Alpha and Rocker - Two Design Approaches that led to the Successful Challenge for the 2007 International C-Class Catamaran Championship

2009 ◽  
Author(s):  
Steve Killing
Keyword(s):  
Cross Section ◽  
Driving Force ◽  
State Of The Art ◽  
Ride Height ◽  
Current State ◽  
New Thinking ◽  
The Usa

In 2007 Canada entered its first challenge for the International C-Class Catamaran Championship and was victorious in capturing the trophy with five straight wins by Alpha CAN 6 over the venerable Cogito from the USA. Two boats were designed for this challenge - the first was Alpha, a wingsail catamaran, which incorporated some new thinking on sail configuration and hull shape. This made it a successful evolutionary, but not revolutionary, step from the current state-of-the-art boats. Compared to Cogito, the main rival, she had a taller, narrower and thinner wing, lighter construction and more circular hull cross section. The second was Rocker, the bold hydrofoil catamaran, using hulls from the same mold as Alpha and an identical wingsail as the driving force. The daggerboard hydrofoils automatically controlled the ride height with trim tabs, while the control of the rudder elevators was left to the helmsman. Although she flew well, was very controllable, and was spectacular to watch, Rocker could not match the 20 knot plus speed of Alpha.

scholarly journals Peritoneal Carcinomatosis: Current State of the Art and Schools of Thought

2021 ◽  
Vol 11 (1) ◽  
pp. 85-91
Author(s):  
Sh. Kh. Gantsev ◽  
M. V. Zabelin ◽  
K. Sh. Gantsev ◽  
A. A. Izmailov ◽  
Sh. R. Kzyrgalin
Keyword(s):  
Peritoneal Carcinomatosis ◽  
State Of The Art ◽  
Global Perspective ◽  
Basic Principles ◽  
Global Challenge ◽  
Current State ◽  
Emerging Therapies ◽  
The World ◽  
The Usa ◽  
Scientific Questions

Peritoneal carcinomatosis (PC) is a global challenge of modern oncology representing the most unfavourable scenario in diverse-locality tumourisation. Despite certain attention by the oncological community, the management of PC patients is currently palliative, which weakly promotes research into the basic principles of this morbidity. This literature review attempts to comprehensively cover the PC problematic from a global perspective and presents a key evidence on the world schools of thought in this area. Briefly taking, peritoneal carcinomatosis is viewed today as a local process in the conventional implantation theory, which imposes a locoregional character on all current or emerging therapies, such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Their inadequate efficacy is largely due to pronounced gaps in our understanding of PC logistics and signalling. PSOGI is a key organisation for centralising the specialty effort in peritoneal carcinomatosis. Despite its global geography and approach to PC discussion, a multitude of scientific questions remain unanswered impeding the establishment of novel effective therapies. The seven countries that nurtured distinguished schools of thought in PC studies are the USA, UK, Japan, China, Italy, France and Germany. Taking peritoneal carcinomatosis in a global perspective, an insufficient attention to its problematic in Russia should be addressed. The founding and fostering of national PC institutions will benefit cancer patients and progress in oncological science.

scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

Social-interactional approaches to SLA

2013 ◽  
Vol 4 (2) ◽  
pp. 134-160 ◽  
Author(s):  
Simona Pekarek Doehler
Keyword(s):  
Conversation Analysis ◽  
Driving Force ◽  
Cognitive Process ◽  
State Of The Art ◽  
Social Practices ◽  
Future Research ◽  
Interactional Competence ◽  
Current State ◽  
The Moment ◽  
Oriented Research

In this paper I address the current state of the art in social-interactional research on SLA. I first provide a brief outline of the historical development of those lines of research that are commonly subsumed under the (broad) heading of ‘social-interactional approaches’, and I discuss their conceptual underpinnings as well as some of their research results. I then focus specifically on current research in what has become a major driving force in socially oriented research on SLA, namely conversation analysis (CA-SLA). I discuss some of the empirical evidence CA-SLA has offered for L2 learning as a socio-cognitive process bound up with the moment-to-moment unfolding of L2 speakers’ social practices. I also review its contribution to our understanding of L2 interactional competence and its development over time. I conclude by sketching avenues for future research.

Behavioral Genetics: Concepts for Research and Practice in Language Development and Disorders

1995 ◽  
Vol 38 (5) ◽  
pp. 1126-1142 ◽  
Author(s):  
Jeffrey W. Gilger
Keyword(s):  
Language Development ◽  
Behavioral Genetics ◽  
State Of The Art ◽  
Genetic Research ◽  
Great Promise ◽  
Behavioral Genetic ◽  
Fine Grained ◽  
Future Goals ◽  
Current State ◽  
Research Designs

This paper is an introduction to behavioral genetics for researchers and practioners in language development and disorders. The specific aims are to illustrate some essential concepts and to show how behavioral genetic research can be applied to the language sciences. Past genetic research on language-related traits has tended to focus on simple etiology (i.e., the heritability or familiality of language skills). The current state of the art, however, suggests that great promise lies in addressing more complex questions through behavioral genetic paradigms. In terms of future goals it is suggested that: (a) more behavioral genetic work of all types should be done—including replications and expansions of preliminary studies already in print; (b) work should focus on fine-grained, theory-based phenotypes with research designs that can address complex questions in language development; and (c) work in this area should utilize a variety of samples and methods (e.g., twin and family samples, heritability and segregation analyses, linkage and association tests, etc.).

Schizophrenia Research: Current State of the Art

1976 ◽  
Vol 21 (7) ◽  
pp. 497-498
Author(s):  
STANLEY GRAND
Keyword(s):  
State Of The Art ◽  
Current State

Umbral Calculus

10.37236/24 ◽  
2002 ◽  
Vol 1000 ◽  
Author(s):  
A. Di Bucchianico ◽  
D. Loeb
Keyword(s):  
19Th Century ◽  
Finite Differences ◽  
State Of The Art ◽  
Umbral Calculus ◽  
Current State ◽  
Logical Foundation ◽  
Complete Bibliography ◽  
The 19Th Century ◽  
Mathematical Literature

We survey the mathematical literature on umbral calculus (otherwise known as the calculus of finite differences) from its roots in the 19th century (and earlier) as a set of “magic rules” for lowering and raising indices, through its rebirth in the 1970’s as Rota’s school set it on a firm logical foundation using operator methods, to the current state of the art with numerous generalizations and applications. The survey itself is complemented by a fairly complete bibliography (over 500 references) which we expect to update regularly.

The Receptor-Dependent QSAR Paradigm: An Overview of the Current State of the Art

2009 ◽  
Vol 5 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Osvaldo Santos-Filho ◽  
Anton Hopfinger ◽  
Artem Cherkasov ◽  
Ricardo de Alencastro
Keyword(s):  
State Of The Art ◽  
Current State

Conclusion

2017 ◽  
Author(s):  
Andrea Harris
Keyword(s):  
New York ◽  
Twentieth Century ◽  
New York City ◽  
Driving Force ◽  
George Balanchine ◽  
Current State ◽  
The Arts ◽  
History Of ◽  
Lincoln Center

The Conclusion briefly examines the current state of the New York City Ballet under the auspices of industrial billionaire David H. Koch at Lincoln Center. In so doing, it to introduces a series of questions, warranting still more exploration, about the rapid and profound evolution of the structure, funding, and role of the arts in America through the course of the twentieth century. It revisits the historiographical problem that drives Making Ballet American: the narrative that George Balanchine was the sole creative genius who finally created an “American” ballet. In contrast to that hagiography, the Conclusion reiterates the book’s major contribution: illuminating the historical construction of our received idea of American neoclassical ballet within a specific set of social, political, and cultural circumstances. The Conclusion stresses that the history of American neoclassicism must be seen as a complex narrative involving several authors and discourses and crossing national and disciplinary borders: a history in which Balanchine was not the driving force, but rather the outcome.

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