 (6) ◽  
pp. 2086-2093 ◽  
Author(s):  
Kohei Matsumoto ◽  
Shin-ichiro Kimura ◽  
Shuji Noguchi ◽  
Shigeru Itai ◽  
Hiromu Kondo ◽  
...  
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
Temperature Sensitive

scholarly journals DEVELOPMENT AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE LOADED OCULAR INSERT BY USING “PLANTAGO OVATA” AS NATURAL POLYMER

2018 ◽  
Vol 10 (4) ◽  
pp. 79
Author(s):  
Ayushi Chourasia ◽  
Shikha Agrawal
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
Release Profile ◽  
Natural Polymer ◽  
Plantago Ovata ◽  
In Vitro Drug Release ◽  
Ciprofloxacin Hydrochloride ◽  
Long Acting ◽  
Ocular Insert

Objective: The present work focus in the direction of “Development and evaluation of Ciprofloxacin Hydrochloride loaded ocular insert by using “plantago ovata” as natural polymer”. The current work was carried out to evaluate the control release profile of ocular insert. Natural polymer in ocular insert was used for studying the long acting property. Natural polymer is also used to enhance the bioavailability of drug and reduce toxicity. It is also used to increase the duration of action of drug for prolongs action and gives better in vitro performance as compare than to the conventional ocular formulation.Methods: Solvent casting method was used in the formulation of Ciprofloxacin Hydrochloride loaded ocular inserts. Different ocular insert formulations of varying polymer concentration were prepared. Ocular insert formulation H-1 to H-3 was prepared by using different concentration of HPMC and formulation P-1 to P-4 was prepared by using different concentration of Plantago Ovata.Results: The ocular inserts formulation was within the acceptable limits. All the pre formulation parameters of polymers such as derived properties, compressibility index, Hausner’s ratio, viscosity, melting point, swelling ratio, loss on drying, PH of mucilage solution and pre formulation of active pharmaceutical ingredient such as estimation of drug by using UV spectroscopy, determination of melting point, solubility, partition coefficient and FTIR for compatibility study of drug and excipient were evaluation. FTIR analysis also confirmed no drug-excipient interaction.Conclusion: Prepared inserts in the present study were semitransparent. The mixing of the drug in to the polymer is uniform, due to this; the drug content of all formulation is good. Formulation P4 was selected because it showed better release profile, drug content and other physicochemical properties than other formulated batch when compare. All the prepared inserts showed in vitro drug release for the period of 4 h as compare to the marketed formulation. An in vitro drug release study revealed that ocular formulation gives a prolong action. The formulation was found to be long acting.

scholarly journals Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

2015 ◽  
Vol 31 (8) ◽  
pp. 920-929 ◽  
Author(s):  
Ali Dabbagh ◽  
Reza Mahmoodian ◽  
Basri Johan Jeet Abdullah ◽  
Hadijah Abdullah ◽  
Mohd Hamdi ◽  
...  
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
Triggered Drug Release

scholarly journals BIOAVAILABILITY AND DISSOLUTION ENHANCEMENT OF GLYBURIDE NANOSUSPENSION

2019 ◽  
pp. 111-118
Author(s):  
PRADEEP KUMAR M
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
Methyl Cellulose ◽  
Rat Plasma ◽  
Water Soluble ◽  
Diffusion Method ◽  
Dissolution Enhancement ◽  
Particle Analysis ◽  
Chromatography Method

Objective: The main objective was to develop nanosuspension of glyburide (GLY) by quasi emulsification solvent diffusion method and to enhance dissolution and bioavailability characteristics of the drug GLY, an antidiabetic drug which belongs to Biopharmaceutical Classification System-II category. Materials and Methods: In this work, nanoparticles were prepared using polyvinyl alcohol, hydroxypropyl methyl cellulose, and Eudragit RL100. Twelve formulations of GLY (GLY-1–GLY-12) were formulated using the excipients at various compositions. Drug and excipient compatibility studies were conducted using Fourier transform infrared and differential scanning calorimeter. The prepared nanosuspension was analyzed using scanning electron microscopy for surface of the particle analysis, melting point, solubility, particle charge zeta (mv), percentage drug entrapment efficiency (%), and in vitro drug release. The optimized formulations of nanosuspension were further studied for in vivo pharmacokinetic evaluation. Reverse-phase high-performance liquid chromatography method was developed, validated, and used for the study of these formulations in rat plasma. Results: From these studies, it was confirmed that drugs and excipients chosen were compatible with each other. GLY-8 was the best formulation with a particle size of 85–96 nm with 168.7°C melting point, freely soluble in phosphate buffer pH 7.4, 93.53% drug entrapment, and 90.26±1 mV of zeta potential. This formulation shows percentage drug release of 99.85% in 24 h. In vivo pharmacokinetic study for optimized formulation (GLY -8) suggested that there was no reaction with the rat plasma. From the results, it was shown that Cmax and Tmax were found to be 0.604±0.03 μg/ml and 2±1.01 h, respectively. The values of t1/2 (h), area under the curve (AUC) (0-t), and AUC (0-∞) were found to be 10.04 h, 2.562±0.41 μg.h/ml, and 2.147±0.45 μg.h/ml, respectively. Conclusion: Based on the results obtained, oral administration of nanosuspension could not only provide the better absorption of poorly water soluble drugs but may also reduce toxicity and provide a new tool in drug delivery system.

scholarly journals EVALUATION OF STERCULIA FOETIDA L. GUM AS NATURAL BASED CONTROLLED RELEASE EXCIPIENT

2019 ◽  
Vol 57 (4) ◽  
pp. 428
Author(s):  
Vu Thi Hong Quan ◽  
Nguyen Thi Quan ◽  
Mai Thanh Phong ◽  
Le Thi Kim Phung
Keyword(s):  
Melting Point ◽  
Controlled Release ◽  
Drug Release ◽  
Physicochemical Properties ◽  
Electron Micrographs ◽  
Dosage Forms ◽  
Particle Sizes ◽  
Scanning Electron Micrographs ◽  
Scanning Electron

Therefore, the physicochemical properties of Sterculia foetida L. gum, including solubility, scanning electron micrographs, melting point, swelling index, pH, viscosity, loss on drying were determined. Furthermore, compressed tablets were successfully prepared for in vitro studies at many different particle sizes, concentrations of gum, rotational speeds and media in order to evaluate the effects of these parameters on the rate of drug release. Besides, SFG tablets were compared with the tablets prepared with Hydroxymethylcellulose E15. The findings indicated that Sterculia foetida L. gum exhibited an excellent potential in managed release dosage forms. 

scholarly journals In vivo temperature-sensitive drug release system trigged by cooling using low-melting-point microcrystalline wax

2019 ◽  
Vol 303 ◽  
pp. 281-288 ◽  
Author(s):  
Kohei Matsumoto ◽  
Shin-ichiro Kimura ◽  
Shigeru Itai ◽  
Hiromu Kondo ◽  
Yasunori Iwao
Keyword(s):  
Melting Point ◽  
Drug Release ◽  
Temperature Sensitive ◽  
Release System ◽  
Drug Release System

Voids in Irradiated Tungsten and Molybdenum

1969 ◽  
Vol 27 ◽  
pp. 190-191
Author(s):  
Robert C. Rau ◽  
Robert L. Ladd
Keyword(s):  
Melting Point ◽  
Fast Neutron ◽  
Neutron Irradiation ◽  
Elevated Temperatures ◽  
Irradiation Temperature ◽  
The Body ◽  
Face Centered Cubic ◽  
Body Centered Cubic ◽  
Cubic Metals ◽  
Face Centered

Recent studies have shown the presence of voids in several face-centered cubic metals after neutron irradiation at elevated temperatures. These voids were found when the irradiation temperature was above 0.3 Tm where Tm is the absolute melting point, and were ascribed to the agglomeration of lattice vacancies resulting from fast neutron generated displacement cascades. The present paper reports the existence of similar voids in the body-centered cubic metals tungsten and molybdenum.

The observation of nano-voids in Au thin films

1987 ◽  
Vol 45 ◽  
pp. 366-367
Author(s):  
William Krakow
Keyword(s):  
Thin Films ◽  
Melting Point ◽  
Present Author ◽  
Stacking Faults ◽  
Damage Threshold ◽  
Ionic Species ◽  
Rare Gases ◽  
Chain Defects ◽  
Vacancy Chains ◽  
Au Thin Films

It has long been known that defects such as stacking faults and voids can be quenched from various alloyed metals heated to near their melting point. Today it is common practice to irradiate samples with various ionic species of rare gases which also form voids containing solidified phases of the same atomic species, e.g. ref. 3. Equivalently, electron irradiation has been used to produce damage events, e.g. ref. 4. Generally all of the above mentioned studies have relied on diffraction contrast to observe the defects produced down to a dimension of perhaps 10 to 20Å. Also all these studies have used ions or electrons which exceeded the damage threshold for knockon events. In the case of higher resolution studies the present author has identified vacancy and interstitial type chain defects in ion irradiated Si and was able to identify both di-interstitial and di-vacancy chains running through the foil.

Modified drug release of poloxamer matrix by including water-soluble and water-insoluble polymer

2009 ◽  
Vol 00 (00) ◽  
pp. 090911111149010-8
Author(s):  
Y.M. Gonzalez ◽  
E.S. Ghaly
Keyword(s):  
Drug Release ◽  
Water Soluble ◽  
Insoluble Polymer
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